Drug-induced HPA axis alterations during acute critical illness: a multivariable association study

Clinical Endocrinology

Volumn 86, Issue 1, 2017, Pages 26-36

  Peeters, Bram ^a   Güiza, Fabian ^a   Boonen, Eva ^a   Meersseman, Philippe ^a,b   Langouche, Lies ^a   Van den Berghe, Greet ^a  

^a LABORATORY OF MOLECULAR AND CELLULAR SIGNALING   (Belgium)

^b UNIVERSITY HOSPITALS LEUVEN   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

ALFENTANIL; CORTICOTROPIN; DESFLURANE; DESMOPRESSIN; DOBUTAMINE; ENOXAPARIN; ENOXIMONE; ETOMIDATE; FENTANYL; HEPARIN; HYDROCORTISONE; MIDAZOLAM; MORPHINE; NORADRENALIN; PARACETAMOL; PIRITRAMIDE; PRESCRIPTION DRUG; PROPOFOL; SEVOFLURANE; SUFENTANIL; TRAMADOL; VASOPRESSIN;

ACUTE DISEASE; AGED; ARTICLE; CONTROLLED STUDY; CORTICOTROPIN BLOOD LEVEL; CRITICAL ILLNESS; CRITICALLY ILL PATIENT; FEMALE; HOSPITAL ADMISSION; HUMAN; HYDROCORTISONE BLOOD LEVEL; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; MAJOR CLINICAL STUDY; MALE; MEDICAL INTENSIVE CARE UNIT; OBSERVATIONAL STUDY; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; SIDE EFFECT; SURGICAL INTENSIVE CARE UNIT; BLOOD; CASE CONTROL STUDY; DRUG EFFECTS; HYPOPHYSIS ADRENAL SYSTEM; HYPOTHALAMUS HYPOPHYSIS SYSTEM; INTENSIVE CARE UNIT; MIDDLE AGED; MULTIVARIATE ANALYSIS; STATISTICAL MODEL; STATISTICS AND NUMERICAL DATA;

ADRENOCORTICOTROPIC HORMONE; AGED; CASE-CONTROL STUDIES; CRITICAL ILLNESS; FEMALE; HUMANS; HYDROCORTISONE; HYPOTHALAMO-HYPOPHYSEAL SYSTEM; INTENSIVE CARE UNITS; LINEAR MODELS; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS; PITUITARY-ADRENAL SYSTEM;

EID: 84994361376     PISSN: 03000664     EISSN: 13652265     Source Type: Journal    
DOI: 10.1111/cen.13155     Document Type: Article

References (39)

1. Vermes, I., Beishuizen, A., Hampsink, R.M. et al. (1995) Dissociation of plasma adrenocorticotropin and cortisol levels in critically ill patients: possible role of endothelin and atrial natriuretic hormone. Journal of Clinical Endocrinology and Metabolism, 80, 1238–1242.
2. Boonen, E., Vervenne, H., Meersseman, P. et al. (2013) Reduced cortisol metabolism during critical illness. New England Journal of Medicine, 368, 1477–1488.
3. Lindgren, C., Dahlqvist, P., Lindvall, P. et al. (2013) Cortisol levels are influenced by sedation in the acute phase after subarachnoid haemorrhage. Acta Anaesthesiologica Scandinavica, 57, 452–460.
4. Plunkett, J.J., Reeves, J.D., Ngo, L. et al. (1997) Urine and plasma catecholamine and cortisol concentrations after myocardial revascularization. Modulation by continuous sedation. Multicenter Study of Perioperative Ischemia (McSPI) Research Group, and the Ischemia Research and Education Foundation (IREF). Anesthesiology, 86, 785–796.
5. Brorsson, C., Dahlqvist, P., Nilsson, L. et al. (2014) Adrenal response after trauma is affected by time after trauma and sedative/analgesic drugs. Injury, 45, 1149–1155.
6. Bruder, E.A., Ball, I.M., Ridi, S. et al. (2015) Single induction dose of etomidate versus other induction agents for endotracheal intubation in critically ill patients. Cochrane Database Systematic Review, 1, CD010225.
7. Molenaar, N., Bijkerk, R.M., Beishuizen, A. et al. (2012) Steroidogenesis in the adrenal dysfunction of critical illness: impact of etomidate. Critical Care, 16, R121.
8. Raff, H., Flemma, R.J. & Findling, J.W. (1988) Fast cortisol-induced inhibition of the adrenocorticotropin response to surgery in humans. Journal of Clinical Endocrinology and Metabolism, 67, 1146–1148.
9. Shinoda, T., Murakami, W., Takamichi, Y. et al. (2013) Effect of remifentanil infusion rate on stress response in orthopedic surgery using a tourniquet application. BMC Anesthesiology, 13, 14.
10. Watanabe, K., Kashiwagi, K., Kamiyama, T. et al. (2014) High-dose remifentanil suppresses stress response associated with pneumoperitoneum during laparoscopic colectomy. Journal of Anesthesia, 28, 334–340.
11. Aitkenhead, A.R., Pepperman, M.L., Willatts, S.M. et al. (1989) Comparison of propofol and midazolam for sedation in critically ill patients. Lancet, 2, 704–709.
12. Skoglund, K., Enblad, P., Hillered, L. et al. (2012) The neurological wake-up test increases stress hormone levels in patients with severe traumatic brain injury. Critical Care Medicine, 40, 216–222.
13. Marty, J., Gauzit, R., Lefevre, P. et al. (1986) Effects of diazepam and midazolam on baroreflex control of heart rate and on sympathetic activity in humans. Anesthesia and Analgesia, 65, 113–119.
14. Dispersyn, G., Sage, D., Challet, E. et al. (2009) Plasma corticosterone in rats is specifically increased at recovery from propofol anesthesia without concomitant rise of plasma ACTH. Chronobiology International, 26, 697–708.
15. Kostopanagiotou, G., Kalimeris, K., Christodoulaki, K. et al. (2010) The differential impact of volatile and intravenous anaesthetics on stress response in the swine. Hormones (Athens), 9, 67–75.
16. Pascoe, J.E., Williams, K.L., Mukhopadhyay, P. et al. (2008) Effects of mu, kappa, and delta opioid receptor agonists on the function of hypothalamic-pituitary-adrenal axis in monkeys. Psychoneuroendocrinology, 33, 478–486.
17. Meersseman, P., Boonen, E., Peeters, B. et al. (2015) Effect of early parenteral nutrition on the Hpa axis and on treatment with corticosteroids in Icu patients. Journal of Clinical Endocrinology and Metabolism, 100, 2613–2620.
18. Boonen, E., Meersseman, P., Vervenne, H. et al. (2014) Reduced nocturnal ACTH-driven cortisol secretion during critical illness. American Journal of Physiology. Endocrinology and Metabolism, 306, E883–E892.
19. Bone, R.C., Balk, R.A., Cerra, F.B. et al. (1992) Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP/SCCM Consensus Conference Committee. American College of Chest Physicians/Society of Critical Care Medicine. Chest, 101, 1644–1655.
20. Midi, H., Sarkar, S.K. & Rana, S. (2010) Collinearity diagnostics of binary logistic regression model. Journal of Interdisciplinary Mathematics, 13, 253–267.
21. Roth-Isigkeit, A.K. & Schmucker, P. (1997) Postoperative dissociation of blood levels of cortisol and adrenocorticotropin after coronary artery bypass grafting surgery. Steroids, 62, 695–699.
22. Gibbison, B., Angelini, G.D. & Lightman, S.L. (2013) Dynamic output and control of the hypothalamic-pituitary-adrenal axis in critical illness and major surgery. British Journal of Anaesthesia, 111, 347–360.
23. Bornstein, S.R., Engeland, W.C., Ehrhart-Bornstein, M. et al. (2008) Dissociation of ACTH and glucocorticoids. Trends in Endocrinology and Metabolism, 19, 175–180.
24. Deutschman, C.S., Raj, N.R., McGuire, E.O. et al. (2013) Orexinergic activity modulates altered vital signs and pituitary hormone secretion in experimental sepsis. Critical Care Medicine, 41, e368–e375.
25. Ehrhart-Bornstein, M., Hinson, J.P., Bornstein, S.R. et al. (1998) Intraadrenal interactions in the regulation of adrenocortical steroidogenesis. Endocrine Reviews, 19, 101–143.
26. Taylor, T., Dluhy, R.G. & Williams, G.H. (1983) beta-endorphin suppresses adrenocorticotropin and cortisol levels in normal human subjects. Journal of Clinical Endocrinology and Metabolism, 57, 592–596.
27. Rittmaster, R.S., Cutler, G.B. Jr, Sobel, D.O. et al. (1985) Morphine inhibits the pituitary-adrenal response to ovine corticotropin-releasing hormone in normal subjects. Journal of Clinical Endocrinology and Metabolism, 60, 891–895.
28. Aloisi, A.M., Aurilio, C., Bachiocco, V. et al. (2009) Endocrine consequences of opioid therapy. Psychoneuroendocrinology, 34(Suppl 1), S162–S168.
29. Abs, R., Verhelst, J., Maeyaert, J. et al. (2000) Endocrine consequences of long-term intrathecal administration of opioids. Journal of Clinical Endocrinology and Metabolism, 85, 2215–2222.
30. Taniguchi, H., Sasaki, T., Fujita, H. et al. (2013) The effect of intraoperative use of high-dose remifentanil on postoperative insulin resistance and muscle protein catabolism: a randomized controlled study. Internation Journal of Medical Sciences, 10, 1099–1107.
31. Vuong, C., Van Uum, S.H., O'Dell, L.E. et al. (2010) The effects of opioids and opioid analogs on animal and human endocrine systems. Endocrine Reviews, 31, 98–132.
32. Hildreth, A.N., Mejia, V.A., Maxwell, R.A. et al. (2008) Adrenal suppression following a single dose of etomidate for rapid sequence induction: a prospective randomized study. Journal of Trauma, 65, 573–579.
33. Watt, I. & Ledingham, I.M. (1984) Mortality amongst multiple trauma patients admitted to an intensive therapy unit. Anaesthesia, 39, 973–981.
34. Kato, K., Nakagawa, C., Murabayashi, H. et al. (2014) Expression and distribution of GABA and GABAB-receptor in the rat adrenal gland. Journal of Anatomy, 224, 207–215.
35. Amenta, F., Collier, W.L., Erdo, S.L. et al. (1988) GABAA receptor sites modulating catecholamine secretion in the rat adrenal gland: evidence from 3H-muscimol autoradiography and in vivo functional studies. Pharmacology, 37, 394–402.
36. Kenyon, C.J., Thomson, I. & Fraser, R. (1999) Stimulation of aldosterone secretion by benzodiazepines in bovine adrenocortical cells. Fundamental & Clinical Pharmacology, 13, 213–219.
37. al-Damluji, S. (1993) Adrenergic control of the secretion of anterior pituitary hormones. Baillieres Clinical Endocrinology and Metabolism, 7, 355–392.
38. Ruffolo, R.R. Jr (1987) The pharmacology of dobutamine. American Journal of the Medical Sciences, 294, 244–248.
39. Seo, D.O., Lee, S. & Rivier, C. (2003) Role of specific adrenergic receptors in mediating the adrenocorticotropic hormone response to increased nitric oxide levels. Journal of Neuroendocrinology, 15, 530–537.