Pharmacodynamic study of the oral hedgehog pathway inhibitor, vismodegib, in patients with metastatic castration-resistant prostate cancer

Cancer Chemotherapy and Pharmacology

Volumn 78, Issue 6, 2016, Pages 1297-1304

  Maughan, Benjamin L ^a   Suzman, Daniel L ^b   Luber, Brandon ^c   Wang, Hao ^c   Glavaris, Stephanie ^c   Hughes, Robert ^c   Sullivan, Rana ^c   Harb, Rana ^c   Boudadi, Karim ^c   Paller, Channing ^c   Eisenberger, Mario ^c   Demarzo, Angelo ^c   Ross, Ashely ^c   Antonarakis, Emmanuel S ^c  

^a UNIVERSITY OF UTAH   (United States)

^b CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

^c JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

Gli; Hedgehog; Metastatic castration resistant prostate cancer; Vismodegib

Indexed keywords

ALANINE AMINOTRANSFERASE; ALKALINE PHOSPHATASE; ASPARTATE AMINOTRANSFERASE; CREATININE; DOCETAXEL; PROTEIN KINASE B; PROTEIN PATCHED 1; TRANSCRIPTION FACTOR GLI1; TRANSCRIPTION FACTOR GLI2; VISMODEGIB; ANILIDE; GLI1 PROTEIN, HUMAN; PROSTATE SPECIFIC ANTIGEN; PYRIDINE DERIVATIVE; SONIC HEDGEHOG PROTEIN;

ADULT; AGED; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALKALINE PHOSPHATASE BLOOD LEVEL; ALOPECIA; ANEMIA; ANOREXIA; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CANCER CHEMOTHERAPY; CANCER INCIDENCE; CANCER PATIENT; CANCER SURVIVAL; CASTRATION RESISTANT PROSTATE CANCER; CLINICAL ARTICLE; CLINICAL OUTCOME; CONSTIPATION; CREATININE BLOOD LEVEL; DEHYDRATION; DIARRHEA; DRUG SAFETY; DYSGEUSIA; DYSPNEA; ERYTHROCYTE DISORDER; FATIGUE; GENE EXPRESSION; GLEASON SCORE; HEADACHE; HEMATOCRIT; HUMAN; HUMAN TISSUE; HYPERLIPIDEMIA; HYPOCALCEMIA; HYPONATREMIA; LIVER DYSFUNCTION; LYMPHATIC SYSTEM DISEASE; MALE; METASTATIC CASTRATION RESISTANT PROSTATE CANCER; MIDDLE AGED; MULTIPLE CYCLE TREATMENT; MUSCLE CRAMP; MUSCULOSKELETAL PAIN; NAUSEA; OVERALL SURVIVAL; PAIN; PARESTHESIA; PHARMACODYNAMICS; PHASE 2 CLINICAL TRIAL; PNEUMONIA; PRIORITY JOURNAL; PROGRESSION FREE SURVIVAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIDE EFFECT; SKIN BIOPSY; SORE THROAT; THROMBOCYTE COUNT; THROMBOCYTE DISORDER; TREATMENT RESPONSE; TUMOR BIOPSY; VOMITING; WEAKNESS; ANTAGONISTS AND INHIBITORS; BLOOD; CLINICAL TRIAL; GENETICS; MORTALITY; PHYSIOLOGY; PROSTATIC NEOPLASMS, CASTRATION-RESISTANT;

AGED; ANILIDES; HEDGEHOG PROTEINS; HUMANS; MALE; MIDDLE AGED; PROSTATE-SPECIFIC ANTIGEN; PROSTATIC NEOPLASMS, CASTRATION-RESISTANT; PYRIDINES; ZINC FINGER PROTEIN GLI1;

EID: 84994462384     PISSN: 03445704     EISSN: 14320843     Source Type: Journal    
DOI: 10.1007/s00280-016-3191-7     Document Type: Article

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