Particulate air pollution and fasting blood glucose in nondiabetic individuals: Associations and epigenetic mediation in the normative aging study, 2000-2011

Environmental Health Perspectives

Volumn 124, Issue 11, 2016, Pages 1715-1721

  Peng, Cheng ^a   Bind, Marie Abele C ^b   Colicino, Elena ^a   Kloog, Itai ^c   Byun, Hyang Min ^d   Cantone, Laura ^e   Trevisi, Letizia ^a   Zhong, Jia ^a   Brennan, Kasey ^a   Dereix, Alexandra E ^a   Vokonas, Pantel S ^f,g   Coull, Brent A ^a   Schwartz, Joel D ^a,h   Baccarelli, Andrea A ^a  

^a HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^b HARVARD UNIVERSITY   (United States)

^c BEN GURION UNIVERSITY OF THE NEGEV   (Israel)

^d NEWCASTLE UNIVERSITY   (United Kingdom)

^e UNIVERSITY OF MILAN   (Italy)

^f VETERANS AFFAIRS MEDICAL CENTER   (United States)

^g BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^h HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 6; TOLL LIKE RECEPTOR 2; GLUCOSE BLOOD LEVEL; PARTICULATE MATTER;

ADULT; AIR POLLUTION; ARTICLE; CELL COMMUNICATION; CELL MIGRATION; DIABETES MELLITUS; DNA METHYLATION; FEMALE; GENETIC ASSOCIATION; GLUCOSE BLOOD LEVEL; HUMAN; INFLAMMATION; MALE; MATHEMATICAL ANALYSIS; PRIORITY JOURNAL; PYROSEQUENCING; SMOKING; TEMPERATURE; AGING; ANALYSIS; DIET RESTRICTION; ENVIRONMENTAL EXPOSURE; GENETIC EPIGENESIS; PARTICLE SIZE; PARTICULATE MATTER;

AGING; AIR POLLUTION; BLOOD GLUCOSE; DNA METHYLATION; ENVIRONMENTAL EXPOSURE; EPIGENESIS, GENETIC; FASTING; HUMANS; PARTICLE SIZE; PARTICULATE MATTER;

EID: 84994229391     PISSN: 00916765     EISSN: 15529924     Source Type: Journal    
DOI: 10.1289/EHP183     Document Type: Article

References (54)

1. American Diabetes Association. 2008. Standards of medical care in diabetes-2008. Diabetes Care 31(suppl 1):S12-S54.
2. American Diabetes Association. 2012. Diagnosis and classification of diabetes mellitus. Diabetes Care 35(suppl 1):S64-S71.
3. Andersen ZJ, Raaschou-Nielsen O, Ketzel M, Jensen SS, Hvidberg M, Loft S, et al. 2012. Diabetes incidence and long-term exposure to air pollution: a cohort study. Diabetes Care 35:92-98.
4. Baron RM, Kenny DA. 1986. The moderator-mediator variable distinction in social psychological research: conceptual, strategic, and statistical considerations. J Pers Soc Psychol 51:1173-1182.
5. Bauer DJ, Preacher KJ, Gil KM. 2006. Conceptualizing and testing random indirect effects and moderated mediation in multilevel models: new procedures and recommendations. Psychol Methods 11:142-163.
6. Bind MA, Baccarelli A, Zanobetti A, Tarantini L, Suh H, Vokonas P, et al. 2012. Air pollution and markers of coagulation, inflammation, and endothelial function: associations and epigene-environment interactions in an elderly cohort. Epidemiology 23:332-340.
7. Bind MA, Lepeule J, Zanobetti A, Gasparrini A, Baccarelli A, Coull BA, et al. 2014. Air pollution and gene-specific methylation in the Normative Aging Study: association, effect modification, and mediation analysis. Epigenetics 9:448-458.
8. Bind MA, Vanderweele TJ, Coull BA, Schwartz JD. 2016. Causal mediation analysis for longitudinal data with exogenous exposure. Biostatistics 17:122-134.
9. Blüher M, Unger R, Rassoul F, Richter V, Paschke R. 2002. Relation between glycaemic control, hyperinsulinaemia and plasma concentrations of soluble adhesion molecules in patients with impaired glucose tolerance or type II diabetes. Diabetologia 45:210-216.
10. Brook RD, Jerrett M, Brook JR, Bard RL, Finkelstein MM. 2008. The relationship between diabetes mellitus and traffic-related air pollution. J Occup Environ Med 50:32-38.
11. Choi YS, Kim S, Kyu Lee H, Lee KU, Pak YK. 2004. In vitro methylation of nuclear respiratory factor-1 binding site suppresses the promoter activity of mitochondrial transcription factor A. Biochem Biophys Res Commun 314:118-122.
12. Crane PK, Walker R, Larson EB. 2013. Glucose levels and risk of dementia. N Engl J Med 369:1863-1864.
13. Diggle PJ, Heagerty P, Liang KY, Zeger SL. 2013. Analysis of Longitudinal Data. Oxford, UK:Oxford University Press.
14. Duckworth WC. 2001. Hyperglycemia and cardiovascular disease. Curr Atheroscler Rep 3:383-391.
15. Esposito K, Petrizzo M, Maiorino MI, Bellastella G, Giugliano D. 2016. Particulate matter pollutants and risk of type 2 diabetes: a time for concern? Endocrine 51:32-37.
16. Eze IC, Hemkens LG, Bucher HC, Hoffmann B, Schindler C, Künzli N, et al. 2015. Association between ambient air pollution and diabetes mellitus in Europe and North America: systematic review and meta-analysis. Environ Health Perspect 123:381-389, doi: 10.1289/ehp.1307823.
17. Guo L, Byun HM, Zhong J, Motta V, Barupal J, Zheng Y, et al. 2014. Effects of short-term exposure to inhalable particulate matter on DNA methylation of tandem repeats. Environ Mol Mutagen 55:322-335.
18. Hak AE, Pols HA, Stehouwer CD, Meijer J, Kiliaan AJ, Hofman A, et al. 2001. Markers of inflammation and cellular adhesion molecules in relation to insulin resistance in nondiabetic elderly: the Rotterdam study. J Clin Endocrinol Metab 86:4398-4405.
19. Herder C, Carstensen M, Ouwens DM. 2013. Anti-inflammatory cytokines and risk of type 2 diabetes. Diabetes Obes Metab 15(suppl 3):39-50.
20. Hernán MA, Hernández-Díaz S, Robins JM. 2004. A structural approach to selection bias. Epidemiology 15:615-625.
21. Hou L, Zhang X, Zheng Y, Wang S, Dou C, Guo L, et al. 2014. Altered methylation in tandem repeat element and elemental component levels in inhalable air particles. Environ Mol Mutagen 55:256-265.
22. Kelishadi R, Mirghaffari N, Poursafa P, Gidding SS. 2009. Lifestyle and environmental factors associated with inflammation, oxidative stress and insulin resistance in children. Atherosclerosis 203:311-319.
23. Kloog I, Nordio F, Coull BA, Schwartz J. 2012. Incorporating local land use regression and satellite aerosol optical depth in a hybrid model of spatiotemporal PM2.5 exposures in the Mid-Atlantic states. Environ Sci Technol 46:11913-11921.
24. Kloog I, Koutrakis P, Coull BA, Lee HJ, Schwartz J. 2011. Assessing temporally and spatially resolved PM2.5 exposures for epidemiological studies using satellite aerosol optical depth measurements. Atmos Environ 45:6267-6275.
25. Lepeule J, Baccarelli A, Motta V, Cantone L, Litonjua AA, Sparrow D, et al. 2012. Gene promoter methylation is associated with lung function in the elderly: the Normative Aging Study. Epigenetics 7:261-269.
26. Lepeule J, Bind MA, Baccarelli AA, Koutrakis P, Tarantini L, Litonjua A, et al. 2014. Epigenetic influences on associations between air pollutants and lung function in elderly men: the Normative Aging Study. Environ Health Perspect 122:566-572, doi: 10.1289/ehp.1206458.
27. Levitan EB, Song Y, Ford ES, Liu S. 2004. Is nondiabetic hyperglycemia a risk factor for cardiovascular disease? A meta-analysis of prospective studies. Arch Intern Med 164:2147-2155.
28. Li E, Beard C, Jaenisch R. 1993. Role for DNA methylation in genomic imprinting. Nature 366:362-365.
29. Luttmer R, Spijkerman AM, Kok RM, Jakobs C, Blom HJ, Serne EH, et al. 2013. Metabolic syndrome components are associated with DNA hypomethylation. Obes Res Clin Pract 7:e106-e115.
30. Madrigano J, Baccarelli A, Mittleman MA, Wright RO, Sparrow D, Vokonas PS, et al. 2011. Prolonged exposure to particulate pollution, genes associated with glutathione pathways, and DNA methylation in a cohort of older men. Environ Health Perspect 119:977-982, doi: 10.1289/ehp.1002773.
31. Madrigano J, Baccarelli A, Wright RO, Suh H, Sparrow D, Vokonas PS, et al. 2010. Air pollution, obesity, genes and cellular adhesion molecules. Occup Environ Med 67:312-317.
32. Madrigano J, Kloog I, Goldberg R, Coull BA, Mittleman MA, Schwartz J. 2013. Long-term exposure to PM2.5 and incidence of acute myocardial infarction. Environ Health Perspect 121:192-196, doi: 10.1289/ehp.1205284.
33. Meigs JB, Hu FB, Rifai N, Manson JE. 2004. Biomarkers of endothelial dysfunction and risk of type 2 diabetes mellitus. JAMA 291:1978-1986.
34. Mendez R, Zheng Z, Fan Z, Rajagopalan S, Sun Q, Zhang K. 2013. Exposure to fine airborne particulate matter induces macrophage infiltration, unfolded protein response, and lipid deposition in white adipose tissue. Am J Transl Res 5:224-234.
35. Newell-Price J, Clark AJ, King P. 2000. DNA methylation and silencing of gene expression. Trends Endocrinol Metab 11:142-148.
36. Nilsson E, Jansson PA, Perfilyev A, Volkov P, Pedersen M, Svensson MK, et al. 2014. Altered DNA methylation and differential expression of genes influencing metabolism and inflammation in adipose tissue from subjects with type 2 diabetes. Diabetes 63:2962-2976.
37. O’Neill MS, Veves A, Sarnat JA, Zanobetti A, Gold DR, Economides PA, et al. 2007. Air pollution and inflammation in type 2 diabetes: a mechanism for susceptibility. Occup Environ Med 64:373-379.
38. Power MC, Weisskopf MG, Alexeeff SE, Coull BA, Spiro A III, Schwartz J. 2011. Traffic-related air pollution and cognitive function in a cohort of older men. Environ Health Perspect 119:682-687, doi: 10.1289/ehp.1002767.
39. Puett RC, Hart JE, Schwartz J, Hu FB, Liese AD, Laden F. 2011. Are particulate matter exposures associated with risk of type 2 diabetes? Environ Health Perspect 119:384-389, doi: 10.1289/ehp.1002344.
40. Rahman A, Fazal F. 2009. Hug tightly and say goodbye: role of endothelial ICAM-1 in leukocyte transmigration. Antioxid Redox Signal 11:823-839.
41. Rajagopalan S, Brook RD. 2012. Air pollution and type 2 diabetes: mechanistic insights. Diabetes 61:3037-3045.
42. Rao X, Patel P, Puett R, Rajagopalan S. 2015. Air pollution as a risk factor for type 2 diabetes. Toxicol Sci 143:231-241.
43. Relton CL, Davey Smith G. 2012. Is epidemiology ready for epigenetics? Int J Epidemiol 41:5-9.
44. Rückerl R, Ibald-Mulli A, Koenig W, Schneider A, Woelke G, Cyrys J, et al. 2006. Air pollution and markers of inflammation and coagulation in patients with coronary heart disease. Am J Respir Crit Care Med 173:432-441.
45. Sarwar N, Aspelund T, Eiriksdottir G, Gobin R, Seshasai SR, Forouhi NG, et al. 2010. Markers of dysglycaemia and risk of coronary heart disease in people without diabetes: Reykjavik prospective study and systematic review. PLoS Med 7:e1000278, doi: 10.1371/journal.pmed.1000278.
46. Sun Q, Yue P, Deiuliis JA, Lumeng CN, Kampfrath T, Mikolaj MB, et al. 2009. Ambient air pollution exaggerates adipose inflammation and insulin resistance in a mouse model of diet-induced obesity. Circulation 119:538-546.
47. Tarantini L, Bonzini M, Apostoli P, Pegoraro V, Bollati V, Marinelli B, et al. 2009. Effects of particulate matter on genomic DNA methylation content and iNOS promoter methylation. Environ Health Perspect 117:217-222, doi: 10.1289/ehp.11898.
48. Tirosh A, Shai I, Tekes-Manova D, Israeli E, Pereg D, Shochat T, et al. 2005. Normal fasting plasma glucose levels and type 2 diabetes in young men. N Engl J Med 353:1454-1462.
49. Tost J, Gut IG. 2007. DNA methylation analysis by pyrosequencing. Nat Protoc 2:2265-2275.
50. Valeri L, Vanderweele TJ. 2013. Mediation analysis allowing for exposure-mediator interactions and causal interpretation: theoretical assumptions and implementation with SAS and SPSS macros. Psychol Methods 18:137-150.
51. van Eeden SF, Tan WC, Suwa T, Mukae H, Terashima T, Fujii T, et al. 2001. Cytokines involved in the systemic inflammatory response induced by exposure to particulate matter air pollutants (PM10). Am J Respir Crit Care Med 164:826-830.
52. Vossoughi M, Schikowski T, Vierkötter A, Sugiri D, Hoffmann B, Teichert T, et al. 2014. Air pollution and subclinical airway inflammation in the SALIA cohort study. Immun Ageing 11:5, doi: 10.1186/1742-4933-11-5.
53. Yagi N, Yokono K, Amano K, Nagata M, Tsukamoto K, Hasegawa Y, et al. 1995. Expression of intercellular adhesion molecule 1 on pancreatic β-cells accelerates β-cell destruction by cytotoxic T-cells in murine autoimmune diabetes. Diabetes 44:744-752.
54. Yang AS, Estécio MR, Doshi K, Kondo Y, Tajara EH, Issa JP. 2004. A simple method for estimating global DNA methylation using bisulfite PCR of repetitive DNA elements. Nucleic Acids Res 32:e38, doi: 10.1093/nar/gnh032