Acid-base interactions in amorphous solid dispersions of lumefantrine prepared by spray-drying and hot-melt extrusion using X-ray photoelectron spectroscopy

International Journal of Pharmaceutics

Volumn 514, Issue 2, 2016, Pages 456-464

  Song, Yang ^a   Zemlyanov, Dmitry ^b   Chen, Xin ^c   Su, Ziyang ^d   Nie, Haichen ^a   Lubach, Joseph W ^e   Smith, Daniel ^a   Byrn, Stephen ^a   Pinal, Rodolfo ^a  

^a PURDUE UNIVERSITY   (United States)

^b PURDUE UNIVERSITY   (United States)

^c GLAXOSMITHKLINE   (United States)

^d CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

^e GENENTECH INC   (United States)

Author keywords

Acid base; Amorphous; Hot melt extrusion; Ionic interaction; Lumefantrine; Salt; Solid dispersion; Spray drying; XPS

Indexed keywords

BENFLUMETOL; EUDRAGIT; HYDROXYPROPYLMETHYLCELLULOSE ACETATE SUCCINATE; HYDROXYPROPYLMETHYLCELLULOSE PHTHALATE; POLYACRYLIC ACID; POLYSTYRENESULFONIC ACID; ACID; ETHANOLAMINE DERIVATIVE; FLUORENE DERIVATIVE; POLYMER; POWDER;

ACID BASE INTERACTION; ACIDITY; ALKALINITY; AMORPHOUS SOLID DISPERSION; ARTICLE; CHEMICAL INTERACTION; CHEMICAL PROCEDURES; CONTROLLED STUDY; DISPERSION; DRUG FORMULATION; DRUG MANUFACTURE; DRUG MIXTURE; EVAPORATION; HOT MELT EXTRUSION; IONIC STRENGTH; PRIORITY JOURNAL; PROTON TRANSPORT; ROTARY EVAPORATION; SPRAY DRYING; X RAY PHOTOELECTRON SPECTROSCOPY; X RAY POWDER DIFFRACTION; CHEMISTRY; DRUG STABILITY; POWDER; PROCEDURES;

ACIDS; DRUG COMPOUNDING; DRUG STABILITY; ETHANOLAMINES; FLUORENES; PHOTOELECTRON SPECTROSCOPY; POLYMERS; POWDERS;

EID: 84994665985     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2016.06.126     Document Type: Article

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