Tangeretin Inhibits IL-12 Expression and NF-κB Activation in Dendritic Cells and Attenuates Colitis in Mice

Planta Medica

Volumn 83, Issue 6, 2017, Pages 527-533

  Eun, Su Hyeon ^a   Woo, Je Te ^b   Kim, Dong Hyun ^a  

^a Kyung Hee University   (South Korea)

^b CHUBU UNIVERSITY   (Japan)

Author keywords

Citrus species; colitis; dendritic cell; NF B; Rutaceae; tangeretin

Indexed keywords

CLAUDIN 1; CYCLOOXYGENASE 2; GAMMA INTERFERON; I KAPPA B KINASE ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1 RECEPTOR ASSOCIATED KINASE 1; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 17; INTERLEUKIN 23; LIPOPOLYSACCHARIDE; MITOGEN ACTIVATED PROTEIN KINASE; MYELOPEROXIDASE; OCCLUDIN; PROTEIN ZO1; RETINOID RELATED ORPHAN RECEPTOR GAMMA; SALAZOSULFAPYRIDINE; STRESS ACTIVATED PROTEIN KINASE; SYNAPTOPHYSIN; TANGERETIN; TOLL LIKE RECEPTOR 4; TRANSCRIPTION FACTOR FOXP3; TRANSCRIPTION FACTOR T BET; TRANSFORMING GROWTH FACTOR BETA ACTIVATED KINASE 1; TUMOR NECROSIS FACTOR; ANTIINFLAMMATORY AGENT; CYTOKINE; FLAVONE DERIVATIVE; NITROBENZENE DERIVATIVE; SYM-TRINITROBENZENE; TRINITROBENZENESULFONIC ACID;

ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL DISRUPTION; COLITIS; CONFOCAL MICROSCOPE; CONTROLLED STUDY; DENDRITIC CELL; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; FLOW CYTOMETER; IN VITRO STUDY; LYMPHOCYTE DIFFERENTIATION; MALE; MOUSE; NONHUMAN; POLYMERASE CHAIN REACTION; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; TH1 CELL; TH17 CELL; ANIMAL; C57BL MOUSE; CHEMICALLY INDUCED; CHEMISTRY; CITRUS; COLON; DRUG EFFECTS; METABOLISM; REGULATORY T LYMPHOCYTE;

ANIMALS; ANTI-INFLAMMATORY AGENTS; CITRUS; COLITIS; COLON; CYTOKINES; DENDRITIC CELLS; FLAVONES; LIPOPOLYSACCHARIDES; MICE; MICE, INBRED C57BL; MITOGEN-ACTIVATED PROTEIN KINASES; NF-KAPPA B; SIGNAL TRANSDUCTION; T-LYMPHOCYTES, REGULATORY; TRINITROBENZENES; TRINITROBENZENESULFONIC ACID;

EID: 84994091514     PISSN: 00320943     EISSN: 14390221     Source Type: Journal    
DOI: 10.1055/s-0042-119074     Document Type: Article

References (26)

1. Maloy K J Powrie F Intestinal homeostasis and its breakdown in inflammatory bowel disease Nature 2011 474 298 306
2. Du Z Hudcovic T Mrazek J Kozakova H Srutkova D Schwarzer M Tlaskalova-Hogenova H Kostovcik M Kverka M Development of gut inflammation in mice colonized with mucosa-associated bacteria from patients with ulcerative colitis Gut Pathog 2015 7 32
3. Niess J H Leithäuser F Adler G Reimann J Commensal gut conditions J Immunol 2008 180 559 568
4. Nourshargh S Alon R Leukocyte migration into inflamed tissues Immunity 2014 41 694 707
5. Owen J L Mohamadzadeh M Microbial activation of gut dendritic cells and the control of mucosal immunity J Interferon Cytokine Res 2013 33 619 631
6. Rutella S Locatelli F Intestinal dendritic cells in the pathogenesis of inflammatory bowel disease World J Gastroenterol 2011 17 3761 3775
7. Kaistha A Levine J Inflammatory bowel disease: the classic gastrointestinal autoimmune disease Curr Probl Pediatr Adolesc Health Care 2014 44 328 334
8. Leppkes M Becker C Ivanov I I Hirth S Wirtz S Neufert C Pouly S Murphy A J Valenzuela D M Yancopoulos G D Becher B Littman D R Neurath M F RORgamma-expressing TH17 cells induce murine chronic intestinal inflammation via redundant effects of IL-17A and IL-17F Gastroenterology 2009 136 257 267
9. Assini J M Mulvihill E E Huff M W Citrus flavonoids and lipid metabolism Curr Opin Lipidol 2013 24 34 40
10. Meiyanto E Hermawan A Anindyajati Natural products for cancer-targeted therapy: citrus flavonoids as potent chemopreventive agents Asian Pac J Cancer Prev 2012 13 427 436
11. Wu X Song M Rakariyatham K Zheng J Guo S Tang Z Zhou S Xiao H Anti-inflammatory effects of 4′-demethylnobiletin, a major metabolite of nobiletin J Funct Foods 2015 19 278 287
12. Yasuda N Ishii T Oyama D Fukuta T Agato Y Sato A Shimizu K Asai T Asakawa T Kan T Yamada S Ohizumi Y Oku N Neuroprotective effect of nobiletin on cerebral ischemia-reperfusion injury in transient middle cerebral artery-occluded rats Brain Res 2014 1559 46 54
13. Xiong Y Chen D Yu C Lv B Peng J Wang J Lin Y Citrus nobiletin ameliorates experimental colitis by reducing inflammation and restoring impaired intestinal barrier function Mol Nutr Food Res 2015 59 829 842
14. Lee Y S Cha B Y Choi S S Choi B K Yonezawa T Teruya T Nagai K Woo J T Nobiletin improves obesity and insulin resistance in high-fat diet-induced obese mice J Nutr Biochem 2013 24 156 162
15. Jang S E Ryu K R Park S H Chung S Teruya Y Han M J Woo J T Kim D H Nobiletin and tangeretin ameliorate scratching behavior in mice by inhibiting the action of histamine and the activation of NF-κB, AP-1 and p 38 Int Immunopharmacol 2013 17 502 507
16. Lopez A Peyrin-Biroulet L 5-Aminosalicylic acid and chemoprevention: does it work? Dig Dis 2013 31 248 253
17. Robinson M Medical therapy of inflammatory bowel disease for the 21st century Eur J Surg 1998 582 90 98
18. Lee Y Y Lee E J Park J S Jang S E Kim D H Kim H S Anti-inflammatory and antioxidant mechanism of tangeretin in activated microglia J Neuroimmune Pharmacol 2016 11 294 305
19. Choi S Y Ko H C Ko S Y Hwang J H Park J G Kang S H Han S H Yun S H Kim S J Correlation between flavonoid content and the NO production inhibitory activity of peel extracts from various citrus fruits Biol Pharm Bull 2007 30 772 778
20. Shu Z Yang B Zhao H Xu B Jiao W Wang Q Wang Z Kuang H Tangeretin exerts anti-neuroinflammatory effects via NF-κB modulation in lipopolysaccharide-stimulated microglial cells Int Immunopharmacol 2014 19 275 282
21. Hagenlocher Y Feilhauer K Schäffer M Bischoff S C Lorentz A Citrus peel polymethoxyflavones nobiletin and tangeretin suppress LPS-and IgE-mediated activation of human intestinal mast cells Eur J Nutr 10.1007/s00394-016-1207-z Advance online publication 28 March 2016
22. Xu J J Liu Z Tang W Wang G C Chung H Y Liu Q Y Zhuang L Li M M Li Y L Tangeretin from Citrus reticulata inhibits respiratory syncytial virus replication and associated inflammation in vivo J Agric Food Chem 2015 63 9520 9527
23. Choi B K Kim T W Lee D R Jung W H Lim J H Jung J Y Yang S H Suh J W A polymethoxy flavonoids-rich Citrus aurantium extract ameliorates ethanol-induced liver injury through modulation of AMPK and Nrf2-related signals in a binge drinking mouse model Phytother Res 2015 29 1577 1584
24. Lutz M B Kukutsch N Ogilvie A L Rossner S Koch F Romani N Schuler G An advanced culture method for generating large quantities of highly pure dendritic cells from mouse bone marrow J Immunol Methods 1999 223 77 92
25. Lim S M Kang G D Jeong J J Choi H S Kim D H Neomangiferin modulates the Th17/Treg balance and ameliorates colitis in mice Phytomedicine 2016 23 131 140
26. Jang S E Han M J Kim S Y Kim D H Lactobacillus plantarum CLP-0611 ameliorates colitis in mice by polarizing M1 to M2-like macrophages Int Immunopharmacol 2014 21 186 192