Severe anemia in Malawian children

Malawi Medical Journal

Volumn 28, Issue 3, 2016, Pages 99-107

  Calis, Job C J ^a,b,c   Phiri, Kamija S ^a,b   Faragher, E Brian ^d   Brabin, Bernard J ^c,d   Bates, Imelda ^d   Cuevas, Luis E ^d   de Haan, Rob J ^e   Phiri, Ajib I ^a,b   Malange, Pelani ^a   Khoka, Mirriam ^a   Hulshof, Paul J M ^f   van Lieshout, Lisette ^g   Beld, Marcel G H M ^h   Teo, Yik Y ⁱ   Rockett, Kirk A ⁱ   Richardson, Anna ⁱ   Kwiatkowski, Dominic P ⁱ   Molyneux, Malcolm E ^a,b,d   van Hensbroek, Michaël Boele ^a,b,c,d  

^a University of Malawi ^*  (Malawi)

^b UNIVERSITY OF MALAWI   (Malawi)

^c EMMA CHILDREN S HOSPITAL   (Netherlands)

^d LIVERPOOL SCHOOL OF TROPICAL MEDICINE   (United Kingdom)

^e ACADEMIC MEDICAL CENTER   (Netherlands)

^f WAGENINGEN UNIVERSITY   (Netherlands)

^g LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^h Department of Medical Microbiology   (United Kingdom)

ⁱ UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE 6 PHOSPHATE DEHYDROGENASE;

ANEMIA; ANEMIA, IRON-DEFICIENCY; BACTEREMIA; CASE CONTROL STUDY; CAUSALITY; CLASSIFICATION; COMPLICATION; FEMALE; GENETICS; HIV INFECTIONS; HOOKWORM INFECTIONS; HUMAN; INFANT; MALARIA; MALAWI; MALE; MULTIVARIATE ANALYSIS; NUTRITION DISORDERS; ODDS RATIO; PRESCHOOL CHILD; SEVERITY OF ILLNESS INDEX;

ANEMIA; ANEMIA, IRON-DEFICIENCY; BACTEREMIA; CASE-CONTROL STUDIES; CAUSALITY; CHILD, PRESCHOOL; FEMALE; GLUCOSEPHOSPHATE DEHYDROGENASE; HIV INFECTIONS; HOOKWORM INFECTIONS; HUMANS; INFANT; MALARIA; MALAWI; MALE; MULTIVARIATE ANALYSIS; NUTRITION DISORDERS; ODDS RATIO; SEVERITY OF ILLNESS INDEX;

EID: 84991769509     PISSN: 19957262     EISSN: 19957270     Source Type: Journal    
DOI: 10.1056/NEJMoa072727     Document Type: Article

References (43)

1. English M, Ahmed M, Ngando C, Berkley J, Ross A. Blood transfusion for severe anaemia in children in a Kenyan hospital. Lancet 2002;359:494-5.
2. Koram KA, Owusu-Agyei S, Utz G, et al. Severe anemia in young children after high and low malaria transmission seasons in the Kassena-Nankana district of northern Ghana. Am J Trop Med Hyg 2000;62:670-4.
3. Lackritz EM, Campbell CC, Ruebush TK II, et al. Effect of blood transfusion on survival among children in a Kenyan hospital. Lancet 1992;340:524-8.
4. Newton CR, Warn PA, Winstanley PA, et al. Severe anaemia in children living in a malaria endemic area of Kenya. Trop Med Int Health 1997;2:165-78.
5. Biemba G, Dolmans D, Thuma PE, Weiss G, Gordeuk VR. Severe anaemia in Zambian children with Plasmodium falciparum malaria. Trop Med Int Health 2000;5:9-16.
6. Dicko A, Klion AD, Thera MA, et al. The etiology of severe anemia in a village and a periurban area in Mali. Blood 2004;104:1198-200.
7. Guidelines for the use of iron supplements to prevent and treat iron deficiency anemia. Geneva: World Health Organization, 1998. (Accessed February 4, 2008, at http://www.who.int/nutrition/publications/anaemia_iron_pub/en/index.html.)
8. Dibley MJ, Goldsby JB, Staehling NW, Trowbridge FL. Development of normalized curves for the international growth reference: historical and technical considerations. Am J Clin Nutr 1987;46:736-48.
9. Gale E, Torrence J, Bothwell T. The quantitative estimation of total iron stores in human bone marrow. J Clin Invest 1963;42:1076-82.
10. Punnonen K, Irjala K, Rajamaki A. Serum transferrin receptor and its ratio to serum ferritin in the diagnosis of iron deficiency. Blood 1997;89:1052-7.
11. Bieri JG, Tolliver TJ, Catignani GL. Simultaneous determination of alpha-tocopherol and retinol in plasma or red cells by high pressure liquid chromatography. Am J Clin Nutr 1979;32:2143-9.
12. Sullivan AD, Ittarat I, Meshnick SR. Patterns of haemozoin accumulation in tissue. Parasitology 1996;112:285-94.
13. Katz N, Coelho PM, Pellegrino J. Evaluation of Katooin accumulation in tissueol and retinol in plasma or rema mansoni eggs added to human feces. J Parasitol 1970;56:1032-3.
14. de Gruijter JM, van Lieshout L, Gasser RB, et al. Polymerase chain reactionbased differential diagnosis of Ancylostoma duodenale and Necator americanus infections in humans in northern Ghana. Trop Med Int Health 2005;10:574-80.
15. Shaker ZA, Hassan SI, el-Attar GM, et al. Use of Kato and nucleopore techniques for qualitative diagnosis of schistosomiasis. J Egypt Soc Parasitol 1994;24:656-62.
16. Graham SM, Walsh AL, Molyneux EM, Phiri AJ, Molyneux ME. Clinical presentation of non-typhoidal Salmonella bacteraemia in Malawian children. Trans R Soc Trop Med Hyg 2000;94:310-4.
17. Boom R, Sol C, Beld M, Weel J, Goudsmit J, Wertheim-van Dillen P. Improved silica-guanidiniumthiocyanate DNA isolation procedure based on selective binding of bovine alpha-casein to silica particles. J Clin Microbiol 1999;37:615-9.
18. Boom R, Sol C, Weel J, Gerrits Y, de Boer M, Wertheim-van Dillen P. A highly sensitive assay for detection and quantitation of human cytomegalovirus DNA in serum and plasma by PCR and electrochemiluminescence. J Clin Microbiol 1999;37:1489-97.
19. Koppelman MH, Cuypers HT, Emrich T, Zaaijer HL. Quantitative real-time detection of parvovirus B19 DNA in plasma. Transfusion 2004;44:97-103.
20. Molyneux EM, Tembo M, Kayira K, et al. The effect of HIV infection on paediatric bacterial meningitis in Blantyre, Malawi. Arch Dis Child 2003;88:1112-8. [Erratum, Arch Dis Child 2004;89:395.]
21. Wilson JN, Rockett K, Jallow M, et al. Analysis of IL10 haplotypic associations with severe malaria. Genes Immun 2005;6:462-6.
22. May J, Lell B, Luty AJ, Meyer CG, Kremsner PG. Plasma interleukin-10:Tumor necrosis factor (TNF)-alpha ratio is associated with TNF promoter variants and predicts malarial complications. J Infect Dis 2000;182:1570-3.
23. Hirono A, Beutler E. Molecular cloning and nucleotide sequence of cDNA for human glucose-6-phosphate dehydrogenase variant A(-). Proc Natl Acad Sci U S A 1988;85:3951-4.
24. Bruzzi P, Green SB, Byar DP, Brinton LA, Schairer C. Estimating the population attributable risk for multiple risk factors using case-control data. Am J Epidemiol 1985;122:904-14.
25. Arbuckle JL. Amos 6.0 userl population attributab, 2007.
26. van den Broek NR, Letsky EA, White SA, Shenkin A. Iron status in pregnant women: which measurements are valid? Br J Haematol 1998;103:817-24.
27. Iron deficiency anaemia: assessment, prevention and control: a guide for programme managers. Geneva: World Health Organization, 2001. (Accessed February 4, 2008, at http://www.who.int/nutrition/publications/en/ida_assessment_prevention_control.pdf.)
28. Sommer A, Tarwotjo I, Hussaini G, Susanto D. Increased mortality in children with mild vitamin A deficiency. Lancet 1983;2:585-8.
29. Shankar AH, Genton B, Semba RD, et al. Effect of vitamin A supplementation on morbidity due to Plasmodium falciparum in young children in Papua New Guinea: a randomised trial. Lancet 1999;354:203-9.
30. Villamor E, Mbise R, Spiegelman D, Ndossi G, Fawzi WW. Vitamin A supplementation and other predictors of anemia among children from Dar Es Salaam, Tanzania. Am J Trop Med Hyg 2000;62:590-7.
31. Chlosta S, Fishman DS, Harrington L, et al. The iron efflux protein ferroportin regulates the intracellular growth of Salmonella enterica. Infect Immun 2006;74:3065-7.
32. Murray MJ, Murray AB, Murray MB, Murray CJ. The adverse effect of iron repletion on the course of certain infections. BMJ 1978;2:1113-5.
33. Sazawal S, Black RE, Ramsan M, et al. Effects of routine prophylactic supplementation with iron and folic acid on admission to hospital and mortality in preschool children in a high malaria transmission setting: community-based, randomised, placebo-controlled trial. Lancet 2006;367:133-43. [Erratum, Lancet 2006;367:302.]
34. van den Hombergh J, Dalderop E, Smit Y. Does iron therapy benefit children with severe malaria-associated anaemia? A clinical trial with 12 weeks supplementation of oral iron in young children from the Turiani Division, Tanzania. J Trop Pediatr 1996;42:220-7.
35. Albonico M, Stoltzfus RJ, Savioli L, et al. Epidemiological evidence for a differential effect of hookworm species, Ancylostoma duodenale or Necator americanus, on iron status of children. Int J Epidemiol 1998;27:530-7.
36. Brent AJ, Oundo JO, Mwangi I, Ochola L, Lowe B, Berkley JA. Salmonella bacteremia in Kenyan children. Pediatr Infect Dis J 2006;25:230-6.
37. Bronzan RN, Taylor TE, Mwenechanya J, et al. Bacteremia in Malawian children with severe malaria: prevalence, etiology, HIV coinfection, and outcome. J Infect Dis 2007;195:895-904.
38. Dierkes J, Domrose U, Ambrosch A, et al. Supplementation with vitamin B12 decreases homocysteine and methylmalonic acid but also serum folate in patients with end-stage renal disease. Metabolism 1999; 48:631-5.
39. Abdalla SH. Iron and folate status in Gambian children with malaria. Ann Trop Paediatr 1990;10:265-72.
40. Van Hensbroek MB, Morris-Jones S, Meisner S, et al. Iron, but not folic acid, combined with effective antimalarial therapy promotes haematological recovery in African children after acute falciparum malaria. Trans R Soc Trop Med Hyg 1995; 89:672-6.
41. Savage DG, Allen RH, Gangaidzo IT, et al. Pancytopenia in Zimbabwe. Am J Med Sci 1999;317:22-32.
42. van den Broek NR, Letsky EA. Etiology of anemia in pregnancy in south Malawi. Am J Clin Nutr 2000;72:Suppl:247S-256S.
43. Kurtzhals JA, Adabayeri V, Goka BQ, et al. Low plasma concentrations of interleukin 10 in severe malarial anaemia compared with cerebral and uncomplicated malaria. Lancet 1998;351:1768-72. [Errata, Lancet 1998;352:242, 1999;353:848.]