Increase in antibiotic-resistant gram-negative bacterial infections in febrile neutropenic children

Infection and Chemotherapy

Volumn 48, Issue 3, 2016, Pages 181-189

  Lee, Joon Hee ^a   Kim, Seul Ki ^a   Kim, Seong Koo ^a   Han, Seung Beom ^a   Lee, Jae Wook ^a   Lee, Dong Gun ^a   Chung, Nack Gyun ^a   Cho, Bin ^a   Jeong, Dae Chul ^a   Kang, Jin Han ^a   Kim, Hack Ki ^a  

^a The Catholic University of Korea   (South Korea)

Author keywords

Antibiotic resistance; Bacteremia; Child; Fever; Neutropenia

Indexed keywords

CEFEPIME; COTRIMOXAZOLE; ISEPAMICIN; MEROPENEM; PIPERACILLIN PLUS TAZOBACTAM; POLYPEPTIDE ANTIBIOTIC AGENT;

ACINETOBACTER BAUMANNII; ADOLESCENT; ADULT; ALPHA HEMOLYTIC STREPTOCOCCUS; ANTIBIOTIC RESISTANCE; ARTICLE; CARBAPENEM RESISTANT ENTEROBACTERIACEAE; CHILD; COAGULASE NEGATIVE STAPHYLOCOCCUS; CONTROLLED STUDY; DRUG SUBSTITUTION; DRUG WITHDRAWAL; ENTEROBACTER; ENTEROCOCCUS; ESCHERICHIA COLI; EXTENDED SPECTRUM BETA LACTAMASE PRODUCING ESCHERICHIA COLI; FEBRILE NEUTROPENIA; GRAM NEGATIVE BACTERIUM; GRAM NEGATIVE SEPSIS; GRAM POSITIVE BACTERIUM; HUMAN; KLEBSIELLA; MAJOR CLINICAL STUDY; MEDICAL RECORD; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; MORTALITY; PNEUMOCYSTIS PNEUMONIA; PSEUDOMONAS AERUGINOSA; RETROSPECTIVE STUDY; STAPHYLOCOCCUS AUREUS; VANCOMYCIN RESISTANT ENTEROCOCCUS;

EID: 84992188045     PISSN: 20932340     EISSN: 20926448     Source Type: Journal    
DOI: 10.3947/ic.2016.48.3.181     Document Type: Article

References (26)

1. Freifeld AG, Bow EJ, Sepkowitz KA, Boeckh MJ, Ito JI, Mullen CA, Raad II, Rolston KV, Young JA, Wingard JR; Infectious Diseases Society of America. Clinical practice guideline for the use of antimicrobial agents in neutropenic patients with cancer: 2010 update by the infectious diseases society of america. Clin Infect Dis 2011;52:e56-93.
2. Blennow O, Ljungman P. The challenge of antibiotic resistance in haematology patients. Br J Haematol 2016;172:497-511.
3. Funada H, Matsuda T. Changes in the incidence and etiological patterns of bacteremia associated with acute leukemia over a 25-year period. Intern Med 1998;37:1014-8.
4. Zinner SH. Changing epidemiology of infections in patients with neutropenia and cancer: emphasis on gram-positive and resistant bacteria. Clin Infect Dis 1999;29:490-4.
5. Ko EY, Kang HJ, Kwon HJ, Choi UY, Lee JW, Lee DG, Park YJ, Chung NG, Cho B, Kim HK, Kang JH. Clinical investigation of bacteremia in children with hemato-oncologic diseases. Infect Chemother 2011;43:191-7.
6. Mikulska M, Viscoli C, Orasch C, Livermore DM, Averbuch D, Cordonnier C, Akova M; Fourth European Conference on Infections in Leukemia Group (ECIL-4), a joint venture of EBMT, EORTC, ICHS, ELN and ESGICH/ESCMID. Aetiology and resistance in bacteraemias among adult and paediatric haematology and cancer patients. J Infect 2014;68:321-31.
7. Ortega M, Marco F, Soriano A, Almela M, Martínez JA, Rovira M, Esteve J, Mensa J. Epidemiology and outcome of bacteraemia in neutropenic patients in a single institution from 1991-2012. Epidemiol Infect 2015;143:734-40.
8. Gudiol C, Bodro M, Simonetti A, Tubau F, González-Barca E, Cisnal M, Domingo-Domenech E, Jiménez L, Carratalà J. Changing aetiology, clinical features, antimicrobial resistance, and outcomes of bloodstream infection in neutropenic cancer patients. Clin Microbiol Infect 2013;19:474-9.
9. Han SB, Jung SW, Bae EY, Lee JW, Lee DG, Chung NG, Jeong DC, Cho B, Kang JH, Kim HK, Park YJ. Extended-spectrum β-lactamase-producing Escherichia coli and Klebsiella pneumoniae bacteremia in febrile neutropenic children. Microb Drug Resist 2015;21:244-51.
10. Haeusler GM, Mechinaud F, Daley AJ, Starr M, Shann F, Connell TG, Bryant PA, Donath S, Curtis N. Antibiotic-resistant Gram-negative bacteremia in pediatric oncology patients-risk factors and outcomes. Pediatr Infect Dis J 2013;32:723-6.
11. Lee DG, Kim SH, Kim SY, Kim CJ, Min CK, Park WB, Park YJ, Song YG, Jang JS, Jang JH, Jin JY, Choi JH. Evidence-based guidelines for empirical therapy of neutropenic fever in Korea. Infect Chemother 2011;43:285-321.
12. Barlam TF, Cosgrove SE, Abbo LM, MacDougall C, Schuetz AN, Septimus EJ, Srinivasan A, Dellit TH, Falck-Ytter YT, Fishman NO, Hamilton CW, Jenkins TC, Lipsett PA, Malani PN, May LS, Moran GJ, Neuhauser MM, Newland JG, Ohl CA, Samore MH, Seo SK, Trivedi KK. Implementing an antibiotic stewardship program: guidelines by the Infectious Diseases Society of America and the Society for Healthcare Epidemiology of America. Clin Infect Dis 2016;62:e51-77.
13. Wisplinghoff H, Seifert H, Wenzel RP, Edmond MB. Current trends in the epidemiology of nosocomial bloodstream infections in patients with hematological malignancies and solid neoplasms in hospital in the United States. Clin Infect Dis 2003;36:1103-10.
14. Turner D, Cheifetz I. Shock. In: Kliegman RM, Stanton BF, St. Geme JW, Schor NF, eds. Nelson Textbook of Pediatrics. 20th ed. Philadelphia, PA: Elsevier; 2016;516-28.
15. Sreedharan R, Avner E. Renal failure. In: Kliegman RM, Stanton BF, St. Geme JW, Schor NF, eds. Nelson Textbook of Pediatrics. 20 th ed. Philadelphia, PA: Elsevier; 2016;2539-47.
16. Suchy F. Fulminant hepatic failure. In: Kliegman RM, Stanton BF, St. Geme JW, Schor NF, eds. Nelson Textbook of Pediatrics. 20th ed. Philadelphia, PA: Elsevier; 2016;1966-8.
17. Ortega M, Rovira M, Almela M, Marco F, de la Bellacasa JP, Martínez JA, Carreras E, Mensa J. Bacterial and fungal bloodstream isolates from 796 hematopoietic stem cell transplant recipients between 1991 and 2000. Ann Hematol 2005;84:40-6.
18. Magiorakos AP, Srinivasan A, Carey RB, Carmeli Y, Falagas ME, Giske CG, Harbarth S, Hindler JF, Kahlmeter G, Olsson-Liljequist B, Paterson DL, Rice LB, Stelling J, Struelens MJ, Vatopoulos A, Weber JT, Monnet DL. Multidrug-resistant, extensively drug-resistant and pandrug-resistant bacteria: an international expert proposal for interim standard definitions for acquired resistance. Clin Microbiol Infect 2012;18:268-81.
19. Miedema KG, Winter RH, Ammann RA, Droz S, Spanjaard L, de Bont ES, Kamps WA, van de Wetering MD, Tissing WJ. Bacteria causing bacteremia in pediatric cancer patients presenting with febrile neutropenia-species distribution and susceptibility patterns. Support Care Cancer 2013;21:2417-26.
20. Greenberg D, Moser A, Yagupsky P, Peled N, Hofman Y, Kapelushnik J, Leibovitz E. Microbiological spectrum and susceptibility patterns of pathogens causing bacteraemia in paediatric febrile neutropenic oncology patients: comparison between two consecutive time periods with use of different antibiotic treatment protocols. Int J Antimicrob Agents 2005;25:469-73.
21. Irfan S, Idrees F, Mehraj V, Habib F, Adil S, Hasan R. Emergence of carbapenem resistant gram negative and vancomycin resistant gram positive organisms in bacteremic isolates of febrile neutropenic patients: a descriptive study. BMC Infect Dis 2008;8:80.
22. Chang MS, Sung KW, Kim YJ. Clinical characteristics of bacteremia in children with cancer. Korean J Pediatr Infect Dis 2011;18:201-6.
23. Kang JE, Seok JY, Yun KW, Kang HJ, Choi EH, Park KD, Shin HY, Lee HJ, Ahn HS. Etiological agents in bacteremia of children with hemato-oncologic diseases (2006-2010): a single center study. Korean J Pediatr Infect Dis 2012;19:131-40.
24. Lee HJ, Lee JW, Kim JH, Lee KH, Chung NG, Lee DG, Lee MJ, Choi SH, Kang JH, Lee SJ, Jeong DC, Cho B, Kim HK. A survey for causative organisms and antimicrobial susceptabilities of bacteremia in a single center children with hemato-oncologic diseases (2004~2006). Clin Pediatr Hematol Oncol 2008;15:65-74.
25. Kwon JC, Kim SH, Choi JK, Cho SY, Park YJ, Park SH, Choi SM, Lee DG, Choi JH, Yoo JH. Epidemiology and clinical features of bloodstream infections in hematology wards: one year experience at the Catholic blood and marrow transplantation center. Infect Chemother 2013;45:51-61.
26. Marin M, Gudiol C, Ardanuy C, Garcia-Vidal C, Calvo M, Arnan M, Carratalà J. Bloodstream infections in neutropenic patients with cancer: differences between patients with haematological malignancies and solid tumours. J Infect 2014;69:417-23.