Glucocorticoids Prevent Enterovirus 71 Capsid Protein VP1 Induced Calreticulin Surface Exposure by Alleviating Neuronal ER Stress

Neurotoxicity Research

Volumn 31, Issue 2, 2017, Pages 204-217

  Hu, Dan Dan ^a,b   Mai, Jian Ning ^b   He, Li Ya ^b   Li, Pei Qing ^b   Chen, Wen Xiong ^b   Yan, Jian Jiang ^b   Zhu, Wei Dong ^b   Deng, Li ^b   Wei, Dan ^c   Liu, Di Hui ^d   Yang, Si Da ^b   Yao, Zhi Bin ^a  

^a SUN YAT SEN UNIVERSITY   (China)

^b Guangzhou Women and Children's Medical Center   (China)

^c FIRST AFFILIATED HOSPITAL OF GUANGXI MEDICAL UNIVERSITY   (China)

^d United Family Healthcare Guangzhou Clinic   (China)

Author keywords

Calreticulin; Enterovirus 71; Glucocorticoids; Hand foot and mouth disease

Indexed keywords

CALRETICULIN; CELL SURFACE PROTEIN; DEXAMETHASONE; GLUCOCORTICOID; PROTEIN VP1; PROTEIN VP2; PROTEIN VP3; PROTEIN VP4; CAPSID PROTEIN; VIRAL PROTEIN; VP1 PROTEIN, FOOT-AND-MOUTH DISEASE VIRUS; VP2 PROTEIN, FOOT-AND-MOUTH DISEASE VIRUS; VP3 PROTEIN, FOOT-AND-MOUTH DISEASE VIRUS; VP4 PROTEIN, FOOT-AND-MOUTH DISEASE VIRUS;

ANIMAL CELL; ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; AUTOPHAGY; BRAIN STEM; CELL ACTIVATION; CELL CULTURE; CELL DEATH; CELL PROTECTION; CELL SURFACE; CELL SURVIVAL; CLINICAL ARTICLE; CONTROLLED STUDY; ECTO CRT GENE; ENDOPLASMIC RETICULUM STRESS; ENTEROVIRUS A71; FEMALE; GENE OVEREXPRESSION; GENE TRANSLOCATION; GLIA; HAND FOOT AND MOUTH DISEASE; HUMAN; HUMAN TISSUE; MALE; NERVE CELL; NEWBORN; NONHUMAN; RAT; UPREGULATION; VP1 GENE; VP2 GENE; VP3 GENE; VP4 GENE; ANIMAL; DRUG EFFECTS; METABOLISM; PATHOPHYSIOLOGY; PHAGOCYTOSIS; PHYSIOLOGY;

ANIMALS; AUTOPHAGY; BRAIN STEM; CALRETICULIN; CAPSID PROTEINS; CELLS, CULTURED; DEXAMETHASONE; ENDOPLASMIC RETICULUM STRESS; FEMALE; HUMANS; MALE; NEURONS; PHAGOCYTOSIS; RATS; UP-REGULATION; VIRAL STRUCTURAL PROTEINS;

EID: 84995477577     PISSN: 10298428     EISSN: 14763524     Source Type: Journal    
DOI: 10.1007/s12640-016-9670-0     Document Type: Article

References (46)

1. Akira S, Uematsu S, Takeuchi O (2006) Pathogen recognition and innate immunity. Cell 124:783–801
2. Barnes PJ (1998) Anti-inflammatory actions of glucocorticoids: molecular mechanisms. Clin Sci 94:557–572
3. Boyce M, Bryant KF, Jousse C, Long K, Harding HP, Scheuner D, Kaufman RJ, Ma D, Coen DM, Ron D, Yuan J (2005) A selective inhibitor of eIF2alpha dephosphorylation protects cells from ER stress. Science 307:935–939
4. Chang SC, Lin JY, Lo LY, Li ML, Shih SR (2004) Diverse apoptotic pathways in enterovirus 71-infected cells. J Neurovirol 10:338–349
5. Chen TC, Lai YK, Yu CK, Juang JL (2007) Enterovirus 71 triggering of neuronal apoptosis through activation of Abl-Cdk5 signalling. Cell Microbiol 9:2676–2688
6. Demetrius L (1975) Natural selection and age-structured populations. Genetics 79:535–544
7. Donnelly OG, Errington-Mais F, Steele L, Hadac E, Jennings V, Scott K, Peach H, Phillips RM, Bond J, Pandha H, Harrington K, Vile R, Russell S, Selby P, Melcher AA (2013) Measles virus causes immunogenic cell death in human melanoma. Gene Ther 20:7–15
8. Flaster H, Bernhagen J, Calandra T, Bucala R (2007) The macrophage migration inhibitory factor-glucocorticoid dyad: regulation of inflammation and immunity. Mol Endocrinol 21:1267–1280
9. Fricker M, Oliva-Martin MJ, Brown GC (2012) Primary phagocytosis of viable neurons by microglia activated with LPS or Abeta is dependent on calreticulin/LRP phagocytic signalling. J Neuroinflamm 9:196
10. Fu D, Li CR, He YX, Zu Y, Cao DZ, Wang GB, Deng JK, Wang HP (2009) Changes of immune function in patients with enterovirus 71 infection. Chin J Pediatr 47:829–834
11. Gardai SJ, McPhillips KA, Frasch SC, Janssen WJ, Starefeldt A, Murphy-Ullrich JE, Bratton DL, Oldenborg PA, Michalak M, Henson PM (2005) Cell-surface calreticulin initiates clearance of viable or apoptotic cells through trans-activation of LRP on the phagocyte. Cell 123:321–334
12. Glass CK, Saijo K, Winner B, Marchetto MC, Gage FH (2010) Mechanisms underlying inflammation in neurodegeneration. Cell 140:918–934
13. Huang SC, Chang CL, Wang PS, Tsai Y, Liu HS (2009) Enterovirus 71-induced autophagy detected in vitro and in vivo promotes viral replication. J Med Virol 81:1241–1252
14. Huang HI, Weng KF, Shih SR (2012a) Viral and host factors that contribute to pathogenicity of enterovirus 71. Future Microbiol 7:467–479
15. Huang SW, Wang YF, Yu CK, Su IJ, Wang JR (2012b) Mutations in VP2 and VP1 capsid proteins increase infectivity and mouse lethality of enterovirus 71 by virus binding and RNA accumulation enhancement. Virology 422:132–143
16. Jheng JR, Ho JY, Horng JT (2014) ER stress, autophagy, and RNA viruses. Front Microbiol 5:388
17. Jiang M, Wei D, Ou WL, Li KX, Luo DZ, Li YQ, Chen E, Nong GM (2012) Autopsy findings in children with hand, foot, and mouth disease. New Engl J Med 367:91–92
18. Kingston RE, Chen CA, Rose JK (2003) Calcium phosphate transfection. Chapter 9: Unit 9-1. In: Ausubel FM et al (eds) Current protocols in molecular biology. Wiley, New York
19. Kivell BM, McDonald FJ, Miller JH (2000) Serum-free culture of rat post-natal and fetal brainstem neurons. Brain Res Dev Brain Res 120:199–210
20. Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ, Abeliovich H, Zughaier SM et al (2016) Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy 12:1–222
21. Kouroku Y, Fujita E, Tanida I, Ueno T, Isoai A, Kumagai H, Ogawa S, Kaufman RJ, Kominami E, Momoi T (2007) ER stress (PERK/eIF2alpha phosphorylation) mediates the polyglutamine-induced LC3 conversion, an essential step for autophagy formation. Cell Death Differ 14:230–239
22. Kroemer G, Galluzzi L, Kepp O, Zitvogel L (2013) Immunogenic cell death in cancer therapy. Annu Rev Immunol 31:51–72
23. Kuo RL, Shih SR (2013) Strategies to develop antivirals against enterovirus 71. Virol J 10:28
24. Lee YR, Wang PS, Wang JR, Liu HS (2014) Enterovirus 71-induced autophagy increases viral replication and pathogenesis in a suckling mouse model. J Biomed Sci 21:80
25. Lei X, Sun Z, Liu X, Jin Q, He B, Wang J (2011) Cleavage of the adaptor protein TRIF by enterovirus 71 3C inhibits antiviral responses mediated by Toll-like receptor 3. J Virol 85:8811–8818
26. Lei X, Xiao X, Xue Q, Jin Q, He B, Wang J (2013) Cleavage of interferon regulatory factor 7 by enterovirus 71 3C suppresses cellular responses. J Virol 87:1690–1698
27. Li ML, Hsu TA, Chen TC, Chang SC, Lee JC, Chen CC, Stollar V, Shih SR (2002) The 3C protease activity of enterovirus 71 induces human neural cell apoptosis. Virology 293:386–395
28. Li P, Wang N, Ma W, Gao Y, Yang S (2014) Hand, foot, and mouth disease in mainland China. Lancet Infect Dis 14:1042
29. Lu J, Yi L, Zhao J, Yu J, Chen Y, Lin MC, Kung HF, He ML (2012) Enterovirus 71 disrupts interferon signaling by reducing the level of interferon receptor 1. J Virol 86:3767–3776
30. Lu J, Zeng H, Zheng H, Yi L, Guo X, Liu L, Sun L, Tan X, Li H, Ke C, Lin J (2014) Hand, foot and mouth disease in Guangdong, China, in 2013: new trends in the continuing epidemic. Clin Microbiol Infect 20:O442–445
31. Lum LC, Wong KT, Lam SK, Chua KB, Goh AY, Lim WL, Ong BB, Paul G, AbuBakar S, Lambert M (1998) Fatal enterovirus 71 encephalomyelitis. J Pediatr 133:795–798
32. Martins I, Kepp O, Schlemmer F, Adjemian S, Tailler M, Shen S, Michaud M, Menger L, Gdoura A, Tajeddine N, Tesniere A, Zitvogel L, Kroemer G (2011) Restoration of the immunogenicity of cisplatin-induced cancer cell death by endoplasmic reticulum stress. Oncogene 30:1147–1158
33. McMinn PC (2002) An overview of the evolution of enterovirus 71 and its clinical and public health significance. FEMS Microbiol Rev 26:91–107
34. Obeid M, Tesniere A, Ghiringhelli F, Fimia GM, Apetoh L, Perfettini JL, Castedo M, Mignot G, Panaretakis T, Casares N, Metivier D, Larochette N, van Endert P, Ciccosanti F, Piacentini M, Zitvogel L, Kroemer G (2007) Calreticulin exposure dictates the immunogenicity of cancer cell death. Nat Med 13:54–61
35. Panaretakis T, Joza N, Modjtahedi N, Tesniere A, Vitale I, Durchschlag M, Fimia GM, Kepp O, Piacentini M, Froehlich KU, van Endert P, Zitvogel L, Madeo F, Kroemer G (2008) The co-translocation of ERp57 and calreticulin determines the immunogenicity of cell death. Cell Death Differ 15:1499–1509
36. Pathinayake PS, Hsu AC, Wark PA (2015) Innate Immunity and Immune Evasion by Enterovirus 71. Viruses 7:6613–6630
37. Song YB, Yu N, He SJ, Chen XX, Wang B, Che XY, Zeng QY (2011) Gene cloning and immunogenicity analysis of the structural proteins VP1-VP4 of enterovirus 71. J South Med Univ 31:1846–1850
38. Talloczy Z, Jiang W, Virgin HW, Leib DA, Scheuner D, Kaufman RJ, Eskelinen EL, Levine B (2002) Regulation of starvation- and virus-induced autophagy by the eIF2alpha kinase signaling pathway. Proc Natl Acad Sci USA 99:190–195
39. Tan X, Huang X, Zhu S, Chen H, Yu Q, Wang H, Huo X, Zhou J, Wu Y, Yan D, Zhang Y, Wang D, Cui A, An H, Xu W (2011) The persistent circulation of enterovirus 71 in People’s Republic of China: causing emerging nationwide epidemics since 2008. PLoS One 6:e25662
40. Wong SS, Yip CC, Lau SK, Yuen KY (2010) Human enterovirus 71 and hand, foot and mouth disease. Epidemiol Infect 138:1071–1089
41. Wu J, Cheng YB, Li ZF, Li YF, Li YP, Xu HM, Li XW, Qian SY (2012) Evaluation of adrenocortical function in children with severe and critical enterovirus 71 infection. Chin J Pediatr 50:249–254
42. Xing W, Liao Q, Viboud C, Zhang J, Sun J, Wu JT, Chang Z, Liu F, Fang VJ, Zheng Y, Cowling BJ, Varma JK, Farrar JJ, Leung GM, Yu H (2014) Hand, foot, and mouth disease in China, 2008-12: an epidemiological study. Lancet Infect Dis 14:308–318
43. Zeng M, Zheng X, Wei R, Zhang N, Zhu K, Xu B, Yang CH, Yang CF, Deng C, Pu D, Wang X, Altmeyer R, Leng Q (2013) The cytokine and chemokine profiles in patients with hand, foot and mouth disease of different severities in Shanghai, China, 2010. PLoS Negl Trop Dis 7:e2599
44. Zhang L, Wang A (2012) Virus-induced ER stress and the unfolded protein response. Front Plant Sci 3:293
45. Zhu J, Newkirk MM (1994) Viral induction of the human autoantigen calreticulin. Clin Invest Med 17:196–205
46. Zitvogel L, Kepp O, Senovilla L, Menger L, Chaput N, Kroemer G (2010) Immunogenic tumor cell death for optimal anticancer therapy: the calreticulin exposure pathway. Clin Cancer Res 16:3100–3104