Characterization of human organ donors testing positive for type 1 diabetes-associated autoantibodies

Clinical and Experimental Immunology

Volumn 182, Issue 3, 2015, Pages 278-288

  Wiberg, A ^a   Granstam, A ^a   Ingvast, S ^a   Harkonen T ^b   Knip, M ^b,c,d   Korsgren, O ^a   Skog, O ^a  

^a UPPSALA UNIVERSITY   (Sweden)

^b UNIVERSITY OF HELSINKI   (Finland)

^c Folkkhälsan Research Center   (Finland)

^d TAMPERE UNIVERSITY HOSPITAL   (Finland)

Author keywords

Autoantibodies; Exocrine pancreas; Fibrosis; Inflammation; Type 1 diabetes

Indexed keywords

AUTOANTIBODY; CD45 ANTIGEN; COLLAGEN; GLUTAMATE DECARBOXYLASE ANTIBODY; HEMOGLOBIN A1C; INSULIN ANTIBODY; INTERLEUKIN 6; INTERLEUKIN 8; ISLET ANTIGEN 2; MONOCYTE CHEMOTACTIC PROTEIN 1; PANCREAS ISLET CELL ANTIBODY; UNCLASSIFIED DRUG; ZINC TRANSPORTER 8 ANTIBODY; GLUTAMATE DECARBOXYLASE; ICA512 AUTOANTIBODY; PTPRN PROTEIN, HUMAN; RECEPTOR LIKE PROTEIN TYROSINE PHOSPHATASE;

ADULT; AGED; ALCOHOL CONSUMPTION; ANTIBODY TITER; ARTICLE; CLINICAL STUDY; CONTROLLED STUDY; FAMILY HISTORY; FEMALE; GENE LOCUS; GENETIC PREDISPOSITION; HUMAN; HUMAN TISSUE; INFLAMMATORY CELL; INSULIN DEPENDENT DIABETES MELLITUS; INSULIN RELEASE; MAJOR CLINICAL STUDY; MALE; ORGAN DONOR; PRIORITY JOURNAL; BLOOD; CLINICAL TRIAL; DIABETES MELLITUS, TYPE 1; DONOR; DONOR SELECTION; IMMUNOLOGY; PANCREAS ISLET TRANSPLANTATION; PROCEDURES;

AUTOANTIBODIES; DIABETES MELLITUS, TYPE 1; DONOR SELECTION; FEMALE; GLUTAMATE DECARBOXYLASE; HUMANS; ISLETS OF LANGERHANS TRANSPLANTATION; MALE; RECEPTOR-LIKE PROTEIN TYROSINE PHOSPHATASES, CLASS 8; TISSUE DONORS;

EID: 84945967120     PISSN: 00099104     EISSN: 13652249     Source Type: Journal    
DOI: 10.1111/cei.12698     Document Type: Article

References (28)

1. Ziegler AG, Eisenbarth GS, Rewers M et al. Seroconversion to multiple islet autoantibodies and risk of progression to diabetes in children. JAMA 2013; 309:2473-9.
2. Tarn AC, Thomas JM, Dean BM et al. Predicting insulin-dependent diabetes. Lancet 1988; 1:845-50.
3. Jaeger C, Hatziagelaki E, Petzoldt R, Bretzel RG. Comparative analysis of organ-specific autoantibodies and celiac disease-associated antibodies in type 1 diabetic patients, their first-degree relatives, and healthy control subjects. Diabetes Care 2001; 24:27-32.
4. Harrison LC. Risk assessment, prediction and prevention of type 1 diabetes. Pediatr Diabetes 2001; 2:71-82.
5. In't Veld P, Lievens D, Grijse JD et al. Screening for insulitis in adult autoantibody-positive organ donors. Diabetes 2007; 56:2400-4.
6. Gianani R, Putnam A, Still T et al. Initial results of screening of nondiabetic organ donors for expression of islet autoantibodies. J Clin Endocrinol Metab 2006; 91:1855-61.
7. Wagner R, Mcnally JM, Bonifacio E et al. Lack of immunohistological changes in the islets of nondiabetic, autoimmune, polyendocrine patients with p-selective GAD-specific islet cell antibodies. Diabetes 1989; 43:851-6.
8. Rodriguez-Calvo T, von Herrath GM. Increased immune cell infiltration of the exocrine pancreas: a possible 2 contribution to the pathogenesis of type 1 diabetes. Diabetes 2014; 63:3880-90.
9. Hardt PD, Krauss A, Bretz L et al. Pancreatic exocrine function in patients with type 1 and type 2 diabetes mellitus. Acta Diabetol 2000; 37:105-10.
10. Campbell-Thompson M, Wasserfall C, Montgomery EL, Atkinson MA, Kaddis JS. Pancreas organ weight in individuals with disease-associated autoantibodies at risk for type 1 diabetes. JAMA 2012; 308:2337-9.
11. Williams AJK, Thrower SL, Sequeiros IM et al. Pancreatic volume is reduced in adult patients with recently diagnosed type 1 diabetes. J Clin Endocrinol Metab 2012; 97:E2109-13.
12. Hardt PD, Ewald N, Bröckling K et al. Distinct autoantibodies against exocrine pancreatic antigens in European patients with type 1 diabetes mellitus and non-alcoholic chronic pancreatitis. JOP 2008; 9:683-9.
13. Cecil RL. A study of the pathological anatomy of the pancreas in ninety cases of diabetes mellitus. J Exp Med 1909; 11:266-90.
14. Hardt PD, Killinger A, Nalop J, Schnell-Kretschmer H, Zekorn T, Klör HU. Chronic pancreatitis and diabetes mellitus. A retrospective analysis of 156 ERCP investigations in patients with insulin-dependent and non-insulin-dependent diabetes mellitus. Pancreatology 2002; 2:30-3.
15. Nakanishi K, Kobayashi T, Miyashita H et al. Exocrine pancreatic ductograms in insulin-dependent diabetes mellitus. Am J Gastroenterol 1994; 89:762-6.
16. Bilgin M, Balci NC, Momtahen AJ, Bilgin Y, Klör H-U, Rau WS. MRI and MRCP findings of the pancreas in patients with diabetes mellitus: compared analysis with pancreatic exocrine function determined by fecal elastase 1. J Clin Gastroenterol 2009; 43:165-70.
17. Okazaki K, Chiba T. Autoimmune related pancreatitis. Gut 2002; 51:1-4.
18. Gröger G, Layer P. Exocrine pancreatic function in diabetes mellitus. Eur J Gastro Hepatol 1995; 7:740-6.
19. Sjoberg RJ, Kidd GS. Pancreatic diabetes mellitus. Diabetes Care 1989; 12:715-24.
20. Goto M, Eich TM, Felldin M et al. Refinement of the automated method for human islet isolation and presentation of a closed system for in vitro islet culture. Transplantation 2004; 78:1367-75.
21. Knip M, Virtanen SM, Seppä K et al. Dietary intervention in infancy and later signs of beta-cell autoimmunity. N Engl J Med 2010; 363:1900-8.
22. Pugliese A, Vendrame F, Reijonen H, Atkinson MA, Campbell-Thompson M, Burke GW. New insight on human type 1 diabetes biology: nPOD and nPOD-transplantation. Curr Diab Rep 2014; 14:530.
23. Bender C, Schlosser M, Christen U, Ziegler AG, Achenbach P. GAD autoantibody affinity in schoolchildren from the general population. Diabetologia 2014; 57:1911-8.
24. Achenbach P, Warncke K, Naserke HE et al. Stratification of type 1 diabetes risk on the basis of islet autoantibody characteristics. Diabetes 2004; 53:384-92.
25. Campbell-Thompson ML, Atkinson MA, Butler AE et al. The diagnosis of insulitis in human type 1 diabetes. Diabetologia 2013; 56:2541-3.
26. Foulis AK, Liddle CN, Farquharson MA, Richmond JA, Weir RS. The histopathology of the pancreas in type 1 (insulin-dependent) diabetes mellitus: a 25-year review of deaths in patients under 20 years of age in the United Kingdom 1986; 1:267-74.
27. In't Veld P, De Munck N, Van Belle K et al. Beta-cell replication is increased in donor organs from young patients after prolonged life support. Diabetes 2010; 59:1702-8.
28. Hoseda H, Okawa-Takatsuji M, Shinmura W, Hasimoto N, Ozaki Y, Ikeda Y. Potential for differential diagnosis of autoimmune pancreatitis and pancreatic cancer using carbonic anhydrase II antibody 2008; 37:1-7.