Locus coeruleus volume and cell population changes during Alzheimer's disease progression: A stereological study in human postmortem brains with potential implication for early-stage biomarker discovery

Alzheimer's and Dementia

Volumn 13, Issue 3, 2017, Pages 236-246

  Theofilas, Panos ^a   Ehrenberg, Alexander J ^a   Dunlop, Sara ^a   Di Lorenzo Alho, Ana T ^b,c   Nguy, Austin ^a   Leite, Renata Elaine Paraizo ^c   Rodriguez, Roberta Diehl ^c   Mejia, Maria B ^a   Suemoto, Claudia K ^c   Ferretti Rebustini, Renata Eloah De Lucena ^c   Polichiso, Livia ^c   Nascimento, Camila F ^c   Seeley, William W ^a   Nitrini, Ricardo ^c   Pasqualucci, Carlos Augusto ^c   Jacob Filho, Wilson ^c   Rueb, Udo ^d   Neuhaus, John ^a   Heinsen, Helmut ^c,e   Grinberg, Lea T ^a,c  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b HOSPITAL ISRAELITA ALBERT EINSTEIN   (Brazil)

^c UNIVERSITY OF SÃO PAULO   (Brazil)

^d GOETHE UNIVERSITY   (Germany)

^e UNIVERSITY OF WÜRZBURG   (Germany)

Author keywords

Alzheimer's disease; Brainstem; Human; Locus coeruleus; Neurofibrillary tangles; Neuron counts; Postmortem; Unbiased stereology; Volumetry

Indexed keywords

BIOLOGICAL MARKER;

ADULT; AGED; ALZHEIMER DISEASE; ARTICLE; AUTOPSY; BIOACCUMULATION; BRAIN ATROPHY; BRAIN SIZE; BRAIN STEM; CELL POPULATION; CONTROLLED STUDY; DISEASE COURSE; FEMALE; HISTOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LOCUS CERULEUS; MALE; MIDDLE AGED; NERVE CELL NECROSIS; NEUROFIBRILLARY TANGLE; NEUROIMAGING; NEUROPATHOLOGY; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; STEREOLOGY; VERY ELDERLY; METABOLISM; NERVE CELL; PATHOLOGY; STEREOTACTIC PROCEDURE;

ADULT; AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; AUTOPSY; BIOMARKERS; DISEASE PROGRESSION; FEMALE; HUMANS; LOCUS COERULEUS; MALE; MIDDLE AGED; NEURONS; STEREOTAXIC TECHNIQUES;

EID: 84994461744     PISSN: 15525260     EISSN: 15525279     Source Type: Journal    
DOI: 10.1016/j.jalz.2016.06.2362     Document Type: Article

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