The Uyghur population and genetic susceptibility to type 2 diabetes: potential role for variants in CAPN10, APM1 and FUT6 genes

Journal of Cellular and Molecular Medicine

Volumn 20, Issue 11, 2016, Pages 2138-2147

  Zhao, Feifei ^a   Mamatyusupu, Dolikun ^b   Wang, Youxin ^a   Fang, Honghong ^a   Wang, Hao ^a   Gao, Qing ^a   Dong, Hao ^a   Ge, Siqi ^a   Yu, Xinwei ^a   Zhang, Jie ^a   Wu, Lijuan ^a   Song, Manshu ^a   Wang, Wei ^a,c  

^a CAPITAL MEDICAL UNIVERSITY   (China)

^b XINJIANG UNIVERSITY   (China)

^c EDITH COWAN UNIVERSITY   (Australia)

Author keywords

APM1; CAPN10; FUT6; susceptibility loci; type 2 diabetes; Uyghur

Indexed keywords

ADIPONECTIN; CALPAIN 10; FUCOSYLTRANSFERASE; ADIPOQ PROTEIN, HUMAN; CALPAIN; FUT6 PROTEIN, HUMAN;

ADULT; ARTICLE; CASE CONTROL STUDY; CONTROLLED STUDY; FEMALE; GENETIC ASSOCIATION; GENETIC SUSCEPTIBILITY; GLYCOSYLATION; HUMAN; MAJOR CLINICAL STUDY; MALE; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; NON INSULIN DEPENDENT DIABETES MELLITUS; OBESITY; PRIORITY JOURNAL; RISK FACTOR; SINGLE NUCLEOTIDE POLYMORPHISM; UYGUR (PEOPLE); ALLELE; ASIAN CONTINENTAL ANCESTRY GROUP; DEMOGRAPHY; ETHNIC GROUP; GENETIC PREDISPOSITION; GENETICS; GENOME-WIDE ASSOCIATION STUDY; MATRIX-ASSISTED LASER DESORPTION-IONIZATION MASS SPECTROMETRY; MIDDLE AGED;

ADIPONECTIN; ALLELES; ASIAN CONTINENTAL ANCESTRY GROUP; CALPAIN; CASE-CONTROL STUDIES; DEMOGRAPHY; DIABETES MELLITUS, TYPE 2; ETHNIC GROUPS; FEMALE; FUCOSYLTRANSFERASES; GENETIC PREDISPOSITION TO DISEASE; GENOME-WIDE ASSOCIATION STUDY; HUMANS; MALE; MIDDLE AGED; OBESITY; POLYMORPHISM, SINGLE NUCLEOTIDE; RISK FACTORS; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION;

EID: 84992467132     PISSN: 15821838     EISSN: None     Source Type: Journal    
DOI: 10.1111/jcmm.12911     Document Type: Article

References (61)

1. World Health Organization. Global health estimates: deaths by cause, age, sex and country, 2000–2012. Geneva: WHO; 2014.
2. Mathers CD, Loncar D. Projections of global mortality and burden of disease from 2002 to 2030. PLoS Med. 2006; 3: e442.
3. International Diabetes Federation. IDF Diabetes Atlas. 5th ed. Brussels: International Diabetes Federation; 2011.
4. Yang WY, Lu JM, Weng JP, et al. Prevalence of diabetes among men and women in China. N Engl J Med. 2010; 362: 1090–101.
5. Stumvoll M, Goldstein BJ, van Haeften TW. Type 2 diabetes: principles of pathogenesis and therapy. Lancet. 2005; 365: 1333–46.
6. Li L, Zhang Y, Du J, et al. Calpain 10 genetype of type 2 diabetes mellitus and environmental factors in Xinjiang Uygur population. Chin J Dis Control Prev. 2006; 10: 245–8.
7. Chen XP, Song QH, Chen ZB, et al. Study on Calpain 10 gene polymorphisms for type 2 diabetic patients among Li minorities from Hainan province of China. Clin Focus. 2006; 21: 1000–2.
8. Huang DZ, Liu J, An YD, et al. Relationship between calpain 10 SNP43(G/A)polymorphism and type 2 diabetes mellitus in people of Dongxiang nationality in Gansu Province. J Lanzhou Univ. 2013; 39: 16–9.
9. Xiang KS, Zhang TS, Jia WP, et al. The impact of polymorphism of calpain-10 gene on glucose intolerance status, insulin secretion and insulin sensitivity. Chin J Endocrinol Metab. 2001; 17: 290–4.
10. Maleki F, Haghani K, Shokouhi S, et al. A case-control study on the association of common variants of CAPN10 gene and the risk of type 2 diabetes in an Iranian population. Clin Lab. 2014; 60: 663–70.
11. Dall'Olio F, Malagolini N, Trinchera M, et al. Mechanisms of cancer-associated glycosylation changes. Front Biosci. 2012; 17: 670–99.
12. Ohtsubo K, Marth JD. Glycosylation in cellular mechanisms of health and disease. Cell. 2006; 126: 855–67.
13. Marth JD, Grewal PK. Mammalian glycosylation in immunity. Nat Rev Immunol. 2008; 8: 874–87.
14. Crocker PR, Paulson JC, Varki A. Siglecs and their roles in the immune system. Nat Rev Immunol. 2007; 7: 255–66.
15. Testa R, Vanhooren V, Bonfigli AR, et al. N-glycomic changes in serum proteins in type 2 diabetes mellitus correlate with complications and with metabolic syndrome parameters. PLoS ONE. 2015; 10: e119983.
16. Lu JP, Knezevic A, Wang YX, et al. Screening novel biomarkers for metabolic syndrome by profiling human plasma N-glycans in Chinese Han and Croatian populations. J Proteome Res. 2011; 10: 4959–69.
17. Xu S, Jin L. A genome-wide analysis of admixture in Uyghurs and a high-density admixture map for disease-gene discovery. Am J Hum Genet. 2008; 83: 322–36.
18. Song M, Zhao F, Ran L, et al. The Uyghur population and genetic susceptibility to type 2 diabetes: potential role for variants in CDKAL1, JAZF1, and IGF1 genes. OMICS. 2015; 19: 230–7.
19. About Xinjiang. Available at http://www.sinkiang.gov.cn/aboutxinjiang/index.htm (accessed 5 August 2015).
20. Mackerras C. The Uighur Empire according to the T'ang Dynastic Histories: a study in Sino-Uyghur relations. Columbia: University of South Carolina Press; 1972. pp. 744–840. ISBN 0872492796.
21. Gulizila KZEBK, Jieensi YSF. The effect of ethnic segregation in southern Xinjiang population. J Chang Ji Univ. 2010; 2: 25–7 (in Chinese).
22. Li J, Lou H, Yang X, et al. Genetic architectures of ADME genes in five Eurasian admixed populations and implications for drug safety and efficacy. J Med Genet. 2014; 51: 614–22.
23. Alberti KG, Zimmet PZ. Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus provisional report of a WHO consultation. Diabet Med. 1998; 15: 539–53.
24. Hindorff LA, MacArthur J, Morales J, et al. A catalog of published genome-wide association studies. Available at www.genome.gov/gwastudies (accessed 15 August 2015).
25. Horikawa Y, Oda N, Cox NJ, et al. Genetic variation in the gene encoding calpain-10 is associated with type 2 diabetes mellitus. Nat Genet. 2000; 26: 163–75.
26. Lauc G, Essafi A, Huffman JE, et al. Genomics meets glycomics-the first GWAS study of human N-Glycome identifies HNF1alpha as a master regulator of plasma protein fucosylation. PLoS Genet. 2010; 6: e1001256.
27. Hamid YH, Urhammer SA, Jensen DP, et al. Variation in the interleukin-6 receptor gene associates with type 2 diabetes in Danish whites. Diabetes. 2004; 53: 3342–5.
28. Hara K, Shojima N, Hosoe J, et al. Genetic architecture of type 2 diabetes. Biochem Biophys Res Commun. 2014; 452: 213–20.
29. Li JZ, Absher DM, Tang H, et al. Worldwide human relationships inferred from genome-wide patterns of variation. Science. 2008; 319: 1100–4.
30. Takeuchi M, Okamoto K, Takagi T, et al. Ethnic difference in patients with type 2 diabetes mellitus in inter-East Asian populations: a systematic review and meta-analysis focusing on gene polymorphism. J Diabetes. 2009; 1: 255–62.
31. Berhouma R, Kouidhi S, Ammar M, et al. Genetic susceptibility to type 2 diabetes: a global meta-analysis studying the genetic differences in Tunisian populations. Hum Biol. 2012; 84: 423–35.
32. Tsuchiya T, Schwarz PE, Bosque-Plata LD, et al. Association of the calpain-10 gene with type 2 diabetes in Europeans: results of pooled and meta-analyses. Mol Genet Metab. 2006; 89: 174–84.
33. Baier LJ, Permana PA, Yang X, et al. A calpain-10 gene polymorphism is associated with reduced muscle mRNA levels and insulin resistance. J Clin Invest. 2000; 106: R69–73.
34. Li YY, Gong G, Geng HY, et al. CAPN10 SNP43G>A gene polymorphism and type 2 diabetes mellitus in the Asian population: a meta-analysis of 9353 participants. Endocr J. 2015; 62: 183–94.
35. Song YQ, You NC, Hsu YH, et al. Common genetic variation in calpain-10 gene (CAPN10) and diabetes risk in a multi-ethnic cohort of women. Diabetes. 2007; 561: A304.
36. Kommoju UJ, Maruda J, Kadarkarai SS, et al. Association of IRS1, CAPN10, and PPARG gene polymorphisms with type 2 diabetes mellitus in the high-risk population of Hyderabad, India. J Diabetes. 2014; 6: 564–73.
37. Evans JC, Frayling TM, Cassell PG, et al. Studies of association between the gene for calpain-10 and type 2 diabetes mellitus in the United Kingdom. Am J Hum Genet. 2001; 69: 544–52.
38. Fingerlin TE, Erdos MR, Watanabe RM, et al. Variation in three single nucleotide polymorphisms in the calpain-10 gene not associated with type 2 diabetes in a large Finnish cohort. Diabetes. 2002; 51: 1644–8.
39. Ezzidi I, Mtiraoui N, Nemr R, et al. Variants within the calpain-10 gene and relationships with type 2 diabetes (T2DM) and T2DM-related traits among Tunisian Arabs. Diabetes Metab. 2010; 36: 357–62.
40. Chen Y, Kittles R, Zhou J, et al. Calpain-10 gene polymorphisms and type 2 diabetes in West Africans: the Africa America Diabetes Mellitus (AADM) Study. Ann Epidemiol. 2005; 15: 153–9.
41. Cassell PG, Jackson AE, North BV, et al. Haplotype combinations of calpain 10 gene polymorphisms associate with increased risk of impaired glucose tolerance and type 2 diabetes in South Indians. Diabetes. 2002; 51: 1622–8.
42. Iwasaki N, Horikawa Y, Tsuchiya T, et al. Genetic variants in the calpain-10 gene and the development of type 2 diabetes in the Japanese population. J Hum Genet. 2005; 50: 92–8.
43. Wu B, Takahashi J, Fu M, et al. Variants of calpain-10 gene and its association with type 2 diabetes mellitus in a Chinese population. Diabetes Res Clin Pract. 2005; 68: 155–61.
44. Family Planning Commission. Chinese family planning yearbook 1997. Beijing: Chinese Family Planning Press; 1997.
45. Abudula BK, Yimiti RHM, Zhuohala SMYL. Inbreeding Rate and its genetics effect in Uyghur. J Xinjiang Normal Univ. 1997; 16: 54–5.
46. Wang W, Wise C, Baric T, et al. The origins and genetic structure of three co-resident Chinese Muslim populations: the Salar, Bo'an and Dongxiang. Hum Genet. 2003; 113: 244–52.
47. Black ML, Wise CA, Wang W, et al. Combining genetics and population history in the study of ethnic diversity in the People's Republic of China. Hum Biol. 2006; 78: 277–93.
48. Siitonen N, Pulkkinen L, Lindstrom J, et al. Association of ADIPOQ gene variants with body weight, type 2 diabetes and serum adiponectin concentrations: the Finnish Diabetes Prevention Study. BMC Med Genet. 2011; 12: 5.
49. Tu Y, Yu Q, Fan G, et al. Assessment of type 2 diabetes risk conferred by SNPs rs2241766 and rs1501299 in the ADIPOQ gene, a case/control study combined with meta-analyses. Mol Cell Endocrinol. 2014; 396: 1–9.
50. Li X, Wei D, He H, et al. Association of the adiponectin gene (ADIPOQ) +45 T > G polymorphism with the metabolic syndrome among Han Chinese in Sichuan province of China. Asia Pac J Clin Nutr. 2012; 21: 296–301.
51. Sun H, Gong ZC, Yin JY, et al. The association of adiponectin allele 45T/G and -11377C/G polymorphisms with Type 2 diabetes and rosiglitazone response in Chinese patients. Br J Clin Pharmacol. 2008; 65: 917–26.
52. Oriol R, Mollicone R, Cailleau A, et al. Divergent evolution of fucosyltransferase genes from vertebrates, invertebrates, and bacteria. Glycobiology. 1999; 9: 323–34.
53. Ryoo H, Ryu J, Lee C. Transcriptional downregulation by nucleotide substitution with the minor allele of rs3760776 located in the promoter of FUT6 gene. Biochem Genet. 2015; 53: 72–8.
54. Becker DJ, Lowe JB. Fucose: biosynthesis and biological function in mammals. Glycobiology. 2003; 13: 41R–53R.
55. Freeze HH. Genetic defects in the human glycome. Nat Rev Genet. 2006; 7: 537–51.
56. Xu M, Bi Y, Xu Y, et al. Combined effects of 19 common variations on type 2 diabetes in Chinese: results from two community-based studies. PLoS ONE. 2010; 5: e14022.
57. Miyake K, Yang W, Hara K, et al. Construction of a prediction model for type 2 diabetes mellitus in the Japanese population based on 11 genes with strong evidence of the association. J Hum Genet. 2009; 54: 236–41.
58. Kahn SE, Hull RL, Utzschneider KM. Mechanisms linking obesity to insulin resistance and type 2 diabetes. Nature. 2006; 444: 840–6.
59. Yamakawa-Kobayashi K, Natsume M, Aoki S, et al. The combined effect of the T2DM susceptibility genes is an important risk factor for T2DM in non-obese Japanese: a population based case-control study. BMC Med Genet. 2012; 13: 11.
60. Manolio TA. Genomewide association studies and assessment of the risk of disease. N Engl J Med. 2010; 363: 166–76.
61. Pearson TA, Manolio TA. How to interpret a genome-wide association study. JAMA. 2008; 299: 1335–44.