MRI study of cryoinjury infarction in pig hearts: I. Effects of intrapericardial delivery of bFGF/VEGF embedded in alginate beads

NMR in Biomedicine

Volumn 25, Issue 1, 2012, Pages 177-188

  Yang, Y ^b   Gruwel, M L ^a   Dreessen de Gervai, P ^a   Sun, J ^a   Jilkina, O ^a,b   Gussakovsky, E ^a   Kupriyanov, V ^a,b,c  

^a NATIONAL RESEARCH COUNCIL CANADA   (Canada)

^b UNIVERSITY OF MANITOBA   (Canada)

^c NONE   (Canada)

Author keywords

Alginate beads; Cryoinjury infarct; Fluorescent microspheres; Gd enhanced MRI; Intrapericardial delivery; Perfusion; Vascular growth factors

Indexed keywords

CELL CULTURE; CHLORINE COMPOUNDS; FLUORESCENCE IMAGING; HEART; LIQUEFIED GASES; MAMMALS; MICROSPHERES; TISSUE;

ALGINATE BEADS; CRYOINJURY INFARCTS; FLUORESCENT MICRO SPHERES; GD-ENHANCED MRIS; INTRAPERICARDIAL DELIVERY; PERFUSION; VASCULAR GROWTH FACTORS;

ALGINATE;

ALGINIC ACID; FIBROBLAST GROWTH FACTOR 2; HEPARIN; MICROSPHERE; RECOMBINANT VASCULOTROPIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; COLD INJURY; CONTROLLED STUDY; EPICARDIUM; EXPERIMENTAL PIG; FIRST PASS EFFECT; FLUORESCENCE IMAGING; HEART; HEART INFARCTION; HEART LEFT VENTRICLE WALL; IN VIVO STUDY; NEAR INFRARED REFLECTANCE SPECTROSCOPY; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PERICARDIUM; PRIORITY JOURNAL;

SUIDAE; SUS SCROFA DOMESTICA;

EID: 84862953962     PISSN: 09523480     EISSN: 10991492     Source Type: Journal    
DOI: 10.1002/nbm.1736     Document Type: Article

References (47)

1. Simons M, Bonow RO, Chronos NA, Cohen DJ, Giordano FJ, Hammond HK, Laham RJ, Li W, Pike M, Selke FW, Stegmann TJ, Udelson JE, Rosengart TK. Clinical Trials in Coronary Angiogenesis: Issues, Problems, Consensus: An Expert Panel Summary. Circulation 2000; 102(11): E73-E86.
2. Hariawala MD, Horowitz JR, Esakof D, Sheriff DD, Walter DH, Keyt B, Isner JM, Symes JF. VEGF Improves Myocardial Blood Flow but Produces EDRF-Mediated Hypotension in Porcine Hearts. J. Surg. Res. 1996; 63(1): 77-82.
3. Pearlman JD, Hibberd MG, Chuang ML, Harada K, Lopez JJ, Gladstone SR, Friedman M, Sellke FW, Simons M. Magnetic Resonance Mapping Demonstrates Benefits of VEGF-Induced Myocardial Angiogenesis. Nat. Med. 1995; 1(10): 1085-1089.
4. Lopez JJ, Laham RJ, Stamler A, Perlman JD, Bunting S, Kaplan A, Carrozza JP, Selke FW, Simons M. VEGF Administration in Chronic Myocardial Ischemia in Pigs. Cardiovasc. Res. 1998; 40(2): 272-281.
5. Hughes GC, Biswas SS, Yin B, Coleman RA, DeGrado TR, Landolfo CK, Lowe JE, Annex BH, Landolfo KP. Therapeutic Angiogenesis in Chronically Ischemic Porcine Myocardium: Comparative Effects of BFGF and VEGF. Ann. Thorac. Surg. 2004; 77(3): 812-818.
6. Annex BH, Simons M. Growth Factor-Induced Therapeutic Angiogenesis in the Heart: Protein Therapy. Cardiovasc. Res. 2005; 65(3): 649-655.
7. Unger EF, Banai S, Shou M, Jaklitsch M, Hodge E, Correa R, Jaye M, Epstein SE. A Model to Assess Interventions to Improve Collateral Blood Flow: Continuous Administration of Agents into the Left Coronary Artery in Dogs. Cardiovasc. Res. 1993; 27(5): 785-791.
8. Lazarous DF, Scheinowitz M, Shou M, Hodge E, Rajanayagam S, Hansburger S, Robison WG, Jr, Stiber JA, Correa R, Epstein SE. Effects of Chronic Systemic Administration of Basic Fibroblast Growth Factor on Collateral Development in the Canine Heart. Circulation 1995; 91(1): 145-153.
9. Sakakibara Y, Tambara K, Sakaguchi G, Lu F, Yamamoto M, Nishimura K, Tabata Y, Komeda M. Toward Surgical Angiogenesis Using Slow-Released Basic Fibroblast Growth Factor. Eur. J. Cardiothorac. Surg. 2003; 24(1): 105-111.
10. Lazarous DF, Shou M, Stiber JA, Dadhania DM, Thirumurti V, Hodge E, Unger EF. Pharmacodynamics of Basic Fibroblast Growth Factor: Route of Administration Determines Myocardial and Systemic Distribution. Cardiovasc. Res. 1997; 36(1): 78-85.
11. Laham RJ, Rezaee M, Post M, Novicki D, Sellke FW, Perlman JD, Simons M, Hung D. Intrapericardial Delivery of Fibroblast Growth Factor-2 Induces Neovascularization in a Porcine Model of Chronic Myocardial Ischemia. J. Pharmacol. Exp. Ther. 2000; 292(2): 795-802.
12. Post MJ, Simons M. The Rational Phase of Therapeutic Angiogenesis. Minerva Cardioangiol. 2003; 51(5): 421-432.
13. Battler A, Scheinowitz M, Bor A, Hasdai D, Vered Z, Di Segni E, Varda-Boom N, Nass D, Engelberg S, Eladar M, Belkin M, Savion N. Intracoronary injection of basic fibroblast growth factor enhances angiogenesis in infarcted swine myocardium. J. Am. Coll. Cardiol. 1993; 22: 2001-2006.
14. Harada K, Grossman W, Friedman M, Edelman ER, Prasad PV, Keighley CS, Manning WJ, Sellke FW, Simons M. Basic fibroblast growth factor improves myocardial function in chronically ischemic porcine hearts. J. Clin. Invest. 1994; 94: 623-630.
15. Lopez JJ, Edelman ER, Stamler A, Hibberd MG, Prasad P, Caputo RP, Carrozza JP, Douglas PS, Sellke FW, Simons M. Basic fibroblast growth factor in a porcine model of chronic myocardial ischemia: a comparison of angiographic, echocardiographic and coronary flow parameters. J. Pharmacol. Exp. Therap. 1997; 282: 385-390.
16. Tonnesen HH, Karlsen J. Alginate in Drug Delivery Systems. Drug Dev. Ind. Pharm. 2002; 28(6): 621-630.
17. Sellke FW, Laham RJ, Edelman ER, Pearlman JD, Simons M. Therapeutic angiogenesis with basic fibroblast growth factor: technique and early results. Ann. Thorac. Surg. 1998; 65: 1540-1544.
18. Laham RJ, Sellke FW, Edelman ER, Pearlman JD, Ware JA, Brown DL, Gold JP, Simons M. Local perivascular delivery of basic fibroblast growth factor in patients undergoing coronary bypass surgery: results of a phase I randomized, double-blind, placebo-controlled trial. Circulation 1999; 100: 1865-1871.
19. Hass GM, Taylor CB. A quantitative hypothermal method for the production of local injury of tissue. Arch. Pathol. 1948; 45: 563-580.
20. Jensen JA, Kosek JC, Hunt TK, Goodson WH, III, Miller DC. Cardiac cryolesions as an experimental model of myocardial wound healing. Ann. Surg. 1987; 206: 798-803.
21. Mikat EM, Hackel DB, Harrison L, Gallagher JJ, Wallace AG. Reaction of the myocardium and coronary arteries to cryosurgery. Lab. Invest. 1977; 37: 632-641.
22. Misaki T, Allwork SP, Bentall HH. Longterm effects of cryosurgery in the sheep heart. Cardiovasc. Res. 1983; 17: 61-69.
23. Murry CE, Wiseman RW, Schwartz SM, Hauschka SD. Skeletal myoblast transplantation for repair of myocardial necrosis. J. Clin. Invest. 1996; 98: 2512-2523.
24. Ohkawa S, Hackel DB, Mikat EM, Gallagher JJ, Cox JL, Sealy WC. Anatomic effects of cryoablation of the atrioventricular conduction system. Circulation 1982; 65: 1155-1162.
25. Skanes AC, Klein G, Krahn A, Yee R. Cryoablation: potentials and pitfalls. J. Cardiovasc. Electrophysiol. 2004; 15: S28-S34.
26. Taylor CB, Davis CB, Jr., Vawter GF, Hass GM. Controlled myocardial injury produced by a hypothermal method. Circulation 1951; 3: 239-253.
27. Watanabe H, Eguchi S, Miyamura H, Hayashi J, Aizawa Y, Wakiya Y, Igarashi T. Histologic findings of long-term cryolesions in a patient with ventricular tachycardia. Cardiovasc. Surg. 1996; 4: 409-411.
28. Wetstein L, Mark R, Kaplan A, Mitamura H, Sauermelch C, Michelson EL. Nonarrhythmogenicity of therapeutic cryothermic lesions of the myocardium. J. Surg. Res. 1985; 39: 543-554.
29. Yang Y, Sun J, Gervai P, Gruwel MLC, Jilkina O, Gussakovsky E, Yang X, Kupriyanov VV. Characterization of cryoinjury-induced infarction with manganese-and gadolinium-enhanced MRI and optical spectroscopy in pig hearts. Magn. Reson. Imaging 2010; 28: 753-766.
30. Raff GL, O'Neill WW, Gentry RE, Dulli A, Bis KG, Shetty AN, Goldstein JA. Microvascular obstruction and myocardial function after acute myocardial infarction: assessment by using contrast-enhanced cine MR imaging. Radiology 2006; 240: 529-536.
31. Rochitte CE, Lima JA, Bluemke DA, Reeder SB, McViegh ER, Furuta T, Becker LC, Melin JA. Magnitude and time course of microvascular obstruction and tissue injury after acute myocardial infarction. Circulation 1998; 98: 1006-1014.
32. Vogel-Claussen J, Rochitte CE, Wu KC, Kamel IR, Foo TK, Lima JA, Bluemke DA. Delayed enhancement MR imaging: utility in myocardial assessment. Radiographics 2006; 26: 795-810.
33. Wu KC, Kim RJ, Bluemke DA, Rochitte CE, Zerhouni EA, Becker LC, Lima JA. Quantification and time course of microvascular obstruction by contrast-enhanced echocardiography and magnetic resonance imaging following acute myocardial infarction and reperfusion. J. Am. Coll. Cardiol. 1998; 32: 1756-1764.
34. Judd RM, Lugo-Olivieri CH, Arai M, Kondo T, Croisille P, Lima JA, Mohan V, Becker LC, Zerhouni EA. Physiological basis of myocardial contrast enhancement in fast magnetic resonance images of 2-day-old reperfused canine infarcts. Circulation 1995; 92: 1902-1910.
35. Pereira RS, Prato FS, Wisenberg G, Sykes J. The determination of myocardial viability using Gd-DTPA in a canine model of acute myocardial ischemia and reperfusion. Magn. Reson. Med. 1996; 36: 684-693.
36. Gruwel MLH, Yang Y, de Gervai P, Sun J, Kupriyanov VV. Magnetic resonance imaging tracking of alginate beads used for drug delivery of growth factors at sites of cardiac damage. Magn. Reson. Imaging 2009; 27: 970-975.
37. Gussakovsky E, Yang Y. On emission intensity of fluorescent microspheres in cardiac tissue image. J. Fluorescene 2010; 24: 857-863. DOI: 10.1007/s10895-010-0629-x.
38. Polimeni PI. Measurement of myocardial electrolyte distribution. In Linden RJ (ed) Techniques in Cardiovascular Physiology - Part II. Physiology, Techniques in the Life Sciences. 1984; P317: 1-34. Elsevier Sci Publ Ireland, County Clare, Ireland.
39. Judd RM, Alatay MK, Rottman GA, Zerhouni EA. Effects of myocardial water exchange on T1 enhancement during bolus administration of MR contrast agents. Magn. Reson. Med. 1995; 33: 215-223.
40. Pereira RS, Prato FS, Wisenberg G, Sykes J, Yvorchuk KJ. The use of Gd-DTPA as a marker of myocardial viability in reperfused acute myocardial infarction. Int. J. Cardiovasc. Imaging 2001; 17: 395-404.
41. Thornhill RE, Prato FS, Wisenberg G, Moran JR, Sykes J. Determining the extent to which delayed enhancement images reflect the partition coefficient of Gd-DTPA in canine studies of reperfused and unreperfused myocardial infarction. Magn. Reson. Med. 2004; 52: 1069-1079.
42. Lu H, Xu X, Zhang M, Cao R, Brakenheilm E, Li C, Lin H, Yao G, Sun H, Qi L, Tang M, Dai H, Zhang Y, Su R, Bi Y, Zhang Y, Cao Y. Combinatorial protein therapy of angiogenic and arteriogenic factors remarkably improves collaterogenesis and cardiac function in pigs. Proc. Natl. Acad. Sci. U.S.A. 2007; 104: 12140-12145.
43. Liu Y, Sun L, Huan Y, Zhao H, Deng J. Application of bFGF and BDNF to improve angiogenesis and cardiac function. J. Surg. Res. 2006; 136: 85-91.
44. Matthews K, Devlin GP, Stuart SP, Jensen JA, Doughty RN, Conaglen JV, Bass JJ. Intrapericardial IGF-1 improves cardiac function in ovine model of chronic heart failure. Heart, Lung Circ. 2005; 14: 98-103.
45. Huwer H, Winning J, Vollmar B, Rissland J, Welter C, Schafers H-J, Menger MD. Microvascularization and ventricular function after local alginate-encapsulated angiogenic growth factor treatment in a rat cryothermia-induced myocardial infarction model. Microvasc. Res. 2001; 62: 211-214.
46. Peters MC, Isenberg BC, Rowley JA, Mooney DJ. Release from alginate enhances the biological activity of vascular endothelial growth factor. J. Biomater. Sci. Polym. Edn 1998; 9: 1267-1278.
47. Arai AE, Kassera CE, Territo PR, Gandjbakhche AH, Balaban RS. Myocardial oxygenation in vivo: optical spectroscopy of cytoplasmic myoglobin and mitochondrial cytochromes. Am. J. Physiol. 1999; 46: H683-H697.