Chronic restraint stress triggers dopaminergic and noradrenergic neurodegeneration: Possible role of chronic stress in the onset of Parkinson's disease

Brain, Behavior, and Immunity

Volumn 51, Issue , 2016, Pages 39-46

  Sugama, Shuei ^a   Sekiyama, Kazunari ^b   Kodama, Tohru ^b   Takamatsu, Yoshiki ^b   Takenouchi, Takato ^c   Hashimoto, Makoto ^b   Bruno, Conti ^d   Kakinuma, Yoshihiko ^a  

^a NIPPON MEDICAL SCHOOL   (Japan)

^b TOKYO METROPOLITAN INSTITUTE OF MEDICAL SCIENCE   (Japan)

^c NATIONAL INSTITUTE OF AGROBIOLOGICAL SCIENCES   (Japan)

^d SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

Dopamine; Microglia; Neurodegeneration; Oxidative stress; Parkinson's disease; Stress; Substantia nigra

Indexed keywords

INDUCIBLE NITRIC OXIDE SYNTHASE; SEROTONIN; TYROSINE 3 MONOOXYGENASE; DOPAMINE; MESSENGER RNA; NORADRENALIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL ACTIVATION; CHRONIC STRESS; CONTROLLED STUDY; DISEASE COURSE; DOPAMINERGIC NERVE CELL; IMMOBILIZATION STRESS; IMMUNOREACTIVITY; IN VIVO STUDY; LOCUS CERULEUS; MALE; MESENCEPHALON; MICROGLIA; NERVE DEGENERATION; NEUROTOXICITY; NONHUMAN; NORADRENERGIC NERVE CELL; OXIDATIVE STRESS; PARKINSON DISEASE; PRIORITY JOURNAL; RAT; SUBSTANTIA NIGRA PARS COMPACTA; VENTRAL TEGMENTUM; WISTAR RAT; ADRENERGIC NERVE CELL; ANIMAL; EXERCISE; GAIT; MENTAL STRESS; METABOLISM; PATHOLOGY;

ADRENERGIC NEURONS; ANIMALS; DOPAMINE; DOPAMINERGIC NEURONS; GAIT; LOCUS COERULEUS; MALE; MICROGLIA; NOREPINEPHRINE; OXIDATIVE STRESS; PARKINSON DISEASE; PARS COMPACTA; RATS; RATS, WISTAR; RESTRAINT, PHYSICAL; RNA, MESSENGER; SEROTONIN; STRESS, PSYCHOLOGICAL; TYROSINE 3-MONOOXYGENASE;

EID: 84992220424     PISSN: 08891591     EISSN: 10902139     Source Type: Journal    
DOI: 10.1016/j.bbi.2015.08.015     Document Type: Article

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