Use of honey associated with Ananas comosus (Bromelin) in the treatment of acute irritative cough;Uso do mel de abelha associado ao Ananas comosus (Bromelin) no tratamento da tosse irritativa aguda

Revista Paulista de Pediatria

Volumn 34, Issue 4, 2016, Pages 412-417

  Peixoto, Décio Medeiros ^a   Rizzo, José Angelo ^a   Schor, Deborah ^a   Silva, Almerinda Rêgo ^a   Oliveira, Dinaldo Cavalcanti de ^a   Solé, Dirceu ^b   Sarinho, Emanuel ^a  

^a FEDERAL UNIVERSITY OF PERNAMBUCO   (Brazil)

^b FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Bromelin; Cough; Honey

Indexed keywords

BROMELAIN; PLACEBO; PLANT EXTRACT;

ACUTE DISEASE; ADOLESCENT; ARTICLE; CHILD; CONTROLLED STUDY; COUGHING; DOUBLE BLIND PROCEDURE; HONEY; HUMAN; IRRITATIVE COUGHING; OBSERVATIONAL STUDY; PINEAPPLE; RANDOMIZED CONTROLLED TRIAL; THERAPY EFFECT; ANANAS; FEMALE; MALE; PHYTOTHERAPY; PRESCHOOL CHILD; CLINICAL ARTICLE; COMPARATIVE STUDY; EMERGENCY CARE; PEDIATRICS;

ACUTE DISEASE; ADOLESCENT; ANANAS; CHILD; CHILD, PRESCHOOL; COUGH; DOUBLE-BLIND METHOD; FEMALE; HONEY; HUMANS; MALE; PHYTOTHERAPY; PLANT EXTRACTS;

EID: 84992393667     PISSN: 01030582     EISSN: 19840462     Source Type: Journal    
DOI: 10.1016/j.rpped.2016.03.006     Document Type: Article

References (27)

1. 1 Kool, M., Monteny, M., van Doornum, G.J., Moll, H.A., Berger, M.Y., Respiratory virus infections in febrile children presenting to a general practice out‐of‐hours service. Eur J Gen Pract 21 (2014), 1–7.
2. 2 Thompson, M., Vodicka, T.A., Blair, P.S., Buckley, D.I., Heneghan, C., Hay, A.D., et al. Duration of symptoms of respiratory tract infections in children: systematic review. BMJ, 11, 2013, f7027.
3. 3 Albert, R.H., Diagnosis and treatment of acute bronchitis. Am Fam Physician 82 (2010), 1345–1349.
4. 4 Smith, S.M., Schroeder, K., Fahey, T., Over‐the‐counter (OTC) medications for acute cough in children and adults in ambulatory settings. Cochrane Database Syst Rev, 23, 2008, CD001831.
5. 5 Shadkam, M., Mozaffari-Khosravi, H., Mozayan, M.R., A comparison of the effect of honey, dextromethorphan, and diphenhydramine on nightly cough and sleep quality in children and their parents. J Altern Complement Med 16 (2010), 787–793.
6. 6 Paul, I.M., Yoder, K.E., Crowell, R.K., Shaffer, M.L., McMillan, H.S., Carlson, M.C., et al. Effect of dextromethorphan, diphenhydramine and placebo on nocturnal cough and sleep quality for coughing children and their parents. Pediatrics 114 (2004), e80–e85.
7. 7 Fitzhugh, D.J., Shan, S., Dewhirst, M.W., Hale, L.P., Bromelain treatment decreases neutrophil migration to sites of inflamation. Clin Immunol 128 (2008), 66–74.
8. 8 Müller, S., März, R., Schmolz, M., Drewelow, B., Eschmann, K., Meiser, P., Placebo‐controlled randomized clinical Trial on the immunomodulating activities of low‐ and high‐dose bromelain after oral administration – new evidence on the antiinflamatory mode of action of bromelain. Phytother Res 27 (2013), 199–204.
9. 9 Seltzer, A.P., Adjunctive use of bromelains in sinusitis: a controlled study. Eye Ear Nose Throat Mon 46 (1967), 1281–1288.
10. 10 Taub, S.J., The use of bromelains in sinusitis: a double‐blind clinical evaluation. Eye Ear Nose Throat Mon 46 (1967), 361–362.
11. 11 Rimoldi, R., Ginesu, F., Giura, R., The use of bromelain in pneumological therapy. Drugs Exp Clin Res 4 (1978), 55–66.
12. 12 Ako, H., Cheung, A.H., Matsuura, P.K., Isolation of a fibrinolysis enzyme activator from commercial bromelain. Arch Int Pharmacodyn Ther 254 (1981), 157–167.
13. 13 Braun, J.M., Schneider, B., Beuth, H.J., Therapeutic use, efficiency and safety of the proteolytic pineapple enzyme Bromelain in children with acute sinusitis in Germany. In Vivo 19 (2005), 417–421.
14. 14 Cohen, H.A., Rosen, J., Kristal, H., Laks, Y., Berkovitch, M., Uziel, Y., et al. Effect of honey on nocturnal cough and sleep quality: a double‐blind, randomized, placebo‐controlled study. Pediatrics 130 (2012), 465–471.
15. 15 Paul, I.M., Beiler, J., McMonagle, A., Shaffer, M.L., Duda, L., Berlin, C.M. Jr., Effect of honey, dextromethorphan, and no treatment on nocturnal cough and sleep quality for coughing children and their parents. Arch Pediatr Adolesc Med 161 (2007), 1140–1146.
16. 16 Evans, H., Tuleu, C., Sutcliffe, A., Is honey a well‐evidenced alternative to over‐the‐counter cough medicines?. J R Soc Med 103 (2010), 164–165.
17. 17 Dicpinigaitis, P.V., Effect of viral upper respiratory tract infection on cough reflex sensitivity. J Thorac Dis 6:Suppl 7 (2014), S708–S711.
18. 18 Walmsley, J., Marshall, G., Over the counter cough medicines for acute cough. The fact that people keep buying the medicines is itself evidence. BMJ, 324, 2002, 1158.
19. 19 Sarmento, D.M., Moura, D.P., Lopes, S.L., Silva, S.C., Bromelain Monograph. Alternat Med Rev 15 (2010), 361–368.
20. 20 Secor, E.R., Carson, W.F., Singh, A., Pensa, M., Guernsey, L.A., Schramm, C.M., et al. Oral bromelain attenuates inflammation in an ovalbumine‐induced murine model of asthma. Evid Based Complement Alternat Med 5 (2008), 61–69.
21. 21 Müller, S., März, R., Schmolz, M., Drewelow, B., Eschmann, K., Meiser, P., Placebo‐controlled randomized clinical trial on the immunomodulating activities of low‐and high‐dose bromelain after oral administration – new evidence on the antiinflamatory mode of action of bromelain. Phytother Res 27 (2013), 199–204.
22. 22 Taussig, S.J., Batkin, S., Bromelain the enzyme complex of pineapple (Ananas comosus) and its clinical application: an update. J Ethnopharmacol 22 (1988), 191–203.
23. 23 Cohen, H.A., Rozen, J., Kristal, H., Laks, Y., Berkovitch, M., Uziel, Y., et al. Effect of honey on nocturnal cough and sleep quality: a double‐blind, randomized, placebo‐controlled study. Pediatrics 130 (2012), 465–471.
24. 24 Warren, M.D., Pont, S.J., Barkin, S.L., Callahan, S.T., Caples, T.L., Carroll, K.N., et al. The effect of honey on nocturnal cough and sleep quality for children and their parents. Arch Paediatr Adolesc Med 161 (2007), 1149–1153.
25. 25 Paul, I.M., Therapeutic options for acute cough due to upper respiratory infections in children. Lung 190 (2012), 41–44.
26. 26 Ahmed, N., Sutcliffe, A., Tipper, C., Feasibility study: honey for treatment of cough in children. Pediatr Rep 5 (2013), 31–34.
27. 27 Miceli Sopo, S., Greco, M., Monaco, S., Varrasi, G., Di Lorenzo, G., Simeone, G., Effect of multiple honey doses on non‐specific acute cough in children. An open randomised study and literature review. Allergol Immunopathol (Madr) 43 (2015), 449–455.