The anti-obesity effect of Taheebo (Tabebuia avellanedae Lorentz ex Griseb) extract in ovariectomized mice and the identification of a potential anti-obesity compound

Biochemical and Biophysical Research Communications

Volumn 478, Issue 3, 2016, Pages 1136-1140

  Iwamoto, Kazuko ^a   Fukuda, Youichi ^a   Tokikura, Chisato ^a   Noda, Mayuko ^a   Yamamoto, Ayami ^a   Yamamoto, Misato ^a   Yamashita, Mitsuaki ^a   Zaima, Nobuhiro ^a   Iida, Akira ^a   Moriyama, Tatsuya ^a  

^a KINKI UNIVERSITY   (Japan)

Author keywords

1 dehydroxy 3,4 dihydroaucubigenin; Anti obesity; Ovariectomized mice; Tabebuia avellanedae Lorentz ex Griseb

Indexed keywords

1 DEHYDROXY 3,4 DIHYDROAUCUBIGENIN; ANTIOBESITY AGENT; BUTANOL; PLANT EXTRACT; TABEBUIA AVELLANEDAE LORENTZ EX GRISEB EXTRACT; TRIACYLGLYCEROL; UNCLASSIFIED DRUG; TAHEEBO;

3T3 CELL LINE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BIOASSAY; BODY WEIGHT; CONTROLLED STUDY; DRUG IDENTIFICATION; DRUG ISOLATION; DRUG PURIFICATION; FAT MASS; FEMALE; MENOPAUSE; MOUSE; NONHUMAN; OBESITY; OVARIECTOMY; PRIORITY JOURNAL; TABEBUIA; TRIACYLGLYCEROL BLOOD LEVEL; 3T3-L1 CELL LINE; ANIMAL; BLOOD; CELL SURVIVAL; CHEMISTRY; DRUG EFFECTS; FECES; ISOLATION AND PURIFICATION; LIVER; METABOLISM; ORGAN SIZE;

1-BUTANOL; 3T3-L1 CELLS; ANIMALS; ANTI-OBESITY AGENTS; BODY WEIGHT; CELL SURVIVAL; FECES; FEMALE; LIVER; MICE; OBESITY; ORGAN SIZE; OVARIECTOMY; PLANT EXTRACTS; TABEBUIA; TRIGLYCERIDES;

EID: 84992730322     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2016.08.081     Document Type: Article

References (24)

1. [1] Lobo, R.A., Metabolic syndrome after menopause and the role of hormones. Maturitas 60 (2008), 10–18.
2. [2] Chang, S.H., Beason, B.S., Hunleth, J.M., Colditz, G.A., A systematic review of body fat distribution and mortality in older people. Maturitas 72 (2013), 175–191.
3. [3] Martinez, M.N., Emfinger, C.H., Overton, M., Hill, S., Ramaswamy, T.S., Cappel, D.A., Wu, K., Fasio, S., McDonald, W.H., Tabb, D.L., Stafford, J.M., Obesity and altered glucose metabolism impact HDL composition in CETP transgenic mice: a role for ovarian hormones. J. Lipid. Res. 53 (2012), 379–389.
4. [4] Meyer, M.R., Clegg, D.J., Prossnitz, E.R., Barton, M., Obesity, insulin resistance and diabetes: sex differences and role of estrogen receptors. Acta. Physiol. 203 (2012), 259–269.
5. [5] Gruber, C.J., Tschugguel, W., Scheneeberger, C., Huber, J.C., Production and actions of estrogens. N. Engl. J. Med. 346 (2002), 340–352.
6. [6] Handgraaf, S., Riant, E., Fabre, A., Waget, A., Burcelin, R., Liere, P., Krust, A., Chambon, P., Arnal, J.F., Gourdy, P., Prevention of obesity and insulin resistance by estrogens requires ERα activation function-2 (ERαAF-2), whereas ERαAF-1 is dispensable. Diabetes 62 (2013), 4098–4108.
7. [7] Tagliaferri, C., Salles, J., Randrier, J.F., Giraudet, C., Patrac, V., Lebecque, P., Davicco, M.J., Chanet, A., Pouyet, C., Dhaussy, A., Huertas, A., Boirie, Y., Wittrant, Y., Coxam, V., Walrand, S., Increased body fat mass and tissue lipotoxicity associated with ovariectomy or high-fat diet differentially affects bone and skeletal muscle metabolism in rats. Eur. J. Nutr. 54 (2015), 1139–1149.
8. [8] Wang, X., Simpson, E.R., Brown, K.A., Aromatase overexpression in dysfunctional adipose tissue links obesity to portmenopausal breast cancer. J. Steroid. Biochem. Mol. Biol. 153 (2015), 35–44.
9. [9] Rogers, N.H., Perfield, J.W., Strissel, K.J., Obin, M.S., Greenberg, A.S., Reduced energy expenditure and increased inflammation are early events in the development of ovariectomy-induced obesity. Endocrinology 150 (2009), 2161–2168.
10. [10] Kanaya, N., Chen, S., Conjugated linoleic acid reduces body weight gain in ovariectomized female C57BL/6J mice. Nut. Res. 30 (2010), 714–721.
11. [11] Shimofuruya, H., Fujii, A., Suzuki, I., Kunieda, Y., Antioxidative effect of Taheebo extract. Chem. Soc. Jap 3 (2002), 481–483.
12. [12] Ueda, S., Umemura, T., Dohguchi, K., Matsuzaki, T., Tokuda, H., Nishino, H., Iwashita, A., Production of anti-rumor-promoting furano-naphthoqunones in Tabebuia avellanedae cell cultures. Phytochemistry 36 (1994), 323–325.
13. [13] Twardowschy, A., Freitas, C.S., Baggio, C.H., Mayer, B., Santos, A.C., Pizzolatti, M.G., Zacarias, A.A., Santos, E.P., Otuki, M.F., Marques, M.C.A., Antiulcerogenic activity of bark extract of Tabebuia avellanedae, Lorentz ex Griseb. J. Ethnopharmacol. 118 (2008), 455–459.
14. [14] Machado, T.B., Pinto, A.V., Pinto, M.C.F.R., Leal, I.C.R., Silva, M.G., Amaral, A.C.F., Kuster, R.M., Netto-DosSantos, K.R., In vitro activity of Brazilian medicinal plants, naturally occurring naphthquniones and their analogues, against methicillin-resistant Staphylococcus aureus. Int. J. Antimicrob. Agents 21 (2003), 279–284.
15. [15] Pinto, C.N., Dantas, A.P., Moura, K.C.G.D., Emery, F.S., Polequevitch, P.F., Pinto, M.C.F.R., Castro, S.L., Pinto, A.V., Chemical reactivity studies with naphthoquinones from Tabebuia with anti-trypanosomal efficacy. Drug. Res. 50 (2000), 1120–1128.
16. [16] Medina, A.R.L.F., Santos, V.S.R.C., Bizani, D., Brandelli, A., In vitro antimicrobial activity of a new series of 1,4-naphthoquinones. Braz. J. Med. Biol. Res. 35 (2002), 811–818.
17. [17] Park, B.S., Lee, K.G., Shibamoto, T., Lee, S.E., Takeoka, G.R., Antioxidant activity and characterization of volatile conctituents of Taheebo (Tabebuia impetiginosa Martius ex DC). J. Agric. Food Chem. 51 (2003), 295–300.
18. [18] Bacowsky, H., Short report on intratumoral injection of Taheebo extract in combination with electrochemical treatment (ECT) in 18 patients suffering from cancer of the prostate. J. New Rem. Clin. 54 (2005), 119–131.
19. [19] Park, B.S., Lee, H.K., Lee, S.E., Piao, X.L., Takeoka, G.R., Wong, R.Y., Ahn, Y.J., Kim, J.H., Antibacterial activity of Tabebuia impetiginosa martius ex DC (Taheebo) against Helicobacter pylori. J. Ethnopharmacol. 105 (2006), 255–262.
20. [20] Lee, M.H., Chol, H.M., Hahm, D.H., Her, E., Yang, H.I., Yoo, M.C., Kim, K.S., Analgesic and anti-inflammatory effects in animal models of an ethanolic extract of Taheebo, the inner bark of Tabebuia avellanedae. Mol. Med. Rep. 6 (2012), 791–796.
21. [21] Choi, W.H., Um, M.Y., Ahn, J., Jung, C.H., Park, M.K., Ha, T.Y., Ethanolic extract of Taheebo attenuates increase in body weight and fatty liver in mice fed a high-fat diet. Molecules 10 (2014), 16013–16023.
22. [22] Pieters, L., Bruyne, T.D., Claeys, M., Vlietinck, A., Isolation of a dihydrobenzofuran lignan from South American dragon's blood (Croton spp.) as an inhibitor of cell proliferatio. J. Nat. Prod. 56 (1993), 899–906.
23. [23] Kajimoto, T., Hidaka, M., Shoyama, K., Nohara, T., Iridoids from Scrophularia ningpoensis. Phytochem 28 (1989), 2701–2704.
24. [24] Bligh, E.G., Dyer, W.J., A rapid method of totallipid extraction and purification, Can. J. Biochem. Physiol. 37 (1959), 911–917.