Structural Insights into the Inhibitory Mechanism of an Antibody against B7-H6, a Stress-Induced Cellular Ligand for the Natural Killer Cell Receptor NKp30

Journal of Molecular Biology

Volumn 428, Issue 22, 2016, Pages 4457-4466

  Xu, Xiaoping ^a,b   Narni Mancinelli, Emilie ^c   Cantoni, Claudia ^d,e   Li, Yili ^a,f   Guia, Sophie ^c   Gauthier, Laurent ^g   Chen, Qianming ^b   Moretta, Alessandro ^d   Vély, Frédéric ^c   Eisenstein, Edward ^a,h   Rangarajan, Sneha ^a,f   Vivier, Eric ^c   Mariuzza, Roy A ^a,f  

^a UNIVERSITY OF MARYLAND BIOTECHNOLOGY INSTITUTE   (United States)

^b SICHUAN UNIVERSITY   (China)

^c AIX MARSEILLE UNIVERSITY   (France)

^d UNIVERSITY OF GENOA   (Italy)

^e G GASLINI INSTITUTE   (Italy)

^f University of Maryland   (United States)

^g INNATE PHARMA   (France)

^h UNIVERSITY OF MARYLAND   (United States)

Author keywords

antibody; antibody ligand complex; crystal structure; NK cell activation; NK cell receptor

Indexed keywords

ANTIBODY; B7 H6 PROTEIN; CD3 ANTIGEN; CELL SURFACE PROTEIN; CELL SURFACE RECEPTOR; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; INTERLEUKIN 2; NATURAL CYTOTOXICITY TRIGGERING RECEPTOR 3; PROTEIN; UNCLASSIFIED DRUG; B7 ANTIGEN; MONOCLONAL ANTIBODY; NCR3 PROTEIN, HUMAN; NCR3LG1 PROTEIN, HUMAN;

ANTIGEN BINDING; ARTICLE; BINDING SITE; CELL ACTIVATION; CELL INTERACTION; CELL STRESS; CRYSTAL STRUCTURE; DIMERIZATION; DRUG MECHANISM; HUMAN; NATURAL KILLER CELL; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; TARGET CELL; ANTAGONISTS AND INHIBITORS; CHEMISTRY; DNA MUTATIONAL ANALYSIS; GENETICS; METABOLISM; MOLECULAR MODEL; PROTEIN CONFORMATION; X RAY CRYSTALLOGRAPHY;

ANTIBODIES, MONOCLONAL; B7 ANTIGENS; CRYSTALLOGRAPHY, X-RAY; DNA MUTATIONAL ANALYSIS; HUMANS; MODELS, MOLECULAR; NATURAL CYTOTOXICITY TRIGGERING RECEPTOR 3; PROTEIN CONFORMATION;

EID: 84992415779     PISSN: 00222836     EISSN: 10898638     Source Type: Journal    
DOI: 10.1016/j.jmb.2016.09.011     Document Type: Article

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