Mast cells infiltrate pancreatic islets in human type 1 diabetes

Diabetologia

Volumn 58, Issue 11, 2015, Pages 2554-2562

  Martino, Luisa ^a   Masini, Matilde ^a   Bugliani, Marco ^a   Marselli, Lorella ^a   Suleiman, Mara ^a   Boggi, Ugo ^a   Nogueira, Tatiane C ^b   Filipponi, Franco ^a   Occhipinti, Margherita ^a   Campani, Daniela ^a   Dotta, Francesco ^c   Syed, Farooq ^a   Eizirik, Decio L ^b   Marchetti, Piero ^a   De Tata, Vincenzo ^a  

^a UNIVERSITY OF PISA   (Italy)

^b UNIVERSITÉ LIBRE DE BRUXELLES   (Belgium)

^c UNIVERSITY OF SIENA   (Italy)

Author keywords

Histamine; Human islets; Insulitis; Mast cells; Type 1 diabetes; Type 2 diabetes

Indexed keywords

AMINE; CASPASE; HISTAMINE;

ADULT; AGED; ARTICLE; CELL DAMAGE; CELL DEATH; CELL INFILTRATION; CELL ISOLATION; CELL SURVIVAL; CLINICAL ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; FEMALE; GENE EXPRESSION; HISTOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; INNATE IMMUNITY; INSULIN DEPENDENT DIABETES MELLITUS; INSULITIS; MALE; MAST CELL; MAST CELL DEGRANULATION; MIDDLE AGED; MITOCHONDRIAL MEMBRANE POTENTIAL; MOLECULAR BIOLOGY; PANCREAS ISLET; PANCREAS ISLET BETA CELL; PANCREATIC TISSUE; PATHOGENESIS; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; YOUNG ADULT; PANCREAS; PATHOLOGY;

ADULT; AGED; CELL SURVIVAL; DIABETES MELLITUS, TYPE 1; FEMALE; HUMANS; ISLETS OF LANGERHANS; MALE; MAST CELLS; MIDDLE AGED; PANCREAS; YOUNG ADULT;

EID: 84942983227     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-015-3734-1     Document Type: Article

References (47)

1. Bluestone JA, Herold K, Eisenbarth G (2010) Genetics, pathogenesis and clinical interventions in type 1 diabetes. Nature 464:1293–1300
2. Eizirik DL, Colli ML, Ortis F (2009) The role of inflammation in insulitis and beta-cell loss in type 1 diabetes. Nat Rev Endocrinol 5:219–226
3. Campbell-Thompson ML, Atkinson MA, Butler AE et al (2013) The diagnosis of insulitis in human type 1 diabetes. Diabetologia 56:2541–2543
4. Hänninen A, Jalkanen S, Salmi M, Toikkanen S, Nikolakaros G, Simell O (1992) Macrophages, T cell receptor usage, and endothelial cell activation in the pancreas at the onset of insulin-dependent diabetes mellitus. J Clin Invest 90:1901–1910
5. Willcox A, Richardson SJ, Bone AJ, Foulis AK, Morgan NG (2009) Analysis of islet inflammation in human type 1 diabetes. Clin Exp Immunol 155:173–181
6. Lernmark A, Klöppel G, Stenger D et al (1995) Heterogeneity of islet pathology in two infants with recent onset diabetes mellitus. Virchows Arch 425:631–640
7. Reddy S, Zeng N, Al-Diery H et al (2015) Analysis of peri-islet CD45-positive leucocytic infiltrates in long-standing type 1 diabetic patients. Diabetologia 58:1024–1035
8. Valle A, Giamporcaro GM, Scavini M et al (2013) Reduction of circulating neutrophils precedes and accompanies type 1 diabetes. Diabetes 62:2072–2077
9. Weller CL, Collington SJ, Williams T, Lamb JR (2011) Mast cells in health and disease. Clin Sci (Lond) 120:473–484
10. Rivera J, Gilfillan AM (2006) Molecular regulation of mast cell activation. J Allergy Clin Immunol 117:1214–1225
11. Castleman WL, Sorkness RL, Lemanske RF Jr, McAllister PK (1990) Viral bronchiolitis during early life induces increased numbers of bronchiolar mast cells and airway hyperresponsiveness. Am J Pathol 137:821–831
12. Galli SJ, Nakae S, Tsai M (2005) Mast cells in the development of adaptive immune responses. Nat Immunol 6:135–142
13. Walker ME, Hatfield JK, Brown MA (2012) New insights into the role of mast cells in autoimmunity: evidence for a common mechanism of action? Biochim Biophys Acta 1822:57–65
14. da Silva EZ, Jamur MC, Oliver C (2014) Mast cell function: a new vision of an old cell. J Histochem Cytochem 62:698–738
15. Pino SC, Kruger AJ, Bortell R (2010) The role of innate immune pathways in type 1 diabetes. Curr Opin Endocrinol Diabetes Obes 17:126–130
16. Geoffrey R, Jia S, Kwitek AE et al (2006) Evidence of a functional role for mast cells in the development of type 1 diabetes mellitus in the BioBreeding rat. J Immunol 177:7275–7286
17. Marselli L, Bugliani M, Suleiman M et al (2013) Beta-cell inflammation in human type 2 diabetes and the role of autophagy. Diabetes Obes Metab 15(Suppl 3):130–136
18. Masini M, Bugliani M, Lupi R et al (2009) Autophagy in human type 2 diabetes pancreatic beta cells. Diabetologia 52:1083–1086
19. Abdou AG, Maraee AH, Antar AG, Fareed S (2014) Role of mast cells in skin tag development: an immunohistochemical study. Anal Quant Cytopathol Histpathol 36:222–230
20. Vitte J (2015) Human mast cell tryptase in biology and medicine. Mol Immunol 63:18–24
21. Dvorak AM (2005) Ultrastructural studies of human basophils and mast cells. J Histochem Cytochem 53:1043–1070
22. Wernersson S, Pejler G (2014) Mast cell secretory granules: armed for battle. Nat Rev Immunol 14:478–494
23. Sturrock RR (1979) A semithin light microscopic, transmission electron microscopic and scanning electron microscopic study of macrophages in the lateral ventricle of mice from embryonic to adult life. J Anat 129:31–44
24. Seemayer TA, Tannenbaum GS, Goldman HY, Colle E (1982) Dynamic time course studies of the spontaneously diabetic BB Wistar rat III. Light-microscopic and ultrastructural observation of pancreatic islets of Langerhans. Am J Pathol 106:237–249
25. Kroemer G, Galluzzi L, Vandenabeele P et al (2009) Classification of cell death: recommendations of the Nomenclature Committee on Cell Death 2009. Cell Death Differ 16:3–11
26. Marchetti P, Bugliani M, Lupi R et al (2007) The endoplasmic reticulum in pancreatic beta cells of type 2 diabetes patients. Diabetologia 50:2486–2494
27. Martino L, Masini M, Novelli M et al (2012) Palmitate activates autophagy in INS-1E β-cells and in isolated rat and human pancreatic islets. PLoS One 7(5):e36188
28. Galluzzi L, Vitale I, Abrams JM et al (2012) Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012. Cell Death Differ 19:107–120
29. Meier JJ, Bhushan A, Butler AE, Rizza RA, Butler PC (2005) Sustained beta cell apoptosis in patients with long-standing type 1 diabetes: indirect evidence for islet regeneration? Diabetologia 48:2221–2228
30. Nogueira TC, Paula FM, Villate O et al (2013) GLIS3, a susceptibility gene for type 1 and type 2 diabetes, modulates pancreatic beta cell apoptosis via regulation of a splice variant of the BH3-only protein Bim. PLoS Genet 9:e1003532
31. Marselli L, Thorne J, Ahn YB et al (2008) Gene expression of purified beta-cell tissue obtained from human pancreas with laser capture microdissection. J Clin Endocrinol Metab 93:1046–1053
32. Piaggi S, Novelli M, Martino L et al (2007) Cell death and impairment of glucose-stimulated insulin secretion induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in the beta-cell line INS-1E. Toxicol Appl Pharmacol 220:333–340
33. Ehses JA, Perren A, Eppler E et al (2007) Increased number of islet-associated macrophages in type 2 diabetes. Diabetes 56:2356–2370
34. Richardson SJ, Willcox A, Bone AJ, Foulis AK, Morgan NG (2009) Islet-associated macrophages in type 2 diabetes. Diabetologia 52:1686–1688
35. In’t Veld P, De Munck N, Van Belle K et al (2010) Beta-cell replication is increased in donor organs from young patients after prolonged life support. Diabetes 59:1702–1708
36. Gutierrez DA, Fu W, Schonefeldt S et al (2014) Type 1 diabetes in NOD mice unaffected by mast cell deficiency. Diabetes 63:3827–3834
37. Dotta F, Censini S, van Halteren AG et al (2007) Coxsackie B4 virus infection of beta cells and natural killer cell insulitis in recent-onset type 1 diabetic patients. Proc Natl Acad Sci U S A 104:5115–5120
38. Collington SJ, Williams TJ, Weller CL (2011) Mechanisms underlying the localisation of mast cells in tissues. Trends Immunol 32:478–485
39. Ylipaasto P, Kutlu B, Rasilainen S et al (2005) Global profiling of coxsackievirus- and cytokine-induced gene expression in human pancreatic islets. Diabetologia 48:1510–1522
40. Cardozo AK, Proost P, Gysemans C, Chen MC, Mathieu C, Eizirik DL (2003) IL-1β and IFN-γ induce the expression of diverse chemokines and IL-15 in human and rat pancreatic islet cells, and in islets from pre-diabetic NOD mice. Diabetologia 46:255–266
41. Eizirik DL, Sammeth M, Bouckenooghe T et al (2012) The human pancreatic islet transcriptome: expression of candidate genes for type 1 diabetes and the impact of pro-inflammatory cytokines. PLoS Genet 8:e1002552
42. Campbell-Thompson M, Wasserfall C, Montgomery EL, Atkinson MA, Kaddis JS (2012) Pancreas organ weight in individuals with disease-associated autoantibodies at risk for type 1 diabetes. JAMA 308:2337–2339
43. Rodriguez-Calvo T, Ekwall O, Amirian N, Zapardiel-Gonzalo J, von Herrath MG (2014) Increased immune cell infiltration of the exocrine pancreas: a possible contribution to the pathogenesis of type 1 diabetes. Diabetes 63:3880–3890
44. Atkinson MA (2014) Losing a grip on the notion of β-cell specificity for immune responses in type 1 diabetes: can we handle the truth? Diabetes 63:3572–3574
45. + T cell recruitment. Blood 106:978–987
46. 3 receptors in pancreatic beta cells. Br J Pharmacol 171:171–185
47. Martin S, Kolb-Bachofen V, Kiesel U, Kolb H (1989) Pathogenesis of low dose streptozotocin induced diabetes in mice: requirement for α1-adrenoceptor activation and vasoactive amine release. Diabetologia 32:140–142