MiR-34a and miR-34c are involved in the pathogenesis of type-2 diabetes by modulating the cell cycle of pancreatic beta-cell

International Journal of Clinical and Experimental Pathology

Volumn 9, Issue 5, 2016, Pages 5340-5345

  Liu, Hongyu ^a   Jin, Mengmeng ^a   Tian, Hui ^a   Li, Jian ^a   Li, Nan ^a   Yan, Shuangtong ^a  

^a CHINESE PLA GENERAL HOSPITAL   (China)

Author keywords

Apoptosis; CCNE2; Cell cycle; MiRNA; Type 2 diabetes

Indexed keywords

EID: 84993993778     PISSN: None     EISSN: 19362625     Source Type: Journal    
DOI: None     Document Type: Article

References (11)

1. Jensen CC, Cnop M, Hull RL, Fujimoto WY, Kahn SE; American Diabetes Association GENNID Study Group. Beta-cell function is a major contributor to oral glucose tolerance in high-risk relatives of four ethnic groups in the U.S. Diabetes 2002; 51: 2170-8.
2. Defronzo RA. Banting Lecture. From the triumvirate to the ominous octet: a new paradigm for the treatment of type 2 diabetes mellitus. Diabetes 2009; 58: 773-95.
3. Butler AE, Janson J, Bonner-Weir S, Ritzel R, Rizza RA, Butler PC. Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes. Diabetes 2003; 52: 102-10.
4. Tugay K, Guay C, Marques AC, Allagnat F, Locke JM, Harries LW, Rutter GA, Regazzi R. Role of microRNAs in the age-associated decline of pancreatic beta cell function in rat islets. Diabetologia 2016; 59: 161-9.
5. Friedman RC, Farh KK, Burge CB, Bartel DP. Most mammalian mRNAs are conserved targets of microRNAs. Genome Res 2009; 19: 92-105.
6. Baldeón R L, Weigelt K, de Wit H, Ozcan B, van Oudenaren A, Sempértegui F, Sijbrands E, Grosse L, van Zonneveld AJ, Drexhage HA, Leenen PJ. Type 2 Diabetes Monocyte Micro- RNA and mRNA Expression: Dyslipidemia As- sociates with Increased Differentiation-Related Genes but Not Inflammatory Activation. PLoS One 2015; 10: e0129421.
7. Baldeón RL, Weigelt K, de Wit H, Ozcan B, van Oudenaren A, Sempértegui F, Sijbrands E, Grosse L, Freire W, Drexhage HA, Leenen PJ. Decreased serum level of miR-146a as sign of chronic inflammation in type 2 diabetic patients. PLoS One 2014; 9: e115209.
8. Wang TT, Chen YJ, Sun LL, Zhang SJ, Zhou ZY, Qiao H. Affection of single-nucleotide polymorphisms in miR-27a, miR-124a, and miR-146a on susceptibility to type 2 diabetes mellitus in Chinese Han people. Chin Med J (Engl) 2015; 128: 533-9.
9. American Diabetes Association. Diagnosis and classification of diabetes mellitus. Diabetes Care 2011; 34 Suppl 1: S62-9.
10. Gotoh M, Maki T, Satomi S, Porter J, Bonner-Weir S, O'Hara CJ, Monaco AP. Reproducible high yield of rat islets by stationary in vitro digestion following pancreatic ductal or portal venous collagenase injection. Transplantation 1987; 43: 725-30.
11. Dumortier O, Hinault C, Van Obberghen E. MicroRNAs and metabolism crosstalk in energy homeostasis. Cell Metab 2013; 18: 312-24.