Crystal structure of a LacY-nanobody complex in a periplasmic-open conformation

Proceedings of the National Academy of Sciences of the United States of America

Volumn 113, Issue 44, 2016, Pages 12420-12425

  Jiang, Xin ^a   Smirnova, Irina ^b   Kasho, Vladimir ^b   Wu, Jianping ^a   Hirata, Kunio ^c,g   Ke, Meng ^a   Pardon, Els ^d,e   Steyaert, Jan ^d,e   Yan, Nieng ^a   Kaback, H Ronald ^b,f  

^a Tsinghua University ^*  (China)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c RIKEN Harima Institute Research   (Japan)

^d DEPARTMENT OF PLANT SYSTEMS BIOLOGY   (Belgium)

^e VRIJE UNIVERSITEIT BRUSSEL   (Belgium)

^f UNIVERSITY OF CALIFORNIA   (United States)

^g JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

Author keywords

Bioenergetics; Fluorescence; Kinetics; Membrane transporter; X ray structure

Indexed keywords

ESCHERICHIA COLI PROTEIN; GALACTOSIDE; LACTOSE PERMEASE; LACTOSE PERMEASE LACY; MUTANT PROTEIN; NANOBODY; SUGAR; UNCLASSIFIED DRUG; COTRANSPORTER; GLUCOSE TRANSPORTER; LACY PROTEIN, E COLI; PROTEIN BINDING;

BINDING AFFINITY; BINDING SITE; CARBOXY TERMINAL SEQUENCE; COMPLEX FORMATION; CONFERENCE PAPER; CRYSTAL STRUCTURE; ENZYME CONFORMATION; NONHUMAN; PERIPLASM; PRIORITY JOURNAL; STOICHIOMETRY; CHEMISTRY; GENETICS; IMMUNOLOGY; METABOLISM; MOLECULAR MODEL; MUTATION; PROTEIN CONFORMATION; X RAY CRYSTALLOGRAPHY;

BINDING SITES; CRYSTALLOGRAPHY, X-RAY; ESCHERICHIA COLI PROTEINS; MODELS, MOLECULAR; MONOSACCHARIDE TRANSPORT PROTEINS; MUTATION; PERIPLASM; PROTEIN BINDING; PROTEIN CONFORMATION; SINGLE-DOMAIN ANTIBODIES; SYMPORTERS;

EID: 84994553250     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1615414113     Document Type: Article

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