Cardiac ryanodine receptor (Ryr2)-mediated calcium signals specifically promote glucose oxidation via pyruvate dehydrogenase

Journal of Biological Chemistry

Volumn 291, Issue 45, 2016, Pages 23490-23505

  Bround, Michael J ^a   Wambolt, Rich ^a,b   Cen, Haoning ^a   Asghari, Parisa ^a   Albu, Razvan F ^a,c   Han, Jun ^d   McAfee, Donald ^a   Pourrier, Marc ^a   Scott, Nichollas E ^a,c   Bohunek, Lubos ^b   Kulpa, Jerzy E ^a   Chen, S R Wayne ^e   Fedida, David ^a   Brownsey, Roger W ^a   Borchers, Christoph H ^d   Foster, Leonard J ^a,c   Mayor, Thibault ^a,c   Moore, Edwin D W ^a   Allard, Michael F ^a,b   Johnson, James D ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^c UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^d UNIVERSITY OF VICTORIA   (Canada)

^e UNIVERSITY OF CALGARY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM; CARDIOLOGY; DISEASES; GLUCOSE; INSECTICIDES; MAMMALS; METABOLISM; MITOCHONDRIA; OXIDATION; PATHOLOGY;

CARDIAC RYANODINE RECEPTOR; CARDIOMYOCYTE CONTRACTION; CELLULAR METABOLISM; CONTRACTILE DYSFUNCTION; FUNCTIONAL NETWORK; GLUCOSE OXIDATION; HYPERPHOSPHORYLATION; OXIDATIVE METABOLISM;

HEART;

PYRUVATE DEHYDROGENASE; RYANODINE RECEPTOR 2; CALCIUM; GLUCOSE; PROTEOME; PYRUVATE DEHYDROGENASE COMPLEX; PYRUVIC ACID DERIVATIVE; RYANODINE RECEPTOR; RYANODINE RECEPTOR 2. MOUSE;

ADULT; AEROBIC METABOLISM; ANIMAL EXPERIMENT; ARTICLE; CALCIUM SIGNALING; CALCIUM TRANSPORT; CONFOCAL LASER SCANNING MICROSCOPY; CONTROLLED STUDY; ECHOCARDIOGRAPHY; ENDOPLASMIC RETICULUM; ENERGY METABOLISM; FATTY ACID OXIDATION; GLUCOSE METABOLISM; GLUCOSE OXIDATION; GLYCOLYSIS; IN VITRO STUDY; IN VIVO STUDY; METABOLOMICS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEOMICS; TRANSCRIPTOMICS; ANIMAL; C57BL MOUSE; CARDIAC MUSCLE; CARDIAC MUSCLE CELL; CYTOLOGY; GENE DELETION; GENETICS; HEART CONTRACTION; METABOLISM; METABOLOME; OXIDATION REDUCTION REACTION; PATHOLOGY;

ANIMALS; CALCIUM; CALCIUM SIGNALING; GENE DELETION; GLUCOSE; METABOLOME; MICE; MICE, INBRED C57BL; MYOCARDIAL CONTRACTION; MYOCARDIUM; MYOCYTES, CARDIAC; OXIDATION-REDUCTION; PROTEOME; PYRUVATE DEHYDROGENASE COMPLEX; PYRUVATES; RYANODINE RECEPTOR CALCIUM RELEASE CHANNEL;

EID: 84994247320     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M116.756973     Document Type: Article

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