Acute respiratory distress syndrome neutrophils have a distinct phenotype and are resistant to phosphoinositide 3-kinase inhibition

American Journal of Respiratory and Critical Care Medicine

Volumn 194, Issue 8, 2016, Pages 961-973

  Juss, Jatinder K ^a,d   House, David ^b   Amour, Augustin ^b   Begg, Malcolm ^b   Herre, Jurgen ^c   Storisteanu, Daniel M L ^a   Hoenderdos, Kim ^a   Bradley, Glyn ^b   Lennon, Mark ^b   Summers, Charlotte ^a   Hessel, Edith M ^b   Condliffe, Alison ^a   Chilvers, Edwin R ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b GLAXOSMITHKLINE   (United Kingdom)

^c CAMBRIDGE UNIVERSITY HOSPITALS NHS FOUNDATION TRUST   (United Kingdom)

^d ST MICHAEL'S HOSPITAL   (Canada)

Author keywords

Acute respiratory distress syndrome; Neutrophil function; Phosphoinositide 3 kinase

Indexed keywords

2 (2 DIFLUOROMETHYLBENZIMIDAZOL 1 YL) 4,6 DIMORPHOLINO 1,3,5 TRIAZINE; C REACTIVE PROTEIN; CD11B ANTIGEN; CELL ADHESION MOLECULE; F ACTIN; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 6; L SELECTIN; MONOCYTE CHEMOTACTIC PROTEIN 1; OXIDOREDUCTASE; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; CYTOKINE; ITGAM PROTEIN, HUMAN;

ADULT; ADULT RESPIRATORY DISTRESS SYNDROME; ANTIGEN EXPRESSION; APOPTOSIS; ARTICLE; BIOASSAY; BRONCHOALVEOLAR LAVAGE FLUID; CELL DEATH; CELL SURFACE; CHEMOLUMINESCENCE; CLINICAL ARTICLE; CONFOCAL MICROSCOPY; CONTROLLED STUDY; ENZYME INHIBITION; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FLOW CYTOMETRY; HUMAN; IMMUNE RESPONSE; LEUKOCYTE DIFFERENTIAL COUNT; LUNG LAVAGE; MALE; MIDDLE AGED; NEUTROPHIL; PHAGOCYTOSIS; PHENOTYPE; PRIORITY JOURNAL; RESPIRATORY BURST; TRANSCRIPTOMICS; VENTILATED PATIENT; ANTAGONISTS AND INHIBITORS; CYTOLOGY; DNA MICROARRAY; DRUG EFFECTS; GENE EXPRESSION PROFILING; IMMUNOLOGY; METABOLISM; PHYSIOLOGY; RESPIRATORY DISTRESS SYNDROME, ADULT;

ANTIGENS, CD11B; BRONCHOALVEOLAR LAVAGE FLUID; CYTOKINES; FEMALE; FLOW CYTOMETRY; GENE EXPRESSION PROFILING; HUMANS; L-SELECTIN; MALE; MIDDLE AGED; NEUTROPHILS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PHENOTYPE; PHOSPHATIDYLINOSITOL 3-KINASES; RESPIRATORY DISTRESS SYNDROME, ADULT;

EID: 84992395828     PISSN: 1073449X     EISSN: 15354970     Source Type: Journal    
DOI: 10.1164/rccm.201509-1818OC     Document Type: Article

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