Recent and future advances in the treatment of status epilepticus

Therapeutic Advances in Neurological Disorders

Volumn 1, Issue 1, 2008, Pages 25-32

  Rosenow, Felix ^a   Knake, Susanne ^a  

^a PHILIPPS UNIVERSITY MARBURG   (Germany)

Author keywords

Antiepileptic drugs; Lacosamide; Levetiracetam; Lorazepam; Status epilepticus

Indexed keywords

EID: 84993820453     PISSN: 17562856     EISSN: None     Source Type: Journal    
DOI: 10.1177/1756285608094263     Document Type: Review

References (79)

1. Treatment of convulsive status epilepticus. ( 1993) Recommendations of the Epilepsy Foundation of America's Working Group on Status Epilepticus. JAMA 270: 854-859.
2. Alldredge, B.K., Gelb, A.M., Isaacs, S.M., Corry, M.D., Allen, F., Ulrich, S. et al. (2001) A comparison of lorazepam, diazepam, and placebo for the treatment of out-of-hospital status epilepticus. N Engl J Med 345: 631-637.
3. Bialer, M., Johannessen, S.I., Kupferberg, H.J., Levy, R.H., Perucca, E. and Tomson, T. (2007) Progress report on new antiepileptic drugs: a summary of the Eigth Eilat Conference (EILAT VIII). Epilepsy Res 73: 1-52.
4. Biton, V., Rosenfeld, W.E., Whitesides, J., Fountain, N.B., Vaiciene, N. and Rudd, G.D. (2008) Intravenous lacosamide as replacement for oral lacosamide in patients with partial-onset seizures. Epilepsia 49: 418-424.
5. Bleck, T.P. (1993) Advances in the management of refractory status epilepticus. Crit Care Med. 21: 955-957.
6. Bleck, T.P. (2005) Refractory status epilepticus. Curr.Opin.Crit Care 11: 117-120.
7. Browne, T.R., Kugler, A.R. and Eldon, M.A. (1996) Pharmacology and pharmacokinetics of fosphenytoin. Neurology 46: S3-S7.
8. Burneo, J.G., Anandan, J.V. and Barkley, G.L. (2001) A prospective study of the incidence of the purple glove syndrome. Epilepsia 42: 1156-1159.
9. Chin, R.F., Neville, B.G., Peckham, C., Bedford, H., Wade, A. and Scott, R.C. (2006) Incidence, cause, and short-term outcome of convulsive status epilepticus in childhood: prospective population-based study. Lancet 368: 222-229.
10. Claassen, J., Hirsch, L.J., Emerson, R.G. and Mayer, S.A. (2002) Treatment of refractory status epilepticus with pentobarbital, propofol, or midazolam: a systematic review. Epilepsia 43: 146-153.
11. Coeytaux, A., Jallon, P., Galobardes, B. and Morabia, A. (2000) Incidence of status epilepticus in French-speaking Switzerland: (EPISTAR). Neurology 55: 693-697.
12. Czapinski, P. and Terczynski, A. (1998) [Intravenous valproic acid administration in status epilepticus]. Neurol Neurochir Pol 32: 11-22.
13. de Lorenzo, R.J., Pellock, J.M., Towne, A.R. and Boggs, J.G. (1995) Epidemiology of status epilepticus. J Clin Neurophysiol 12: 316-325.
14. de Lorenzo, R.J., Waterhouse, E.J., Towne, A.R., Boggs, J.G., Ko, D., de Lorenzo, G.A. et al. (1998) Persistent nonconvulsive status epilepticus after the control of convulsive status epilepticus. Epilepsia 39: 833-840.
15. Doty, P., Rudd, G.D., Stoehr, T. and Thomas, D. (2007) Lacosamide. Neurotherapeutics 4: 145-148.
16. Dreifuss, F.E., Rosman, N.P., Cloyd, J.C., Pellock, J.M., Kuzniecky, R.I., Lo, W.D. et al. (1998) A comparison of rectal diazepam gel and placebo for acute repetitive seizures. N Engl J Med 338: 1869-1875.
17. Eldon, M.A. and Loewen, G. (1993) Pharmacokinetics and tolerance of fosphenytoin and phenytoin administration intravenously to healthy subjects. Can J Neurol Sci 20: 5180.
18. Fountain, N.B. (2000) Status epilepticus: risk factors and complications. Epilepsia 41(Suppl 2): S23-S30.
19. Del gado-Escueta, A.V., Wasterlain, C., Treiman, D.M. and Porter, R.J. (1982) Current concepts in neurology: management of status epilepticus. N Engl J Med 306: 1337-1340.
20. Garzon, E., Fernandes, R.M. and Sakamoto, A.C. (2003) Analysis of clinical characteristics and risk factors for mortality in human status epilepticus. Seizure 12: 337-345.
21. Gibbs, J.E. and Cock, H.R. (2007) Administration of levetiracetam after prolonged status epilepticus does not protect from mitochondrial dysfunction in a rodent model. Epilepsy Res 73: 208-212.
22. Gibbs, J.E., Walker, M.C. and Cock, H.R. (2006) Levetiracetam: antiepileptic properties and protective effects on mitochondrial dysfunction in experimental status epilepticus. Epilepsia 47: 469-478.
23. Greenblatt, D.J. and Divoll, M. (1983) Diazepam versus lorazepam: relationship of drug distribution to duration of clinical action. Adv Neurol 34: 487-491.
24. Grosse, P., Rusch, L. and Schmitz, B. (1999) Pancreatitis complicating treatment of status epilepticus with intravenous valproate. Epilepsia 40: S267.
25. Hauser, W.A. (1990) Status epilepticus: epidemiologic considerations. Neurology 40: 9-13.
26. Hesdorffer, D.C., Logroscino, G., Cascino, G., Annegers, J.F. and Hauser, W.A. (1998) Incidence of status epilepticus in Rochester, Minnesota, 1965-1984. Neurology 50: 735-741.
27. Holtkamp, M., Othman, J., Buchheim, K. and Meierkord, H. (2005) Predictors and prognosis of refractory status epilepticus treated in a neurological intensive care unit. J Neurol Neurosurg Psychiatry 76: 534-539.
28. Jallon, P., Coeytaux, A., Galobardes, B. and Morabia, A. (1999) Incidence and case-fatality rate of status epilepticus in the Canton of Geneva. Lancet 353: 1496.
29. Jamerson, B.D., Dukes, G.E., Brouwer, K.L., Donn, K.H., Messenheimer, J.A. and Powell, J.R. (1994) Venous irritation related to intravenous administration of phenytoin versus fosphenytoin. Pharmacotherapy 14: 47-52.
30. Kaplan, P.W. (2000) Prognosis in nonconvulsive status epilepticus. Epileptic Disord 2: 185-193.
31. Kilarski, D.J., Buchanan, C. and von Behren, L. (1984) Soft-tissue damage associated with intravenous phenytoin. N Engl J Med 311: 1186-1187.
32. Knake, S., Gruener, J., Hattemer, K., Klein, K.M., Bauer, S., Oertel, W.H. et al. (2008) Intravenous levetiracetam in the treatment of benzodiazepine refractory status epilepticus. J Neurol Neurosurg Psychiatry 79: 588-589.
33. Knake, S., Rosenow, F., Vescovi, M., Oertel, W.H., Mueller, H.H., Wirbatz, A. et al. (2001) Incidence of status epilepticus in adults in Germany: a prospective, population-based study. Epilepsia 42: 714-718.
34. Krauss, G., Ben-Menache, M.E., Mameniskiene, R., Vaiciene, N., Brock, M., Whitesides, J. et al. (2007). Intravenous lacosamide as replacemant for oral lacosamide in subjects with partial seizure onset: a multicenter, open-label, inpatient trial examining safety and tolerability of 10- and 15-minute infusions. Poster presented at the Annual Meeting of the American Epilepsy Society.
35. Krishnamurthy, K.B. and Drislane, F.W. (1996) Relapse and survival after barbiturate anesthetic treatment of refractory status epilepticus. Epilepsia 37: 863-867.
36. Leppik, I.E., Derivan, A.T., Homan, R.W., Walker, J., Ramsay, R.E. and Patrick, B. (1983) Double-blind study of lorazepam and diazepam in status epilepticus. JAMA 249: 1452-1454.
37. Limdi, N.A., Shimpi, A.V., Faught, E., Gomez, C.R. and Burneo, J.G. (2005) Efficacy of rapid IV administration of valproic acid for status epilepticus. Neurology 64: 353-355.
38. Logroscino, G., Hesdorffer, D.C., Cascino, G., Annegers, J.F. and Hauser, W.A. (1997) Short-term mortality after a first episode of status epilepticus. Epilepsia 38: 1344-1349.
39. Lowenstein, D.H. and Alldredge, B.K. (1993) Status epilepticus at an urban public hospital in the 1980s. Neurology 43: 483-488.
40. Lowenstein, D.H. and Alldredge, B.K. (1998) Status epilepticus. N Engl J Med 338: 970-976.
41. Lukyanetz, E.A., Shkryl, V.M. and Kostyuk, P.G. (2002) Selective blockade of N-type calcium channels by levetiracetam. Epilepsia 43: 9-18.
42. Mayer, S.A., Claassen, J., Lokin, J., Mendelsohn, F., Dennis, L.J. and Fitzsimmons, B.F. (2002) Refractory status epilepticus: frequency, risk factors, and impact on outcome. Arch.Neurol 59: 205-210.
43. Mazarati, A.M., Baldwin, R., Klitgaard, H., Matagne, A. and Wasterlain, C.G. (2004) Anticonvulsant effects of levetiracetam and levetiracetam-diazepam combinations in experimental status epilepticus. Epilepsy Res 58: 167-174.
44. Meierkord, H., Boon, P., Engelsen, B., Göcke, K., Shorvon, S., Tinuper, P. et al. (2006) EFNS guideline on the management of status epilepticus. Eur J Neurol 13: 445-450.
45. Minicucci, F., Muscas, G., Perucca, E., Capovilla, G., Vigevano, F. and Tinuper, P. (2006) Treatment of status epilepticus in adults: guidelines of the Italian League against Epilepsy. Epilepsia 47(Suppl 50): 9-15.
46. Mirsattari, S.M., Sharpe, M.D. and Young, G.B. (2004) Treatment of refractory status epilepticus with inhalational anesthetic agents isoflurane and desflurane. Arch Neurol 61: 1254-1259.
47. Misra, U.K., Kalita, J. and Patel, R. (2006) Sodium valproate vs phenytoin in status epilepticus: a pilot study. Neurology 67: 340-342.
48. O'Brien, T.J., Cascino, G.D., So, E.L. and Hanna, D.R. (1998) Incidence and clinical consequence of the purple glove syndrome in patients receiving intravenous phenytoin. Neurology 51: 1034-1039.
49. Olsen, K.B., Tauboll, E. and Gjerstad, L. (2007) Valproate is an effective, well-tolerated drug for treatment of status epilepticus / serial attacks in adults. Acta Neurol Scand Suppl 187: 51-54.
50. Prasad, K., Al Roomi, K., Krishnan, P.R. and Sequeira, R. (2005) Anticonvulsant therapy for status epilepticus. Cochrane Database Syst Rev (4): CD003723.
51. Ramael, S., Daoust, A., Otoul, C., Toublanc, N., Troenaru, M., Lu, Z.S. et al. (2006 a) Levetiracetam intravenous infusion: a randomized, placebo-controlled safety and pharmacokinetic study. Epilepsia 47: 1128-1135.
52. Ramael, S., De, S.F., Toublanc, N., Otoul, C., Boulanger, P., Riethuisen, J.M. et al. (2006 b) Single-dose bioavailability of levetiracetam intravenous infusion relative to oral tablets and multiple-dose pharmacokinetics and tolerability of levetiracetam intravenous infusion compared with placebo in healthy subjects. Clin Ther 28: 734-744.
53. Ramsay, R.E., Philbrook, B. and Martinez, D. (1995) A double-blind, randomized safety comparison of rapidly infused intravenous loading doses of fosphenytoin vs phenytoin. Epilepsia 36: S90.
54. Rao, V.K., Feldman, P.D. and Dibbell, D.G. (1988) Extravasation injury to the hand by intravenous phenytoin. Report of three cases. J Neurosurg 68: 967-969.
55. Rosenow, F., Arzimanoglou, A. and Baulac, M. (2002) Recent developments in treatment of status epilepticus: a review. Epileptic Disord 4(Suppl 2): S41-S51.
56. Rosenow, F., Hamer, H.M. and Knake, S. (2007) The epidemiology of convulsive and nonconvulsive status epilepticus. Epilepsia 48(Suppl 8): 82-84.
57. Rossetti, A.O. (2007) Which anesthetic should be used in the treatment of refractory status epilepticus? Epilepsia 48(Suppl 8): 52-55.
58. Rossetti, A.O., Logroscino, G. and Bromfield, E.B. (2005) Refractory status epilepticus: effect of treatment aggressiveness on prognosis. Arch Neurol 62: 1698-1702.
59. Schulze-Bonhage, A., Hefft, S. and Oehl, B. (2007) Termination of complex partial status epilepticus by intravenous levetiracetam - a case report. J Neurol Neurosurg Psychiatry Epub ahead, Mar 2007; doi:10.1136/jnnp.2006.113951.
60. Sheth, R.D. and Gidal, B.E. (1998) Refractory status epilepticus: response to ketamine. Neurology 51: 1765-1766.
61. Sinha, S. and Naritoku, D.K. (2000) Intravenous valproate is well tolerated in unstable patients with status epilepticus. Neurology 55: 722-724.
62. Stecker, M.M., Kramer, T.H., Raps, E.C., O'Meeghan, R., Dulaney, E. and Skaar, D.J. (1998) Treatment of refractory status epilepticus with propofol: clinical and pharmacokinetic findings. Epilepsia 39: 18-26.
63. Stohr, T., Baldwin, R., Walton, N. and Westerlain, C. (2003) SPM 927 is Anticonvulsive and neuroprotective in rat models for self-sustaining status epilepticus. Poster presented at the American Epilepsy Society meeting 2003 in Boston. Ref Type: Abstract.
64. Stohr, T., Krause, E. and Selve, N. (2006) Lacosamide displays potent antinociceptive effects in animal models for inflammatory pain. Eur J Pain 10: 241-249.
65. Stohr, T., Kupferberg, H.J., Stables, J.P., Choi, D., Harris, R.H., Kohn, H. et al. (2007) Lacosamide, a novel anti-convulsant drug, shows efficacy with a wide safety margin in rodent models for epilepsy. Epilepsy Res 74: 147-154.
66. Stohr, T. and Westerlain, C. (2006) Lacosamide in in vitro and in vivo animal models for Neuroprotection. Poster presented at the American Epilepsy Society Meeting 2006. Ref Type: Abstract.
67. Tomson, T. (2000) Mortality in epilepsy. J Neurol 247: 15-21.
68. Towne, A.R., Pellock, J.M., Ko, D. and de Lorenzo, R.J. (1994) Determinants of mortality in status epilepticus. Epilepsia 35: 27-34.
69. Treiman, D.M. (1998) Clinical trials for status epilepticus. Adv Neurol 76: 173-178.
70. Treiman, D.M., Meyers, P.D., Walton, N.Y., Collins, J.F., Colling, C., Rowan, A.J. et al. (1998) A comparison of four treatments for generalized convulsive status epilepticus. Veterans Affairs Status Epilepticus Cooperative Study Group. N Engl J Med 339: 792-798.
71. Uberall, M.A., Trollmann, R., Wunsiedler, U. and Wenzel, D. (2000) Intravenous valproate in pediatric epilepsy patients with refractory status epilepticus. Neurology 54: 2188-2189.
72. Uusimaa, J., Hinttala, R., Rantala, H., Päivärinta, M., Herra, R., Röyttä, M. et al. (2008) Homozygous W748S mutation in the POLG 1 gene in patients with juvenile-onset Alpers syndrome and status epilepticus. Epilepsia.
73. Velioglu, S.K. and Gazioglu, S. (2007) Non-convulsive status epilepticus secondary to valproic acid-induced hyperammonemic encephalopathy. Acta Neurol Scand 116: 128-132.
74. Venkataraman, V. and Wheless, J.W. (1999) Safety of rapid intravenous infusion of valproate loading doses in epilepsy patients. Epilepsy Res 35: 147-153.
75. Vignatelli, L., Rinaldi, R., Galeotti, M., de, C.P. and D'Alessandro, R. (2005) Epidemiology of status epilepticus in a rural area of northern Italy: a 2-year population-based study. Eur J Neurol 12: 897-902.
76. Vignatelli, L., Tonon, C. and D'Alessandro, R. (2003) Incidence and short-term prognosis of status epilepticus in adults in Bologna, Italy. Epilepsia 44: 964-968.
77. Walton, N.Y., Uthman, B.M., El Yafi, K., Kim, J.M. and Treiman, D.M. (1999) Phenytoin penetration into brain after administration of phenytoin or fosphenytoin. Epilepsia 40: 153-156.
78. Wu, Y.W., Shek, D.W., Garcia, P.A., Zhao, S. and Johnston, S.C. (2002) Incidence and mortality of generalized convulsive status epilepticus in California. Neurology 58: 1070-1076.
79. Yaffe, K. and Lowenstein, D.H. (1993) Prognostic factors of pentobarbital therapy for refractory generalized status epilepticus. Neurology 43: 895-900.