Toxoplasma gondii mitogen-activated protein kinases are associated with inflammasome activation in infected mice

Microbes and Infection

Volumn 18, Issue 11, 2016, Pages 696-700

  Wang, Shuchao ^a   Wang, Zedong ^a   Gu, Yi ^a   Li, Zhongyu ^a   Li, Zhongyuan ^a   Wei, Feng ^b   Liu, Quan ^a  

^a BEIJING INSTITUTE OF MICROBIOLOGY AND EPIDEMIOLOGY   (China)

^b JILIN AGRICULTURAL UNIVERSITY   (China)

Author keywords

IFN ; IL 18; Inflammasome; Mitogen activated protein kinase; Toxoplasma gondii

Indexed keywords

BETA INTERFERON; CRYOPYRIN; GAMMA INTERFERON; INFLAMMASOME; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 18; INTERLEUKIN 1BETA CONVERTING ENZYME; INTERLEUKIN 6; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE P38; STAT1 PROTEIN; STAT3 PROTEIN; TRANSCRIPTION FACTOR RELA; TUMOR NECROSIS FACTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; FEMALE; HOST RESISTANCE; INNATE IMMUNITY; MOUSE; NONHUMAN; PARASITE VIRULENCE; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; TOXOPLASMA GONDII; TOXOPLASMOSIS; ANIMAL; BAGG ALBINO MOUSE; ENZYMOLOGY; GENE DELETION; GENETICS; HOST PATHOGEN INTERACTION; METABOLISM; PATHOGENICITY; TOXOPLASMA; VIRULENCE;

ANIMALS; FEMALE; GENE DELETION; HOST-PATHOGEN INTERACTIONS; INFLAMMASOMES; MICE, INBRED BALB C; MITOGEN-ACTIVATED PROTEIN KINASES; TOXOPLASMA; VIRULENCE;

EID: 84992223551     PISSN: 12864579     EISSN: 1769714X     Source Type: Journal    
DOI: 10.1016/j.micinf.2016.07.004     Document Type: Article

References (25)

1. [1] Tenter, A.M., Heckeroth, A.R., Weiss, L.M., Toxoplasma gondii: from animals to humans. Int J Parasitol 30 (2000), 1217–1258.
2. [2] Robert-Gangneux, F., Darde, M.L., Epidemiology of and diagnostic strategies for toxoplasmosis. Clin Microbiol Rev 25 (2012), 264–296.
3. [3] Ma, H., Wang, Z., Wang, C., Li, C., Wei, F., Liu, Q., Fatal Toxoplasma gondii infection in the giant panda. Parasite, 22, 2015, 30.
4. [4] Liu, Q., Wang, Z.D., Huang, S.Y., Zhu, X.Q., Diagnosis of toxoplasmosis and typing of Toxoplasma gondii. Parasit Vectors, 8, 2015, 292.
5. [5] Nguyen, T.D., Bigaignon, G., Markine-Goriaynoff, D., Heremans, H., Nguyen, T.N., Warnier, G., et al. Virulent Toxoplasma gondii strain RH promotes T-cell-independent overproduction of proinflammatory cytokines IL12 and gamma-interferon. J Med Microbiol 52 (2003), 869–876.
6. [6] Mordue, D.G., Monroy, F., La Regina, M., Dinarello, C.A., Sibley, L.D., Acute toxoplasmosis leads to lethal overproduction of Th1 cytokines. J Immunol 167 (2001), 4574–4584.
7. [7] Zamboni, D.S., Lima-Junior, D.S., Inflammasomes in host response to protozoan parasites. Immunol Rev 265 (2015), 156–171.
8. [8] Gorfu, G., Cirelli, K.M., Melo, M.B., Mayer-Barber, K., Crown, D., Koller, B.H., et al. Dual role for inflammasome sensors NLRP1 and NLRP3 in murine resistance to Toxoplasma gondii. MBio 5 (2014), e01117–13.
9. [9] Wei, F., Wang, W., Liu, Q., Protein kinases of Toxoplasma gondii: functions and drug targets. Parasitol Res 112 (2013), 2121–2129.
10. [10] Brumlik, M.J., Pandeswara, S., Ludwig, S.M., Jeansonne, D.P., Lacey, M.R., Murthy, K., et al. TgMAPK1 is a Toxoplasma gondii MAP kinase that hijacks host MKK3 signals to regulate virulence and interferon-gamma-mediated nitric oxide production. Exp Parasitol 134 (2013), 389–399.
11. [11] Huang, H., Ma, Y.F., Bao, Y., Lee, H., Lisanti, M.P., Tanowitz, H.B., et al. Molecular cloning and characterization of mitogen-activated protein kinase 2 in Toxoplasma gondii. Cell Cycle 10 (2011), 3519–3526.
12. [12] Cao, L., Wang, Z., Wang, S., Li, J., Wang, X., Wei, F., et al. Deletion of mitogen-activated protein kinase 1 inhibits development and growth of Toxoplasma gondii. Parasitol Res 115 (2016), 797–805.
13. [13] Li, Z.Y., Wang, Z.D., Huang, S.Y., Zhu, X.Q., Liu, Q., TgERK7 is involved in the intracellular proliferation of Toxoplasma gondii. Parasitol Res, 2016, 10.1007/s00436-016-5103-5.
14. [14] Elliott, E.I., Sutterwala, F.S., Initiation and perpetuation of NLRP3 inflammasome activation and assembly. Immunol Rev 265 (2015), 35–52.
15. [15] Mankan, A.K., Kubarenko, A., Hornung, V., Immunology in clinic review series; focus on autoinflammatory diseases: inflammasomes: mechanisms of activation. Clin Exp Immunol 167 (2012), 369–381.
16. [16] Triantafilou, M., Hughes, T.R., Morgan, B.P., Triantafilou, K., Complementing the inflammasome. Immunology 147:2 (2016), 152–164.
17. [17] Bauernfeind, F.G., Horvath, G., Stutz, A., Alnemri, E.S., MacDonald, K., Speert, D., et al. Cutting edge: NF-kappaB activating pattern recognition and cytokine receptors license NLRP3 inflammasome activation by regulating NLRP3 expression. J Immunol 183 (2009), 787–791.
18. [18] Guarda, G., Braun, M., Staehli, F., Tardivel, A., Mattmann, C., Forster, I., et al. Type I interferon inhibits interleukin-1 production and inflammasome activation. Immunity 34 (2011), 213–223.
19. [19] Lang, C., Gross, U., Luder, C.G., Subversion of innate and adaptive immune responses by Toxoplasma gondii. Parasitol Res 100 (2007), 191–203.
20. [20] Pifer, R., Yarovinsky, F., Innate responses to Toxoplasma gondii in mice and humans. Trends Parasitol 27 (2011), 388–393.
21. [21] de Paus, R.A., van Wengen, A., Schmidt, I., Visser, M., Verdegaal, E.M., van Dissel, J.T., et al. Inhibition of the type I immune responses of human monocytes by IFN-α and IFN-β. Cytokine 61 (2013), 645–655.
22. [22] Carey, A.J., Tan, C.K., Ulett, G.C., Infection-induced IL-10 and JAK-STAT: a review of the molecular circuitry controlling immune hyperactivity in response to pathogenic microbes. JAKSTAT 1 (2012), 159–167.
23. [23] Omosun, Y., McKeithen, D., Ryans, K., Kibakaya, C., Blas-Machado, U., Li, D., et al. Interleukin-10 modulates antigen presentation by dendritic cells through regulation of NLRP3 inflammasome assembly during Chlamydia infection. Infect Immun 83 (2015), 4662–4672.
24. [24] Lee, M.S., Kim, Y.J., Signaling pathways downstream of pattern-recognition receptors and their cross talk. Annu Rev Biochem 76 (2007), 447–480.
25. [25] Mahmoud, M.E., Ui, F., Salman, D., Nishimura, M., Nishikawa, Y., Mechanisms of interferon-beta-induced inhibition of Toxoplasma gondii growth in murine macrophages and embryonic fibroblasts: role of immunity-related GTPase M1. Cell Microbiol 17 (2015), 1069–1083.