Nitric oxide donors increase the pregnancy rate in patients with unexplained infertility undergoing clomiphene citrate stimulation and intrauterine insemination: a randomized controlled pilot study

Gynecological Endocrinology

Volumn 33, Issue 3, 2017, Pages 199-202

  Abdel Razik, Mohamed ^a   El Berry, Seham ^a   El Nezamy, Ahmed ^a   Saad, Ahmed ^a   Abdel Wahab, Ahmed ^a  

^a BENHA UNIVERSITY   (Egypt)

Author keywords

IUI; NO donors; Unexplained infertility

Indexed keywords

CHORIONIC GONADOTROPIN; CLOMIFENE CITRATE; ISOSORBIDE MONONITRATE; PLACEBO; CLOMIFENE; FERTILITY PROMOTING AGENT; ISOSORBIDE DINITRATE; NITRIC OXIDE DONOR; TABLET; VASODILATOR AGENT;

ADULT; ARTERY RESISTANCE; ARTICLE; BLOOD FLOW; CONTROLLED STUDY; EGYPT; ENDOMETRIAL THICKNESS; ENDOMETRIUM; FEMALE; FEMALE INFERTILITY; HUMAN; INTRAUTERINE INSEMINATION; LUTEAL PHASE; MAJOR CLINICAL STUDY; OVARY FOLLICLE; OVULATION INDUCTION; PILOT STUDY; PREGNANCY RATE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; TRANSVAGINAL ECHOGRAPHY; UTERINE ARTERY; UTERUS BLOOD FLOW; ANALOGS AND DERIVATIVES; ARTIFICIAL INSEMINATION; DRUG EFFECTS; FOLLICULAR PHASE; INFERTILITY, FEMALE; INTRAVAGINAL DRUG ADMINISTRATION; PATHOPHYSIOLOGY; PREGNANCY; TABLET; UNIVERSITY HOSPITAL; VASCULAR RESISTANCE; VASCULARIZATION; YOUNG ADULT;

ADMINISTRATION, INTRAVAGINAL; ADULT; CLOMIPHENE; EGYPT; ENDOMETRIUM; FEMALE; FERTILITY AGENTS, FEMALE; FOLLICULAR PHASE; HOSPITALS, UNIVERSITY; HUMANS; INFERTILITY, FEMALE; INSEMINATION, ARTIFICIAL; ISOSORBIDE DINITRATE; NITRIC OXIDE DONORS; OVULATION INDUCTION; PILOT PROJECTS; PREGNANCY; PREGNANCY RATE; REGIONAL BLOOD FLOW; TABLETS; UTERINE ARTERY; VASCULAR RESISTANCE; VASODILATOR AGENTS; YOUNG ADULT;

EID: 84994174914     PISSN: 09513590     EISSN: 14730766     Source Type: Journal    
DOI: 10.1080/09513590.2016.1240775     Document Type: Article

References (30)

1. Aboulghar M, Mansour R, Serour GI, Al-Inany HG., Diagnosis and management of unexplained infertility:an update. Arch Gynecol Obstet 2003;267:177–88
2. Veltman-Verhulst SM, Cohlen BJ, Hughes E, Heineman MJ., Intra-uterine insemination for unexplained subfertility. Cochrane Database Syst Rev 2012;9:CD001838
3. ESHRE Capri Workshop Group Intrauterine insemination. Hum Reprod Update 2009;15:265–77
4. Goswamy RK, Williams G, Stepto PC., Decreased uterine perfusion–a cause of infertility. Hum Reprod 1988;3:955–9
5. Takasaki A, Tamura H, Taketani T, et al. A pilot study to prevent a thin endometrium in patients undergoing clomiphene citrate treatment. J Ovarian Res 2013;6:9428
6. Devroey P, Bourgain C, Macklon NS, Fauser BC., Reproductive biology and IVF:ovarian stimulation and endometrial receptivity. Trends Endocrinol Metab 2004;15:84–90
7. Zaidi J, Jacobs H, Campbell S, Tan SL., Blood flow changes in ovarian and uterine arteries in women with polycystic ovary syndrome who respond to clomiphene citrate:correlation with serum hormone concentrations. Ultrasound Obstet Gynecol 1998;12:188–96
8. Kurjak A, Kupesic S, Schulman H, Zalud I., Transvaginal color flow Doppler in the assessment of ovarian and uterine blood flow in infertile women. Fertil Steril 1991;56:870–3
9. Edi-Osagie EC, Seif MW, Aplin JD, et al. Characterizing the endometrium in unexplained and tubal factor infertility:a multi-parametric investigation. Fertil Steril 2004;82:1379–89
10. Moncada S, Palmer RM, Higgs EA., Nitric oxide:physiology, pathophysiology, and pharmacology. Pharmacol Rev 1991;43:109–42
11. Moncada S. The 1991 Ulf von Euler Lecture. The L-arginine:nitric oxide pathway. Acta Physiol Scand 1992;145:201–27
12. Tahler CD, Epel D., Nitric oxide in oocyte maturation, ovulation, fertilization, cleavage and implantation:a little dab'll do ya. Curr Pharm Des 2003;9:399–409
13. Chwalisz K, Garfield RE., Role of nitric oxide in implantation and menstruation. Hum Reprod 2000;3:96–111
14. Dubey PK, Tripathi V, Singh RP, Sharma GT., Influence of nitric oxide on in vitro growth, survival, steroidogenesis, and apoptosis of follicle stimulating hormone stimulated buffalo (Bubalus bubalis) preantral follicles. J Vet Sci 2011;12:257–65
15. Morlin B, Hammarstrom M., Nitric oxide increases endocervical secretion at the ovulatory phase in the female. Acta Obstet Gynecol Scand 2005;84:833–6
16. Tempfer C, Moreno RM, O'Brien WE, Gregg AR., Genetic contributions of the endothelial nitric oxide synthase gene to ovulation and menopause in a mouse model. Fertil Steril 2000;73:1025–31
17. Zamberlam G, Sahmi F, Price CA., Nitric oxide synthase activity is critical for the preovulatory epidermal growth factor-like cascade induced by luteinizing hormone in bovine granulosa cells. Free Radic Biol Med 2014;5849:270–6
18. Pallares P, Garcia-Fernandez RA, Criado LM, et al. Disruption of the endothelial nitric oxide synthase gene affects ovulation, fertilization and early embryo survival in a knockout mouse model. Reproduction 2008;136:573–9
19. Dubey PK, Tripathi V, Singh RP, et al. Expression of nitric oxide synthase isoforms in different stages of buffalo (Bubalus bubalis) ovarian follicles:effect of nitric oxide on in vitro development of preantral follicle. Theriogenology 2012;77:280–91
20. Hefler LA, Gregg AR., Inducible and endothelial nitric oxide synthase:genetic background affects ovulation in mice. Fertil Steril 2002;77:147–51
21. Cooper TG, Noonan E, von Eckardstein S, et al. World Health Organization reference values for human semen characteristics. Hum Reprod Update 2010;16:231–45
22. Ashrafi M, Rashidi M, Ghasemi A, et al. The role of infertility etiology in success rate of intrauterine insemination cycles:an evaluation of predictive factors for pregnancy rate. Int J Fertil Steril 2013;7:100–7
23. Leanza V, Coco L, Grasso F, et al. Ovulation induction with clomiphene citrate for infertile couple. Minerva Ginecol 2014;66:309–12
24. Van Buren GA, Yang DS, Clark KE., Estrogen-induced uterine vasodilatation is antagonized by L-nitroarginine methyl ester, an inhibitor of nitric oxide synthesis. Am J Obstet Gynecol 1992;167:828–33
25. Abdel Razik M, El-Berry S, Mostafa A., The effects of nitric oxide donors on uterine artery and sub-endometrial blood flow in patients with unexplained recurrent abortion. J Reprod Infertil 2014;15:142–6
26. Battaglia C, Regnani G, Marsella T, et al. Adjuvant L-arginine treatment in controlled ovarian hyperstimulation:a double-blind, randomized study. Hum Reprod 2002;17:659–65
27. Battaglia C, Salvatori M, Maxia N, et al. Adjuvant L-arginine treatment for in-vitro fertilization in poor responder patients. Hum Reprod 1999;14:1690–7
28. Hale SA, Jones CW, Osol G, et al. Sildenafil increases uterine blood flow in nonpregnant nulliparous women. Reprod Sci 2010;17:358–65
29. El-Far M, El-Metwally A-G, Hashem IA, Bakry N., Biochemical role on intravaginal sildenafil citrate as a novel anti-abortive agent in unexplained recurrent spontaneous miscarriage:first clinical study of four cases report from Egypt. Clin Chem Lap Med 2009;47:1433–8
30. Amin AF, Shaaban OM, Bediway MA. N. N-acetyl cysteine for treatment of recurrent unexplained pregnancy loss. Reprod Biomed Online 2008;17:722–6