VEGF-loaded microsphere patch for local protein delivery to the ischemic heart

Acta Biomaterialia

Volumn 45, Issue , 2016, Pages 169-181

  Rodness, Jonathan ^a,b   Mihic, Anton ^a,b   Miyagi, Yasuo ^a,b   Wu, Jun ^a,b   Weisel, Richard D ^a,b   Li, Ren Ke ^a,b  

^a UNIVERSITY HEALTH NETWORK   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

Author keywords

Angiogenesis; Microsphere; Myocardial infarction; Protein delivery; VEGF

Indexed keywords

BIOACTIVITY; BLOOD VESSELS; CARDIOLOGY; CHITOSAN; ENDOTHELIAL CELLS; HEART; HYDROGELS; MAGNETIC RESONANCE IMAGING; PROTEINS; REPAIR; SCAFFOLDS (BIOLOGY);

ANGIOGENESIS; GROWTH FACTOR; HEART ATTACK; IN-VITRO; MECHANICAL RESTRAINTS; MYOCARDIAL INFARCTION; PROLONGED RELEASE; PROTEIN DELIVERY; TISSUE REPAIR; VASCULAR ENDOTHELIAL GROWTH FACTOR;

MICROSPHERES;

CALCIUM ALGINATE; CHITOSAN; MICROSPHERE; RECOMBINANT VASCULOTROPIN; ALGINIC ACID; BIOMATERIAL; CALCIUM; GLUCURONIC ACID; HEXURONIC ACID; VASCULOTROPIN A;

ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BIOCOMPATIBILITY; CAPILLARY DENSITY; CELL THERAPY; CONTROLLED STUDY; DRUG DELIVERY DEVICE; DRUG DELIVERY SYSTEM; DRUG EFFICACY; DRUG RELEASE; ECHOCARDIOGRAPHY; EPICARDIUM; FEMALE; HEART FUNCTION; HEART INFARCTION; HEART MUSCLE ISCHEMIA; HISTOLOGY; IN VITRO STUDY; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; RAT; ANIMAL; CHEMISTRY; DRUG EFFECTS; HUMAN; IMPLANT; MYOCARDIAL ISCHEMIA; PATHOLOGY; PERICARDIUM; SPRAGUE DAWLEY RAT;

ALGINATES; ANIMALS; BIOCOMPATIBLE MATERIALS; CALCIUM; DRUG DELIVERY SYSTEMS; FEMALE; GLUCURONIC ACID; HEXURONIC ACIDS; HUMANS; IMPLANTS, EXPERIMENTAL; MICROSPHERES; MYOCARDIAL ISCHEMIA; NEOVASCULARIZATION, PHYSIOLOGIC; PERICARDIUM; RATS, SPRAGUE-DAWLEY; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 84992346102     PISSN: 17427061     EISSN: 18787568     Source Type: Journal    
DOI: 10.1016/j.actbio.2016.09.009     Document Type: Article

References (36)

1. [1] Gnecchi, M., Zhang, Z., Ni, A., Dzau, V.J., Paracrine mechanisms in adult stem cell signaling and therapy. Circ. Res. 103 (2008), 1204–1219.
2. [2] Edelman, E.R., Nugent, M.A., Karnovsky, M.J., Perivascular and intravenous administration of basic fibroblast growth factor: vascular and solid organ deposition. Proc. Natl. Acad. Sci. U.S.A. 90 (1993), 1513–1517.
3. [3] Sato, K., Wu, T., Laham, R.J., Johnson, R.B., Douglas, P., Li, J., Sellke, F.W., Bunting, S., Simons, M., Post, M.J., Efficacy of intracoronary or intravenous VEGF165 in a pig model of chronic myocardial ischemia. J. Am. Coll. Cardiol. 37 (2001), 616–623.
4. [4] Henry, T.D., Annex, B.H., McKendall, G.R., Azrin, M.A., Lopez, J.J., Giordano, F.J., Shah, P.K., Willerson, J.T., Benza, R.L., Berman, D.S., Gibson, C.M., Bajamonde, A., Rundle, A.C., Fine, J., McCluskey, E.R., Investigators, V.I.V.A., The VIVA trial: vascular endothelial growth factor in ischemia for vascular angiogenesis. Circulation 107 (2003), 1359–1365.
5. [5] Wu, J., Zeng, F., Huang, X.-P., Chung, J.C.-Y., Konecny, F., Weisel, R.D., Li, R.-K., Infarct stabilization and cardiac repair with a VEGF-conjugated, injectable hydrogel. Biomaterials 32 (2011), 579–586.
6. [6] Dhingra, S., Li, P., Huang, X.-P., Guo, J., Wu, J., Mihic, A., Li, S.-H., Zang, W.-F., Shen, D., Weisel, R.D., Singal, P.K., Li, R.-K., Preserving prostaglandin E2 level prevents rejection of implanted allogeneic mesenchymal stem cells and restores post infarction ventricular function. Circulation 128 (2013), S69–S78.
7. [7] Sabbah, H.N., Wang, M., Gupta, R.C., Rastogi, S., Ilsar, I., Sabbah, M.S., Kohli, S., Helgerson, S., Lee, R.J., Augmentation of left ventricular wall thickness with alginate hydrogel implants improves left ventricular function and prevents progressive remodeling in dogs with chronic heart failure. JACC Heart Fail. 1 (2013), 252–258.
8. [8] Jay, S.M., Saltzman, W.M., Controlled delivery of VEGF via modulation of alginate microparticle ionic crosslinking. J. Control. Release 134 (2009), 26–34.
9. [9] Cittadini, A., Monti, M.G., Petrillo, V., Esposito, G., Imparato, G., Luciani, A., Urciuolo, F., Bobbio, E., Natale, C.F., Saccà, L., Netti, P.A., Complementary therapeutic effects of dual delivery of insulin-like growth factor-1 and vascular endothelial growth factor by gelatin microspheres in experimental heart failure. Eur. J. Heart Fail. 13 (2011), 1264–1274.
10. [10] Formiga, F.R., Pelacho, B., Garbayo, E., Abizanda, G., Gavira, J.J., Simon-Yarza, T., Mazo, M., Tamayo, E., Jauquicoa, C., Ortiz-de-Solorzano, C., Prósper, F., Blanco-Prieto, M.J., Sustained release of VEGF through PLGA microparticles improves vasculogenesis and tissue remodeling in an acute myocardial ischemia-reperfusion model. J. Control. Release 147 (2010), 30–37.
11. [11] Laham, R.J., Post, M., Rezaee, M., Donnell-Fink, L., Wykrzykowska, J.J., Lee, S.U., Baim, D.S., Sellke, F.W., Transendocardial and transepicardial intramyocardial fibroblast growth factor-2 administration: myocardial and tissue distribution. Drug Metab. Dispos. 33 (2005), 1101–1107.
12. [12] Miyagi, Y., Chiu, L.L.Y., Cimini, M., Weisel, R.D., Radisic, M., Li, R.-K., Biodegradable collagen patch with covalently immobilized VEGF for myocardial repair. Biomaterials 32 (2011), 1280–1290.
13. [13] Mihic, A., Li, J., Miyagi, Y., Gagliardi, M., Li, S.-H., Zu, J., Weisel, R.D., Keller, G., Li, R.-K., The effect of cyclic stretch on maturation and 3D tissue formation of human embryonic stem cell-derived cardiomyocytes. Biomaterials 35 (2014), 2798–2808.
14. [14] Kang, K., Sun, L., Xiao, Y., Li, S.-H., Wu, J., Guo, J., Jiang, S.-L., Yang, L., Yau, T.M., Weisel, R.D., Radisic, M., Li, R.-K., Aged human cells rejuvenated by cytokine enhancement of biomaterials for surgical ventricular restoration. J. Am. Coll. Cardiol. 60 (2012), 2237–2249.
15. [15] Miyagi, Y., Zeng, F., Huang, X.-P., Foltz, W.D., Wu, J., Mihic, A., Yau, T.M., Weisel, R.D., Li, R.-K., Surgical ventricular restoration with a cell- and cytokine-seeded biodegradable scaffold. Biomaterials 31 (2010), 7684–7694.
16. [16] Vunjak-Novakovic, G., Tandon, N., Godier, A., Maidhof, R., Marsano, A., Martens, T.P., Radisic, M., Challenges in cardiac tissue engineering. Tissue Eng. B Rev. 16 (2010), 169–187.
17. [17] Gürsoy, A., Karakuş, D., Okar, I., Polymers for sustained release formulations of dipyridamole-alginate microspheres and tabletted microspheres. J. Microencapsul. 16 (1999), 439–452.
18. [18] Yan, P., Gong, H., Zhai, X., Feng, Y., Wu, J., He, S., Guo, J., Wang, X., Guo, R., Xie, J., Li, R.-K., Decreasing CNPY2 expression diminishes colorectal tumor growth and development through activation of p53 pathway. Am. J. Pathol. 186 (2016), 1015–1024.
19. [19] Aranda, E., Owen, G.I., A semi-quantitative assay to screen for angiogenic compounds and compounds with angiogenic potential using the EA.hy926 endothelial cell line. Biol. Res. 42 (2009), 377–389.
20. [20] Sun, Y., Zhang, J.Q., Zhang, J., Lamparter, S., Cardiac remodeling by fibrous tissue after infarction in rats. J. Lab. Clin. Med. 135 (2000), 316–323.
21. [21] Sun, M., Opavsky, M.A., Stewart, D.J., Rabinovitch, M., Dawood, F., Wen, W.-H., Liu, P.P., Temporal response and localization of integrins beta1 and beta3 in the heart after myocardial infarction: regulation by cytokines. Circulation 107 (2003), 1046–1052.
22. [22] Chung, J.C., Mihic, A., Weisel, R.D., Li, R.-K., Injectable scaffolds for cardiac regeneration. Adapt Biol Med Cell Adapt Chall, 2011, Narosa Publishing House Pvt. Ltd, 1–15.
23. [23] Tous, E., Purcell, B., Ifkovits, J.L., Burdick, J.A., Injectable acellular hydrogels for cardiac repair. J. Cardiovasc. Transl. Res. 4 (2011), 528–542.
24. [24] Hao, X., Silva, E.A., Månsson-Broberg, A., Grinnemo, K.-H., Siddiqui, A.J., Dellgren, G., Wärdell, E., Brodin, L.A., Mooney, D.J., Sylvén, C., Angiogenic effects of sequential release of VEGF-A165 and PDGF-BB with alginate hydrogels after myocardial infarction. Cardiovasc. Res. 75 (2007), 178–185.
25. [25] Yang, Y., Gruwel, M.L., Dreessen de Gervai, P., Sun, J., Jilkina, O., Gussakovsky, E., Kupriyanov, V., MRI study of cryoinjury infarction in pig hearts: i. Effects of intrapericardial delivery of bFGF/VEGF embedded in alginate beads. NMR Biomed. 25 (2012), 177–188.
26. [26] Birdi, G., Bridson, R.H., Smith, A.M., Bohari, S.P.M., Grover, L.M., Modification of alginate degradation properties using orthosilicic acid. J. Mech. Behav. Biomed. Mater. 6 (2012), 181–187.
27. [27] Ruvinov, E., Leor, J., Cohen, S., The promotion of myocardial repair by the sequential delivery of IGF-1 and HGF from an injectable alginate biomaterial in a model of acute myocardial infarction. Biomaterials 32 (2011), 565–578.
28. [28] Gürsoy, A., Cevik, S., Sustained release properties of alginate microspheres and tabletted microspheres of diclofenac sodium. J. Microencapsul. 17 (2000), 565–575.
29. [29] Pasparakis, G., Bouropoulos, N., Swelling studies and in vitro release of verapamil from calcium alginate and calcium alginate-chitosan beads. Int. J. Pharm. 323 (2006), 34–42.
30. [30] Wells, L.A., Sheardown, H., Extended release of high pI proteins from alginate microspheres via a novel encapsulation technique. Eur. J. Pharm. Biopharm. 65 (2007), 329–335.
31. [31] Elçin, Y.M., Dixit, V., Gitnick, G., Extensive in vivo angiogenesis following controlled release of human vascular endothelial cell growth factor: implications for tissue engineering and wound healing. Artif. Organs 25 (2001), 558–565.
32. [32] Gu, F., Amsden, B., Neufeld, R., Sustained delivery of vascular endothelial growth factor with alginate beads. J. Control. Release 96 (2004), 463–472.
33. [33] Xu, S.-W., Lu, Y., Li, J., Zhang, Y.-F., Jiang, Z.-Y., Preparation of novel silica-coated alginate gel beads for efficient encapsulation of yeast alcohol dehydrogenase. J. Biomater. Sci. Polym. Ed. 18 (2007), 71–80.
34. [34] Lee, J., Bhang, S.H., Park, H., Kim, B.-S., Lee, K.Y., Active blood vessel formation in the ischemic hindlimb mouse model using a microsphere/hydrogel combination system. Pharm. Res. 27 (2010), 767–774.
35. [35] Leor, J., Tuvia, S., Guetta, V., Manczur, F., Castel, D., Willenz, U., Petneházy, O., Landa, N., Feinberg, M.S., Konen, E., Goitein, O., Tsur-Gang, O., Shaul, M., Klapper, L., Cohen, S., Intracoronary injection of in situ forming alginate hydrogel reverses left ventricular remodeling after myocardial infarction in Swine. J. Am. Coll. Cardiol. 54 (2009), 1014–1023.
36. [36] Landa, N., Miller, L., Feinberg, M.S., Holbova, R., Shachar, M., Freeman, I., Cohen, S., Leor, J., Effect of injectable alginate implant on cardiac remodeling and function after recent and old infarcts in rat. Circulation 117 (2008), 1388–1396.