Controlling uncertainty in aptamer selection

Proceedings of the National Academy of Sciences of the United States of America

Volumn 113, Issue 43, 2016, Pages 12076-12081

  Spill, Fabian ^a,b   Weinstein, Zohar B ^c   Shemirani, Atena Irani ^b   Ho, Nga ^b   Desai, Darash ^b   Zaman, Muhammad H ^b,d  

^a Massachusetts Institute of Technology Cambridge   (United States)

^b Boston University   (United States)

^c BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d BOSTON UNIVERSITY   (United States)

Author keywords

Aptamer; Evolutionary dynamics; Hybrid model; SELEX; Stochastic process

Indexed keywords

APTAMER; LIGAND; NUCLEIC ACID; PROTEIN;

CONFERENCE PAPER; ENVIRONMENTAL PARAMETERS; HYBRID; LIGAND BINDING; POPULATION DYNAMICS; PRIORITY JOURNAL; STOCHASTIC MODEL; SYSTEMATIC EVOLUTION OF LIGANDS BY EXPONENTIAL ENRICHMENT APTAMER TECHNIQUE; UNCERTAINTY; BINDING COMPETITION; BINDING SITE; CHEMISTRY; HUMAN; KINETICS; MARKOV CHAIN; MOLECULAR LIBRARY; MONTE CARLO METHOD; STATISTICS AND NUMERICAL DATA;

APTAMERS, NUCLEOTIDE; BINDING SITES; BINDING, COMPETITIVE; HUMANS; KINETICS; LIGANDS; MONTE CARLO METHOD; NUCLEIC ACIDS; PROTEINS; SELEX APTAMER TECHNIQUE; SMALL MOLECULE LIBRARIES; STOCHASTIC PROCESSES; UNCERTAINTY;

EID: 84992346019     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1605086113     Document Type: Article

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