Effect of remote ischemic conditioning on myocardial perfusion in patients with suspected ischemic coronary artery disease

Journal of Nuclear Cardiology

Volumn 25, Issue 3, 2018, Pages 887-896

  Pryds, Kasper ^a,b   Nielsen, Roni Ranghøj ^a   Hoff, Camilla Molich ^a   Tolbod, Lars Poulsen ^a   Bouchelouche, Kirsten ^a   Li, Jing ^c   Schmidt, Michael Rahbek ^a   Redington, Andrew N ^d   Frøkiær, Jørgen ^a   Bøtker, Hans Erik ^a  

^a AARHUS UNIVERSITY HOSPITAL   (Denmark)

^b AARHUS UNIVERSITY   (Denmark)

^c HOSPITAL FOR SICK CHILDREN   (Canada)

^d UNIVERSITY OF CINCINNATI   (United States)

Author keywords

82Rb PET CT; ischemic heart disease; ischemic preconditioning; microRNA 144; myocardial perfusion; positron emission tomography computed tomography; remote ischemic conditioning

Indexed keywords

ADENOSINE; CIRCULATING MICRORNA; MICRORNA 144; RUBIDIUM 82; UNCLASSIFIED DRUG; MICRORNA; MIRN144 MICRORNA, HUMAN; RUBIDIUM; RUBIDIUM-82;

ADULT; ARTICLE; CLINICAL ARTICLE; CORONARY ARTERY DISEASE; FEMALE; HEART LEFT VENTRICLE EJECTION FRACTION; HEART MUSCLE PERFUSION; HEART WORK; HEMODYNAMICS; HUMAN; ISCHEMIC PRECONDITIONING; MALE; MIDDLE AGED; POSITRON EMISSION TOMOGRAPHY-COMPUTED TOMOGRAPHY; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; REMOTE ISCHEMIC CONDITIONING; VASCULAR RESISTANCE; AGED; BLOOD; DIAGNOSTIC IMAGING; EXERCISE TEST; HEART INFARCTION PREVENTION; HEART MUSCLE ISCHEMIA; MYOCARDIAL PERFUSION IMAGING; PATHOPHYSIOLOGY; PROSPECTIVE STUDY;

AGED; CORONARY ARTERY DISEASE; EXERCISE TEST; FEMALE; HUMANS; ISCHEMIC PRECONDITIONING, MYOCARDIAL; MALE; MICRORNAS; MIDDLE AGED; MYOCARDIAL ISCHEMIA; MYOCARDIAL PERFUSION IMAGING; POSITRON EMISSION TOMOGRAPHY COMPUTED TOMOGRAPHY; PROSPECTIVE STUDIES; RUBIDIUM RADIOISOTOPES;

EID: 84994111901     PISSN: 10713581     EISSN: 15326551     Source Type: Journal    
DOI: 10.1007/s12350-016-0709-7     Document Type: Article

References (26)

1. Heusch G, Botker HE, Przyklenk K, Redington A, Yellon D. Remote ischemic conditioning. J Am Coll Cardiol 2015;65:177–95.
2. Heusch G. Molecular basis of cardioprotection: Signal transduction in ischemic pre-, post-, and remote conditioning. Circ Res 2015;116:674–99.
3. Kharbanda RK, Mortensen UM, White PA, Kristiansen SB, Schmidt MR, Hoschtitzky JA, et al. Transient limb ischemia induces remote ischemic preconditioning in vivo. Circulation 2002;106:2881–3.
4. Heusch G. The coronary circulation as a target of cardioprotection. Circ Res 2016;118:1643–58.
5. Konstantinov IE, Arab S, Kharbanda RK, Li J, Cheung MM, Cherepanov V, et al. The remote ischemic preconditioning stimulus modifies inflammatory gene expression in humans. Physiol Genom 2004;19:143–50.
6. Shimizu M, Konstantinov IE, Kharbanda RK, Cheung MH, Redington AN. Effects of intermittent lower limb ischaemia on coronary blood flow and coronary resistance in pigs. Acta Physiol (Oxf) 2007;190:103–9.
7. Zhou K, Yang B, Zhou XM, Tan CM, Zhao Y, Huang C, et al. Effects of remote ischemic preconditioning on the flow pattern of the left anterior descending coronary artery in normal subjects. Int J Cardiol 2007;122:250–1.
8. Kono Y, Fukuda S, Hanatani A, Nakanishi K, Otsuka K, Taguchi H, et al. Remote ischemic conditioning improves coronary microcirculation in healthy subjects and patients with heart failure. Drug Design Dev Therapy 2014;8:1175–81.
9. Li J, Rohailla S, Gelber N, Rutka J, Sabah N, Gladstone RA, et al. MicroRNA-144 is a circulating effector of remote ischemic preconditioning. Basic Res Cardiol 2014;109:423.
10. Lortie M, Beanlands RS, Yoshinaga K, Klein R, Dasilva JN, DeKemp RA. Quantification of myocardial blood flow with 82Rb dynamic PET imaging. Eur J Nucl Med Mol Imaging 2007;34:1765–74.
11. 2O and a clinical PET/CT scanner. Eur J Nucl Med Mol Imaging 2011;38:930–9.
12. Czernin J, Muller P, Chan S, Brunken RC, Porenta G, Krivokapich J, et al. Influence of age and hemodynamics on myocardial blood flow and flow reserve. Circulation 1993;88:62–9.
13. Cerqueira MD, Weissman NJ, Dilsizian V, Jacobs AK, Kaul S, Laskey WK, et al. Standardized myocardial segmentation and nomenclature for tomographic imaging of the heart. A statement for healthcare professionals from the Cardiac Imaging Committee of the Council on Clinical Cardiology of the American Heart Association. Circulation 2002;105:539–42.
14. Van Tosh A, Votaw JR, Reichek N, Palestro CJ, Nichols KJ. The relationship between ischemia-induced left ventricular dysfunction, coronary flow reserve, and coronary steal on regadenoson stress-gated Rb-82 PET myocardial perfusion imaging. J Nucl Cardiol 2013;20:1060–8.
15. Naya M, Murthy VL, Taqueti VR, Foster CR, Klein J, Garber M, et al. Preserved coronary flow reserve effectively excludes high-risk coronary artery disease on angiography. J Nucl Med 2014;55:248–55.
16. Spinelli L, Petretta M, Acampa W, He W, Petretta A, Bonaduce D, et al. Prognostic value of combined assessment of regional left ventricular function and myocardial perfusion by dobutamine and rest gated SPECT in patients with uncomplicated acute myocardial infarction. J Nucl Med 2003;44:1023–9.
17. von Ziegler F, Brendel M, Uebleis C, Helbig S, Greif M, Ruemmler J, et al. SPECT myocardial perfusion imaging as an adjunct to coronary calcium score for the detection of hemodynamically significant coronary artery stenosis. BMC Cardiovasc Disor 2012;12:1.
18. Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods 2001;25:402–8.
19. Efseaff M, Klein R, Ziadi MC, Beanlands RS, deKemp RA. Short-term repeatability of resting myocardial blood flow measurements using rubidium-82 PET imaging. J Nucl Cardiol 2012;19:997–1006.
20. Hoole SP, Heck PM, White PA, Khan SN, O’Sullivan M, Clarke SC, et al. Remote ischemic preconditioning stimulus does not reduce microvascular resistance or improve myocardial blood flow in patients undergoing elective percutaneous coronary intervention. Angiology 2009;60:403–11.
21. Salerno M, Beller GA. Noninvasive assessment of myocardial perfusion. Circ Cardiovasc Imaging 2009;2:412–24.
22. Ramanathan T, Skinner H. Coronary blood flow. Contin Educ Anaesth Crit Care Pain 2005;5:61–4.
23. Murry CE, Richard VJ, Reimer KA, Jennings RB. Ischemic preconditioning slows energy metabolism and delays ultrastructural damage during a sustained ischemic episode. Circ Res 1990;66:913–31.
24. Johnsen J, Pryds K, Salman R, Lofgren B, Kristiansen SB, Botker HE. The remote ischemic preconditioning algorithm: Effect of number of cycles, cycle duration and effector organ mass on efficacy of protection. Basic Res Cardiol 2016;111:10.
25. Prior JO, Allenbach G, Valenta I, Kosinski M, Burger C, Verdun FR, et al. Quantification of myocardial blood flow with 82Rb positron emission tomography: Clinical validation with 15O-water. Eur J Nucl Med Mol Imaging 2012;39:1037–47.
26. Saraste A, Kajander S, Han C, Nesterov SV, Knuuti J. PET: Is myocardial flow quantification a clinical reality? J Nucl Cardiol 2012;19:1044–59.