Mortality and Costs in Clostridium difficile Infection among the Elderly in the United States

Infection Control and Hospital Epidemiology

Volumn 37, Issue 11, 2016, Pages 1331-1336

  Shorr, Andrew F ^a   Zilberberg, Marya D ^b,c   Wang, Li ^d   Baser, Onur ^d,e   Yu, Holly ^f  

^a WASHINGTON HOSPITAL CENTER   (United States)

^b EviMed Research Group LLC   (United States)

^c UNIVERSITY OF MASSACHUSETTS   (United States)

^d STATINMED RESEARCH   (United States)

^e Och Spine at New York Presbyterian Hospitals   (United States)

^f PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AGED; ANTIBIOTIC THERAPY; ARTICLE; CLOSTRIDIUM DIFFICILE INFECTION; COMORBIDITY; FEMALE; HEALTH CARE COST; HEALTH CARE UTILIZATION; HOSPITALIZATION; HUMAN; ICD-9-CM; MAJOR CLINICAL STUDY; MALE; MEDICARE; MORTALITY; NURSING HOME; RETROSPECTIVE STUDY; UNITED STATES; CLOSTRIDIUM INFECTION; COHORT ANALYSIS; CROSS INFECTION; ECONOMICS; LENGTH OF STAY; PEPTOCLOSTRIDIUM DIFFICILE; RISK FACTOR; STATISTICAL MODEL; STATISTICS AND NUMERICAL DATA; VERY ELDERLY;

ANTIINFECTIVE AGENT;

AGED; AGED, 80 AND OVER; ANTI-BACTERIAL AGENTS; CLOSTRIDIUM DIFFICILE; CLOSTRIDIUM INFECTIONS; COHORT STUDIES; CROSS INFECTION; FEMALE; HEALTH CARE COSTS; HUMANS; LENGTH OF STAY; LOGISTIC MODELS; MALE; MEDICARE; RETROSPECTIVE STUDIES; RISK FACTORS; UNITED STATES;

EID: 84992346090     PISSN: 0899823X     EISSN: 15596834     Source Type: Journal    
DOI: 10.1017/ice.2016.188     Document Type: Article

References (28)

1. Healthcare Cost and Utilization Project (HCUP). HCUP projections: Clostridium difficile infection 2011 to 2012. Report 2012-01. HCUP website. http://www.hcup-us.ahrq.gov/reports/ projections/CDI-Regional-projections-Final.pdf. Accessed August 12, 2016
2. Lessa FC, Mu Y, Bamberg WM, et al. Burden of Clostridium difficile infection in the United States. N Engl J Med 2015;372: 825-834
3. Zilberberg MD, Shorr AF, Kollef MH. Increase in adult Clostridium difficile-related hospitalizations and case-fatality rate, United States, 2000-2005. Emerg Infect Dis 2008;14: 929-931
4. Hall AJ, Curns AT, McDonald LC, Parashar UD, Lopman BA. The roles of Clostridium difficile and norovirus among gastroenteritis-associated deaths in the United States, 1999-2007. Clin Infect Dis 2012;55:216-223
5. US Census Bureau. 65 + in the United States: 2010 P23-212 Washington, DC: US Government Printing Office; 2014
6. Kwon JH, Olsen MA, Dubberke ER. The morbidity, mortality, and costs associated with Clostridium difficile infection. Infect Dis Clin N Am 2015;29:123-134
7. Normand ST, Landrum MB, Guadagnoli E, et al. Validating recommendations for coronary angiography following acute myocardial infarction in the elderly: a matched analysis using propensity scores. J Clin Epidemiol 2001;54:387-398
8. Baser O. Choosing propensity score matching over regression adjustment for causal inference: when, why and how it makes sense. J Med Econ 2007;10:379-391
9. Deyo RA, Cherkin DC, Ciol MA. Adapting a clinical comorbidity index for use with ICD-9-CM administrative databases. J Clin Epidemiol 1992;45:613-619
10. Berg AM, Kelly CP, Farraye FA. Clostridium difficile infection in the inflammatory bowel disease patient. Inflamm Bowel Dis 2013;19:194-204
11. Miller MA, Hyland M, Ofner-Agostini M, Gourdeau M, Ishak M. Morbidity, mortality, and healthcare burden of nosocomial Clostridium difficile-associated diarrhea in Canadian hospitals. Infect Control Hosp Epidemiol 2002;23:137-140
12. Dallal RM, Harbrecht BG, Boujoukas AJ, et al. Fulminant Clostridium difficile: an underappreciated and increasing cause of death and complications. Ann Surg 2002;235:363-372
13. Kyne L, Hamel MB, Polavaram R, Kelly CP. Health care costs and mortality associated with nosocomial diarrhea due to Clostridium difficile. Clin Infect Dis 2002;34:346-353
14. Dubberke ER, Butler AM, Reske KA, et al. Attributable outcomes of endemic Clostridium difficile-associated disease in nonsurgical patients. Emerg Infect Dis 2008;14:1031-1038
15. Gravel D, Miller M, Simor A, et al. Health care-associated Clostridium difficile infection in adults admitted to acute care hospitals in Canada: a Canadian Nosocomial Infection Surveillance Program Study. Clin Infect Dis 2009;48:568-576
16. Tabak YP, Zilberberg MD, Johannes RS, Sun X, McDonald LC. Attributable burden of hospital onset Clostridium difficile infection: a propensity score matching study. Infect Control Hosp Epidemiol 2013;34:588-596
17. Pepin J, Valiquette L, Cossette B. Mortality attributable to nosocomial Clostridium difficile-associated disease during an epidemic caused by a hypervirulent strain in Quebec. CMAJ 2005;173:1037-1042
18. Loo VG, Poirier L, Miller MA, et al. A predominantly clonal multi-institutional outbreak of Clostridium difficile-associated diarrhea with high morbidity and mortality. N Engl J Med 2005;353:2442-2449
19. Song X, Bartlett JG, Speck K, Naegeli A, Carroll K, Perl TM. Rising economic impact of Clostridium difficile-associated disease in adult hospitalized patient population. Infect Control Hosp Epidemiol 2008;29:823-828
20. O'Brien JA, Lahue BJ, Caro JJ, Davidson DM. The emerging infectious challenge of Clostridium difficile-associated disease in Massachusetts hospitals: clinical and economic consequences. Infect Control Hosp Epidemiol 2007;28:1219-1227
21. Stewart DB, Hollenbeak CS. Clostridium difficile colitis: factors associated with outcome and assessment of mortality at a national level. J Gastrointest Surg 2011;15:1548-1555
22. Lipp MJ, Nero DC, Callahan MA. Impact of hospital-acquired Clostridium difficile. J Gastroenterol Hepatol 2012;27:1733-1737
23. Pakyz A, Carroll NV, Harpe SE, et al. Economic impact of Clostridium difficile infection in a multihospital cohort of academic health centers. Pharmacotherapy 2011;31:546-551
24. Zilberberg MD, Shorr AF, Micek ST, Kollef MH. Clostridium difficile recurrence is a strong predictor of 30-day rehospitalization among patients in intensive care. Infect Control Hosp Epidemiol 2015;36:273-279
25. Olsen MA, Yan Y, Reske KA, Zilberberg M, Dubberke ER. Impact of Clostridium difficile recurrence on hospital readmissions. Am J Infect Control 2015;43:318-322
26. Dubberke ER, Reske KA, McDonald LC, Fraser VJ. ICD-9 codes and surveillance for Clostridium difficile-associated disease. Emerg Infect Dis 2006;12:1576-1579
27. Kitsios GD, Dahabreh IJ, Callahan S, Paulus JK, Campagna AC, Dargin JM. Can we trust observational studies using propensity scores in the critical care literature? A systematic comparison with randomized clinical trials. Crit Care Med 2015;43:1870-1879
28. Cohen SH, Gerding DN, Johnson S, et al. Clinical practice guidelines for Clostridium difficile infection in adults: 2010 update by the Society for Healthcare Epidemiology of America (SHEA) and the Infectious Diseases Society of America (IDSA). Infect Control Hosp Epidemiol 2010;31:431-455