Epigenetic influences on associations between air pollutants and lung function in elderly men: The normative aging study

Environmental Health Perspectives

Volumn 122, Issue 6, 2014, Pages 566-572

  Lepeule, Johanna ^a   Bind, Marie Abele Catherine ^a   Baccarelli, Andrea A ^a   Koutrakis, Petros ^a   Tarantini, Letizia ^b   Litonjua, Augusto ^c   Sparrow, David ^d   Vokonas, Pantel ^d   Schwartz, Joel D ^a,c  

^a HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^b UNIVERSITY OF MILAN   (Italy)

^c BRIGHAM AND WOMEN S HOSPITAL   (United States)

^d BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

8 OXOGUANINE DNA GLYCOSYLASE 1; BLACK CARBON; CARBON MONOXIDE; CARNITINE ACETYLTRANSFERASE; DNA GLYCOSYLTRANSFERASE; GAMMA INTERFERON; GLUCOCORTICOID RECEPTOR; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 6; METHACHOLINE; NITROGEN DIOXIDE; OZONE; THROMBOPLASTIN; TOLL LIKE RECEPTOR 2; UNCLASSIFIED DRUG; AIR POLLUTANT; PARTICULATE MATTER;

AGED; AIR POLLUTANT; ARTICLE; CHRONIC BRONCHITIS; DNA METHYLATION; EMPHYSEMA; EPIGENETICS; EXHAUST GAS; EXPOSURE; FORCED EXPIRATORY VOLUME; FORCED VITAL CAPACITY; HUMAN; LUNG FUNCTION; LUNG FUNCTION TEST; MALE; PARTICULATE MATTER; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROMOTER REGION; PYROSEQUENCING; QUESTIONNAIRE; SPIROMETRY; ADVERSE EFFECTS; AIR POLLUTION; ENVIRONMENTAL EXPOSURE; GENETIC EPIGENESIS; RESPIRATORY FUNCTION; STATISTICS AND NUMERICAL DATA; TOXICITY; UNITED STATES;

AGED; AIR POLLUTANTS; AIR POLLUTION; DNA METHYLATION; ENVIRONMENTAL EXPOSURE; EPIGENESIS, GENETIC; EPIGENOMICS; FORCED EXPIRATORY VOLUME; HUMANS; MALE; MASSACHUSETTS; PARTICULATE MATTER; RESPIRATORY FUNCTION TESTS; RESPIRATORY PHYSIOLOGICAL PHENOMENA;

EID: 84901807040     PISSN: 00916765     EISSN: 15529924     Source Type: Journal    
DOI: 10.1289/ehp.1206458     Document Type: Article

References (52)

1. AceView. 2013. The AceView genes. Available: http://www. ncbi.nlm.nih.gov/IEB/Research/Acembly/ [accessed 20 July 2011].
2. Alexeeff S.E., Litonjua AA, Sparrow D, Vokonas PS, Schwartz J. 2007. Statin use reduces decline in lung function: VA Normative Aging Study. Am J Respir Crit Care Med 176:742-747; doi:10.1164/rccm.200705-656OC.
3. Baccarelli A., Wright R, Bollati V, Litonjua A, Zanobetti A, Tarantini L., et al. 2010. Ischemic heart disease and stroke in relation to blood DNA methylation. Epidemiology 21:819-828; doi:10.1097/EDE.0b013e3181f20457.
4. Barraza-Villarreal A, Sunyer J, Hernandez-Cadena L, Escamilla-Nunez M.C., Sienra-Monge JJ, Ramirez-Aguilar M, et al. 2008. Air pollution, airway inflammation, and lung function in a cohort study of Mexico City schoolchildren. Environ Health Perspect 116:832-838; doi:10.1289/ehp.10926.
5. Bell B., Rose CL, Damon A. 1966. The Veterans Administration longitudinal study of healthy aging. Gerontologist 6:179-184.
6. Brunekreef B., Dockery DW, Krzyzanowski M. 1995. Epidemiologic studies on short-term effects of low levels of major ambient air pollution components. Environ Health Perspect 103(suppl 2):3-13.
7. Budulac S.E., Boezen HM, Hiemstra PS, Lapperre TS, Vonk JM, Timens W., et al. 2012. Toll-like receptor (TLR2 and TLR4) polymorphisms and chronic obstructive pulmonary disease. PLoS ONE 7:e43124; doi:10.1371/journal.pone.0043124.
8. Chang Y.K., Wu CC, Lee LT, Lin RS, Yu YH, Chen YC. 2012. The short-term effects of air pollution on adolescent lung function in Taiwan. Chemosphere 87:26-30; doi:10.1016/j. chemosphere.2011.11.048.
9. Chatham M., Bleecker ER, Norman P, Smith PL, Mason P. 1982. A screening test for airways reactivity. An abbreviated methacholine inhalation challenge. Chest 82:15-8.
10. de Hartog JJ, Ayres JG, Karakatsani A, Analitis A, Brink HT, Hameri K., et al. 2009. Lung function and indicators of exposure to indoor and outdoor particulate matter among asthma and COPD patients. Occup Environ Med 67:2-10; doi:10.1136/oem.2008.040857.
11. Ferris BG. 1978. Epidemiology Standardization Project (American Thoracic Society). Am Rev Respir Dis 118(6 pt 2):1-120.
12. Gouveia N., Fletcher T. 2000. Time series analysis of air pollution and mortality: effects by cause, age and socioeconomic status. J Epidemiol Community Health 54:750-755; doi:10.1136/jech.54.10.750.
13. Hashimshony T., Zhang J, Keshet I, Bustin M, Cedar H. 2003. The role of DNA methylation in setting up chromatin structure during development. Nat Genet 34:187-192; doi:10.1038/ng1158.
14. He J.Q., Foreman MG, Shumansky K, Zhang X, Akhabir L, Sin D.D., et al. 2009. Associations of IL6 polymorphisms with lung function decline and COPD. Thorax 64:698-704; doi:10.1136/thx.2008.111278.
15. Herman J.G., Baylin SB. 2003. Gene silencing in cancer in association with promoter hypermethylation. N Engl J Med 349:2042-2054; doi:10.1056/NEJMra023075.
16. Hernan M.A., Lanoy E, Costagliola D, Robins JM. 2006. Comparison of dynamic treatment regimes via inverse probability weighting. Basic Clin Pharmacol Toxicol 98:237-242.
17. Hoek G., Brunekreef B. 1993. Acute effects of a winter air pollution episode on pulmonary function and respiratory symptoms of children. Arch Environ Health 48:328-335.
18. Hoek G., Fischer P, Brunekreef B, Lebret E, Hofschreuder P, Mennen MG. 1993. Acute effects of ambient ozone on pulmonary function of children in the Netherlands. Am Rev Respir Dis 147:111-117.
19. Islam T., Breton C, Salam MT, McConnell R, Wenten M, Gauderman W.J., et al. 2009. Role of inducible nitric oxide synthase in asthma risk and lung function growth during adolescence. Thorax 65:139-145; doi:10.1136/thx.2009.114355.
20. Kerkhof M., Postma DS, Brunekreef B, Reijmerink NE, Wijga AH, de Jongste JC, et al. 2010. Toll-like receptor 2 and 4 genes influence susceptibility to adverse effects of traffic-related air pollution on childhood asthma. Thorax 65:690-697; doi:10.1136/thx.2009.119636.
21. Lagorio S., Forastiere F, Pistelli R, Iavarone I, Michelozzi P, Fano V., et al. 2006. Air pollution and lung function among susceptible adult subjects: a panel study. Environ Health 5:11; doi:10.1186/1476-069X-5-11.
22. Lange N.E., Sordillo J, Tarantini L, Bollati V, Sparrow D, Vokonas P., et al. 2012. Alu and LINE-1 methylation and lung function in the Normative Aging Study. BMJ Open 2(5):e001231; doi:10.1136/bmjopen-2012-001231.
23. Lee J.T., Son JY, Cho YS. 2007. The adverse effects of fine particle air pollution on respiratory function in the elderly. Sci Total Environ 385:28-36; doi:10.1016/j.scitotenv.2007.07.005.
24. Lepeule J., Baccarelli A, Tarantini L, Motta V, Cantone L, Litonjua A., et al. 2012. Gene promoter methylation is associated with lung function in the elderly. Epigenetics 7:261-269.
25. Litonjua A.A., Sparrow D, Guevarra L, O'Connor GT, Weiss ST, Tollerud DJ. 2003. Serum interferon-gamma is associated with longitudinal decline in lung function among asthmatic patients: the Normative Aging Study. Ann Allergy Asthma Immunol 90:422-428; doi:10.1016/S1081-1206(10)61827-3.
26. Mackman N., Tilley RE, Key NS. 2007. Role of the extrinsic pathway of blood coagulation in hemostasis and thrombosis. Arterioscler Thromb Vasc Biol 27:1687-1693; doi:10.1161/ ATVBAHA.107.141911.
27. Madrigano J., Baccarelli A, Mittleman MA, Sparrow D, Vokonas P.S., Tarantini L, et al. 2012. Aging and epigenetics: longitudinal changes in gene-specific DNA methylation. Epigenetics 7:63-70; doi:10.4161/epi.7.1.18749.
28. Miller G.E., Chen E, Sze J, Marin T, Arevalo JM, Doll R, et al. 2008. A functional genomic fingerprint of chronic stress in humans: blunted glucocorticoid and increased NF-κB signaling. Biol Psychiatry 64:266-272; doi:10.1016/j. biopsych.2008.03.017.
29. Moshammer H., Hutter HP, Hauck H, Neuberger M. 2006. Low levels of air pollution induce changes of lung function in a panel of schoolchildren. Eur Respir J 27:1138-1143; doi:10. 1183/09031936.06.00089605.
30. Park S.K., O'Neill MS, Stunder BJ, Vokonas PS, Sparrow D, Koutrakis P., et al. 2007. Source location of air pollution and cardiac autonomic function: trajectory cluster analysis for exposure assessment. J Expo Sci Environ Epidemiol 17:488-497.
31. Peacock J.L., Anderson HR, Bremner SA, Marston L, Seemungal T.A., Strachan DP, et al. 2011. Outdoor air pollution and respiratory health in patients with COPD. Thorax 66:591-596; doi:10.1136/thx.2010.155358.
32. Poole J.A., Wyatt TA, Kielian T, Oldenburg P, Gleason AM, Bauer A., et al. 2011. Toll-like receptor 2 (TLR2) regulates organic dust-induced airway inflammation. Am J Respir Cell Mol Biol 45:711-719; doi:10.1165/rcmb.2010-0427OC.
33. 2.5 carbon measurements in New York: diurnal, day of week and seasonal patterns. Atmos Environ 44:2043-2053.
34. Salvi S., Blomberg A, Rudell B, Kelly F, Sandstrom T, Holgate S.T., et al. 1999. Acute inflammatory responses in the airways and peripheral blood after short-term exposure to diesel exhaust in healthy human volunteers. Am J Respir Crit Care Med 159:702-709.
35. Sandstrom T., Frew AJ, Svartengren M, Viegi G. 2003. The need for a focus on air pollution research in the elderly. Eur Respir J Suppl 40:92s-95s.
36. Schindler C., Kunzli N, Bongard JP, Leuenberger P, Karrer W, Rapp R., et al. 2001. Short-term variation in air pollution and in average lung function among never-smokers. The Swiss Study on Air Pollution and Lung Diseases in Adults (SAPALDIA). Am J Respir Crit Care Med 163:356-361.
37. Schwabe K., Vacca G, Duck R, Gillissen A. 2009. Glucocorticoid receptor gene polymorphisms and potential association to chronic obstructive pulmonary disease susceptibility and severity. Eur J Med Res 14 Suppl 4:210-215.
38. Schwartz J., Litonjua A, Suh H, Verrier M, Zanobetti A, Syring M., et al. 2005. Traffic related pollution and heart rate variability in a panel of elderly subjects. Thorax 60:455-461; doi:10.1136/thx.2004.024836.
39. Sin D.D., Man SF. 2008. Interleukin-6: a red herring or a real catch in COPD? Chest 133:4-6; doi:10.1378/chest.07-2085.
40. Smit L.A., Siroux V, Bouzigon E, Oryszczyn MP, Lathrop M, Demenais F., et al. 2009. CD14 and toll-like receptor gene polymorphisms, country living, and asthma in adults. Am J Respir Crit Care Med 179:363-368; doi:10.1164/ rccm.200810-1533OC.
41. Smoak K.A., Cidlowski JA. 2004. Mechanisms of glucocorticoid receptor signaling during inflammation. Mech Ageing Dev 125:697-706.
42. Sparrow D., O'Connor G, Colton T, Barry CL, Weiss ST. 1987. The relationship of nonspecific bronchial responsiveness to the occurrence of respiratory symptoms and decreased levels of pulmonary function. The Normative Aging Study. Am Rev Respir Dis 135:1255-1260.
43. Steinvil A., Fireman E, Kordova-Biezuner L, Cohen M, Shapira I, Berliner S., et al. 2009. Environmental air pollution has decremental effects on pulmonary function test parameters up to one week after exposure. Am J Med Sci 338:273-279; doi:10.1097/MAJ.0b013e3181adb3ed.
44. Stenvinkel P., Karimi M, Johansson S, Axelsson J, Suliman M, Lindholm B., et al. 2007. Impact of inflammation on epigenetic DNA methylation-a novel risk factor for cardiovascular disease? J Intern Med 261:488-499; doi:10.1111/j.1365-2796.2007.01777.x.
45. Sunyer J., Pistelli R, Plana E, Andreani M, Baldari F, Kolz M, et al. 2008. Systemic inflammation, genetic susceptibility and lung function. Eur Respir J 32:92-97; doi:10.1183/09031936.00052507.
46. Tost J., Gut IG. 2007. DNA methylation analysis by pyrosequencing. Nat Protoc 2:2265-2275.
47. Trenga C.A., Sullivan JH, Schildcrout JS, Shepherd KP, Shapiro G.G., Liu LJ, et al. 2006. Effect of particulate air pollution on lung function in adult and pediatric subjects in a Seattle panel study. Chest 129:1614-1622; doi:10.1378/ chest.129.6.1614.
48. U.S. Department of Health and Human Services. 2014. Aging Statistics. Available: http://www.aoa.gov/aoaroot/aging_ statistics/index.aspx [accessed 12 February 2014].
49. Yang I.A., Fong KM, Zimmerman PV, Holgate ST, Holloway JW. 2008. Genetic susceptibility to the respiratory effects of air pollution. Thorax 63:555-563; doi:10.1136/thx.2007.079426.
50. Zanobetti A., Schwartz J. 2007. Particulate air pollution, progression, and survival after myocardial infarction. Environ Health Perspect 115:769-775; doi:10.1289/ehp.9201.
51. Zarember K.A., Godowski PJ. 2002. Tissue expression of human Toll-like receptors and differential regulation of Toll-like receptor mRNAs in leukocytes in response to microbes, their products, and cytokines. J Immunol 168:554-561.
52. Zeger S.L., Thomas D, Dominici F, Samet JM, Schwartz J, Dockery D., et al. 2000. Exposure measurement error in time-series studies of air pollution: concepts and consequences. Environ Health Perspect 108:419-426.