Human Cardiac Function Simulator for the Optimal Design of a Novel Annuloplasty Ring with a Sub-valvular Element for Correction of Ischemic Mitral Regurgitation

Cardiovascular Engineering and Technology

Volumn 6, Issue 2, 2015, Pages 105-116

  Baillargeon, Brian ^a   Costa, Ivan ^b   Leach, Joseph R ^c   Lee, Lik Chuan ^d   Genet, Martin ^c,e   Toutain, Arnaud ^c   Wenk, Jonathan F ^f   Rausch, Manuel K ^g   Rebelo, Nuno ^a   Acevedo Bolton, Gabriel ^c   Kuhl, Ellen ^g   Navia, Jose L ^h   Guccione, Julius M ^c,i  

^a DASSAULT SYSTÈMES   (France)

^b UNIVERSITY OF BRASILIA   (Brazil)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d Michigan State University   (United States)

^e ETH ZURICH   (Switzerland)

^f UNIVERSITY OF KENTUCKY   (United States)

^g STANFORD UNIVERSITY   (United States)

^h LERNER RESEARCH INSTITUTE   (United States)

ⁱ UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Finite element method; Ischemic mitral regurgitation; Mitral annuloplasty; Myocardial infarction; Realistic simulation; Ventricular function

Indexed keywords

DIMENSIONAL STABILITY; HEART; MECHANICS; MUSCLE; SIMULATORS;

ANNULOPLASTY; MITRAL REGURGITATION; MYOCARDIAL INFARCTION; REALISTIC SIMULATION; VENTRICULAR FUNCTIONS;

FINITE ELEMENT METHOD;

ANNULOPLASTY RING; ARTICLE; FINITE ELEMENT ANALYSIS; HEART LEFT VENTRICLE EJECTION FRACTION; HEART LEFT VENTRICLE INFARCTION; ISCHEMIC MITRAL VALVE REGURGITATION; MITRAL ANNULOPLASTY; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL (TOPIC); SIMULATOR; ANATOMIC MODEL; ANATOMY AND HISTOLOGY; ANIMAL; BIOLOGICAL MODEL; COMPUTER SIMULATION; DEVICES; HEART INFARCTION; HEART LEFT VENTRICLE FUNCTION; HEART VENTRICLE REMODELING; HUMAN; MALE; MITRAL VALVE; MITRAL VALVE INSUFFICIENCY; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; PIG; SOFTWARE; TRICUSPID VALVE;

ANIMALS; COMPUTER SIMULATION; HUMANS; MALE; MITRAL VALVE; MITRAL VALVE ANNULOPLASTY; MITRAL VALVE INSUFFICIENCY; MODELS, ANATOMIC; MODELS, CARDIOVASCULAR; MYOCARDIAL INFARCTION; SOFTWARE; SWINE; TRICUSPID VALVE; VENTRICULAR DYSFUNCTION, LEFT; VENTRICULAR REMODELING;

EID: 84929081749     PISSN: 1869408X     EISSN: 18694098     Source Type: Journal    
DOI: 10.1007/s13239-015-0216-z     Document Type: Article

References (20)

1. Acker, M. A., A. C. Gelijns, and I. L. Kron. Surgery for severe ischemic mitral regurgitation. N. Engl. J. Med. 370:1463, 2014.
2. Acker, M. A., M. K. Parides, L. P. Perrault, A. J. Moskowitz, A. C. Gelijns, P. Voisine, et al. Mitral-valve repair versus replacement for severe ischemic mitral regurgitation. N. Engl. J. Med. 370:23–32, 2014.
3. Baillargeon, B., N. Rebelo, D. D. Fox, R. L. Taylor, and E. Kuhl. The living heart project: a robust and integrative simulator for human heart function. Eur. J. Mech. A/Solids. 48:38–47, 2014.
4. Bothe, W., M. K. Rausch, J.-P. E. Kvitting, D. K. Echtner, M. Walther, N. B. Ingels, et al. How do annuloplasty rings affect mitral annular strains in the normal beating ovine heart? Circulation. 126:S231–S238, 2012.
5. Dokos, S., B. H. Smaill, A. A. Young, and I. J. LeGrice. Shear properties of passive ventricular myocardium. Am. J. Physiol. Heart Circ. Physiol. 283:H2650–H2659, 2002.
6. Einstein, D. R., F. Del Pin, X. Jiao, A. P. Kuprat, J. P. Carson, K. S. Kunzelman, et al. Fluid-structure interactions of the mitral valve and left heart: comprehensive strategies, past, present and future. Int. J. Numer. Methods Eng. 26:348–380, 2010.
7. Gammie, J. S., S. Sheng, B. P. Griffith, E. D. Peterson, J. S. Rankin, S. M. O’Brien, et al. Trends in mitral valve surgery in the United States: results from the Society of Thoracic Surgeons Adult Cardiac Surgery Database. Ann. Thorac. Surg. 87:1431–1437, 2009; (; discussion 1437–9, 2009).
8. Genet, M., L. C. Lee, R. Nguyen, H. Haraldsson, G. Acevedo-Bolton, Z. Zhang, et al. Distribution of normal human left ventricular myofiber stress at end diastole and end systole: a target for in silico design of heart failure treatments. J. Appl. Physiol. 117:142–152, 2014.
9. Gorman, R. C., M. J. Gillespie, and J. H. Gorman. Surgery for severe ischemic mitral regurgitation. N. Engl. J. Med. 370:1462, 2014.
10. Kunzelman, K. S., and R. P. Cochran. Mechanical properties of basal and marginal mitral valve chordae tendineae. ASAIO Trans. 36:M405–M408, 1990.
11. Kunzelman, K. S., D. R. Einstein, and R. P. Cochran. Fluid-structure interaction models of the mitral valve: function in normal and pathological states. Philos. Trans. R. Soc. Lond. B. Biol. Sci. 362:1393–1406, 2007.
12. Lee, L. C., M. Genet, A. B. Dang, L. Ge, J. M. Guccione, and M. B. Ratcliffe. Applications of computational modeling in cardiac surgery. J. Card. Surg. 29:293–302, 2014.
13. May-Newman, K., and F. C. Yin. Biaxial mechanical behavior of excised porcine mitral valve leaflets. Am. J. Physiol. 269:H1319–H1327, 1995.
14. Pfisterer, M. E., A. Battler, and B. L. Zaret. Range of normal values for left and right ventricular ejection fraction at rest and during exercise assessed by radionuclide angiocardiography. Eur. Heart J. 6:647–655, 1985.
15. Rausch, M. K., W. Bothe, J.-P. E. Kvitting, J. C. Swanson, D. C. Miller, and E. Kuhl. Mitral valve annuloplasty: a quantitative clinical and mechanical comparison of different annuloplasty devices. Ann. Biomed. Eng. 40:750–761, 2012.
16. Rogers, W. J., E. P. Shapiro, J. L. Weiss, M. B. Buchalter, F. E. Rademakers, M. L. Weisfeldt, et al. Quantification of and correction for left ventricular systolic long-axis shortening by magnetic resonance tissue tagging and slice isolation. Circulation. 84:721–731, 1991.
17. Siefert, A. W., J.-P. M. Rabbah, N. Saikrishnan, K. S. Kunzelman, and A. P. Yoganathan. Isolated effect of geometry on mitral valve function for in silico model development. Engin: Comput. Methods Biomech. Biomed., 2013.
18. Wenk, J. F., S. T. Wall, R. C. Peterson, S. L. Helgerson, H. N. Sabbah, M. Burger, et al. A method for automatically optimizing medical devices for treating heart failure: designing polymeric injection patterns. J. Biomech. Eng. 131:121011, 2009.
19. Wenk, J. F., Z. Zhang, G. Cheng, D. Malhotra, G. Acevedo-Bolton, M. Burger, et al. First finite element model of the left ventricle with mitral valve: insights into ischemic mitral regurgitation. Ann. Thorac. Surg. 89:1546–1553, 2010.
20. Wong, V. M., J. F. Wenk, Z. Zhang, G. Cheng, G. Acevedo-Bolton, M. Burger, et al. The effect of mitral annuloplasty shape in ischemic mitral regurgitation: a finite element simulation. Ann. Thorac. Surg. 93:776–782, 2012.