Engineering Yarrowia lipolytica for poly-3-hydroxybutyrate production

Journal of Industrial Microbiology and Biotechnology

Volumn 44, Issue 4-5, 2017, Pages 605-612

  Li, Zheng Jun ^a,b   Qiao, Kangjian ^a   Liu, Nian ^a   Stephanopoulos, Gregory ^a  

^a Massachusetts Institute of Technology   (United States)

^b BEIJING UNIVERSITY OF CHEMICAL TECHNOLOGY   (China)

Author keywords

Acetate; Metabolic engineering; phaCAB; PHB; Poly 3 hydroxybutyrate; Yarrowia lipolytica

Indexed keywords

ACETIC ACID; ACETOACETYL COA REDUCTASE; ACETYL COENZYME A; ACETYL COENZYME A ACYLTRANSFERASE; GLUCOSE; PHA SYNTHASE; POLY(3 HYDROXYBUTYRIC ACID); SYNTHETASE; UNCLASSIFIED DRUG; ACETOACETYL-COA REDUCTASE; ALCOHOL DEHYDROGENASE; FUNGAL RNA; HYDROXYBUTYRIC ACID; NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; POLY-BETA-HYDROXYBUTYRATE; POLYESTER;

ARTICLE; BIOREACTOR; CARBON SOURCE; CELL GROWTH; COMPARATIVE STUDY; CONTROLLED STUDY; DISPERSITY; DRY WEIGHT; EXPRESSION VECTOR; FED BATCH FERMENTATION; MOLECULAR CLONING; MOLECULAR WEIGHT; NONHUMAN; PH; PROCESS OPTIMIZATION; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; SYNTHESIS; YARROWIA LIPOLYTICA; BIOSYNTHESIS; CELL ENGINEERING; CHEMISTRY; CULTURE MEDIUM; FERMENTATION; GENETIC ENGINEERING; GENETICS; METABOLISM; MICROBIOLOGY; YARROWIA;

ACETYL COENZYME A; ALCOHOL OXIDOREDUCTASES; BIOREACTORS; BIOSYNTHETIC PATHWAYS; CELL ENGINEERING; CULTURE MEDIA; FERMENTATION; GENETIC ENGINEERING; HYDROXYBUTYRATES; INDUSTRIAL MICROBIOLOGY; NADP; POLYESTERS; RNA, FUNGAL; YARROWIA;

EID: 84994427154     PISSN: 13675435     EISSN: 14765535     Source Type: Journal    
DOI: 10.1007/s10295-016-1864-1     Document Type: Article

References (20)

1. Carlson R, Srienc F (2006) Effects of recombinant precursor pathway variations on poly [(R)-3-hydroxybutyrate] synthesis in Saccharomyces cerevisiae. J Biotechnol 124:561–573. doi:10.1016/j.jbiotec.2006.01.035
2. Chu A, Mavinic DS, Ramey WD, Kelly HG (1996) A biochemical model describing volatile fatty acid metabolism in thermophilic aerobic digestion of wastewater sludge. Water Res 30:1759–1770. doi:10.1016/0043-1354(96)00051-6
3. 2 fixation by the acetogenic bacterium Moorella thermoacetica. AIChE J 59:3176–3183. doi:10.1002/aic.14127
4. Jiang JG, Zhang YJ, Li KM, Wang Q, Gong CX, Li ML (2013) Volatile fatty acids production from food waste: effects of pH, temperature, and organic loading rate. Bioresour Technol 143:525–530. doi:10.1016/j.biortech.2013.06.025
5. Jiang XR, Wang H, Shen R, Chen GQ (2015) Engineering the bacterial shapes for enhanced inclusion bodies accumulation. Metab Eng 29:227–237. doi:10.1016/j.ymben.2015.03.017
6. Kocharin K, Chen Y, Siewers V, Nielsen J (2012) Engineering of acetyl-CoA metabolism for the improved production of polyhydroxybutyrate in Saccharomyces cerevisiae. AMB Express 2:52. doi:10.1186/2191-0855-2-52
7. Kocharin K, Siewers V, Nielsen J (2013) Improved polyhydroxybutyrate production by Saccharomyces cerevisiae through the use of the phosphoketolase pathway. Biotechnol Bioeng 110:2216–2224. doi:10.1002/bit.24888
8. Leaf TA, Peterson MS, Stoup SK, Somers D, Srienc F (1996) Saccharomyces cerevisiae expressing bacterial polyhydroxybutyrate synthase produces poly-3-hydroxybutyrate. Microbiol 142:1169–1180. doi:10.1099/13500872-142-5-1169
9. Lian JZ, Si T, Nair NU, Zhao HM (2014) Design and construction of acetyl-CoA overproducing Saccharomyces cerevisiae strains. Metab Eng 24:139–149. doi:10.1016/j.ymben.2014.05.010
10. Matsusaki H, Abe H, Taguchi K, Fukui T, Doi Y (2000) Biosynthesis of poly(3-hydroxybutyrate-co-3-hydroxyalkanoates) by recombinant bacteria expressing the PHA synthase gene phaC1 from Pseudomonas sp 61-3. Appl Microbiol Biotechnol 53:401–409. doi:10.1007/s002530051633
11. Philip S, Keshavarz T, Roy I (2007) Polyhydroxyalkanoates: biodegradable polymers with a range of applications. J Chem Technol Biotechnol 82:233–247. doi:10.1002/jctb.1667
12. Qiao K, Imam Abidi SH, Liu H, Zhang H, Chakraborty S, Watson N, Kumaran Ajikumar P, Stephanopoulos G (2015) Engineering lipid overproduction in the oleaginous yeast Yarrowia lipolytica. Metab Eng 29:56–65. doi:10.1016/j.ymben.2015.02.005
13. Sandstrom AG, de Las Munoz, Heras A, Portugal-Nunes D, Gorwa-Grauslund MF (2015) Engineering of Saccharomyces cerevisiae for the production of poly-3-hydroxybutyrate from xylose. AMB Express 5:14. doi:10.1186/s13568-015-0100-0
14. Sim SJ, Snell KD, Hogan SA, Stubbe J, Rha C, Sinskey AJ (1997) PHA synthase activity controls the molecular weight and polydispersity of polyhydroxybutyrate in vivo. Nat Biotech 15:63–67. doi:10.1038/nbt0197-63
15. Suriyamongkol P, Weselake R, Narine S, Moloney M, Shah S (2007) Biotechnological approaches for the production of polyhydroxyalkanoates in microorganisms and plants–a review. Biotechnol Adv 25:148–175. doi:10.1016/j.biotechadv.2006.11.007
16. Taguchi S, Yamadaa M, Matsumoto K, Tajima K, Satoh Y, Munekata M, Ohno K, Kohda K, Shimamura T, Kambe H, Obata S (2008) A microbial factory for lactate-based polyesters using a lactate-polymerizing enzyme. Proc Natl Acad Sci USA 105:17323–17327. doi:10.1073/pnas.0805653105
17. Wu H, Chen J, Chen GQ (2016) Engineering the growth pattern and cell morphology for enhanced PHB production by Escherichia coli. Appl Microbiol Biotechnol. doi:10.1007/s00253-016-7715-1
18. Wu H, Fan Z, Jiang X, Chen J, Chen GQ (2016) Enhanced production of polyhydroxybutyrate by multiple dividing E. coli. Microb Cell Fact 15:128. doi:10.1186/s12934-016-0531-6
19. Xue ZX, Sharpe PL, Hong SP, Yadav NS, Xie DM, Short DR, Damude HG, Rupert RA, Seip JE, Wang J, Pollak DW, Bostick MW, Bosak MD, Macool DJ, Hollerbach DH, Zhang HX, Arcilla DM, Bledsoe SA, Croker K, McCord EF, Tyreus BD, Jackson EN, Zhu Q (2013) Production of omega-3 eicosapentaenoic acid by metabolic engineering of Yarrowia lipolytica. Nat Biotechnol 31:734–740. doi:10.1038/nbt.2622
20. Yin J, Wang H, Fu XZ, Gao X, Wu Q, Chen GQ (2015) Effects of chromosomal gene copy number and locations on polyhydroxyalkanoate synthesis by Escherichia coli and Halomonas sp. Appl Microbiol Biotechnol 99:5523–5534. doi:10.1007/s00253-015-6510-8