-
1
-
-
66249108601
-
Understanding the Warburg effect: the metabolic requirements of cell proliferation
-
M.G.Vander Heiden, L.C.Cantley, C.B.Thompson Understanding the Warburg effect:the metabolic requirements of cell proliferation. Science 2009;324:1029–1033.
-
(2009)
Science
, vol.324
, pp. 1029-1033
-
-
Vander Heiden, M.G.1
Cantley, L.C.2
Thompson, C.B.3
-
2
-
-
84927133194
-
Targeting mitochondria metabolism for cancer therapy
-
S.E.Weinberg, N.S.Chandel Targeting mitochondria metabolism for cancer therapy. Nat Chem Biol 2015;11:9–15.
-
(2015)
Nat Chem Biol
, vol.11
, pp. 9-15
-
-
Weinberg, S.E.1
Chandel, N.S.2
-
3
-
-
35448960851
-
Functions and dysfunctions of mitochondrial dynamics
-
S.A.Detmer, D.C.Chan Functions and dysfunctions of mitochondrial dynamics. Nat Rev Mol Cell Biol 2007;8:870–879.
-
(2007)
Nat Rev Mol Cell Biol
, vol.8
, pp. 870-879
-
-
Detmer, S.A.1
Chan, D.C.2
-
4
-
-
0035487808
-
The role of dynamin-related protein 1, a mediator of mitochondrial fission, in apoptosis
-
S.Frank, B.Gaume, E.S.Bergmann-Leitner, W.W.Leitner, E.G.Robert, F.Catez,. The role of dynamin-related protein 1, a mediator of mitochondrial fission, in apoptosis. Dev Cell 2001;1:515–525.
-
(2001)
Dev Cell
, vol.1
, pp. 515-525
-
-
Frank, S.1
Gaume, B.2
Bergmann-Leitner, E.S.3
Leitner, W.W.4
Robert, E.G.5
Catez, F.6
-
5
-
-
6344274848
-
Roles of the mammalian mitochondrial fission and fusion mediators Fis1, Drp1, and Opa1 in apoptosis
-
Y.J.Lee, S.Y.Jeong, M.Karbowski, C.L.Smith, R.J.Youle Roles of the mammalian mitochondrial fission and fusion mediators Fis1, Drp1, and Opa1 in apoptosis. Mol Biol Cell 2004;15:5001–5011.
-
(2004)
Mol Biol Cell
, vol.15
, pp. 5001-5011
-
-
Lee, Y.J.1
Jeong, S.Y.2
Karbowski, M.3
Smith, C.L.4
Youle, R.J.5
-
6
-
-
84867740975
-
Mitophagy is triggered by mild oxidative stress in a mitochondrial fission dependent manner
-
M.Frank, S.Duvezin-Caubet, S.Koob, A.Occhipinti, R.Jagasia, A.Petcherski,. Mitophagy is triggered by mild oxidative stress in a mitochondrial fission dependent manner. Biochim Biophys Acta 2012;1823:2297–2310.
-
(2012)
Biochim Biophys Acta
, vol.1823
, pp. 2297-2310
-
-
Frank, M.1
Duvezin-Caubet, S.2
Koob, S.3
Occhipinti, A.4
Jagasia, R.5
Petcherski, A.6
-
7
-
-
46749156297
-
Mitochondrial fission mediates high glucose-induced cell death through elevated production of reactive oxygen species
-
T.Yu, S.S.Sheu, J.L.Robotham, Y.Yoon Mitochondrial fission mediates high glucose-induced cell death through elevated production of reactive oxygen species. Cardiovasc Res 2008;79:341–351.
-
(2008)
Cardiovasc Res
, vol.79
, pp. 341-351
-
-
Yu, T.1
Sheu, S.S.2
Robotham, J.L.3
Yoon, Y.4
-
8
-
-
84865544952
-
Mitochondrial fission, fusion, and stress
-
R.J.Youle, A.M.van der Bliek Mitochondrial fission, fusion, and stress. Science 2012;337:1062–1065.
-
(2012)
Science
, vol.337
, pp. 1062-1065
-
-
Youle, R.J.1
van der Bliek, A.M.2
-
9
-
-
79960621726
-
Human MIEF1 recruits Drp1 to mitochondrial outer membranes and promotes mitochondrial fusion rather than fission
-
J.Zhao, T.Liu, S.Jin, X.Wang, M.Qu, P.Uhlén,. Human MIEF1 recruits Drp1 to mitochondrial outer membranes and promotes mitochondrial fusion rather than fission. EMBO J 2011;30:2762–2778.
-
(2011)
EMBO J
, vol.30
, pp. 2762-2778
-
-
Zhao, J.1
Liu, T.2
Jin, S.3
Wang, X.4
Qu, M.5
Uhlén, P.6
-
10
-
-
78650167618
-
Mff is an essential factor for mitochondrial recruitment of Drp1 during mitochondrial fission in mammalian cells
-
H.Otera, C.Wang, M.M.Cleland, K.Setoguchi, S.Yokota, R.J.Youle, K.Mihara Mff is an essential factor for mitochondrial recruitment of Drp1 during mitochondrial fission in mammalian cells. J Cell Biol 2010;191:1141–1158.
-
(2010)
J Cell Biol
, vol.191
, pp. 1141-1158
-
-
Otera, H.1
Wang, C.2
Cleland, M.M.3
Setoguchi, K.4
Yokota, S.5
Youle, R.J.6
Mihara, K.7
-
11
-
-
57349100367
-
Mitofusin 2 tethers endoplasmic reticulum to mitochondria
-
O.M.de Brito, L.Scorrano Mitofusin 2 tethers endoplasmic reticulum to mitochondria. Nature 2008;456:605–610.
-
(2008)
Nature
, vol.456
, pp. 605-610
-
-
de Brito, O.M.1
Scorrano, L.2
-
13
-
-
14844314135
-
The mitochondrial inner membrane protein mitofilin controls cristae morphology
-
G.B.John, Y.Shang, L.Li, C.Renken, C.A.Mannella, J.M.Selker,. The mitochondrial inner membrane protein mitofilin controls cristae morphology. Mol Biol Cell 2005;16:1543–1554.
-
(2005)
Mol Biol Cell
, vol.16
, pp. 1543-1554
-
-
John, G.B.1
Shang, Y.2
Li, L.3
Renken, C.4
Mannella, C.A.5
Selker, J.M.6
-
14
-
-
84857730145
-
Roles for the lipid-signaling enzyme MitoPLD in mitochondrial dynamics, piRNA biogenesis, and spermatogenesis
-
Q.Gao, M.A.Frohman Roles for the lipid-signaling enzyme MitoPLD in mitochondrial dynamics, piRNA biogenesis, and spermatogenesis. BMB Rep 2012;45:7–13.
-
(2012)
BMB Rep
, vol.45
, pp. 7-13
-
-
Gao, Q.1
Frohman, M.A.2
-
15
-
-
3242752786
-
Molecular events associated with reactive oxygen species and cell cycle progression in mammalian cells
-
J.Boonstra, J.A.Post Molecular events associated with reactive oxygen species and cell cycle progression in mammalian cells. Gene 2004;337:1–13.
-
(2004)
Gene
, vol.337
, pp. 1-13
-
-
Boonstra, J.1
Post, J.A.2
-
16
-
-
0035371184
-
Redox environment of the cell as viewed through the redox state of the glutathione disulfide/glutathione couple
-
F.Q.Schafer, G.R.Buettner Redox environment of the cell as viewed through the redox state of the glutathione disulfide/glutathione couple. Free Radic Biol Med 2001;30:1191–1212.
-
(2001)
Free Radic Biol Med
, vol.30
, pp. 1191-1212
-
-
Schafer, F.Q.1
Buettner, G.R.2
-
17
-
-
60349087959
-
Oxidative-induced membrane damage in diabetes lymphocytes: effects on intracellular Ca(2+) homeostasis
-
S.Belia, F.Santilli, S.Beccafico, L.De Feudis, C.Morabito, G.Davi,. Oxidative-induced membrane damage in diabetes lymphocytes:effects on intracellular Ca(2+) homeostasis. Free Radic Res 2009;43:138–148.
-
(2009)
Free Radic Res
, vol.43
, pp. 138-148
-
-
Belia, S.1
Santilli, F.2
Beccafico, S.3
De Feudis, L.4
Morabito, C.5
Davi, G.6
-
18
-
-
84858129800
-
Oxidative and non-oxidative DNA damage and cardiovascular disease
-
Q.Malik, K.E.Herbert Oxidative and non-oxidative DNA damage and cardiovascular disease. Free Radic Res 2012;46:554–564.
-
(2012)
Free Radic Res
, vol.46
, pp. 554-564
-
-
Malik, Q.1
Herbert, K.E.2
-
19
-
-
84920453952
-
A mitochondrial superoxide theory for oxidative stress diseases and aging
-
H.P.Indo, H.C.Yen, I.Nakanishi, K.Matsumoto, M.Tamura, Y.Nagano,. A mitochondrial superoxide theory for oxidative stress diseases and aging. J Clin Biochem Nutr 2015;56:1–7.
-
(2015)
J Clin Biochem Nutr
, vol.56
, pp. 1-7
-
-
Indo, H.P.1
Yen, H.C.2
Nakanishi, I.3
Matsumoto, K.4
Tamura, M.5
Nagano, Y.6
-
20
-
-
33644552417
-
Increased production of reactive oxygen species in hyperglycemic conditions requires dynamic change of mitochondrial morphology
-
T.Yu, J.L.Robotham, Y.Yoon Increased production of reactive oxygen species in hyperglycemic conditions requires dynamic change of mitochondrial morphology. Proc Natl Acad Sci U S A 2006;103:2653–2658.
-
(2006)
. Proc Natl Acad Sci U S A
, vol.103
, pp. 2653-2658
-
-
Yu, T.1
Robotham, J.L.2
Yoon, Y.3
-
21
-
-
79952520044
-
Mitochondrial oxidative stress causes mitochondrial fragmentation via differential modulation of mitochondrial fission-fusion proteins
-
S.Wu, F.Zhou, Z.Zhang, D.Xing Mitochondrial oxidative stress causes mitochondrial fragmentation via differential modulation of mitochondrial fission-fusion proteins. FEBS J 2011;278:941–954.
-
(2011)
FEBS J
, vol.278
, pp. 941-954
-
-
Wu, S.1
Zhou, F.2
Zhang, Z.3
Xing, D.4
-
23
-
-
79952369437
-
Mutations in PINK1 and Parkin impair ubiquitination of Mitofusins in human fibroblasts
-
A.Rakovic, A.Grünewald, J.Kottwitz, N.Brüggemann, P.P.Pramstaller, K.Lohmann, C.Klein Mutations in PINK1 and Parkin impair ubiquitination of Mitofusins in human fibroblasts. PLoS One 2011;6:e16746.
-
(2011)
PLoS One
, vol.6
, pp. e16746
-
-
Rakovic, A.1
Grünewald, A.2
Kottwitz, J.3
Brüggemann, N.4
Pramstaller, P.P.5
Lohmann, K.6
Klein, C.7
-
24
-
-
84883271527
-
Mfn2 modulates the UPR and mitochondrial function via repression of PERK
-
J.P.Muñoz, S.Ivanova, J.Sánchez-Wandelmer, P.Martínez-Cristóbal, E.Noguera, A.Sancho,. Mfn2 modulates the UPR and mitochondrial function via repression of PERK. EMBO J 2013;32:2348–2361.
-
(2013)
EMBO J
, vol.32
, pp. 2348-2361
-
-
Muñoz, J.P.1
Ivanova, S.2
Sánchez-Wandelmer, J.3
Martínez-Cristóbal, P.4
Noguera, E.5
Sancho, A.6
-
25
-
-
84887212354
-
Heterozygous mutation of Opa1 in Drosophila shortens lifespan mediated through increased reactive oxygen species production
-
S.Tang, P.K.Le, S.Tse, D.C.Wallace, T.Huang Heterozygous mutation of Opa1 in Drosophila shortens lifespan mediated through increased reactive oxygen species production. PLoS One 2009;4:e4492.
-
(2009)
PLoS One
, vol.4
, pp. e4492
-
-
Tang, S.1
Le, P.K.2
Tse, S.3
Wallace, D.C.4
Huang, T.5
-
26
-
-
84864968186
-
Contribution of mitochondrial network dynamics to intracellular ROS signaling
-
J.Park, C.Choi Contribution of mitochondrial network dynamics to intracellular ROS signaling. Commun Integr Biol 2012;5:81–83.
-
(2012)
Commun Integr Biol
, vol.5
, pp. 81-83
-
-
Park, J.1
Choi, C.2
-
27
-
-
77955351652
-
New insights into the role of mitochondria in aging: mitochondrial dynamics and more
-
A.Y.Seo, A.M.Joseph, D.Dutta, J.C.Hwang, J.P.Aris, C.Leeuwenburgh New insights into the role of mitochondria in aging:mitochondrial dynamics and more. J Cell Sci 2010;123:2533–2542.
-
(2010)
J Cell Sci
, vol.123
, pp. 2533-2542
-
-
Seo, A.Y.1
Joseph, A.M.2
Dutta, D.3
Hwang, J.C.4
Aris, J.P.5
Leeuwenburgh, C.6
-
28
-
-
78649413837
-
Mitochondrial fusion and fission in cell life and death
-
B.Westermann Mitochondrial fusion and fission in cell life and death. Nat Rev Mol Cell Biol 2010;11:872–884.
-
(2010)
Nat Rev Mol Cell Biol
, vol.11
, pp. 872-884
-
-
Westermann, B.1
-
29
-
-
84889242417
-
Mitochondrial dynamics – mitochondrial fission and fusion in human diseases
-
S.L.Archer. Mitochondrial dynamics – mitochondrial fission and fusion in human diseases. N Engl J Med 2013;369:2236–2251.
-
(2013)
N Engl J Med
, vol.369
, pp. 2236-2251
-
-
Archer, S.L.1
-
30
-
-
84929448792
-
Curcumin induces ER stress-mediated apoptosis through selective generation of reactive oxygen species in cervical cancer cells
-
B.Kim, H.S.Kim, E.J.Jung, J.Y.Lee, B.K Tsang, J.M.Lim, Y.S.Song Curcumin induces ER stress-mediated apoptosis through selective generation of reactive oxygen species in cervical cancer cells. Mol Carcinog 2016;55:918–928.
-
(2016)
Mol Carcinog
, vol.55
, pp. 918-928
-
-
Kim, B.1
Kim, H.S.2
Jung, E.J.3
Lee, J.Y.4
K Tsang, B.5
Lim, J.M.6
Song, Y.S.7
-
31
-
-
84940101852
-
ROS accumulation by PEITC selectively kills ovarian cancer cells via UPR-mediated apoptosis
-
Y.H.Hong, M.H.Uddin, U.Jo, B.Kim, J.Song, D.H.Suh,. ROS accumulation by PEITC selectively kills ovarian cancer cells via UPR-mediated apoptosis. Front Oncol 2015;5:167.
-
(2015)
Front Oncol
, vol.5
, pp. 167
-
-
Hong, Y.H.1
Uddin, M.H.2
Jo, U.3
Kim, B.4
Song, J.5
Suh, D.H.6
-
32
-
-
84920616812
-
PGC-1α mediates mitochondrial biogenesis and oxidative phosphorylation in cancer cells to promote metastasis
-
V.S.LeBleu, J.T.O’Connell, K.N.Gonzalez Herrera, H.Wikman, K.Pantel, M.C.Haigis,. PGC-1α mediates mitochondrial biogenesis and oxidative phosphorylation in cancer cells to promote metastasis. Nat Cell Biol 2014;16:992–1003.
-
(2014)
Nat Cell Biol
, vol.16
, pp. 992-1003
-
-
LeBleu, V.S.1
O’Connell, J.T.2
Gonzalez Herrera, K.N.3
Wikman, H.4
Pantel, K.5
Haigis, M.C.6
-
33
-
-
84941950274
-
SIRT1/PGC1α-dependent increase in oxidative phosphorylation supports chemotherapy resistance of colon cancer
-
T.T.Vellinga, T.Borovski, V.C.de Boer, S.Fatrai, S.van Schelven, K.Trumpi,. SIRT1/PGC1α-dependent increase in oxidative phosphorylation supports chemotherapy resistance of colon cancer. Clin Cancer Res 2015;21:2870–2879.
-
(2015)
Clin Cancer Res
, vol.21
, pp. 2870-2879
-
-
Vellinga, T.T.1
Borovski, T.2
de Boer, V.C.3
Fatrai, S.4
van Schelven, S.5
Trumpi, K.6
-
34
-
-
84926639320
-
Mitochondrial dynamics protein Drp1 is overexpressed in oncocytic thyroid tumors and regulates cancer cell migration
-
A.Ferreira-da-Silva, C.Valacca, E.Rios, H.Populo, P.Soares, M.Sobrinho-Simões,. Mitochondrial dynamics protein Drp1 is overexpressed in oncocytic thyroid tumors and regulates cancer cell migration. PLoS One 2015;10:e0122308.
-
(2015)
PLoS One
, vol.10
, pp. e0122308
-
-
Ferreira-da-Silva, A.1
Valacca, C.2
Rios, E.3
Populo, H.4
Soares, P.5
Sobrinho-Simões, M.6
-
35
-
-
84903190525
-
Involvement of Drp1 in hypoxia-induced migration of human glioblastoma U251 cells
-
Y.Y.Wan, J.F.Zhang, Z.J.Yang, L.P.Jiang, Y.F.Wei, Q.N.Lai,. Involvement of Drp1 in hypoxia-induced migration of human glioblastoma U251 cells. Oncol Rep 2014;32:619–626.
-
(2014)
Oncol Rep
, vol.32
, pp. 619-626
-
-
Wan, Y.Y.1
Zhang, J.F.2
Yang, Z.J.3
Jiang, L.P.4
Wei, Y.F.5
Lai, Q.N.6
-
37
-
-
33745752671
-
Interactions of mitochondria with the actin cytoskeleton
-
I.R.Boldogh, L.A.Pon Interactions of mitochondria with the actin cytoskeleton. Biochim Biophys Acta 2006;1763:450–462.
-
(2006)
Biochim Biophys Acta
, vol.1763
, pp. 450-462
-
-
Boldogh, I.R.1
Pon, L.A.2
-
38
-
-
84885181954
-
Mitochondrial dynamics regulates migration and invasion of breast cancer cells
-
J.Zhao, J.Zhang, M.Yu, Y.Xie, Y.Huang, D.W.Wolff,. Mitochondrial dynamics regulates migration and invasion of breast cancer cells. Oncogene 2013;32:4814–4824.
-
(2013)
Oncogene
, vol.32
, pp. 4814-4824
-
-
Zhao, J.1
Zhang, J.2
Yu, M.3
Xie, Y.4
Huang, Y.5
Wolff, D.W.6
-
39
-
-
0034492210
-
Actin-dependent lamellipodia formation and microtubule-dependent tail retraction control-directed cell migration
-
C.Ballestrem, B.Wehrle-Haller, B.Hinz, B.A.Imhof Actin-dependent lamellipodia formation and microtubule-dependent tail retraction control-directed cell migration. Mol Biol Cell 2000;11:2999–3012.
-
(2000)
Mol Biol Cell
, vol.11
, pp. 2999-3012
-
-
Ballestrem, C.1
Wehrle-Haller, B.2
Hinz, B.3
Imhof, B.A.4
-
40
-
-
0033818298
-
Redundancy of lamellipodia in locomoting Walker carcinosarcoma cells
-
H.U.Keller Redundancy of lamellipodia in locomoting Walker carcinosarcoma cells. Cell Motil Cytoskeleton 2000;46:247–256.
-
(2000)
Cell Motil Cytoskeleton
, vol.46
, pp. 247-256
-
-
Keller, H.U.1
-
41
-
-
84924768387
-
Mitochondrial division is requisite to RAS-induced transformation and targeted by oncogenic MAPK pathway inhibitors
-
M.N.Serasinghe, S.Y.Wieder, T.T.Renault, R.Elkholi, J.J.Asciolla, J.L.Yao,. Mitochondrial division is requisite to RAS-induced transformation and targeted by oncogenic MAPK pathway inhibitors. Mol Cell 2015;57:521–536.
-
(2015)
Mol Cell
, vol.57
, pp. 521-536
-
-
Serasinghe, M.N.1
Wieder, S.Y.2
Renault, T.T.3
Elkholi, R.4
Asciolla, J.J.5
Yao, J.L.6
-
42
-
-
84925755753
-
Mitochondrial control by DRP1 in brain tumor initiating cells
-
Q.Xie, Q.Wu, C.M.Horbinski, W.A.Flavahan, K.Yang, W.Zhou,. Mitochondrial control by DRP1 in brain tumor initiating cells. Nat Neurosci 2015;18:501–510.
-
(2015)
Nat Neurosci
, vol.18
, pp. 501-510
-
-
Xie, Q.1
Wu, Q.2
Horbinski, C.M.3
Flavahan, W.A.4
Yang, K.5
Zhou, W.6
-
43
-
-
33749846225
-
Role of Bax and Bak in mitochondrial morphogenesis
-
M.Karbowski, K.L.Norris, M.M.Cleland, S.Y.Jeong, R.J.Youle Role of Bax and Bak in mitochondrial morphogenesis. Nature 2006;443:658–662.
-
(2006)
Nature
, vol.443
, pp. 658-662
-
-
Karbowski, M.1
Norris, K.L.2
Cleland, M.M.3
Jeong, S.Y.4
Youle, R.J.5
-
45
-
-
45349094984
-
Mitochondrial dynamics and apoptosis
-
D.F.Suen, K.L.Norris, R.J.Youle Mitochondrial dynamics and apoptosis. Genes Dev 2008;22:1577–1590.
-
(2008)
Genes Dev
, vol.22
, pp. 1577-1590
-
-
Suen, D.F.1
Norris, K.L.2
Youle, R.J.3
-
46
-
-
49349105966
-
Bax- or Bak-induced mitochondrial fission can be uncoupled from cytochrome C release
-
C.Sheridan, P.Delivani, S.P.Cullen, S.J.Martin Bax- or Bak-induced mitochondrial fission can be uncoupled from cytochrome C release. Mol Cell 2008;31:570–585.
-
(2008)
Mol Cell
, vol.31
, pp. 570-585
-
-
Sheridan, C.1
Delivani, P.2
Cullen, S.P.3
Martin, S.J.4
-
47
-
-
39049149816
-
The role of mitochondria in apoptosis
-
S.Y.Jeong, D.W.Seol The role of mitochondria in apoptosis. BMB Rep 2008;41:11–22.
-
(2008)
BMB Rep
, vol.41
, pp. 11-22
-
-
Jeong, S.Y.1
Seol, D.W.2
-
48
-
-
84876312885
-
A novel Drp1 inhibitor diminishes aberrant mitochondrial fission and neurotoxicity
-
X.Qi, N.Qvit, Y.C.Su, D.Mochly-Rosen A novel Drp1 inhibitor diminishes aberrant mitochondrial fission and neurotoxicity. J Cell Sci 2013;126:789–802.
-
(2013)
J Cell Sci
, vol.126
, pp. 789-802
-
-
Qi, X.1
Qvit, N.2
Su, Y.C.3
Mochly-Rosen, D.4
-
49
-
-
84903779388
-
Increased mitochondrial fission and neuronal dysfunction in Huntington’s disease: implications for molecular inhibitors of excessive mitochondrial fission
-
P.H.Reddy Increased mitochondrial fission and neuronal dysfunction in Huntington’s disease:implications for molecular inhibitors of excessive mitochondrial fission. Drug Discov Today 2014;19:951–955.
-
(2014)
Drug Discov Today
, vol.19
, pp. 951-955
-
-
Reddy, P.H.1
|