Viability and topographical analysis of microencapsulated β-cells exposed to a biotransformed tertiary bile acid: An ex vivo study

International Journal of Nano and Biomaterials

Volumn 6, Issue 2, 2016, Pages 74-82

  Mooranian, Armin ^a   Negrulj, Rebecca ^a   Al Salami, Hani ^a  

^a CURTIN UNIVERSITY   (Australia)

Author keywords

Diabetes; Inflammation; Insulin; Microencapsulation; Pancreatic NIT 1 cells; Taurocholic acid

Indexed keywords

CELLS; CYTOLOGY; GELATION; INSULIN; MEDICAL PROBLEMS;

CELL VIABILITY; CLINICAL APPLICATION; GELATION TIME; INFLAMMATION; PANCREATIC BETA CELLS; POTENTIAL BENEFITS; TAUROCHOLIC ACIDS; TOPOGRAPHICAL ANALYSIS;

MICROENCAPSULATION;

INSULIN; INTERLEUKIN 6; OXYGEN; TAUROCHOLIC ACID; TUMOR NECROSIS FACTOR;

ANIMAL CELL; ARTICLE; BIOTRANSFORMATION; CELL GROWTH; CELL PROLIFERATION; CELL STRUCTURE; CELL VIABILITY; CYTOKINE RELEASE; ENERGY; EX VIVO STUDY; GELATION; HOMEOSTASIS; INFLAMMATION; INSULIN RELEASE; MEMBRANE TRANSPORT; MICROCAPSULE; MICROENCAPSULATION; MOISTURE; MOUSE; NONHUMAN; NUTRIENT; OSTEOBLAST; OXYGEN CONSUMPTION; PANCREAS ISLET BETA CELL; RAT; SCANNING ELECTRON MICROSCOPY; STRENGTH; TEMPERATURE;

EID: 84991747001     PISSN: 17528933     EISSN: 17528941     Source Type: Journal    
DOI: 10.1504/IJNBM.2016.079684     Document Type: Article

References (23)

1. Chen, G., Kawazoe, N. and Tateishi, T. (2008) 'Effects of ECM proteins and cationic polymers on the adhesion and proliferation of rat islet cells', Open Biotechnology Journal, Vol. 2, No. 1, pp.133-137.
2. Chien, H.W., Tan, S.F., Wei, K.L. and Tsai W.B. (2011) 'Modulation of the functions of osteoblast-like cells on poly(allylamine hydrochloride) and poly(acrylic acid) multilayer films', Colloids Surf. B Biointerfaces, Vol. 88, No. 1, pp.297-303.
3. Donath, M.Y., Böni-Schnetzler, M., Ellingsgaard, H. and Ehses, J.A. (2009) 'Islet inflammation impairs the pancreatic β-cell in type 2 diabetes', Physiology (Bethesda), 8 December, Vol. 24, No. 6, pp.325-331, DOI: 10.1152/physiol.00032.2009.
4. Mooranian, A., Negrulj, R., Chen-Tan, N., Al-Sallami, H.S., Fang, Z., Mukkur, T. et al. (2014a) 'Novel artificial cell microencapsulation of a complex gliclazide-deoxycholic bile acid formulation: a characterization study', Drug Des. Devel. Ther., Vol. 8, pp.1003-1012.
5. Mooranian, A., Negrulj, R., Mathavan, S., Martinez, J., Sciarretta, J., Chen-Tan, N. et al. (2014b) 'Stability and release kinetics of an advanced gliclazide-cholic acid formulation: the use of artificial-cell microencapsulation in slow release targeted oral delivery of antidiabetics', J. Pharm. Innov., Vol. 9, pp.150-157.
6. Mooranian, A., Negrulj R., Arfuso, F. and Al-Salami, H. (2015a) 'The effect of a tertiary bile acid, taurocholic acid, on the morphology and physical characteristics of microencapsulated probucol: potential applications in diabetes: a characterization study', Drug Deliv. Transl. Res., Vol. 5, No. 5, pp.511-522.
7. Mooranian, A., Negrulj, R. and Al-Salami, H. (2015b) 'The effects of ionic gelation - vibrational jet flow technique in fabrication of microcapsules incorporating β-cell: applications in type-1 diabetes', Curr. Diabetes Rev., Epub ahead of print.
8. Mooranian, A., Negrulj, R. and Al-Salami, H. (2015c) 'The incorporation of water-soluble gel matrix into bile acid-based microcapsules for the delivery of viable β-cells of the pancreas, in diabetes treatment: biocompatibility and functionality studies', Drug Deliv. and Transl. Res., in press.
9. Mooranian, A., Negrulj, R., Al-Sallami, H.S., Fang, Z., Mikov, M., Golocorbin-Kon, S. et al. (2015d) 'Release and swelling studies of an innovative antidiabetic-bile acid microencapsulated formulation, as a novel targeted therapy for diabetes treatment', J. Microencapsul., Vol. 32, No. 2, pp.151-156.
10. Mooranian, A., Negrulj, R., Mathavan, S., Martinez, J., Sciarretta, J., Chen-Tan, N. et al. (2015e) 'An advanced microencapsulated system: a platform for optimized oral delivery of antidiabetic drug-bile acid formulations', Pharm. Dev. Technol., Vol. 20, No. 6, pp.702-709.
11. Mooranian, A., Negrulj, R., Mikov, M., Golocorbin-Kon, S., Arfuso, F. and Al-Salami, H. (2015f) 'Novel chenodeoxycholic acid-sodium alginate matrix in the microencapsulation of the potential antidiabetic drug, probucol. An in vitro study', J. Microencapsul., Vol. 32, No. 6, pp.589-597.
12. Mooranian, A., Negrulj, R. and Al-Salami, H. (2016a) 'Flow vibration-doubled concentric system coupled with low ratio amine to produce bile acid-macrocapsules of beta-cells', Therapeutic Delivery, Vol. 7, No. 3, pp.171-178.
13. Mooranian, A., Negrulj, R. and Al-Salami, H. (2016b) 'The influence of stabilized deconjugated ursodeoxycholic acid on polymer-hydrogel system of transplantable NIT-1 cells', Pharm. Res.
14. Mooranian, A., Negrulj, R., Arfuso, F. and Al-Salami, H. (2016c) 'Characterization of a novel bile acid-based delivery platform for microencapsulated pancreatic beta-cells', Artif. Cells Nanomed. Biotechnol., Vol. 44, No. 1, pp.194-200.
15. Mooranian, A., Negrulj, R., Chen-Tan, N., Fakhoury, M., Arfuso, F., Jones, F. et al. (2016d) 'Advanced bile acid-based multi-compartmental microencapsulated pancreatic beta-cells integrating a polyelectrolyte-bile acid formulation, for diabetes treatment', Artif. Cells Nanomed. Biotechnol., Vol. 44, No. 2, pp.588-595.
16. Mooranian, A., Negrulj, R., Morahan, G., Jamieson, E. and Al-Salami, H. (2016e) 'Designing anti-diabetic beta-cells microcapsules using polystyrenic sulfonate, polyallylamine and a tertiary bile acid: morphology, bioenergetics and cytokine analysis', Biotechnology Progress.
17. Naldini, A., Carraro, F., Silvestri, S. and Bocci, V. (1997) 'Hypoxia affects cytokine production and proliferative responses by human peripheral mononuclear cells', J. Cell Physiol., Vol. 173, No. 3, pp.335-342.
18. Negrulj, R., Mooranian, A., Chen-Tan, N., Al-Sallami, H.S., Mikov, M., Golocorbin-Kon, S. et al. (2015) 'Swelling, mechanical strength, and release properties of probucol microcapsules with and without a bile acid, and their potential oral delivery in diabetes', Artif. Cells Nanomed. Biotechnol., pp.1-8.
19. Orive, G., Maria Hernández, R., Rodríguez Gascón, A., Calafiore, R., Swi Chang, T.M., Vos, Pd. et al. (2004) 'History, challenges and perspectives of cell microencapsulation', Trends Biotechnol., Vol. 22, No. 2, pp.87-92.
20. Vaithilingam, V. and Tuch, B.E. (2011) 'Islet transplantation and encapsulation: an update on recent developments', Rev. Diabet. Stud., Vol. 8, No. 1, pp.51-67.
21. Weir, G.C. (2013) 'Islet encapsulation: advances and obstacles', Diabetologia, Vol. 56, No. 7, pp.1458-1461.
22. Zhao, L., Ding, J., He, P., Xiao, C., Tang, Z., Zhuang, X. et al. (2011) 'An efficient pH sensitive oral insulin delivery system enhanced by deoxycholic acid', Journal of Controlled Release, Vol. 152, Supplement 1, pp.e184-e186.
23. Zheng, X., Zheng, X., Wang, X., Ma, Z., Gupta Sunkari, V., Botusan, I. et al. (2012) 'Acute hypoxia induces apoptosis of pancreatic [beta]-cell by activation of the unfolded protein response and upregulation of CHOP', Cell Death and Disease, Vol. 3, p.e322.