Patient-Specific Computational Analysis of Ventricular Mechanics in Pulmonary Arterial Hypertension

Journal of Biomechanical Engineering

Volumn 138, Issue 11, 2016, Pages

  Xi, Ce ^a   Latnie, Candace ^a   Zhao, Xiaodan ^b   Tan, Ju Le ^b   Wall, Samuel T ^c   Genet, Martin ^d   Zhong, Liang ^b,e   Lee, Lik Chuan ^a  

^a Michigan State University   (United States)

^b DEPARTMENT OF CARDIOLOGY   (Singapore)

^c SIMULA RESEARCH LABORATORY   (Norway)

^d UNIVERSITÉ PARIS SACLAY   (France)

^e DUKE NUS MEDICAL SCHOOL   (Singapore)

Author keywords

[No Author keywords available]

Indexed keywords

COMPUTATIONAL METHODS; MAGNETIC RESONANCE IMAGING; PRESSURE GRADIENT; STRAIN;

CIRCUMFERENTIAL STRAIN; COMPUTATIONAL ANALYSIS; COMPUTATIONAL MODEL; CURVATURE MEASUREMENT; LINEAR RELATIONSHIPS; PASSIVE STIFFNESS; PULMONARY ARTERIAL HYPERTENSION; PULMONARY ARTERIAL HYPERTENSION (PAH);

MAGNETIC RESONANCE;

ADULT; ARTICLE; BIOMECHANICS; CARDIAC MUSCLE CELL; CARDIOPULMONARY HEMODYNAMICS; CASE REPORT; CELL STRUCTURE; CONTROLLED STUDY; DISEASE COURSE; FINITE ELEMENT ANALYSIS; GEOMETRY; HEART; HEART AFTERLOAD; HEART EJECTION FRACTION; HEART LEFT VENTRICLE; HEART LEFT VENTRICLE ENDDIASTOLIC PRESSURE; HEART LEFT VENTRICLE ENDSYSTOLIC VOLUME; HEART PRELOAD; HEART RIGHT VENTRICLE; HEART RIGHT VENTRICLE ENDSYSTOLIC VOLUME; HEART STRESS; HEART VENTRICLE; HEART VENTRICLE CONTRACTILITY; HEART VENTRICLE ENDDIASTOLIC PRESSURE; HEART VENTRICLE FUNCTION; HEART VENTRICLE PRESSURE; HEART VENTRICLE REMODELING; HEART VENTRICLE VOLUME; HUMAN; IMAGE RECONSTRUCTION; INTERVENTRICULAR SEPTUM; MALE; MECHANICAL TORSION; NUCLEAR MAGNETIC RESONANCE IMAGING; NUCLEAR MAGNETIC RESONANCE SCANNER; PEAK SYSTOLIC VELOCITY; PULMONARY HYPERTENSION; BIOLOGICAL MODEL; BLOOD PRESSURE; COMPLICATION; COMPRESSIVE STRENGTH; COMPUTER ASSISTED DIAGNOSIS; COMPUTER SIMULATION; DIAGNOSTIC IMAGING; ECHOCARDIOGRAPHY; HEART CONTRACTION; PATHOPHYSIOLOGY; PROCEDURES; PULMONARY ARTERY; TENSILE STRENGTH; YOUNG MODULUS;

ADULT; BLOOD PRESSURE; COMPRESSIVE STRENGTH; COMPUTER SIMULATION; ECHOCARDIOGRAPHY; ELASTIC MODULUS; HUMANS; HYPERTENSION, PULMONARY; IMAGE INTERPRETATION, COMPUTER-ASSISTED; MALE; MODELS, CARDIOVASCULAR; MYOCARDIAL CONTRACTION; PULMONARY ARTERY; TENSILE STRENGTH; VENTRICULAR DYSFUNCTION;

EID: 84994030817     PISSN: 01480731     EISSN: 15288951     Source Type: Journal    
DOI: 10.1115/1.4034559     Document Type: Article

References (52)

1. McLaughlin, V. V., Archer, S. L., Badesch, D. B., Barst, R. J., Farber, H. W., Lindner, J. R., Mathier, M. A., McGoon, M. D., Park, M. H., Rosenson, R. S., Rubin, L. J., Tapson, V. F., and Varga, J., 2009, "ACCF/AHA 2009 Expert Consensus Document on Pulmonary Hypertension: A Report of the American College of Cardiology Foundation Task Force on Expert Consensus Documents and the American Heart Association Developed in Collaboration With the American College of Chest Physicians; American Thoracic Society, Inc.; and the Pulmonary Hypertension Association," J. Am. Coll. Cardiol., 53(17), pp. 1573-1619.
2. Thenappan, T., Shah, S. J., Rich, S., and Gomberg-Maitland, M., 2007, "A USA-Based Registry for Pulmonary Arterial Hypertension: 1982-2006," Eur. Respir. J., 30(6), pp. 1103-1110.
3. Humbert, M., Sitbon, O., Yaïci, A., Montani, D., O'Callaghan, D. S., Jaïs, X., Parent, F., Savale, L., Natali, D., Günther, S., Chaouat, A., Chabot, F., Cordier, J. F., Habib, G., Gressin, V., Jing, Z. C., Souza, R., and Simonneau, G., 2010, "Survival in Incident and Prevalent Cohorts of Patients With Pulmonary Arterial Hypertension," Eur. Respir. J., 36(3), pp. 549-555.
4. Vonk Noordegraaf, A., and Galiè, N., 2011, "The Role of the Right Ventricle in Pulmonary Arterial Hypertension," Eur. Respir. Rev., 20(122), pp. 243-253.
5. Jessup, M., Sutton, M. S., Weber, K. T., and Janicki, J. S., 1987, "The Effect of Chronic Pulmonary Hypertension on Left Ventricular Size, Function, and Interventricular Septal Motion," Am. Heart J., 113(5), pp. 1114-1122.
6. Borgdorff, M. A. J., Dickinson, M. G., Berger, R. M. F., and Bartelds, B., 2015, "Right Ventricular Failure Due to Chronic Pressure Load: What Have We Learned in Animal Models Since the NIH Working Group Statement?" Heart Failure Rev., 20(4), pp. 475-491.
7. Hill, M. R., Simon, M. A., Valdez-Jasso, D., Zhang, W., Champion, H. C., and Sacks, M. S., 2014, "Structural and Mechanical Adaptations of Right Ventricle Free Wall Myocardium to Pressure Overload," Ann. Biomed. Eng., 42(12), pp. 2451-2465.
8. Wang, Z., Schreier, D. A., Hacker, T. A., and Chesler, N. C., 2013, "Progressive Right Ventricular Functional and Structural Changes in a Mouse Model of Pulmonary Arterial Hypertension," Physiol. Rep., 1(7), p. e00184.
9. McCabe, C., White, P. A., Hoole, S. P., Axell, R. G., Priest, A. N., Gopalan, D., Taboada, D., MacKenzie Ross, R., Morrell, N. W., Shapiro, L. M., and Pepke-Zaba, J., 2014, "Right Ventricular Dysfunction in Chronic Thromboembolic Obstruction of the Pulmonary Artery: A Pressure-Volume Study Using the Conductance Catheter," J. Appl. Physiol., 116(29), pp. 355-363.
10. Trip, P., Rain, S., Handoko, M. L., Van Der Bruggen, C., Bogaard, H. J., Marcus, J. T., Boonstra, A., Westerhof, N., Vonk-Noordegraaf, A., and De Man, F. S., 2015, "Clinical Relevance of Right Ventricular Diastolic Stiffness in Pulmonary Hypertension," Eur. Respir. J., 45(6), pp. 1603-1612.
11. Lee, L. C., Wenk, J. F., Klepach, D., Zhang, Z., Saloner, D., Wallace, A. W., Ge, L., Ratcliffe, M. B., and Guccione, J. M., 2011, "A Novel Method for Quantifying In-Vivo Regional Left Ventricular Myocardial Contractility in the Border Zone of a Myocardial Infarction," ASME J. Biomech. Eng., 133(9), p. 094506.
12. Aguado-Sierra, J., Krishnamurthy, A., Villongco, C., Chuang, J., Howard, E., Gonzales, M. J., Omens, J., Krummen, D. E., Narayan, S., Kerckhoffs, R. C. P., and McCulloch, A. D., 2011, "Patient-Specific Modeling of Dyssynchronous Heart Failure: A Case Study," Prog. Biophys. Mol. Biol., 107(1), pp. 147-155.
13. Baillargeon, B., Costa, I., Leach, J. R., Lee, L. C., Genet, M., Toutain, A., Wenk, J. F., Rausch, M. K., Rebelo, N., Acevedo-Bolton, G., Kuhl, E., Navia, J. L., and Guccione, J. M., 2015, "Human Cardiac Function Simulator for the Optimal Design of a Novel Annuloplasty Ring With a Sub-Valvular Element for Correction of Ischemic Mitral Regurgitation," Cardiovasc. Eng. Technol., 6(2), pp. 105-116.
14. Wenk, J. F., Zhang, Z., Cheng, G., Malhotra, D., Acevedo-Bolton, G., Burger, M., Suzuki, T., Saloner, D. A., Wallace, A. W., Guccione, J. M., and Ratcliffe, M. B., 2010, "First Finite Element Model of the Left Ventricle With Mitral Valve: Insights Into Ischemic Mitral Regurgitation," Ann. Thorac. Surg., 89(5), pp. 1546-1553.
15. Lee, L. C., Wall, S. T., Genet, M., Hinson, A., and Guccione, J. M., 2014, "Bioinjection Treatment: Effects of Post-Injection Residual Stress on Left Ventricular Wall Stress," J. Biomech., 47(12), pp. 3115-3119.
16. Hunter, K. S., Feinstein, J. A., Ivy, D. D., and Shandas, R., 2010, "Computational Simulation of the Pulmonary Arteries and Its Role in the Study of Pediatric Pulmonary Hypertension," Prog. Pediatr. Cardiol., 30(1-2), pp. 63-69.
17. Kheyfets, V. O., Rios, L., Smith, T., Schroeder, T., Mueller, J., Murali, S., Lasorda, D., Zikos, A., Spotti, J., Reilly, J. J., and Finol, E. A., 2015, "Patient-Specific Computational Modeling of Blood Flow in the Pulmonary Arterial Circulation," Comput. Methods Programs Biomed., 120(2), pp. 88-101.
18. Voelkel, N. F., Quaife, R. A., Leinwand, L. A., Barst, R. J., McGoon, M. D., Meldrum, D. R., Dupuis, J., Long, C. S., Rubin, L. J., Smart, F. W., Suzuki, Y. J., Gladwin, M., Denholm, E. M., and Gail, D. B., 2006, "Right Ventricular Function and Failure: Report of a National Heart, Lung, and Blood Institute Working Group on Cellular and Molecular Mechanisms of Right Heart Failure," Circulation, 114(17), pp. 1883-1891.
19. Geuzaine, C., and Remacle, J.-F. F., 2009, "Gmsh: A 3-D Finite Element Mesh Generator With Built-In Pre-and Post-Processing Facilities," Int. J. Numer. Methods Eng., 79(11), pp. 1309-1331.
20. Redington, A. N., Gray, H. H., Hodson, M. E., Rigby, M. L., and Oldershaw, P. J., 1988, "Characterisation of the Normal Right Ventricular Pressure-Volume Relation by Biplane Angiography and Simultaneous Micromanometer Pressure Measurements," Br. Heart J., 59(1), pp. 23-30.
21. Kelly, R. P., Ting, C. T., Yang, T. M., Liu, C. P., Maughan, W. L., Chang, M. S., and Kass, D. A., 1992, "Effective Arterial Elastance as Index of Arterial Vascular Load in Humans," Circulation, 86(2), pp. 513-521.
22. Maas, S. A., Ellis, B. J., Ateshian, G. A., and Weiss, J. A., 2012, "FEBio: Finite Elements for Biomechanics," ASME J. Biomech. Eng., 134(1), p. 011005.
23. Veress, A. I., Gullberg, G. T., and Weiss, J. A., 2005, "Measurement of Strain in the Left Ventricle During Diastole With Cine-MRI and Deformable Image Registration," ASME J. Biomech. Eng., 127(7), pp. 1195-1207.
24. Phatak, N. S., Maas, S. A., Veress, A. I., Pack, N. A., Di Bella, E. V. R., and Weiss, J. A., 2009, "Strain Measurement in the Left Ventricle During Systole With Deformable Image Registration," Med. Image Anal., 13(2), pp. 354-361.
25. Bayer, J. D., Blake, R. C., Plank, G., and Trayanova, N. A., 2012, "A Novel Rule-Based Algorithm for Assigning Myocardial Fiber Orientation to Computational Heart Models," Ann. Biomed. Eng., 40(10), pp. 2243-2254.
26. Streeter, D. D., Spotnitz, H. M., Patel, D. P., Ross, J., and Sonnenblick, E. H., 1969, "Fiber Orientation in the Canine Left Ventricle During Diastole and Systole," Circ. Res., 24(3), pp. 339-347.
27. Sundnes, J., Wall, S., Osnes, H., Thorvaldsen, T., and McCulloch, A. D., 2012, "Improved Discretisation and Linearisation of Active Tension in Strongly Coupled Cardiac Electro-Mechanics Simulations," Comput. Methods Biomech. Biomed. Eng., 17(6), pp. 604-615.
28. Lee, L., Sundnes, J., Genet, M., Wenk, J., and Wall, S. T., 2016, "An Integrated Electromechanical-Reversible Growth Heart Model for Simulating Cardiac Therapies," Biomech. Model. Mechanobiol., 15(4), pp. 791-803.
29. Winslow, R. L., Rice, J., Jafri, S., Marban, E., and O'Rourke, B., 1999, "Mechanisms of Altered Excitation-Contraction Coupling in Canine Tachycardia-Induced Heart Failure, II: Model Studies," Circ. Res., 84(5), pp. 571-586.
30. Rice, J. J., Wang, F., Bers, D. M., and de Tombe, P. P., 2008, "Approximate Model of Cooperative Activation and Crossbridge Cycling in Cardiac Muscle Using Ordinary Differential Equations," Biophys. J., 95(5), pp. 2368-2390.
31. Moskowitz, S. E., 1981, "Effects of Inertia and Viscoelasticity in Late Rapid Filling of the Left Ventricle," J. Biomech., 14(6), pp. 443-445.
32. Walker, J. C., Ratcliffe, M. B., Zhang, P., Wallace, A. W., Hsu, E. W., Saloner, D. A., and Guccione, J. M., 2008, "Magnetic Resonance Imaging-Based Finite Element Stress Analysis After Linear Repair of Left Ventricular Aneurysm," J. Thorac. Cardiovasc. Surg., 135(5), pp. 1094-1102.e2.
33. Smith, B. C. F., Dobson, G., Dawson, D., Charalampopoulos, A., Grapsa, J., and Nihoyannopoulos, P., 2014, "Three-Dimensional Speckle Tracking of the Right Ventricle: Toward Optimal Quantification of Right Ventricular Dysfunction in Pulmonary Hypertension," J. Am. Coll. Cardiol., 64(1), pp. 41-51.
34. Oyama-Manabe, N., Sato, T., Tsujino, I., Kudo, K., Manabe, O., Kato, F., Osman, N. F., and Terae, S., 2013, "The Strain-Encoded (SENC) MR Imaging for Detection of Global Right Ventricular Dysfunction in Pulmonary Hypertension," Int. J. Cardiovasc. Imaging, 29(2), pp. 371-378.
35. Puwanant, S., Park, M., Popovic, Z. B., Tang, W. H. W., Farha, S., George, D., Sharp, J., Puntawangkoon, J., Loyd, J. E., Erzurum, S. C., and Thomas, J. D., 2010, "Ventricular Geometry, Strain, and Rotational Mechanics in Pulmonary Hypertension," Circulation, 121(2), pp. 259-266.
36. Bellofiore, A., and Chesler, N. C., 2013, "Methods for Measuring Right Ventricular Function and Hemodynamic Coupling With the Pulmonary Vasculature," Ann. Biomed. Eng., 41(7), pp. 1384-1398.
37. Cohn, J. N., Ferrari, R., and Sharpe, N., 2000, "Cardiac Remodeling Concepts and Clinical Implications: A Consensus Paper From an International Forum on Cardiac Remodeling," J. Am. Coll. Cardiol., 35(3), pp. 569-582.
38. Rain, S., Handoko, L., Trip, P., Gan, T.-J., Westerhof, N., Stienen, G., Paulus, W., Ottenheijm, C., Marcus, T., Dorfmüller, P., Guignabert, C., Humbert, M., MacDonald, P., dos Remedios, C., Postmus, P., Saripalli, C., Hidalgo, C., Granzier, H., Vonk-Noordegraaf, A., van der Velden, J., and de Man, F., 2013, "Right Ventricular Diastolic Impairment in Patients With Pulmonary Arterial Hypertension," Circulation, 128(18), pp. 2016-2025.
39. De Man, F. S., Handoko, M. L., Van Ballegoij, J. J. M., Schalij, I., Bogaards, S. J. P., Postmus, P. E., Van Der Velden, J., Westerhof, N., Paulus, W. J., and Vonk-Noordegraaf, A., 2012, "Bisoprolol Delays Progression Towards Right Heart Failure in Experimental Pulmonary Hypertension," Circ.: Heart Failure, 5(1), pp. 97-105.
40. Vonk-Noordegraaf, A., Haddad, F., Chin, K. M., Forfia, P. R., Kawut, S. M., Lumens, J., Naeije, R., Newman, J., Oudiz, R. J., Provencher, S., Torbicki, A., Voelkel, N. F., and Hassoun, P. M., 2013, "Right Heart Adaptation to Pulmonary Arterial Hypertension: Physiology and Pathobiology," J. Am. Coll. Cardiol., 62(Suppl. 25), pp. D22-D33.
41. Hardziyenka, M., Campian, M. E., Verkerk, A. O., Surie, S., van Ginneken, A. C., Hakim, S., Linnenbank, A. C., de Bruin-Bon, H. A., Beekman, L., van der Plas, M. N., Remme, C. A., van Veen, T. A., Bresser, P., de Bakker, J. M., and Tan, H. L., 2012, "Electrophysiologic Remodeling of the Left Ventricle in Pressure Overload-Induced Right Ventricular Failure," J. Am. Coll. Cardiol., 59(24), pp. 2193-2202.
42. Haddad, F., Hunt, S. A., Rosenthal, D. N., and Murphy, D. J., 2008, "Right Ventricular Function in Cardiovascular Disease, Part I: Anatomy, Physiology, Aging, and Functional Assessment of the Right Ventricle," Circulation, 117(11), pp. 1436-1448.
43. Marcus, J. T., Vonk Noordegraaf, A., Roeleveld, R. J., Postmus, P. E., Heethaar, R. M., Van Rossum, A. C., and Boonstra, A., 2001, "Impaired Left Ventricular Filling Due to Right Ventricular Pressure Overload in Primary Pulmonary Hypertension: Noninvasive Monitoring Using MRI," Chest, 119(6), pp. 1761-1765.
44. Tanaka, H., Tei, C., Nakao, S., Tahara, M., Sakurai, S., Kashima, T., and Kanehisa, T., 1980, "Diastolic Bulging of the Interventricular Septum Toward the Left Ventricle. An Echocardiographic Manifestation of Negative Interventricular Pressure Gradient Between Left and Right Ventricles During Diastole," Circulation, 62(3), pp. 558-563.
45. Beyar, R., Dong, S. J., Smith, E. R., Belenkie, I., and Tyberg, J. V., 1993, "Ventricular Interaction and Septal Deformation: A Model Compared With Experimental Data," Am. J. Physiol., 265(6 Pt. 2), pp. H2044-H2056.
46. King, M. E., Braun, H., Goldblatt, A., Liberthson, R., and Weyman, A. E., 1983, "Interventricular Septal Configuration as a Predictor of Right Ventricular Systolic Hypertension in Children: A Cross-Sectional Echocardiographic Study," Circulation, 68(1), pp. 68-75.
47. Zhong, L., Su, Y., Yeo, S.-Y., Tan, R.-S., Ghista, D. N., and Kassab, G., 2009, "Left Ventricular Regional Wall Curvedness and Wall Stress in Patients With Ischemic Dilated Cardiomyopathy," Am. J. Physiol.: Heart Circ. Physiol., 296(3), pp. H573-H584.
48. Zhong, L., Su, Y., Gobeawan, L., Sola, S., Tan, R.-S., Navia, J. L., Ghista, D. N., Chua, T., Guccione, J., and Kassab, G. S., 2011, "Impact of Surgical Ventricular Restoration on Ventricular Shape, Wall Stress, and Function in Heart Failure Patients," Am. J. Physiol.: Heart Circ. Physiol., 300(5), pp. H1653-H1660.
49. Zhong, L., Gobeawan, L., Su, Y., Tan, J.-L., Ghista, D., Chua, T., Tan, R.-S., and Kassab, G., 2012, "Right Ventricular Regional Wall Curvedness and Area Strain in Patients With Repaired Tetralogy of Fallot," Am. J. Physiol.: Heart Circ. Physiol., 302(6), pp. H1306-H1316.
50. Walker, J. C., Ratcliffe, M. B., Zhang, P., Wallace, A. W., Fata, B., Hsu, E. W., Saloner, D., and Guccione, J. M., 2005, "MRI-Based Finite-Element Analysis of Left Ventricular Aneurysm," Am. J. Physiol., 289(2), pp. H692-H700.
51. Kerckhoffs, R. C. P., 2010, Patient-Specific Modeling of the Cardiovascular System: Technology-Driven Personalized Medicine, Springer Science + Business Media, New York, pp. 1-240.
52. Genet, M., Lee, L. C., Nguyen, R., Haraldsson, H., Acevedo-Bolton, G., Zhang, Z., Ge, L., Ordovas, K., Kozerke, S., and Guccione, J. M., 2014, "Distribution of Normal Human Left Ventricular Myofiber Stress at End-Diastole and End-Systole - A Target for In Silico Studies of Cardiac Procedures," J. Appl. Physiol., 117(2), pp. 142-152.