Effect of honey, dextromethorphan, and no treatment on nocturnal cough and sleep quality for coughing children and their parents

Archives of Pediatrics and Adolescent Medicine

Volumn 161, Issue 12, 2007, Pages 1140-1146

  Paul, Ian M ^a,b   Beiler, Jessica ^a   McMonagle, Amyee ^a   Shaffer, Michele L ^a   Duda, Laura ^a   Berlin Jr , Cheston M ^a  

^a PENN STATE COLLEGE OF MEDICINE   (United States)

^b PENN STATE MILTON S HERSHEY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DEXTROMETHORPHAN; HERBACEOUS AGENT;

ADOLESCENT; ADULT; ARTICLE; BOTHERSOMENESS; BUCKWHEAT; CHILD; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; COUGHING; DISEASE DURATION; DISEASE SEVERITY; DOUBLE BLIND PROCEDURE; FEMALE; HEALTH SURVEY; HONEY; HUMAN; MAJOR CLINICAL STUDY; MALE; PRESCHOOL CHILD; PRIORITY JOURNAL; SCORING SYSTEM; SINGLE DRUG DOSE; SLEEP; SLEEP DISORDER; TREATMENT OUTCOME; UPPER RESPIRATORY TRACT INFECTION;

ADOLESCENT; ANTITUSSIVE AGENTS; CHILD; CHILD WELFARE; CHILD, PRESCHOOL; COUGH; DEXTROMETHORPHAN; FEMALE; HEALTH SURVEYS; HONEY; HUMANS; MALE; PARENTS; RESPIRATORY TRACT INFECTIONS; SLEEP; SLEEP DISORDERS;

EID: 36849060281     PISSN: 10724710     EISSN: 15383628     Source Type: Journal    
DOI: 10.1001/archpedi.161.12.1140     Document Type: Article

References (70)

1. Middleton KR, Hing E. National Hospital Ambulatory Medical Care Survey: 2004 outpatient department summary. Adv Data. 2006;(373):1-27.
2. American Academy of Pediatrics Committee on Drugs. Use of codeine- and dextromethorphan-containing cough remedies in children. Pediatrics. 1997;99(6):918-920.
3. Chang AB, Glomb WB. Guidelines for evaluating chronic cough in pediatrics: ACCP evidence-based clinical practice guidelines. Chest. 2006;129(1)(suppl):260S-283S.
4. Rosendahl I. Expense of physician care spurs OTC, self-care market. Drug Topics. 1988;132(15):62-63.
5. Morice AH. Epidemiology of cough. Pulm Pharmacol Ther. 2002;15(3):253-259.
6. Paul IM, Yoder KE, Crowell KR, et al. Effect of dextromethorphan, diphenhydramine, and placebo on nocturnal cough and sleep quality for coughing children and their parents. Pediatrics. 2004;114(1):e85-e90.
7. Pfeiffer WF. A multicultural approach to the patient who has a common cold. Pediatr Rev. 2005;26(5):170-175.
8. Subrahmanyam M. Topical application of honey in treatment of burns. Br J Surg. 1991;78(4):497-498.
9. Efem SE. Recent advances in the management of Fournier's gangrene: preliminary observations. Surgery. 1993;113(2):200-204.
10. Hamzaoglu I, Saribeyoglu K, Durak H, et al. Protective covering of surgical wounds with honey impedes tumor implantation. Arch Surg. 2000;135(12):1414-1417.
11. Vardi A, Barzilay Z, Linder N, Cohen HA, Paret G, Barzilai A. Local application of honey for treatment of neonatal postoperative wound infection. Acta Paediatr. 1998;87(4):429-432.
12. Department of Child and Adolescent Health. Cough and Cold Remedies for the Treatment of Acute Respiratory Infections in Young Children. Geneva, Switzerland: World Health Organization; 2001.
13. Allen KL, Molan PC, Reid GM. A survey of the antibacterial activity of some New Zealand honeys. J Pharm Pharmacol. 1991;43(12):817-822.
14. Wahdan HA. Causes of the antimicrobial activity of honey. Infection. 1998;26(1):26-31.
15. Gheldof N, Wang XH, Engeseth NJ. Identification and quantification of antioxidant components of honeys from various floral sources. J Agric Food Chem. 2002;50(21):5870-5877.
16. Schramm DD, Karim M, Schrader HR, Holt RR, Cardetti M, Keen CL. Honey with high levels of antioxidants can provide protection to healthy human subjects. J Agric Food Chem. 2003;51(6):1732-1735.
17. Tonks AJ, Cooper RA, Jones KP, Blair S, Parton J, Tonks A. Honey stimulates inflammatory cytokine production from monocytes. Cytokine. 2003;21(5):242-247.
18. Skoner DP. Effect of dextromethorphan, diphenhydramine, and placebo on nocturnal cough and sleep quality for coughing children and their parents. Pediatrics. 2005;115(2):512-513.
19. Haver K, Hardy SC, Weber TM, Zurakowski D, Hartnick CJ. Validation of a pediatric cough questionnaire. Poster presented at: American Thoracic Society 2006 International Conference; May 19-24, 2006; San Diego, CA. Abstract 374.
20. Paul IM, Shaffer ML, Yoder KE, Sturgis SA, Baker MS, Berlin CM Jr. Dose-response relationship with increasing doses of dextromethorphan for children with cough. Clin Ther. 2004;26(9):1508-1514.
21. Korppi M, Laurikainen K, Pietikainen M, Silvasti M. Antitussives in the treatment of acute transient cough in children. Acta Paediatr Scand. 1991;80(10):969-971.
22. Taylor JA, Novack AH, Almquist JR, Rogers JE. Efficacy of cough suppressants in children. J Pediatr. 1993;122(5, pt 1):799-802.
23. Gheldof N, Engeseth NJ. Antioxidant capacity of honeys from various floral sources based on the determination of oxygen radical absorbance capacity and inhibition of in vitro lipoprotein oxidation in human serum samples. J Agric Food Chem. 2002;50(10):3050-3055.
24. Henriques A, Jackson S, Cooper R, Burton N. Free radical production and quenching in honeys with wound healing potential. J Antimicrob Chemother. 2006;58(4):773-777.
25. Lusby PE, Coombes AL, Wilkinson JM. Bactericidal activity of different honeys against pathogenic bacteria. Arch Med Res. 2005;36(5):464-467.
26. French VM, Cooper RA, Molan PC. The antibacterial activity of honey against coagulase-negative staphylococci. J Antimicrob Chemother. 2005;56(1):228-231.
27. Cooper RA, Halas E, Molan PC. The efficacy of honey in inhibiting strains of Pseudomonas aeruginosa from infected burns. J Burn Care Rehabil. 2002;23(6):366-370.
28. Cooper RA, Molan PC, Harding KG. The sensitivity to honey of Gram-positive cocci of clinical significance isolated from wounds. J Appl Microbiol. 2002;93(5):857-863.
29. Tonks A, Cooper RA, Price AJ, Molan PC, Jones KP. Stimulation of TNF-alpha release in monocytes by honey. Cytokine. 2001;14(4):240-242.
30. Adeleye IA, Opiah L. Antimicrobial activity of extracts of local cough mixtures on upper respiratory tract bacterial pathogens. West Indian Med J. 2003;52(3):188-190.
31. Gheldof N, Wang XH, Engeseth NJ. Buckwheat honey increases serum antioxidant capacity in humans. J Agric Food Chem. 2003;51(5):1500-1505.
32. Eccles R. Mechanisms of the placebo effect of sweet cough syrups. Respir Physiol Neurobiol. 2006;152(3):340-348.
33. Kogan MD, Pappas G, Yu SM, Kotelchuck M. Over-the-counter medication use among US preschool-age children. JAMA. 1994;272(13):1025-1030.
34. Lee PCL, Jawad MS, Eccles R. Antitussive efficacy of dextromethorphan in cough associated with acute upper respiratory tract infection. J Pharm Pharmacol. 2000;52(9):1137-1142.
35. Schroeder K, Fahey T. Over-the-counter medications for acute cough in children and adults in ambulatory settings. Cochrane Database Syst Rev. 2001;(3):CD001831.
36. Schroeder K, Fahey T. Systematic review of randomised controlled trials of over the counter cough medicines for acute cough in adults. BMJ. 2002;324(7333):329-331.
37. Schroeder K, Fahey T. Should we advise parents to administer over the counter cough medicines for acute cough? systematic review of randomised controlled trials. Arch Dis Child. 2002;86(3):170-175.
38. Yoder KE, Shaffer ML, La Tournous SJ, Paul IM. Child assessment of dextromethorphan, diphenhydramine, and placebo for nocturnal cough due to upper respiratory infection. Clin Pediatr (Phila). 2006;45(7):633-640.
39. Graudins A, Fern RP. Acute dystonia in a child associated with therapeutic ingestion of a dextromethorphan containing cough and cold syrup. J Toxicol Clin Toxicol. 1996;34(3):351-352.
40. Knowles SR, Weber E. Dextromethorphan anaphylaxis. J Allergy Clin Immunol. 1998;102(2):316-317.
41. Cook J, Stith M, Sahn EE. Bullous mastocytosis in an infant associated with the use of a nonprescription cough suppressant. Pediatr Dermatol. 1996;13(5):410-414.
42. Fleming PM. Dependence on dextromethorphan hydrobromide. Br Med J (Clin Res Ed). 1986;293(6547):597.
43. Miller SC. Dextromethorphan psychosis, dependence and physical withdrawal. Addict Biol. 2005;10(4):325-327.
44. Dodds A, Revai E. Toxic psychosis due to dextromethorphan hydrobromide. Med J Aust. 1967;2:231.
45. Sharma A, Dewan V, Petty F. Acute psychosis with Coricidin cold medicine. Ann Pharmacother. 2005;39(9):1577-1578.
46. Walker J, Yatham LN. Benylin (dextromethorphan) abuse and mania. BMJ. 1993;306(6882):896.
47. Polles A, Griffith JL. Dextromethorphan-induced mania. Psychosomatics. 1996;37(1):71-74.
48. Nairn SJ, Díaz JE. Cold-syrup induced movement disorder. Pediatr Emerg Care. 2001;17(3):191-192.
49. Shaul WL, Wandell M, Robertson WO. Dextromethorphan toxicity: reversal by naloxone. Pediatrics. 1977;59(1):117-118.
50. Katona B, Wason S. Dextromethorphan danger. N Engl J Med. 1986;314(15):993.
51. Konrad D, Sobetzko D, Schmitt B, Schoenle EJ. Insulin-dependent diabetes mellitus induced by the antitussive agent dextromethorphan. Diabetologia. 2000;43(2):261-262.
52. Au WY, Tsang J, Cheng TS, et al. Cough mixture abuse as a novel cause of megaloblastic anaemia and peripheral neuropathy. Br J Haematol. 2003;123(5):956-958.
53. Au WY, Cheng TS, Siu TS, Tam S. Cerebellar degeneration and folate deficiency due to cough mixture abuse. Haematologica. 2005;90(suppl):ECR28.
54. Rammer L, Holmgren P, Sandler H. Fatal intoxication by dextromethorphan: a report on two cases. Forensic Sci Int. 1988;37(4):233-236.
55. McCarthy JP. Some less familiar drugs of abuse. Med J Aust. 1971;2(21):1078-1081.
56. Murray S, Brewerton T. Abuse of over-the-counter dextromethorphan by teenagers. South Med J. 1993;86(10):1151-1153.
57. Darboe MN, Keenan GR Jr, Richards TK. The abuse of dextromethorphan-based cough syrup: a pilot study of the community of Waynesboro, Pennsylvania. Adolescence. 1996;31(123):633-644.
58. Cranston JW, Yoast R. Abuse of dextromethorphan. Arch Fam Med. 1999;8(2):99-100.
59. McFee RB, Mofenson HC, Caraccio TR. Dextromethorphan: another "ecstasy"? Arch Fam Med. 2000;9(2):123.
60. Noonan WC, Miller WR, Feeney DM. Dextromethorphan abuse among youth. Arch Fam Med. 2000;9(9):791-792.
61. Schwartz RH. Adolescent abuse of dextromethorphan. Clin Pediatr (Phila). 2005;44(7):565-568.
62. Joffe A. Your role in curbing prescription and OTC drug abuse by adolescents. Contemp Pediatr. 2006;23:97-102.
63. Falck R, Li L, Carlson R, Wang J. The prevalence of dextromethorphan abuse among high school students. Pediatrics. 2006;118(5):2267-2269.
64. Bryner JK, Wang UK, Hui JW, Bedodo M, MacDougall C, Anderson IB. Dextromethorphan abuse in adolescence: an increasing trend: 1999-2004. Arch Pediatr Adolesc Med. 2006;160(12):1217-1222.
65. Midura TF, Arnon SS. Infant botulism: identification of Clostridium botulinum and its toxins in faeces. Lancet. 1976;2(7992):934-936.
66. Arnon SS, Midura TF, Clay SA, Wood RM, Chin J. Infant botulism: epidemiological, clinical, and laboratory aspects. JAMA. 1977;237(18):1946-1951.
67. Arnon SS, Midura TF, Damus K, Thompson B, Wood RM, Chin J. Honey and other environmental risk factors for infant botulism. J Pediatr. 1979;94(2):331-336.
68. Midura TF, Snowden S, Wood RM, Arnon SS. Isolation of Clostridium botulinum from honey. J Clin Microbiol. 1979;9(2):282-283.
69. Lampe KF. Rhododendrons, mountain laurel, and mad honey. JAMA. 1988;259(13):2009.
70. Hutton N, Wilson MH, Mellits ED, et al. Effectiveness of an antihistamine-decongestant combination for young children with the common cold: a randomized, controlled clinical trial. J Pediatr. 1991;118(1):125-130.