Insulitis in human diabetes: a histological evaluation of donor pancreases

Diabetologia

Volumn 60, Issue 2, 2017, Pages 346-353

  Lundberg, Marcus ^a   Seiron, Peter ^a   Ingvast, Sofie ^a   Korsgren, Olle ^a   Skog, Oskar ^a  

^a UPPSALA UNIVERSITY   (Sweden)

Author keywords

HLA; Inflammation; Insulin secretion; Insulitis; Islets; Macrophages; T cells; Type 1 diabetes; Type 2 diabetes

Indexed keywords

AUTOANTIBODY; CD20 ANTIGEN; CD3 ANTIGEN; CD45 ANTIGEN; CD68 ANTIGEN; GLUCOSE; HEMOGLOBIN A1C; HLA ANTIGEN CLASS 1; INSULIN; MYELOPEROXIDASE;

ADULT; AGE; AGED; ARTICLE; B LYMPHOCYTE; BODY MASS; CONTROLLED STUDY; FEMALE; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IN VITRO STUDY; INSULIN DEPENDENT DIABETES MELLITUS; INSULIN RELEASE; INSULITIS; MACROPHAGE; MAJOR CLINICAL STUDY; MALE; NEUTROPHIL; NON INSULIN DEPENDENT DIABETES MELLITUS; ORGAN DONOR; PANCREAS BIOPSY; PRIORITY JOURNAL; T LYMPHOCYTE; IMMUNOHISTOCHEMISTRY; INSULIN RESISTANCE; METABOLISM; MIDDLE AGED; PANCREAS; PATHOLOGY; PHYSIOLOGY; SECRETION (PROCESS); VERY ELDERLY;

ADULT; AGED; AGED, 80 AND OVER; ANTIGENS, CD45; DIABETES MELLITUS, TYPE 1; DIABETES MELLITUS, TYPE 2; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; INSULIN; INSULIN RESISTANCE; MACROPHAGES; MALE; MIDDLE AGED; PANCREAS; T-LYMPHOCYTES;

EID: 84992709182     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-016-4140-z     Document Type: Article

References (25)

1. Campbell-Thompson ML, Atkinson MA, Butler AE et al (2013) The diagnosis of insulitis in human type 1 diabetes. Diabetologia 56:2541–2543
2. In’t Veld P (2011) Insulitis in human type 1 diabetes: the quest for an elusive lesion. Islets 3:131–138
3. Willcox A, Richardson SJ, Bone AJ, Foulis AK, Morgan NG (2009) Analysis of islet inflammation in human type 1 diabetes. Clin Exp Immunol 155:173–181
4. Valle A, Giamporcaro GM, Scavini M et al (2013) Reduction of circulating neutrophils precedes and accompanies type 1 diabetes. Diabetes 62:2072–2077
5. Korsgren S, Molin Y, Salmela K, Lundgren T, Melhus A, Korsgren O (2012) On the etiology of type 1 diabetes: a new animal model signifying a decisive role for bacteria eliciting an adverse innate immunity response. Am J Pathol 181:1735–1748
6. In’t Veld P, Lievens D, De Grijse J et al (2007) Screening for insulitis in adult autoantibody-positive organ donors. Diabetes 56:2400–2404
7. Boni-Schnetzler M, Ehses JA, Faulenbach M, Donath MY (2008) Insulitis in type 2 diabetes. Diabetes Obes Metab 10(Suppl 4):201–204
8. Donath MY, Boni-Schnetzler M, Ellingsgaard H, Ehses JA (2009) Islet inflammation impairs the pancreatic beta-cell in type 2 diabetes. Physiology (Bethesda) 24:325–331
9. Rodriguez-Calvo T, Ekwall O, Amirian N, Zapardiel-Gonzalo J, von Herrath MG (2014) Increased immune cell infiltration of the exocrine pancreas: a possible contribution to the pathogenesis of type 1 diabetes. Diabetes 63:3880–3890
10. Martino L, Masini M, Bugliani M et al (2015) Mast cells infiltrate pancreatic islets in human type 1 diabetes. Diabetologia 58:2554–2562
11. Larsen CM, Faulenbach M, Vaag A et al (2007) Interleukin-1-receptor antagonist in type 2 diabetes mellitus. N Engl J Med 356:1517–1526
12. Reddy S, Zeng N, Al-Diery H et al (2015) Analysis of peri-islet CD45-positive leucocytic infiltrates in long-standing type 1 diabetic patients. Diabetologia 58:1024–1035
13. Krogvold L, Wiberg A, Edwin B et al (2016) Insulitis and characterisation of infiltrating T cells in surgical pancreatic tail resections from patients at onset of type 1 diabetes. Diabetologia 59:492–501
14. Richardson SJ, Willcox A, Bone AJ, Foulis AK, Morgan NG (2009) The prevalence of enteroviral capsid protein vp1 immunostaining in pancreatic islets in human type 1 diabetes. Diabetologia 52:1143–1151
15. Richardson SJ, Rodriguez-Calvo T, Gerling IC et al (2016) Islet cell hyperexpression of HLA class I antigens: a defining feature in type 1 diabetes. Diabetologia 59:2448–2458
16. Hng TM, Hor A, Ravi S et al (2016) Diabetes case finding in the emergency department, using HbA1c: an opportunity to improve diabetes detection, prevention, and care. BMJ Open Diabetes Res Care 4:e000191
17. Goto M, Eich TM, Felldin M et al (2004) Refinement of the automated method for human islet isolation and presentation of a closed system for in vitro islet culture. Transplantation 78:1367–1375
18. Saito K, Iwama N, Takahashi T (1978) Morphometrical analysis on topographical difference in size distribution, number and volume of islets in the human pancreas. Tohoku J Exp Med 124:177–186
19. Hellman B (1959) Actual distribution of the number and volume of the islets of Langerhans in different size classes in non-diabetic humans of varying ages. Nature 184(Suppl 19):1498–1499
20. Hellman B (1961) The frequency distribution of the number and volume of the islets of Langerhans in man. 2. Studies in diabetes of adult onset. Acta Pathol Microbiol Scand 51:95–102
21. Bonner-Weir S, O’Brien TD (2008) Islets in type 2 diabetes: in honor of Dr. Robert C. Turner. Diabetes 57:2899–2904
22. Igoillo-Esteve M, Marselli L, Cunha DA et al (2010) Palmitate induces a pro-inflammatory response in human pancreatic islets that mimics CCL2 expression by beta cells in type 2 diabetes. Diabetologia 53:1395–1405
23. Marchetti P (2016) Islet inflammation in type 2 diabetes. Diabetologia 59:668–672
24. Hathout EH, Thomas W, El-Shahawy M, Nahab F, Mace JW (2001) Diabetic autoimmune markers in children and adolescents with type 2 diabetes. Pediatrics 107:E102
25. Wiberg A, Granstam A, Ingvast S et al (2015) Characterization of human organ donors testing positive for type 1 diabetes-associated autoantibodies. Clin Exp Immunol 182:278–288