Integrin-αiibβ3-mediated outside-in signalling activates a negative feedback pathway to suppress platelet activation

Thrombosis and Haemostasis

Volumn 116, Issue 5, 2016, Pages 918-930

  Dai, Baiyun ^a   Wu, Peng ^a   Xue, Feng ^b   Yang, Renchi ^b   Yu, Ziqiang ^c   Dai, Kesheng ^c   Ruan, Changgeng ^c   Liu, Gang ^a   Newman, Peter J ^d,e   Gao, Cunji ^a,e  

^a ZHEJIANG UNIVERSITY   (China)

^b INSTITUTE OF HEMATOLOGY AND BLOOD DISEASES HOSPITAL   (China)

^c THE FIRST AFFILIATED HOSPITAL OF SOOCHOW UNIVERSITY   (China)

^d MEDICAL COLLEGE OF WISCONSIN   (United States)

^e BLOOD RESEARCH INSTITUTE   (United States)

Author keywords

ATP; Integrins; Platelets; RGD peptide; Talin

Indexed keywords

ACETYLSALICYLIC ACID; ADENOSINE TRIPHOSPHATE; ALPHA2 INTEGRIN; BETA3 INTEGRIN; C REACTIVE PROTEIN; FIBRINOGEN; PROSTAGLANDIN E1; PROTEIN KINASE B; PROTEIN TYROSINE PHOSPHATASE SHP; TALIN; THROMBIN RECEPTOR ACTIVATING PEPTIDE; FIBRINOGEN RECEPTOR; INPP5D PROTEIN, HUMAN; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 5 PHOSPHATASE;

ADULT; ARTICLE; CONTROLLED STUDY; FLOW CYTOMETRY; GLANZMANN DISEASE; HUMAN; IMMUNOBLOTTING; IMMUNOPRECIPITATION; LUMINESCENCE; MOUSE; NEGATIVE FEEDBACK; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEPHOSPHORYLATION; SIGNAL TRANSDUCTION; THROMBOCYTE ACTIVATION; THROMBOCYTE AGGREGATION; WESTERN BLOTTING; METABOLISM; THROMBOCYTE;

BLOOD PLATELETS; HUMANS; PHOSPHATIDYLINOSITOL 3-KINASES; PHOSPHATIDYLINOSITOL-3,4,5-TRISPHOSPHATE 5-PHOSPHATASES; PLATELET ACTIVATION; PLATELET GLYCOPROTEIN GPIIB-IIIA COMPLEX; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION; TALIN;

EID: 84994571270     PISSN: 03406245     EISSN: None     Source Type: Journal    
DOI: 10.1160/TH16-02-0096     Document Type: Article

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