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Volumn 11, Issue 9, 2016, Pages

EPGA: AWeb-based information system for translational pharmacogenomics

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; DRUG METABOLISM; GENE; GENE EXPRESSION PROFILING; GENETIC VARIABILITY; GENOTYPE; HAPLOTYPE; HUMAN; INTERNET; MEDICAL INFORMATION SYSTEM; PHARMACOGENOMICS; PHENOTYPE; PRACTICE GUIDELINE; STATISTICS; UGT1A5 GENE; INFORMATION SYSTEM; PHARMACOGENETICS; THEORETICAL MODEL;

EID: 84992391779     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0162801     Document Type: Article
Times cited : (15)

References (40)
  • 1
    • 84931274093 scopus 로고    scopus 로고
    • From integrative disease modeling to predictive, preventive, personalized and participatory (P4) medicine
    • PMID: 24195840
    • Younesi E, Hofmann-Apitius M. From integrative disease modeling to predictive, preventive, personalized and participatory (P4) medicine. EPMA J. BioMed Central Ltd; 2013; 4: 23. doi:10.1186/1878-5085-4-23PMID: 24195840.
    • (2013) EPMA J. BioMed Central Ltd , vol.4 , pp. 23
    • Younesi, E.1    Hofmann-Apitius, M.2
  • 2
    • 84873181536 scopus 로고    scopus 로고
    • An exhaustive epistatic SNP association analysis on expandedWellcome Trust data
    • PMID: 23346356
    • Lippert C, Listgarten J, Davidson RI, Baxter S, Poon H, Poong H, et al. An exhaustive epistatic SNP association analysis on expandedWellcome Trust data. Sci Rep. 2013; 3: 1099. doi:10.1038/srep01099 PMID: 23346356.
    • (2013) Sci Rep , vol.3 , pp. 1099
    • Lippert, C.1    Listgarten, J.2    Davidson, R.I.3    Baxter, S.4    Poon, H.5    Poong, H.6
  • 3
    • 84904820682 scopus 로고    scopus 로고
    • Deciphering next-generation pharmacogenomics: An information technology perspective
    • Potamias G, Lakiotaki K, Katsila T, Lee MTM, Topouzis S, Cooper DN, et al. Deciphering next-generation pharmacogenomics: An information technology perspective. Open Biol. 2014; 4. doi:10.1098/rsob.140071.
    • (2014) Open Biol , pp. 4
    • Potamias, G.1    Lakiotaki, K.2    Katsila, T.3    Lee, M.T.M.4    Topouzis, S.5    Cooper, D.N.6
  • 7
    • 84880734212 scopus 로고    scopus 로고
    • Challenges in the pharmacogenomic annotation of whole genomes
    • PMID: 23708745
    • Altman RB, Whirl-Carrillo M, Klein TE. Challenges in the pharmacogenomic annotation of whole genomes. Clin Pharmacol Ther. 2013; 94: 211-3. doi:10.1038/clpt.2013.111 PMID: 23708745.
    • (2013) Clin Pharmacol Ther , vol.94 , pp. 211-213
    • Altman, R.B.1    Whirl-Carrillo, M.2    Klein, T.E.3
  • 8
    • 84866740789 scopus 로고    scopus 로고
    • The success of pharmacogenomics in moving genetic association studies from bench to bedside: Study design and implementation of precision medicine in the post-GWAS era
    • PMID: 22923055
    • Ritchie MD. The success of pharmacogenomics in moving genetic association studies from bench to bedside: study design and implementation of precision medicine in the post-GWAS era. Hum Genet. 2012; 131: 1615-26. doi:10.1007/s00439-012-1221-z PMID: 22923055.
    • (2012) Hum Genet , vol.131 , pp. 1615-1626
    • Ritchie, M.D.1
  • 9
    • 84901440756 scopus 로고    scopus 로고
    • The emerging era of pharmacogenomics: Current successes, future potential, and challenges
    • PMID: 24684508
    • Lee JW, Aminkeng F, Bhavsar A. P, Shaw K, Carleton BC, Hayden MR, et al. The emerging era of pharmacogenomics: Current successes, future potential, and challenges. Clin Genet. 2014; 86: 21-28. doi:10.1111/cge.12392 PMID: 24684508.
    • (2014) Clin Genet , vol.86 , pp. 21-28
    • Lee, J.W.1    Aminkeng, F.2    Bhavsar, A.P.3    Shaw, K.4    Carleton, B.C.5    Hayden, M.R.6
  • 10
    • 77955628006 scopus 로고    scopus 로고
    • Realities and expectations of pharmacogenomics and personalized medicine: Impact of translating genetic knowledge into clinical practice
    • PMID: 20712531
    • Squassina A, Manchia M, Manolopoulos VG, Artac M, Lappa-Manakou C, Karkabouna S, et al. Realities and expectations of pharmacogenomics and personalized medicine: impact of translating genetic knowledge into clinical practice. Pharmacogenomics. 2010; 11: 1149-1167. doi:10.2217/pgs.10.97 PMID: 20712531.
    • (2010) Pharmacogenomics. , vol.11 , pp. 1149-1167
    • Squassina, A.1    Manchia, M.2    Manolopoulos, V.G.3    Artac, M.4    Lappa-Manakou, C.5    Karkabouna, S.6
  • 11
    • 84869396522 scopus 로고    scopus 로고
    • Pharmacogenomics in clinical practice and drug development
    • Nature Publishing Group, PMID: 23138311
    • Harper AR, Topol EJ. Pharmacogenomics in clinical practice and drug development. Nat Biotechnol. Nature Publishing Group; 2012; 30: 1117-24. doi:10.1038/nbt.2424 PMID: 23138311.
    • (2012) Nat Biotechnol , vol.30 , pp. 1117-1124
    • Harper, A.R.1    Topol, E.J.2
  • 12
    • 84906886294 scopus 로고    scopus 로고
    • InformationTechnology meets Pharmacogenomics: Design specifications of an integrated personalized pharmacogenomics information system
    • Lakiotaki K, Patrinos GP, Potamias G. InformationTechnology meets Pharmacogenomics: Design Specifications of an Integrated Personalized Pharmacogenomics Information System. IEEE-EMBS Int Conf Biomed Heal Informatics. 2014; 13-16.
    • (2014) IEEE-EMBS Int Conf, Biomed Heal Informatics , pp. 13-16
    • Lakiotaki, K.1    Patrinos, G.P.2    Potamias, G.3
  • 13
    • 84891810471 scopus 로고    scopus 로고
    • Developments in FINDbaseworldwide database for clinically relevant genomic variation allele frequencies
    • PMID: 24234438
    • Papadopoulos P, Viennas E, Gkantouna V, Pavlidis C, Bartsakoulia M, Ioannou Z-M, et al. Developments in FINDbaseworldwide database for clinically relevant genomic variation allele frequencies. Nucleic Acids Res. 2014; 42: D1020- D6. doi:10.1093/nar/gkt1125 PMID: 24234438.
    • (2014) Nucleic Acids Res , vol.42
    • Papadopoulos, P.1    Viennas, E.2    Gkantouna, V.3    Pavlidis, C.4    Bartsakoulia, M.5    Ioannou, Z.-M.6
  • 15
    • 79955008129 scopus 로고    scopus 로고
    • Databases in the area of pharmacogenetics
    • PMID: 21309040
    • Sim SC, Altman RB, Ingelman-Sundberg M. Databases in the area of pharmacogenetics. Human Mutation. 2011. pp. 526-531. doi:10.1002/humu.21454 PMID: 21309040.
    • (2011) Human Mutation , pp. 526-531
    • Sim, S.C.1    Altman, R.B.2    Ingelman-Sundberg, M.3
  • 16
    • 84880727398 scopus 로고    scopus 로고
    • The pharmacogenomics research network translational pharmacogenetics Program: Overcoming Challenges of real- world implementation
    • PMID: 23588301
    • Shuldiner AR, Relling M V, Peterson JF, Hicks JK, Freimuth RR, SadeeW, et al. The Pharmacogenomics Research Network Translational Pharmacogenetics Program: Overcoming Challenges of Real- World Implementation. Clin Pharmacol Ther. 2013; 94: 207-210. doi:10.1038/clpt.2013.59 PMID: 23588301.
    • (2013) Clin Pharmacol Ther , vol.94 , pp. 207-210
    • Shuldiner, A.R.1    Relling, M.V.2    Peterson, J.F.3    Hicks, J.K.4    Freimuth, R.R.5    Sadee, W.6
  • 17
    • 79955463893 scopus 로고    scopus 로고
    • Pharmacogenetics: From bench to byte-An update of guidelines
    • Nature Publishing Group, PMID: 21412232
    • Swen JJ, Nijenhuis M, de Boer A, Grandia L, Maitland-van der Zee A H, Mulder H, et al. Pharmacogenetics: from bench to byte-An update of guidelines. Clin Pharmacol Ther. Nature Publishing Group; 2011; 89: 662-73. doi:10.1038/clpt.2011.34 PMID: 21412232.
    • (2011) Clin Pharmacol Ther , vol.89 , pp. 662-673
    • Swen, J.J.1    Nijenhuis, M.2    De Boer, A.3    Grandia, L.4    Maitland-Van Der Zee, A.H.5    Mulder, H.6
  • 19
    • 84901675919 scopus 로고    scopus 로고
    • Towards structural systems pharmacology to study complex diseases and personalized medicine
    • Xie L, Ge X, Tan H, Xie L, Zhang Y, Hart T, et al. Towards Structural Systems Pharmacology to Study Complex Diseases and Personalized Medicine. PLoS Comput Biol. 2014; 10. doi:10.1371/journal.pcbi.1003554.
    • (2014) PLoS Comput Biol. , pp. 10
    • Xie, L.1    Ge, X.2    Tan, H.3    Xie, L.4    Zhang, Y.5    Hart, T.6
  • 20
    • 84861139246 scopus 로고    scopus 로고
    • Pharmacogenomics and public health: Implementing populationalized medicine
    • PMID: 22594512
    • Mette L, Mitropoulos K, Vozikis A, Patrinos GP. Pharmacogenomics and public health: implementing "populationalized" medicine. Pharmacogenomics. 2012; 13: 803-813. doi:10.2217/pgs.12.52 PMID: 22594512.
    • (2012) Pharmacogenomics. , vol.13 , pp. 803-813
    • Mette, L.1    Mitropoulos, K.2    Vozikis, A.3    Patrinos, G.P.4
  • 21
    • 84909960398 scopus 로고    scopus 로고
    • Stakeholder analysis in pharmacogenomics and genomic medicine in Greece
    • PMID: 25228172
    • Mitropoulou C, Mai Y, Van Schaik RH, Vozikis A, Patrinos GP. Stakeholder analysis in pharmacogenomics and genomic medicine in Greece. Public Health Genomics. 2014; 17: 280-286. doi:10.1159/000365896 PMID: 25228172.
    • (2014) Public Health Genomics , vol.17 , pp. 280-286
    • Mitropoulou, C.1    Mai, Y.2    Van Schaik, R.H.3    Vozikis, A.4    Patrinos, G.P.5
  • 22
    • 84926451219 scopus 로고    scopus 로고
    • Whole genome sequencing in pharmacogenomics
    • PMID: 25805991
    • Katsila T, Patrinos GP. Whole genome sequencing in pharmacogenomics. Front Pharmacol. 2015; 6: 1-3. doi:10.3389/fphar.2015.00061 PMID: 25805991.
    • (2015) Front Pharmacol. , vol.6 , pp. 1-3
    • Katsila, T.1    Patrinos, G.P.2
  • 23
    • 84882970247 scopus 로고    scopus 로고
    • Systematic pharmacogenomics analysis of a Malay whole Genome: Proof of concept for personalized medicine
    • Salleh MZ, Teh LK, Lee LS, Ismet RI, Patowary A, Joshi K, et al. Systematic Pharmacogenomics Analysis of a Malay Whole Genome: Proof of Concept for Personalized Medicine. PLoS One. 2013; 8. doi:10.1371/journal.pone.0071554.
    • (2013) PLoS One , vol.8
    • Salleh, M.Z.1    Teh, L.K.2    Lee, L.S.3    Ismet, R.I.4    Patowary, A.5    Joshi, K.6
  • 24
    • 79951809825 scopus 로고    scopus 로고
    • CPIC: Clinical pharmacogenetics implementation consortiumof the pharmacogenomics research network
    • Nature Publishing Group, PMID: 21270786
    • Relling MV, Klein TE. CPIC: Clinical Pharmacogenetics Implementation Consortiumof the Pharmacogenomics Research Network. Clin Pharmacol Ther. Nature Publishing Group; 2011; 89: 464-7. doi:10.1038/clpt.2010.279 PMID: 21270786.
    • (2011) Clin Pharmacol Ther , vol.89 , pp. 464-467
    • Relling, M.V.1    Klein, T.E.2
  • 25
    • 33847641458 scopus 로고    scopus 로고
    • The pharmacogenetics research network: From SNP discovery to clinical drug response
    • PMID: 17339863
    • Giacomini KM, Brett CM, Altman RB, Benowitz NL, Dolan ME, Flockhart D a, et al. The pharmacogenetics research network: from SNP discovery to clinical drug response. Clin Pharmacol Ther. 2007; 81: 328-45. doi:10.1038/sj.clpt.6100087 PMID: 17339863.
    • (2007) Clin Pharmacol Ther , vol.81 , pp. 328-345
    • Giacomini, K.M.1    Brett, C.M.2    Altman, R.B.3    Benowitz, N.L.4    Dolan, M.E.5    Flockhart, D.A.6
  • 27
    • 34547917189 scopus 로고    scopus 로고
    • The Star-Allele Nomenclature: Retooling for translational genomics
    • PMID: 17700589
    • Robarge JD, Li L, Desta Z, Nguyen A, Flockhart DA. The Star-Allele Nomenclature: Retooling for Translational Genomics. Clin Pharmacol Ther. 2007; 82: 244-248. doi:10.1038/sj.clpt.6100284PMID: 17700589.
    • (2007) Clin Pharmacol Ther , vol.82 , pp. 244-248
    • Robarge, J.D.1    Li, L.2    Desta, Z.3    Nguyen, A.4    Flockhart, D.A.5
  • 28
    • 79955768389 scopus 로고    scopus 로고
    • Pharmacogenetics, pharmacogenomics, and individualized medicine
    • PMID: 21436344
    • Ma Q, Lu A. Pharmacogenetics, pharmacogenomics, and individualized medicine. Pharmacol Rev. 2011; 63: 437-459. doi:10.1124/pr.110.003533.nome-disease PMID: 21436344.
    • (2011) Pharmacol Rev. , vol.63 , pp. 437-459
    • Ma, Q.1    Lu, A.2
  • 29
    • 84866593873 scopus 로고    scopus 로고
    • Pharmacogenomics and Individualized Medicine: Translating science into practice
    • PMID: 22948889
    • Crews KR, Hicks JK, Pui C-H, RellingM V, Evans WE. Pharmacogenomics and Individualized Medicine: Translating Science Into Practice. Clin Pharmacol Ther. 2012; 92: 467-475. doi:10.1038/clpt.2012.120 PMID: 22948889.
    • (2012) Clin Pharmacol Ther , vol.92 , pp. 467-475
    • Crews, K.R.1    Hicks, J.K.2    Pui, C.-H.3    RellingM, V.4    Evans, W.E.5
  • 30
    • 84881167398 scopus 로고    scopus 로고
    • RCircos: An R package for Circos 2D track plots
    • PMID: 23937229
    • Zhang H, Meltzer P, Davis S. RCircos: An R package for Circos 2D track plots. BMC Bioinformatics. 2013; 14: 244. doi:10.1186/1471-2105-14-244 PMID: 23937229.
    • (2013) BMC Bioinformatics , vol.14 , pp. 244
    • Zhang, H.1    Meltzer, P.2    Davis, S.3
  • 31
    • 84975742565 scopus 로고    scopus 로고
    • A map of human genome variation from population-scale sequencing
    • Project 1000 Genomes, PMID: 20981092
    • Project 1000 Genomes, Durbin RM, Abecasis GR, Altshuler DL, Auton A, Brooks LD, et al. A map of human genome variation from population-scale sequencing. Nature. 2010; 467: 1061-1073. doi:10.1038/nature09534 PMID: 20981092.
    • (2010) Nature , vol.467 , pp. 1061-1073
    • Durbin, R.M.1    Abecasis, G.R.2    Altshuler, D.L.3    Auton, A.4    Brooks, L.D.5
  • 32
    • 80053628299 scopus 로고    scopus 로고
    • Sequencing technologies and genome sequencing
    • Berlin/Heidelberg: Springer-Verlag, PMID: 21698376
    • Pareek CS, Smoczynski R, Tretyn A. Sequencing technologies and genome sequencing. J Appl Genet. Berlin/Heidelberg: Springer-Verlag; 2011; 52: 413-435. doi:10.1007/s13353-011-0057-x PMID: 21698376.
    • (2011) J Appl Genet , vol.52 , pp. 413-435
    • Pareek, C.S.1    Smoczynski, R.2    Tretyn, A.3
  • 33
    • 84919981142 scopus 로고    scopus 로고
    • DruGeVar: An online resource triangulating drugs with genes and genomic biomarkers for clinical pharmacogenomics
    • PMID: 25228099
    • Dalabira E, Viennas E, Daki E, Komianou A, Bartsakoulia M, Poulas K, et al. DruGeVar: An Online Resource Triangulating Drugs with Genes and Genomic Biomarkers for Clinical Pharmacogenomics. Public Health Genomics. 2014; 17: 265-271. doi:10.1159/000365895 PMID: 25228099.
    • (2014) Public Health Genomics , vol.17 , pp. 265-271
    • Dalabira, E.1    Viennas, E.2    Daki, E.3    Komianou, A.4    Bartsakoulia, M.5    Poulas, K.6
  • 34
    • 85027954420 scopus 로고    scopus 로고
    • The human cytochrome P450 (CYP) Allele Nomenclature website: A peer-reviewed database of CYP variants and their associated effects
    • Available:, PMID: 20511141
    • Sim SC, Ingelman-Sundberg M. The Human Cytochrome P450 (CYP) Allele Nomenclature website: A peer-reviewed database of CYP variants and their associated effects. Hum Genomics. 2010; 4: 278-81. Available: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3525213&tool=pmcentrez&rendertype=abstractPMID: 20511141.
    • (2010) Hum Genomics , vol.4 , pp. 278-281
    • Sim, S.C.1    Ingelman-Sundberg, M.2
  • 36
    • 84906539283 scopus 로고    scopus 로고
    • Personalized pharmacogenomics profiling using whole-genome sequencing
    • Available:, PMID: 25141897
    • Mizzi C, Peters B, Mitropoulou C, Mitropoulos K, Katsila T, Agarwal MR, et al. Personalized pharmacogenomics profiling using whole-genome sequencing. Pharmacogenomics. 2014; 15: 1223-34. Available: http://www.ncbi.nlm.nih.gov/pubmed/25141897doi:10.2217/pgs.14.102 PMID: 25141897.
    • (2014) Pharmacogenomics , vol.15 , pp. 1223-1234
    • Mizzi, C.1    Peters, B.2    Mitropoulou, C.3    Mitropoulos, K.4    Katsila, T.5    Agarwal, M.R.6
  • 37
    • 80455126100 scopus 로고    scopus 로고
    • Evidence for association of an ACCN1 gene variant with response to lithium treatment in sardinian patients with bipolar disorder
    • PMID: 21961650
    • Squassina A, Manchia M, Borg J, Congiu D, Costa M, Georgitsi M, et al. Evidence for association of an ACCN1 gene variant with response to lithium treatment in Sardinian patients with bipolar disorder. Pharmacogenomics. 2011; 12: 1559-69. doi:10.2217/pgs.11.102 PMID: 21961650.
    • (2011) Pharmacogenomics. , vol.12 , pp. 1559-1569
    • Squassina, A.1    Manchia, M.2    Borg, J.3    Congiu, D.4    Costa, M.5    Georgitsi, M.6
  • 38
    • 84867449920 scopus 로고    scopus 로고
    • Microattribution and nanopublication as means to incentivize the placement of human genome variation data into the public domain
    • PMID: 22736453
    • Patrinos GP, Cooper DN, van Mulligen E, Gkantouna V, Tzimas G, Tatum Z, et al. Microattribution and nanopublication as means to incentivize the placement of human genome variation data into the public domain.Hum Mutat. 2012; 33: 1503-1512. doi:10.1002/humu.22144 PMID: 22736453.
    • (2012) Hum Mutat , vol.33 , pp. 1503-1512
    • Patrinos, G.P.1    Cooper, D.N.2    Van Mulligen, E.3    Gkantouna, V.4    Tzimas, G.5    Tatum, Z.6
  • 39
    • 79953216652 scopus 로고    scopus 로고
    • Systematic documentation and analysis of human genetic variation in hemoglobinopathies using the microattribution approach
    • PMID: 21423179
    • Giardine B, Borg J, Higgs DR, Peterson KR, Philipsen S, Maglott D, et al. Systematic documentation and analysis of human genetic variation in hemoglobinopathies using the microattribution approach. Nat Genet. 2011; 43: 295-301. doi:10.1038/ng.785 PMID: 21423179.
    • (2011) Nat Genet , vol.43 , pp. 295-301
    • Giardine, B.1    Borg, J.2    Higgs, D.R.3    Peterson, K.R.4    Philipsen, S.5    Maglott, D.6
  • 40
    • 84947613905 scopus 로고    scopus 로고
    • Human genotype-phenotype databases: Aims, challenges and opportunities
    • PMID: 26553330
    • Brookes AJ, Robinson PN. Human genotype-phenotype databases: Aims, challenges and opportunities. Nat Rev Genet. Nature Publishing Group; 2015; 16: 702-715. doi:10.1038/nrg3932 PMID: 26553330.
    • (2015) Nat Rev Genet Nature Publishing Group , vol.16 , pp. 702-715
    • Brookes, A.J.1    Robinson, P.N.2


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