Ultra-pH-Responsive and Tumor-Penetrating Nanoplatform for Targeted siRNA Delivery with Robust Anti-Cancer Efficacy

Angewandte Chemie - International Edition

Volumn 55, Issue 25, 2016, Pages 7091-7094

  Xu, Xiaoding ^a   Wu, Jun ^a   Liu, Yanlan ^a   Yu, Mikyung ^a   Zhao, Lili ^a   Zhu, Xi ^a   Bhasin, Sushant ^a   Li, Qing ^a   Ha, Emily ^a   Shi, Jinjun ^a   Farokhzad, Omid C ^a,b  

^a HARVARD MEDICAL SCHOOL   (United States)

^b KING ABDULAZIZ UNIVERSITY   (Saudi Arabia)

Author keywords

cancer therapy; nanoparticles; pH responsive; siRNA delivery; tumor penetration

Indexed keywords

CARDIOVASCULAR SYSTEM; DISEASES; GENES; GENETIC ENGINEERING; NANOPARTICLES; ONCOLOGY; POLYMERS; RNA;

CANCER THERAPY; FUNCTION RELATIONSHIPS; GENE SILENCING TECHNOLOGY; INHIBITION OF TUMOR GROWTH; PH-RESPONSIVE; SIRNA DELIVERY; SMALL INTERFERENCE RNA; TUMOR PENETRATION;

TUMORS;

ARGINYL-GLYCYL-ASPARTIC ACID; BIRC5 PROTEIN, HUMAN; INHIBITOR OF APOPTOSIS PROTEIN; MACROGOL; NANOPARTICLE; OLIGOPEPTIDE; POLYMER; SMALL INTERFERING RNA;

CHEMISTRY; DELAYED RELEASE FORMULATION; GENE TRANSFER; GENETICS; HELA CELL LINE; HUMAN; NEOPLASM; PH; PROCEDURES; RNAI THERAPEUTICS; TUMOR CELL LINE;

CELL LINE, TUMOR; DELAYED-ACTION PREPARATIONS; GENE TRANSFER TECHNIQUES; HELA CELLS; HUMANS; HYDROGEN-ION CONCENTRATION; INHIBITOR OF APOPTOSIS PROTEINS; NANOPARTICLES; NEOPLASMS; OLIGOPEPTIDES; POLYETHYLENE GLYCOLS; POLYMERS; RNA, SMALL INTERFERING; RNAI THERAPEUTICS;

EID: 84992311489     PISSN: 14337851     EISSN: 15213773     Source Type: Journal    
DOI: 10.1002/anie.201601273     Document Type: Article

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