TgMAPK1 is a Toxoplasma gondii MAP kinase that hijacks host MKK3 signals to regulate virulence and interferon-γ-mediated nitric oxide production

Experimental Parasitology

Volumn 134, Issue 3, 2013, Pages 389-399

  Brumlik, Michael J ^a   Pandeswara, Srilakshmi ^a   Ludwig, Sara M ^a   Jeansonne, Duane P ^a   Lacey, Michelle R ^b   Murthy, Kruthi ^a,c   Daniel, Benjamin J ^a   Wang, Rong Fu ^d   Thibodeaux, Suzanne R ^a   Church, Kristina M ^a   Hurez, Vincent ^a   Kious, Mark J ^a   Zhang, Bin ^a   Alagbala, Adebusola ^d   Xia, Xiaojun ^d   Curiel, Tyler J ^a  

^a CTRC Institute for Drug Development   (United States)

^b Tulane University   (United States)

^c Mays Cancer Center at UT Health San Antonio   (United States)

^d CENTER FOR CELL AND GENE THERAPY   (United States)

Author keywords

INOS; MAPK; Toxoplasma gondii; Virulence

Indexed keywords

GAMMA INTERFERON; INDOLEAMINE 2,3 DIOXYGENASE; INDUCIBLE NITRIC OXIDE SYNTHASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE KINASE 3; NITRIC OXIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVATION; ENZYME REGULATION; FEMALE; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PARASITE CONTROL; PARASITE LOAD; PARASITE VIRULENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SENSITIVITY ANALYSIS; SIGNAL TRANSDUCTION; TACHYZOITE; TISSUE SPECIFICITY; TOXOPLASMA GONDII; TOXOPLASMOSIS;

ANIMALS; CELL LINE; FEMALE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HUMANS; INTERFERON-GAMMA; LIVER; MACROPHAGES; MICE; MICE, INBRED C57BL; MITOGEN-ACTIVATED PROTEIN KINASE 1; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE II; SPLEEN; TOXOPLASMA; TOXOPLASMOSIS, ANIMAL; VIRULENCE; VIRULENCE FACTORS;

EID: 84877888397     PISSN: 00144894     EISSN: 10902449     Source Type: Journal    
DOI: 10.1016/j.exppara.2013.03.016     Document Type: Article

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