Stimulation of aldosterone secretion by benzodiazepines in bovine adrenocortical cells

Fundamental and Clinical Pharmacology

Volumn 13, Issue 2, 1999, Pages 213-219

  Kenyon, Christopher J ^a   Thomson, Ian ^a   Fraser, Robert ^a  

^a WESTERN INFIRMARY   (United Kingdom)

Author keywords

Adrenal cortex; Aldosterone; Deoxycorticosterone; Diazepam; High density lipoprotein; Peripheral benzodiazepine receptors; PK11195; Ro5 4864; Zona glomerulosa

Indexed keywords

4' CHLORODIAZEPAM; ANGIOTENSIN; BENZODIAZEPINE DERIVATIVE; BENZODIAZEPINE RECEPTOR; CHOLESTEROL; DEOXYCORTICOSTERONE; DIAZEPAM; HIGH DENSITY LIPOPROTEIN; LIGAND; N SEC BUTYL 1 (2 CHLOROPHENYL) N METHYL 3 ISOQUINOLINECARBOXAMIDE; POTASSIUM;

ADRENAL CORTEX CELL; ALDOSTERONE RELEASE; ANIMAL CELL; ARTICLE; CATTLE; CELL CULTURE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG POTENTIATION; NONHUMAN; PRIORITY JOURNAL; STEROIDOGENESIS; ZONA GLOMERULOSA;

EID: 0033278557     PISSN: 07673981     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1472-8206.1999.tb00341.x     Document Type: Article

References (41)

1. Diazepam-binding inhibitor and its processing products stimulate mitochondrial steroid synthesis via an interaction with benzodiazepine receptors
2. Mitochondrial benzodiazepine receptors regulate steroid biosynthesis
3. Peripheral-type benzodiazepine receptors mediate translocation of cholesterol from outer to inner mitochondrial membranes in adrenocortical cells
4. Hormone-stimulated steriodogenesis is coupled to mitochondrial benzodiazepine receptors. Tropic hormone action on steroid biosynthesis is inhibited by flunitrazepam
5. The peripheral-type benzodiazepine receptors in endocrine organs: Autoradiographic localisation in rat pituitary, adrenal and testis
6. The peripheral-type benzodiazepine receptor. Localisation to the mitochondrial outer membrane
7. Structure and function of the peripheral-type benzodiazepine receptor in steroidogenic cells
8. Localization of diazepam-binding inhibitor-related peptides and peripheral type benzadiazepine receptors in frog adrenal gland
9. Characterization of endozepine-related peptides in the central nervous system and peripheral tissues of the rat
10. Effect of the triakontetraneuropeptide (TTN) on corticosteroid secretion by the frog adrenal gland
11. Effects of the benzodiazepines, diazepam, des-n-methyldiazepam and midazolam on steroid biosynthesis in bovine adrenocortical cells in vitro: Location of site of action
12. Diazepam inhibits potassium-induced aldosterone secretion in adrenal glomerulosa cells
13. Benzodiazepine receptor-mediated inhibition of steroidogenesis in rat adrenocortical cells
14. Inhibition of bovine adrenocortical steroidogenesis by benzodiazepines: A direct effect on microsomal hydroxylation or an inhibition of calcium uptake?
15. Cell surface localisation of the peripheral-type benzodiazepine receptor (PBR) in the adrenal cortex
16. Diazepam-binding inhibitor is a paracrine/autocrine regulator of Leydig cell proliferation and steroidogenesis: Action via peripheral-type benzodiazepine receptors and independent mechanisms
17. Dantrolene inhibits steroidogenesis by a mechanism independent of effects on stored calcium release
18. Angiotensin-II causes sustained elevations in cytosolic calcium in glomerulosa cells
19. The distribution and chemical composition of ultracentrifugally separated lipoproteins in human serum
20. The peripheral-type benzodiazepine receptor is functionally linked to Leydig cell steroidogenesis
21. The polypeptide diazepam-binding inhibitor and a higher affinity mitochondrial peripheral-type benzadiazepine receptor sustain constitutive steroidogenesis in the R2C Leydig tumour cell line
22. Generation and role of calcium signal in adrenal glomerulosa cells
23. Electrical responses in cat adrenal cortex: Possible relation to aldosterone secretion
24. Role of calcium in angiotensin-II-mediated aldosterone secretion
25. + uptake processes in guinea pig cerebral cortex synaptosomes
26. Electrophysiological and pharmacological characterisation of peripheral benzodiazepine receptors in a guinea pig heart preparation
27. Electrophysiological and pharmacological evidence that peripheral-type benzodiazepine receptors are coupled to calcium channels in the heart
28. Effects of cholesterol and lipoproteins on aldosterone secretion by bovine zona glomerulosa cells
29. + sensitivity of rat glomerulosa cells
30. Peripheral-type benzodiazepine receptors inhibit calcium channels and aldosterone production in adrenal glomerulosa cells
31. Regulation of cholesterol movement to mitochondrial cytochrome P450scc in steroid hormone synthesis
32. Topological analysis of the peripheral benzodiazepine receptor in yeast mitochondrial membranes supports a five-transmembrane structure
33. Targeted disruption of the peripheral-type benzodiazepine receptor gene inhibits steroidogenesis in the R2C Leydig tumor cell line
34. Multifactorial regulation of the final steps of aldosterone synthesis in the rat
35. Angiotensin-II stimulates both early and late pathways in aldosterone biosynthesis in isolated bovine glomerulosa cells
36. Regulatory actions of angiotensin-II on receptors and steroidogenic enzymes in adrenal glomerulosa cells
37. The effects of potassium on early and late steps in aldosterone synthesis in cells of the zona glomerulosa
38. Topography of the Leydig cell mitochondrial peripheral-type benzodiazepine receptor
39. Isolation of the mitochondrial benzodiazepine receptor: Association with voltage-dependent anion channel and the adenine dinucleotide carrier
40. Pyridine nucleotide redox state parallels aldosterone production in potassium-stimulated adrenal glomerulosa cells
41. Molecular characterisation and mitochondrial density of a recognition site for peripheral-type benzodiazepine ligands