TRP family proteins in the lower urinary tract: Translating basic science into new clinical prospective

Therapeutic Advances in Urology

Volumn 1, Issue 1, 2009, Pages 33-42

  Lazzeri, Massimo ^a   Costantini, Elisabetta ^b   Porena, Massimo ^b  

^a SANTA CHIARA HOSPITAL   (Italy)

^b UNIVERSITY OF PERUGIA   (Italy)

Author keywords

bladder cancer; capsaicin; detrusor overactivity; lower urinary tract; prostate cancer; sensory nerves; TRP family; TRPV1

Indexed keywords

EID: 84993661333     PISSN: 17562872     EISSN: None     Source Type: Journal    
DOI: 10.1177/1756287209103922     Document Type: Review

References (64)

1. Acs, G., Palkovits, M. and Blumberg, P.M. (1994) Comparison of [3H] resiniferatoxin binding by the vanilloid receptor in dorsal root ganglia, spinal cord, dorsal vagal complex, sciatic and vagal nerve and urinary bladder of the rat. Life Sci 55: 1017-26.
2. Apostolidis, A., Popat, R., Yiangou, Y., Cockayne, D., Ford, A.P., Davis, J.B. et al. (2005) Decreased sensory receptors P2X3 and TRPV1 in suburothelial nerve fibers following intradetrusor injections of botulinum toxin for human detrusor overactivity. J Urol 174: 977-82.
3. Barbanti, G., Maggi, C.A., Beneforti, P., Baroldi, P. and Turini, D. (1993) Relief of pain following intravesical capsaicin in patients with hypersensitive disorders of the lower urinary tract. Br J Urol Int 71: 686-91.
4. Bidaux, G., Flourakis, M., Thebault, S., Zholos, A., Beck, B., Gkika, D. et al. (2007) Differentiation status of prostate cells determines TRPM8 channel subcellular localization and function: involvement in carcinogenesis. J Clin Invest 117: 1647-57.
5. Bidaux, G., Roudbaraki, M., Merle, C., Crepin, A., Delcourt, P. and Slomianny, C. (2005) Evidence for specific TRPM8 expression in human prostate secretory epithelial cells: functional androgen receptor requirement. Endocr-Relat Cancer 12: 367-82.
6. Birder, L.A., Kanai, A.J., De Groat, W.C., Kiss, S., Nealan, M.L., Burke, N.E. et al. (2001) Vanilloid receptor expression suggests a sensory role for urinary bladder epithelial cells. Proc Natl Acad Sci USA 98: 13396-401.
7. Bödding, M. (2007) TRP proteins and cancer. Cell. Signal 19: 617-24.
8. Bödding, M. and Flockerzi, V. (2004) Ca2+ dependence of the Ca2+-selective TRPV6 channel. J Biol Chem 279: 36546-52.
9. Brady, C.M., Apostolidis, A.N., Harper, M., Yiangou, Y., Beckett, A., Jacques, T.S. et al. (2004) Parallel changes in bladder suburothelial vanilloid receptor TRPV1 and pan-neuronal marker PGP9.5 immunoreactivity in patients with neurogenic detrusor overactivity after intravesical resiniferatoxin treatment. Br J Urol Int 93: 770-6.
10. Caprodossi, S., Lucciarini, R., Amantini, C., Nabissi, M., Canesin, G., Ballarini, P. et al. (2008) Transient receptor potential vanilloid type 2 (TRPV2) expression in normal urothelium and in urothelial carcinoma of human bladder: correlation with the pathologic stage. Eur Urol 54: 612-20.
11. Caterina, M.J., Schumacher, M.A., Tominaga, M., Rosen, T.A., Levine, J.D. and Julius, D. (1997) The capsaicin receptor: a heat-activated ion channel in the pain pathway. Nature 389: 816-24.
12. Cruz, F., Guimarães, M., Silva, C., Rio, M.E., Coimbra, A. and Reis, M. (1997) Desensitization of bladder sensory fibers by intravesical capsaicin has long lasting clinical and urodynamic effects in patients with hyperactive or hypersensitive bladder dysfunction. J Urol 157: 585-9.
13. de Groat, W.C. (1996) Nervous control of the urinary bladder in the cat. Brain Research 87: 201-11.
14. de Groat, W.C., Kawatani, M., Hisamitsu, T., Cheng, C.L., Ma, C.P., Thor, K. et al. (1990) Mechanisms underlying the recovery of urinary bladder function following spinal cord injury. Journal of Autonomic Nervous System 30(Suppl.): 571-7.
15. Dinis, P., Charrua, A., Avelino, A., Nagy, I., Quintas, J., Ribau, U. et al. (2005) The distribution of sensory fibers immunoreactive for the TRPV1 (capsaicin) receptor in the human prostate. Eur Urol 48: 162-7.
16. Dinis, P., Charrua, A., Avelino, A., Yaqoob, M., Bevan, S., Nagy, I. et al. (2004) Anandamide-evoked activation of vanilloid receptor 1 contributes to the development of bladder hyperreflexia and nociceptive transmission to spinal dorsal horn neurons in cystitis. J Neurosci 24: 11253-63.
17. Eisenberger, M.A., Blumenstein, B.A., Crawford, E.D., Miller, G., McLeod, D.G., Loehrer, P.J. et al. (1998) Bilateral orchiectomy with or without flutamide for metastatic prostate cancer. N Engl J Med 339: 1036-42.
18. Fixemer, T., Wissenbach, U., Flockerzi, V. and Bonkhoff, H. (2003) Expression of the Ca2+-selective cation channel TRPV6 in human prostate cancer: a novel prognostic marker for tumour progression. Oncogene 22: 7858-61.
19. Fowler, C.J., Jewkes, D., McDonald, W.I., Lynn, B. and de Groat, W.C. (1992) Intravesical capsaicin for neurogenic bladder dysfunction. Lancet 339: 1239.
20. Fuessel, S., Sickert, D., Meye, A., Klenk, U., Schmidt, U., Schmitz, M. et al. (2003) Multiple tumour marker analyses (PSA, hK2, PSCA, trp-p8) in primary prostate cancers using quantitative RT-PCR. Int J Oncol 23: 221-8.
21. Guerios, S.D., Wang, Z.Y. and Bjorling, D.E. (2006) Nerve growth factor mediates peripheral mechanical hypersensitivity that accompanies experimental cystitis in mice. Neurosci Lett 392: 193-7.
22. Güler, A.D., Lee, H., Iida, T., Shimizu, I., Tominaga, M. and Caterina, M.J. (2002) Heat-evoked activation of the ion channel, TRPV4. J Neurosci 22: 6408-14.
23. Harteneck, C. (2005) Function and pharmacology of TRPM cation channels. Naunyn-Schmiedeberg's Arch Pharmacol 371: 307-14.
24. Henshall, S.M., Afar, D.E., Hiller, J., Horvath, L.G., Quinn, D.I., Rasiah, K.K. et al. (2003) Survival analysis of genome-wide gene expression profiles of prostate cancers identifies new prognostic targets of disease relapse. Cancer Res 63: 4196-203.
25. Ji, R.R., Samad, T.A., Jin, S.X., Schmoll, R. and Woolf, C.J. (2002) p38 MAPK activation in primary sensory neurons after inflammation increases TRPV1 levels and maintains heat hyperalgesia. Neuron 36: 57-68.
26. Jung, M.Y., Kang, H.J. and Moon, A. (2001) Capsaicin-induced apoptosis in SK-Hep-1 hepatocarcinoma cells involves Bcl-2 downregulation and caspase-3 activation. Cancer Lett 165: 139-45.
27. Kiessling, A., Fussel, S., Schmitz, M., Stevanovic, S., Meye, A. and Weigle, B. (2003) Identification of an HLA-A*0201-restricted T-cell epitope derived from the prostate cancer-associated protein TRP-P8. Prostate 56: 270-9.
28. Kim, J.C., Beckel, J.M., Birder, L.A., Kiss, S., Washabaugh, C., Kanai, A. et al. (2001) Identification of functional vanilloid receptors in human bladder urothelial cells using a nitric oxide microsensor technique and reverse transcriptase polymerase chain reaction. J Urol 165(Suppl. 5): 34.
29. Kuo, H.C. (2003) Effectiveness of intravesical resiniferatoxin in treating detrusor hyper-reflexia and external sphincter dyssynergia in patients with chronic spinal cord lesions. Br J Urol Int 92: 597-601.
30. Lazzeri, M., Vannucchi, M.G., Bizzocco, E., Spinelli, M., Beneforti, P., Turini, D. et al. (2005) Transient receptor potential vanilloid type 1 (TRPV1) expression changes from normal urothelium to transitional cell carcinoma of human bladder. Eur Urol 48: 691-8.
31. Lazzeri, M., Beneforti, P., Spinelli, M., Zanollo, A., Barbagli, G. and Turini, D. (2000) Intravesical resiniferatoxin for the treatment of hypersensitive disorder: a randomized placebo controlled study. J Urol 164: 676-9.
32. Lazzeri, M., Barbanti, G., Beneforti, P., Maggi, C.A., Taddei, I., Ungar, A. et al. (1995) Vesical-renal reflex: diuresis and natriuresis activated by intravesical capsaicin. Scand J Urol Nephrol 29: 39-43.
33. Lecci, A. and Maggi, C.A. (2001) Tachykinins as modulators of the micturition reflex in the central and peripheral nervous system. Regul Peptides 101: 1-18.
34. Lee, Y.S., Nam, D.H. and Kim, J.A. (2000) Induction of apoptosis by capsaicin in A172 human glioblastoma cells. Cancer Lett 161: 121-30.
35. Liu, B. and Qin, F.J. (2005) Functional control of cold-menthol-sensitive TRPM8 ion channels by phosphatidylinositol 4,5-bisphosphate. Neuroscience 25: 1674-81.
36. MacDiamid, J.A., Mugridge, N.B., Weiss, J.C., Phillips, L., Burn, A.L., Paulin, R.P. et al. (2007) Bacterially derived 400 nm particules for encapsulation and cancer cell targeting of chemotherapeutics. Cancer Cell 11: 431-45.
37. Macho, A., Calzado, M.A., Munoz-Blanco, J., Goómez-Díaz, C., Gajate, C., Mollinedo, F. et al. (1999) Selective induction of apoptosis by capsaicin in transformed cells: the role of reactive oxygen species and calcium. Cell Death Differ 6: 155-65.
38. Maggi, C.A., Barbanti, G., Santicioli, P., Beneforti, P., Misuri, D., Meli, A. et al. (1989) Cystometric evidence that capsaicin-sensitive nerves modulate the afferent branch of micturition reflex in humans. J Urol 142: 150-4.
39. Maggi, C.A. and Meli, A. (1988) The sensory efferent function of capsaicin-sensitive neurons. Gen Pharmac 19: 1-43.
40. Miller, L.J., Fischer, K.A., Goralnick, S.J., Litt, M., Burleson, J.A., Albertsen, P. et al. (2002) Nerve growth factor and chronic prostatitis/chronic pelvic pain syndrome. Urology 59: 603-8.
41. Montell, C., Jones, K., Hafen, E. and Rubin, G. (1985) Rescue of the Drosophila phototransduction mutation trp by germline transformation. Science 230: 1040-3.
42. Myers-Irvin, J.M., Van Le, T.S. and Getzenberg, R.H. (2005) Mechanistic Analysis of the Role of BLCA-4 in Bladder Cancer Pathobiology. Cancer Research 65: 7145-7150.
43. Nilius, B., Owsianik, G., Voets, T. and Peters, J.A. (2007) Transient receptor cation channels in disease. Physiol Rev 87: 165-217.
44. Payne, C.K., Mosbaugh, P.G., Forrest, J.B., Evans, R.J., Whitmore, K.E., Antoci, J.P. et al. (2005) Intravesical resiniferatoxin for the treatment of interstitial cystitis: a randomized, double-blind, placebo controlled trial. J Urol 173: 1590-4.
45. Peier, A.M., Moqrich, A., Hergarden, A.C., Reeve, A.J., Andersson, D.A., Story, G.M. et al. (2002) A TRP channel that senses cold stimuli and menthol. Cell 108: 705-15.
46. Peng, J.B., Zhuang, L., Berger, U.V., Adam, R.M., Williams, B.J., Brown, E.M. et al. (2001) CaT1 expression correlates with tumour grade in prostate cancer. Biochem Biophys Res Commun 282: 729-34.
47. Putney Jr, J.W. (2004) The enigmatic TRPCs: multifunctional cation channels. Trends Cell Biol 14: 282-6.
48. Ramsey, S.I., Delling, M. and Clapham, D.E. (2006) An introduction to TRP channels. Ann Rev Physio 68: 18.1-18.29.
49. Reilly, C.A., Taylor, J.C., Lanza, D.L., Carr, B.A., Crouch, D.J. and Yost, G.S. (2003) Capsaicinoids cause inflammation and epithelial cell death through activation of vanilloid receptors. Toxicol Sci 73: 170-81.
50. Silva, C., Silva, J., Ribeiro, M.J., Avelino, A. and Cruz, F. (2005) Urodynamic effect of intravesical resiniferatoxin in patients with neurogenic detrusor overactivity of spinal origin: results of a double-blind randomized placebo-controlled trial. Eur Urol 48: 650-5.
51. Smart, D., Gunthorpe, M.J., Jerman, J.C., Nasir, S., Gray, J., Muir, A.I. et al. (2000) The endogenous lipid anandamide is a full agonist at the human vanilloid receptor (hVR1). Br J Pharmacol 129: 227-30.
52. Sydorenko, V., Shuba, Y., Thebault, S., Roudbaraki, M., Lepage, G., Prevarskaya, N. et al. (2003) Receptor-coupled, DAG-gated Ca2+-permeable cationic channels in LNCaP human prostate cancer epithelial cells. J Physiol 548: 823-36.
53. Szallasi, A., Conte, B., Goso, C., Blumberg, P.M. and Manzini, S. (1993) Characterization of a peripheral vanilloid (capsaicin) receptor in the rat urinary bladder. Life Sci 52: PL221-PL226.
54. Tapia-Vieyra, J.V. and Mas-Oliva, J. (2001) Apoptosis and cell death channels in prostate cancer. Arch Med Res 32: 175-85.
55. Trevisani, M., Smart, D., Gunthorpe, M.J., Tognetto, M., Barbieri, M., Campi, B. et al. (2002) Ethanol elicits and potentiates nociceptor responses via the vanilloid receptor-1. Nat Neurosci 5: 546-51.
56. Tsavaler, L., Shapero, M.H., Morkowski, S. and Laus, R. (2001) Trp-p8, a novel prostate-specific gene, is up-regulated in prostate cancer and other malignancies and shares high homology with transient receptor potential calcium channel proteins. Cancer Res 61: 3760-9.
57. Turini, D., Beneforti, P., Spinelli, M., Malagutti, S. and Lazzeri, M. (2006) Heat/burning sensation induced by topical application of capsaicin on perineal cutaneous area: new approach in diagnosis and treatment of chronic prostatitis/chronic pelvic pain syndrome? Urology 67: 910-3.
58. Vanden Abeele, F., Shuba, Y., Roudbaraki, M., Lemonnier, L., Vanoverberghe, K., Mariot, P. et al. (2003) Store-operated Ca2+ channels in prostate cancer epithelial cells: function, regulation, and role in carcinogenesis. Cell Calcium 33: 357-73.
59. Wissenbach, U., Niemeyer, B.A., Fixemer, T., Schniedewind, A., Trost, C., Cavalie, A. et al. (2001) Expression of CaTlike, a novel calcium-selective channel, correlates with the malignancy of prostate cancer. J Biol Chem 276: 19461-8.
60. Xu, H., Ramsey, I.S., Kotecha, S.A., Moran, M.M., Chong, J.A., Lawson, D. et al. (2002) TRPV3 is a calcium-permeable temperature-sensitive cation channel. Nature 418: 181-6.
61. Zhang, L. and Barritt, G.J. (2006) TRPM8 in prostate cancer cells: a potential diagnostic and prognostic marker with a secretory function? Endocr-Relat Cancer 13: 27-38.
62. Zhang, L. and Barritt, G.J. (2004) Evidence that TRPM8 is an androgen-dependent Ca2+ channel required for the survival of prostate cancer cells. Cancer Res 64: 8365-73.
63. Zhang, L., Brereton, H.M., Hahn, M., Froscio, M., Tilley, W.D., Brown, M.P. et al. (2003) Expression of Drosophila Ca2+ permeable transient receptor potential-like channel protein in a prostate cancer cell line decreases cell survival. Cancer Gene Ther 10: 611-25.
64. Zhu, Y., Wang, Y. and Wang, D.H. (2005) Diuresis and natriuresis caused by activation of VR1-positive sensory nerves in renal pelvis of rats. Hypertension 46: 992-7.