NF-κB-dependent transcriptional upregulation of cyclin D1 exerts cytoprotection against hypoxic injury upon EGFR activation

Experimental Cell Research

Volumn 347, Issue 1, 2016, Pages 52-59

  Chen, Zhi Dong ^a   Xu, Liang ^b   Tang, Kan Kai ^a   Gong, Fang Xiao ^b   Liu, Jing Quan ^b   Ni, Yin ^b   Jiang, Ling Zhi ^b   Hong, Jun ^b   Han, Fang ^b   Li, Qian ^b   Yang, Xiang Hong ^b   Sun, Ren Hua ^b   Mo, Shi Jing ^b  

^a The First Affiliated Hospital of Huzhou Normal College   (China)

^b ZHEJIANG PROVINCIAL PEOPLE'S HOSPITAL   (China)

Author keywords

Cyclin D1; Epidermal growth factor receptor; Hypoxia; Injury; Nuclear factor B

Indexed keywords

CYCLIN D1; EPIDERMAL GROWTH FACTOR; EPIDERMAL GROWTH FACTOR RECEPTOR; I KAPPA B KINASE ALPHA; I KAPPA B KINASE BETA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; NEUTRALIZING ANTIBODY; SMALL INTERFERING RNA; SYNAPTOTAGMIN I;

APOPTOSIS; ARTICLE; CELL DAMAGE; CELL HYPOXIA; CELL PROTECTION; CYTOTOXICITY; DOWN REGULATION; ENZYME PHOSPHORYLATION; PC12 CELL LINE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DEPHOSPHORYLATION; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION; UBIQUITINATION; UPREGULATION; ANIMAL; GENETIC TRANSCRIPTION; GENETICS; METABOLISM; RAT;

ANIMALS; CELL HYPOXIA; CYCLIN D1; CYTOPROTECTION; DOWN-REGULATION; NF-KAPPA B; PC12 CELLS; PROMOTER REGIONS, GENETIC; RATS; RECEPTOR, EPIDERMAL GROWTH FACTOR; TRANSCRIPTION, GENETIC; UP-REGULATION;

EID: 84992743740     PISSN: 00144827     EISSN: 10902422     Source Type: Journal    
DOI: 10.1016/j.yexcr.2016.07.004     Document Type: Article

References (27)

1. [1] George, P.M., Steinberg, G.K., Novel Stroke therapeutics: unraveling stroke pathophysiology and its impact on clinical treatments. Neuron 87 (2015), 297–309.
2. [2] Wrighton, K.H., Cell signalling: EGF signalling – it's all in SHC1's timing. Nat. Rev. Mol. Cell Biol., 14, 2013, 463.
3. [3] Mariga, A., Mitre, M., Chao, M.V., Consequences of brain-derived neurotrophic factor withdrawal in CNS neurons and implications in disease. Neurobiol. Dis., 2016.
4. [4] Xu, C.J., Wang, J.L., Jin, W.L., The emerging therapeutic role of NGF in Alzheimer's disease. Neurochem. Res. 41 (2016), 1211–1218.
5. [5] Worster, D.T., Schmelzle, T., Solimini, N.L., Lightcap, E.S., Millard, B., Mills, G.B., Brugge, J.S., Albeck, J.G., Akt and ERK control the proliferative response of mammary epithelial cells to the growth factors IGF-1 and EGF through the cell cycle inhibitor p57Kip2. Sci. Signal, 5, 2012 ra19.
6. [6] Orian, A., Delrow, J.J., Rosales Nieves, A.E., Abed, M., Metzger, D., Paroush, Z., Eisenman, R.N., Parkhurst, S.M., A Myc-Groucho complex integrates EGF and Notch signaling to regulate neural development. Proc. Natl. Acad. Sci. USA 104 (2007), 15771–15776.
7. [7] Li, B., Antonyak, M.A., Druso, J.E., Cheng, L., Nikitin, A.Y., Cerione, R.A., EGF potentiated oncogenesis requires a tissue transglutaminase-dependent signaling pathway leading to Src activation. Proc. Natl. Acad. Sci. USA 107 (2010), 1408–1413.
8. [8] Shen, K., Sheng, Y., Ji, L., Wang, Z., Involvement of c-Jun N-terminal kinase and extracellular signal-regulated kinase 1/2 in EGF-induced angiogenesis. Cell Biol. Int. 34 (2010), 1213–1218.
9. [9] Tang, Y., Ye, M., Du, Y., Qiu, X., Lv, X., Yang, W., Luo, J., EGFR signaling upregulates surface expression of the GluN2B-containing NMDA receptor and contributes to long-term potentiation in the hippocampus. Neuroscience 304 (2015), 109–121.
10. [10] Mahanthappa, N.K., Schwarting, G.A., Peptide growth factor control of olfactory neurogenesis and neuron survival in vitro: Roles of EGF and TGF-beta s. Neuron 10 (1993), 293–305.
11. [11] Sun, Y., Goderie, S.K., Temple, S., Asymmetric distribution of EGFR receptor during mitosis generates diverse CNS progenitor cells. Neuron 45 (2005), 873–886.
12. [12] Joung, I., Yoo, M., Woo, J.H., Chang, C.Y., Heo, H., Kwon, Y.K., Secretion of EGF-like domain of heregulinbeta promotes axonal growth and functional recovery of injured sciatic nerve. Mol. Cells 30 (2010), 477–484.
13. [13] Hermann, P.M., Nicol, J.J., Nagle, G.T., Bulloch, A.G., Wildering, W.C., Epidermal growth factor-dependent enhancement of axonal regeneration in the pond snail Lymnaea stagnalis: role of phagocyte survival. J. Comp. Neurol. 492 (2005), 383–400.
14. [14] Li, X.L., Liu, J., Wang, X.Y., Li, L.Y., Ni, W., Zheng, R.Y., Yang, H.J., Lu, Y.C., Qi, J.G., Wang, T.H., Temporal changes in the expression of TGF-beta 1 and EGF in the ventral horn of the spinal cord and associated precentral gyrus in adult Rhesus monkeys subjected to cord hemisection. J. Neurol. Sci. 268 (2008), 163–171.
15. [15] Dorrance, A.M., Osborn, H.L., Grekin, R., Webb, R.C., Spironolactone reduces cerebral infarct size and EGF-receptor mRNA in stroke-prone rats. Am. J. Physiol. Regul. Integr. Comp. Physiol. 281 (2001), R944–R950.
16. [16] Oyagi, A., Morimoto, N., Hamanaka, J., Ishiguro, M., Tsuruma, K., Shimazawa, M., Hara, H., Forebrain specific heparin-binding epidermal growth factor-like growth factor knockout mice show exacerbated ischemia and reperfusion injury. Neuroscience 185 (2011), 116–124.
17. [17] Barco-Herrera, D. Garcia Del, Martinez, N.S., Coro-Antich, R.M., Machado, J.M., Alba, J.S., Salgueiro, S.R., Acosta, J.B., Epidermal growth factor and growth hormone-releasing peptide-6: Combined therapeutic approach in experimental stroke. Restor. Neurol. Neurosci. 31 (2013), 213–223.
18. [18] Mo, S.J., Hong, J., Chen, X., Han, F., Ni, Y., Zheng, Y., Liu, J.Q., Xu, L., Li, Q., Yang, X.H., Sun, R.H., Yin, X.Y., VEGF-mediated NF-kappaB activation protects PC12 cells from damage induced by hypoxia. Neurosci. Lett. 610 (2015), 54–59.
19. [19] Jia, Y., Mo, S.J., Feng, Q.Q., Zhan, M.L., OuYang, L.S., Chen, J.C., Ma, Y.X., Wu, J.J., Lei, W.L., EPO-dependent activation of PI3K/Akt/FoxO3a signalling mediates neuroprotection in in vitro and in vivo models of Parkinson's disease. J. Mol. Neurosci. 53 (2014), 117–124.
20. [20] Mo, S.J., Zhong, Q., Zhou, Y.F., Deng, D.B., Zhang, X.Q., Bone marrow-derived mesenchymal stem cells prevent the apoptosis of neuron-like PC12 cells via erythropoietin expression. Neurosci. Lett. 522 (2012), 92–97.
21. [21] Gharibani, P.M., Modi, J., Pan, C., Menzie, J., Ma, Z., Chen, P.C., Tao, R., Prentice, H., Wu, J.Y., The mechanism of taurine protection against endoplasmic reticulum stress in an animal stroke model of cerebral artery occlusion and stroke-related conditions in primary neuronal cell culture. Adv. Exp. Med Biol. 776 (2013), 241–258.
22. [22] Grau, C.M., Greene, L.A., Use of PC12 cells and rat superior cervical ganglion sympathetic neurons as models for neuroprotective assays relevant to Parkinson's disease. Methods Mol. Biol. 846 (2012), 201–211.
23. [23] Jin, X., Yin, J., Kim, S.H., Sohn, Y.W., Beck, S., Lim, Y.C., Nam, D.H., Choi, Y.J., Kim, H., EGFR-AKT-Smad signaling promotes formation of glioma stem-like cells and tumor angiogenesis by ID3-driven cytokine induction. Cancer Res. 71 (2011), 7125–7134.
24. [24] Eberl, M., Klingler, S., Mangelberger, D., Loipetzberger, A., Damhofer, H., Zoidl, K., Schnidar, H., Hache, H., Bauer, H.C., Solca, F., Hauser-Kronberger, C., Ermilov, A.N., Verhaegen, M.E., Bichakjian, C.K., Dlugosz, A.A., Nietfeld, W., Sibilia, M., Lehrach, H., Wierling, C., Aberger, F., Hedgehog-EGFR cooperation response genes determine the oncogenic phenotype of basal cell carcinoma and tumour-initiating pancreatic cancer cells. EMBO Mol. Med. 4 (2012), 218–233.
25. [25] Fan, Q.W., Cheng, C.K., Gustafson, W.C., Charron, E., Zipper, P., Wong, R.A., Chen, J., Lau, J., Knobbe-Thomsen, C., Weller, M., Jura, N., Reifenberger, G., Shokat, K.M., Weiss, W.A., EGFR phosphorylates tumor-derived EGFRvIII driving STAT3/5 and progression in glioblastoma. Cancer Cell 24 (2013), 438–449.
26. [26] Zhang, X., Zhu, J., Li, Y., Lin, T., Siclari, V.A., Chandra, A., Candela, E.M., Koyama, E., Enomoto-Iwamoto, M., Qin, L., Epidermal growth factor receptor (EGFR) signaling regulates epiphyseal cartilage development through beta-catenin-dependent and -independent pathways. J. Biol. Chem. 288 (2013), 32229–32240.
27. [27] Huang, E.J., Reichardt, L.F., Trk receptors: roles in neuronal signal transduction. Annu. Rev. Biochem. 72 (2003), 609–642.