Protective effects of quercetin on mitochondrial biogenesis in experimental traumatic brain injury via the Nrf2 signaling pathway

PLoS ONE

Volumn 11, Issue 10, 2016, Pages

  Li, Xiang ^a   Wang, Handong ^a   Gao, Yongyue ^a   Li, Liwen ^a   Tang, Chao ^a   Wen, Guodao ^a   Zhou, Yuan ^a   Zhou, Mengliang ^a   Mao, Lei ^a   Fan, Youwu ^a  

^a MEDICAL SCHOOL OF NANJING UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; CYTOCHROME C; MALONALDEHYDE; PROTEIN BAX; QUERCETIN; SUPEROXIDE DISMUTASE; TRANSCRIPTION FACTOR NRF2; NFE2L2 PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; CELL LEVEL; CELL PROTECTION; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; MALE; MITOCHONDRIAL BIOGENESIS; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRIAL RESPIRATION; MOUSE; NONHUMAN; OXIDATIVE STRESS; PROTEIN EXPRESSION; PROTEIN TRANSPORT; SIGNAL TRANSDUCTION; TRAUMATIC BRAIN INJURY; UPREGULATION; ANIMAL; BRAIN INJURIES, TRAUMATIC; DISEASE MODEL; DRUG EFFECTS; GENE EXPRESSION REGULATION; INTRAPERITONEAL DRUG ADMINISTRATION; METABOLISM; MITOCHONDRION; ORGANELLE BIOGENESIS;

ANIMALS; BRAIN INJURIES, TRAUMATIC; CYTOCHROMES C; DISEASE MODELS, ANIMAL; GENE EXPRESSION REGULATION; INJECTIONS, INTRAPERITONEAL; MALE; MALONDIALDEHYDE; MICE; MITOCHONDRIA; NF-E2-RELATED FACTOR 2; ORGANELLE BIOGENESIS; OXIDATIVE STRESS; PROTEIN TRANSPORT; QUERCETIN; SIGNAL TRANSDUCTION; SUPEROXIDE DISMUTASE; UP-REGULATION;

EID: 84992692299     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0164237     Document Type: Article

References (40)

1. Algattas H, Huang JH (2014) Traumatic Brain Injury pathophysiology and treatments: early, intermediate, and late phases post-injury. Int J Mol Sci 15: 309-341.
2. Ding K, Xu J, Wang H, Zhang L, Wu Y, Li T (2015) Melatonin protects the brain from apoptosis by enhancement of autophagy after traumatic brain injury in mice. Neurochem Int 91: 46-54. doi: 10. 1016/j.neuint.2015.10.008 PMID: 26527380
3. El HN, Stein KP, Hagel V, Dammann P, Sure U, Mueller O (2014) The role of decompressive craniectomy in children with severe traumatic brain injury. Eur J Trauma Emerg Surg 40: 481-487. doi: 10. 1007/s00068-013-0337-8 PMID: 26816244
4. Kompanje EJ (2007) 'No Time to be Lost!' Ethical considerations on consent for inclusion in emergency pharmacological research in severe traumatic brain injury in the European Union. Sci Eng Ethics 13: 371-381. doi: 10.1007/s11948-007-9027-4 PMID: 18210230
5. Kambe Y, Miyata A (2016) Mitochondrial c-Fos May Increase the Vulnerability of Neuro2a Cells to Cellular Stressors. J Mol Neurosci.
6. Sanganahalli BG, Herman P, Hyder F, Kannurpatti SS (2013) Mitochondrial functional state impacts spontaneous neocortical activity and resting state FMRI. PLoS One 8: e63317. doi: 10.1371/journal. pone.0063317 PMID: 23650561
7. Hu Y, Duan M, Liang S, Wang Y, Feng Y (2015) Senkyunolide I protects rat brain against focal cerebral ischemia-reperfusion injury by up-regulating p-Erk1/2, Nrf2/HO-1 and inhibiting caspase 3. Brain Res 1605: 39-48. doi: 10.1016/j.brainres.2015.02.015 PMID: 25698615
8. Yan W, Wang HD, Hu ZG, Wang QF, Yin HX (2008) Activation of Nrf2-ARE pathway in brain after traumatic brain injury. Neurosci Lett 431: 150-154. doi: 10.1016/j.neulet.2007.11.060 PMID: 18162315
9. Hailer NP (2008) Immunosuppression after traumatic or ischemic CNS damage: it is neuroprotective and illuminates the role of microglial cells. Prog Neurobiol 84: 211-233. doi: 10.1016/j.pneurobio. 2007.12.001 PMID: 18262323
10. Petzold A (2007) CSF biomarkers for improved prognostic accuracy in acute CNS disease. Neurol Res 29: 691-708. doi: 10.1179/016164107X240080 PMID: 18173909
11. Lei X, Lei L, Zhang Z, Cheng Y (2016) Neuroprotective effects of lycopene pretreatment on transient global cerebral ischemiareperfusion in rats: The role of the Nrf2/HO1 signaling pathway. Mol Med Rep 13: 412-418. doi: 10.3892/mmr.2015.4534 PMID: 26572165
12. Liu Y, Zhang L, Liang J (2015) Activation of the Nrf2 defense pathway contributes to neuroprotective effects of phloretin on oxidative stress injury after cerebral ischemia/reperfusion in rats. J Neurol Sci 351: 88-92. doi: 10.1016/j.jns.2015.02.045 PMID: 25770876
13. Whitman SA, Long M, Wondrak GT, Zheng H, Zhang DD (2013) Nrf2 modulates contractile and metabolic properties of skeletal muscle in streptozotocin-induced diabetic atrophy. Exp Cell Res 319: 2673-2683. doi: 10.1016/j.yexcr.2013.07.015 PMID: 23896025
14. Bournival J, Plouffe M, Renaud J, Provencher C, Martinoli MG (2012) Quercetin and sesamin protect dopaminergic cells from MPP+-induced neuroinflammation in a microglial (N9)-neuronal (PC12) coculture system. Oxid Med Cell Longev 2012: 921941. doi: 10.1155/2012/921941 PMID: 22919443
15. Bachmetov L, Gal-Tanamy M, Shapira A, Vorobeychik M, Giterman-Galam T, et al. (2012) Suppression of hepatitis C virus by the flavonoid quercetin is mediated by inhibition of NS3 protease activity. J Viral Hepat 19: e81-88. doi: 10.1111/j.1365-2893.2011.01507.x PMID: 22239530
16. Flierl MA, Stahel PF, Beauchamp KM, Morgan SJ, Smith WR, Shohami E (2009) Mouse closed head injury model induced by a weight-drop device. Nat Protoc 4: 1328-1337. doi: 10.1038/nprot.2009.148 PMID: 19713954
17. Xu J, Wang H, Ding K, Lu X, Li T, et al. (2013) Inhibition of cathepsin S produces neuroprotective effects after traumatic brain injury in mice. Mediators Inflamm 2013: 187873. doi: 10.1155/2013/187873 PMID: 24282339
18. Shen J, Huang C, Jiang L, Gao F, Wang Z, et al. (2007) Enhancement of cisplatin induced apoptosis by suberoylanilide hydroxamic acid in human oral squamous cell carcinoma cell lines. Biochem Pharmacol 73: 1901-1909. doi: 10.1016/j.bcp.2007.03.009 PMID: 17445779
19. Xu J, Wang H, Ding K, Zhang L, Wang C, et al. (2014) Luteolin provides neuroprotection in models of traumatic brain injury via the Nrf2-ARE pathway. Free Radic Biol Med 71: 186-195. doi: 10.1016/j. freeradbiomed.2014.03.009 PMID: 24642087
20. Kimura T, Watanabe Y, AUID-Oho (2016) Tryptophan protects hepatocytes against reactive oxygen species-dependent cell death via multiple pathways including Nrf2-dependent gene induction. Amino Acids.
21. Wang L, Lv Y, Yao H, Yin L, Shang J (2015) Curcumin prevents the non-alcoholic fatty hepatitis via mitochondria protection and apoptosis reduction. Int J Clin Exp Pathol 8: 11503-11509. PMID: 26617882
22. Bouitbir J, Charles AL, Echaniz-Laguna A, Kindo M, Daussin F, et al. (2012) Opposite effects of statins on mitochondria of cardiac and skeletal muscles: a 'mitohormesis' mechanism involving reactive oxygen species and PGC-1. Eur Heart J 33: 1397-1407. doi: 10.1093/eurheartj/ehr224 PMID: 21775390
23. Kulkarni GV, Lee W, Seth A, McCulloch CA (1998) Role of mitochondrial membrane potential in concanavalin A-induced apoptosis in human fibroblasts. Exp Cell Res 245: 170-178. doi: 10.1006/excr. 1998.4245 PMID: 9828113
24. Chen CT, Shih YR, Kuo TK, Lee OK, Wei YH (2008) Coordinated changes of mitochondrial biogenesis and antioxidant enzymes during osteogenic differentiation of human mesenchymal stem cells. Stem Cells 26: 960-968. doi: 10.1634/stemcells.2007-0509 PMID: 18218821
25. Ashton JC, Glass M (2007) The cannabinoid CB2 receptor as a target for inflammation-dependent neurodegeneration. Curr Neuropharmacol 5: 73-80. PMID: 18615177
26. Lawrence NJ, Sacco JJ, Brownstein DG, Gillingwater TH, Melton DW (2008) A neurological phenotype in mice with DNA repair gene Ercc1 deficiency. DNA Repair (Amst) 7: 281-291.
27. Go KL, Lee S, Zendejas I, Behrns KE, Kim JS (2015) Mitochondrial Dysfunction and Autophagy in Hepatic Ischemia/Reperfusion Injury. Biomed Res Int 2015: 183469. doi: 10.1155/2015/183469 PMID: 26770970
28. Baburamani AA, Hurling C, Stolp H, Sobotka K, Gressens P, et al. (2015) Mitochondrial Optic Atrophy (OPA) 1 Processing Is Altered in Response to Neonatal Hypoxic-Ischemic Brain Injury. Int J Mol Sci 16: 22509-22526. doi: 10.3390/ijms160922509 PMID: 26393574
29. Liu P, Zou D, Yi L, Chen M, Gao Y, et al. (2015) Quercetin ameliorates hypobaric hypoxia-induced memory impairment through mitochondrial and neuron function adaptation via the PGC-1α pathway. Restor Neurol Neurosci 33: 143-157. doi: 10.3233/RNN-140446 PMID: 25588463
30. Sharma DR, Sunkaria A, Wani WY, Sharma RK, Verma D, et al. (2015) Quercetin protects against aluminium induced oxidative stress and promotes mitochondrial biogenesis via activation of the PGC-1α signaling pathway. Neurotoxicology 51: 116-137. doi: 10.1016/j.neuro.2015.10.002 PMID: 26493151
31. Halder S, Kar R, Mehta AK, Bhattacharya SK, Mediratta PK, Banerjee BD (2016) Quercetin Modulates the Effects of Chromium Exposure on Learning, Memory and Antioxidant Enzyme Activity in F1 Generation Mice. Biol Trace Elem Res 171: 391-398. doi: 10.1007/s12011-015-0544-8 PMID: 26521059
32. Carrasco-Pozo C, Castillo RL, Beltrán C, Miranda A, Fuentes J, GottelandM (2016) Molecular mechanisms of gastrointestinal protection by quercetin against indomethacin-induced damage: role of NF-κB and Nrf2. J Nutr Biochem 27: 289-298. doi: 10.1016/j.jnutbio.2015.09.016 PMID: 26507542
33. Halder S, Kar R, Galav V, Mehta AK, Bhattacharya SK, et al. (2016) Cadmium exposure during lactation causes learning and memory-impairment in F1 generation mice: amelioration by quercetin. Drug Chem Toxicol 39: 272-278. doi: 10.3109/01480545.2015.1092042 PMID: 26446883
34. Liu WC, Wen L, Xie T, Wang H, Gong JB, Yang XF (2016) Therapeutic effect of erythropoietin in patients with traumatic brain injury: a meta-analysis of randomized controlled trials. J Neurosurg: 1-8.
35. Chen C, Jiang ZY, Yu B, Wu XL, Dai CQ, et al. (2012) Study on the anti-H1N1 virus effects of quercetin and oseltamivir and their mechanism related to TLR7 pathway. J Asian Nat Prod Res 14: 877-885. doi: 10.1080/10286020.2012.702108 PMID: 22924574
36. Sharma DR, Wani WY, Sunkaria A, Kandimalla RJ, Verma D, et al. (2013) Quercetin protects against chronic aluminum-induced oxidative stress and ensuing biochemical, cholinergic, and neurobehavioral impairments in rats. Neurotox Res 23: 336-357. doi: 10.1007/s12640-012-9351-6 PMID: 22918785
37. Marcolin E, San-Miguel B, Vallejo D, Tieppo J, Marroni N, et al. (2012) Quercetin treatment ameliorates inflammation and fibrosis in mice with nonalcoholic steatohepatitis. J Nutr 142: 1821-1828. doi: 10.3945/jn.112.165274 PMID: 22915297
38. Li R, Luo X, Wu J, Thangthaeng N, Jung ME, et al. (2015) Mitochondrial Dihydrolipoamide Dehydrogenase is Upregulated in Response to Intermittent Hypoxic Preconditioning. Int J Med Sci 12: 432-440. doi: 10.7150/ijms.11402 PMID: 26078703
39. Kysenius K, Brunello CA, Huttunen HJ (2014) Mitochondria and NMDA receptor-dependent toxicity of berberine sensitizes neurons to glutamate and rotenone injury. PLoS One 9: e107129. doi: 10.1371/journal.pone.0107129 PMID: 25192195
40. Kilbaugh TJ, Karlsson M, Byro M, Bebee A, Ralston J, et al. (2015) Mitochondrial bioenergetic alterations after focal traumatic brain injury in the immature brain. Exp Neurol 271: 136-144. doi: 10.1016/j.expneurol.2015.05.009 PMID: 26028309