메뉴 건너뛰기




Volumn 65, Issue 4, 2016, Pages 700-710

Serum hepatitis B virus RNA is encapsidated pregenome RNA that may be associated with persistence of viral infection and rebound

(22)  Wang, Jie a   Shen, Tao a   Huang, Xiangbo a   Kumar, G Renuka b   Chen, Xiangmei a   Zeng, Zhenzhen a   Zhang, Ruiyang a   Chen, Ran a   Li, Tong a   Zhang, Tianying c   Yuan, Quan c   Li, Pao Chen b   Huang, Qi b   Colonno, Richard b   Jia, Jidong d   Hou, Jinlin e   McCrae, Malcolm A f   Gao, Zhiliang g   Ren, Hong h   Xia, Ningshao c   more..


Author keywords

HBV pgRNA virion; Hepatitis B virus; Nucleot(s)ide analogues therapy

Indexed keywords

DNA POLYMERASE; NUCLEOSIDE DERIVATIVE; NUCLEOTIDE DERIVATIVE; PREGENOME RNA; RNA; UNCLASSIFIED DRUG; VIRUS DNA; MACROGOL DERIVATIVE; NONIDET P-40; VIRUS RNA;

EID: 84991619847     PISSN: 01688278     EISSN: 16000641     Source Type: Journal    
DOI: 10.1016/j.jhep.2016.05.029     Document Type: Article
Times cited : (389)

References (41)
  • 1
    • 84857358267 scopus 로고    scopus 로고
    • Global epidemiology of hepatitis B virus infection: new estimates of age-specific HBsAg seroprevalence and endemicity
    • [1] Ott, J.J., Stevens, G.A., Groeger, J., Wiersma, S.T., Global epidemiology of hepatitis B virus infection: new estimates of age-specific HBsAg seroprevalence and endemicity. Vaccine 30 (2012), 2212–2219.
    • (2012) Vaccine , vol.30 , pp. 2212-2219
    • Ott, J.J.1    Stevens, G.A.2    Groeger, J.3    Wiersma, S.T.4
  • 2
    • 84876149257 scopus 로고    scopus 로고
    • Global epidemiology of hepatitis C virus infection: new estimates of age-specific antibody to HCV seroprevalence
    • [2] Mohd, H.K., Groeger, J., Flaxman, A.D., Wiersma, S.T., Global epidemiology of hepatitis C virus infection: new estimates of age-specific antibody to HCV seroprevalence. Hepatology 57 (2013), 1333–1342.
    • (2013) Hepatology , vol.57 , pp. 1333-1342
    • Mohd, H.K.1    Groeger, J.2    Flaxman, A.D.3    Wiersma, S.T.4
  • 3
    • 84919848147 scopus 로고    scopus 로고
    • Hepatitis B virus infection
    • [3] Trepo, C., Chan, H.L., Lok, A., Hepatitis B virus infection. Lancet 384 (2014), 2053–2063.
    • (2014) Lancet , vol.384 , pp. 2053-2063
    • Trepo, C.1    Chan, H.L.2    Lok, A.3
  • 4
    • 1542316127 scopus 로고    scopus 로고
    • Hepatitis B virus infection–natural history and clinical consequences
    • [4] Ganem, D., Prince, A.M., Hepatitis B virus infection–natural history and clinical consequences. N Engl J Med 350 (2004), 1118–1129.
    • (2004) N Engl J Med , vol.350 , pp. 1118-1129
    • Ganem, D.1    Prince, A.M.2
  • 5
    • 21744449452 scopus 로고    scopus 로고
    • Natural history and clinical consequences of hepatitis B virus infection
    • [5] Pan, C.Q., Zhang, J.X., Natural history and clinical consequences of hepatitis B virus infection. Int J Med Sci 2 (2005), 36–40.
    • (2005) Int J Med Sci , vol.2 , pp. 36-40
    • Pan, C.Q.1    Zhang, J.X.2
  • 6
    • 84855463651 scopus 로고    scopus 로고
    • HBV life cycle: entry and morphogenesis
    • [6] Schadler, S., Hildt, E., HBV life cycle: entry and morphogenesis. Viruses 1 (2009), 185–209.
    • (2009) Viruses , vol.1 , pp. 185-209
    • Schadler, S.1    Hildt, E.2
  • 7
    • 0029968181 scopus 로고    scopus 로고
    • Hepatitis B virus nucleic acids associated with human peripheral blood mononuclear cells do not originate from replicating virus
    • [7] Kock, J., Theilmann, L., Galle, P., Schlicht, H.J., Hepatitis B virus nucleic acids associated with human peripheral blood mononuclear cells do not originate from replicating virus. Hepatology 23 (1996), 405–413.
    • (1996) Hepatology , vol.23 , pp. 405-413
    • Kock, J.1    Theilmann, L.2    Galle, P.3    Schlicht, H.J.4
  • 8
    • 0034777487 scopus 로고    scopus 로고
    • Circulating hepatitis B virus nucleic acids in chronic infection: representation of differently polyadenylated viral transcripts during progression to nonreplicative stages
    • [8] Su, Q., Wang, S.F., Chang, T.E., Breitkreutz, R., Hennig, H., Takegoshi, K., et al. Circulating hepatitis B virus nucleic acids in chronic infection: representation of differently polyadenylated viral transcripts during progression to nonreplicative stages. Clin Cancer Res 7 (2001), 2005–2015.
    • (2001) Clin Cancer Res , vol.7 , pp. 2005-2015
    • Su, Q.1    Wang, S.F.2    Chang, T.E.3    Breitkreutz, R.4    Hennig, H.5    Takegoshi, K.6
  • 9
    • 84959894989 scopus 로고    scopus 로고
    • Hepatitis B virus pregenomic RNA is present in virions in plasma and is associated with a response to pegylated interferon alfa-2a and nucleos(t)ide analogues
    • [9] Jansen, L., Kootstra, N.A., van Dort, K.A., Takkenberg, R.B., Reesink, H.W., Zaaijer, H.L., Hepatitis B virus pregenomic RNA is present in virions in plasma and is associated with a response to pegylated interferon alfa-2a and nucleos(t)ide analogues. J Infect Dis 213 (2016), 224–232.
    • (2016) J Infect Dis , vol.213 , pp. 224-232
    • Jansen, L.1    Kootstra, N.A.2    van Dort, K.A.3    Takkenberg, R.B.4    Reesink, H.W.5    Zaaijer, H.L.6
  • 10
    • 84892792474 scopus 로고    scopus 로고
    • Serum HBV RNA and HBeAg are useful markers for the safe discontinuation of nucleotide analogue treatments in chronic hepatitis B patients
    • [10] Tsuge, M., Murakami, E., Imamura, M., Abe, H., Miki, D., Hiraga, N., et al. Serum HBV RNA and HBeAg are useful markers for the safe discontinuation of nucleotide analogue treatments in chronic hepatitis B patients. J Gastroenterol 48 (2013), 1188–1204.
    • (2013) J Gastroenterol , vol.48 , pp. 1188-1204
    • Tsuge, M.1    Murakami, E.2    Imamura, M.3    Abe, H.4    Miki, D.5    Hiraga, N.6
  • 11
    • 34248674959 scopus 로고    scopus 로고
    • Serum HBV RNA is a predictor of early emergence of the YMDD mutant in patients treated with lamivudine
    • [11] Hatakeyama, T., Noguchi, C., Hiraga, N., Mori, N., Tsuge, M., Imamura, M., et al. Serum HBV RNA is a predictor of early emergence of the YMDD mutant in patients treated with lamivudine. Hepatology 45 (2007), 1179–1186.
    • (2007) Hepatology , vol.45 , pp. 1179-1186
    • Hatakeyama, T.1    Noguchi, C.2    Hiraga, N.3    Mori, N.4    Tsuge, M.5    Imamura, M.6
  • 12
    • 33749031000 scopus 로고    scopus 로고
    • Hepatitis B virus RNA is measurable in serum and can be a new marker for monitoring lamivudine therapy
    • [12] Rokuhara, A., Matsumoto, A., Tanaka, E., Umemura, T., Yoshizawa, K., Kimura, T., et al. Hepatitis B virus RNA is measurable in serum and can be a new marker for monitoring lamivudine therapy. J Gastroenterol 41 (2006), 785–790.
    • (2006) J Gastroenterol , vol.41 , pp. 785-790
    • Rokuhara, A.1    Matsumoto, A.2    Tanaka, E.3    Umemura, T.4    Yoshizawa, K.5    Kimura, T.6
  • 13
    • 84947234369 scopus 로고    scopus 로고
    • On-treatment low serum HBV RNA level predicts initial virological response in chronic hepatitis B patients receiving nucleoside analogue therapy
    • [13] Huang, Y.W., Takahashi, S., Tsuge, M., Chen, C.L., Wang, T.C., Abe, H., et al. On-treatment low serum HBV RNA level predicts initial virological response in chronic hepatitis B patients receiving nucleoside analogue therapy. Antivir Ther 20 (2015), 369–375.
    • (2015) Antivir Ther , vol.20 , pp. 369-375
    • Huang, Y.W.1    Takahashi, S.2    Tsuge, M.3    Chen, C.L.4    Wang, T.C.5    Abe, H.6
  • 14
    • 84920983133 scopus 로고    scopus 로고
    • Serum hepatitis B virus RNA levels as an early predictor of hepatitis B envelope antigen seroconversion during treatment with polymerase inhibitors
    • [14] van Bommel, F., Bartens, A., Mysickova, A., Hofmann, J., Kruger, D.H., Berg, T., et al. Serum hepatitis B virus RNA levels as an early predictor of hepatitis B envelope antigen seroconversion during treatment with polymerase inhibitors. Hepatology 61 (2015), 66–76.
    • (2015) Hepatology , vol.61 , pp. 66-76
    • van Bommel, F.1    Bartens, A.2    Mysickova, A.3    Hofmann, J.4    Kruger, D.H.5    Berg, T.6
  • 15
    • 84896029673 scopus 로고    scopus 로고
    • Specific and nonhepatotoxic degradation of nuclear hepatitis B virus cccDNA
    • [15] J. Lucifora Y. Xia, Reisinger, F., Zhang, K., Stadler, D., Cheng, X., et al. Specific and nonhepatotoxic degradation of nuclear hepatitis B virus cccDNA. Science 343 (2014), 1221–1228.
    • (2014) Science , vol.343 , pp. 1221-1228
    • Lucifora, B.1    Xia, B.2    Reisinger, F.3    Zhang, K.4    Stadler, D.5    Cheng, X.6
  • 16
    • 84940107277 scopus 로고    scopus 로고
    • Dual gRNAs guided CRISPR/Cas9 system inhibits hepatitis B virus replication
    • [16] Wang, J., Xu, Z.W., Liu, S., Zhang, R.Y., Ding, S.L., Xie, X.M., et al. Dual gRNAs guided CRISPR/Cas9 system inhibits hepatitis B virus replication. World J Gastroenterol 21 (2015), 9554–9565.
    • (2015) World J Gastroenterol , vol.21 , pp. 9554-9565
    • Wang, J.1    Xu, Z.W.2    Liu, S.3    Zhang, R.Y.4    Ding, S.L.5    Xie, X.M.6
  • 17
    • 78650807161 scopus 로고    scopus 로고
    • Hepatitis B virus resistance to antiviral drugs: where are we going?
    • [17] Zoulim, F., Hepatitis B virus resistance to antiviral drugs: where are we going?. Liver Int 31 (2011), 111–116.
    • (2011) Liver Int , vol.31 , pp. 111-116
    • Zoulim, F.1
  • 18
    • 0019966544 scopus 로고
    • Growth of human hepatoma cells lines with differentiated functions in chemically defined medium
    • [18] Nakabayashi, H., Taketa, K., Miyano, K., Yamane, T., Sato, J., Growth of human hepatoma cells lines with differentiated functions in chemically defined medium. Cancer Res 42 (1982), 3858–3863.
    • (1982) Cancer Res , vol.42 , pp. 3858-3863
    • Nakabayashi, H.1    Taketa, K.2    Miyano, K.3    Yamane, T.4    Sato, J.5
  • 19
    • 0000934401 scopus 로고
    • Production of hepatitis B virus particles in HepG2 cells transfected with cloned hepatitis B virus DNA
    • [19] Sells, M.A., Chen, M.L., Acs, G., Production of hepatitis B virus particles in HepG2 cells transfected with cloned hepatitis B virus DNA. Proc Natl Acad Sci U S A 84 (1987), 1005–1009.
    • (1987) Proc Natl Acad Sci U S A , vol.84 , pp. 1005-1009
    • Sells, M.A.1    Chen, M.L.2    Acs, G.3
  • 20
    • 0030842540 scopus 로고    scopus 로고
    • Inducible expression of human hepatitis B virus (HBV) in stably transfected hepatoblastoma cells: a novel system for screening potential inhibitors of HBV replication
    • [20] Ladner, S.K., Otto, M.J., Barker, C.S., Zaifert, K., Wang, G.H., Guo, J.T., et al. Inducible expression of human hepatitis B virus (HBV) in stably transfected hepatoblastoma cells: a novel system for screening potential inhibitors of HBV replication. Antimicrob Agents Chemother 41 (1997), 1715–1720.
    • (1997) Antimicrob Agents Chemother , vol.41 , pp. 1715-1720
    • Ladner, S.K.1    Otto, M.J.2    Barker, C.S.3    Zaifert, K.4    Wang, G.H.5    Guo, J.T.6
  • 21
    • 84879327902 scopus 로고    scopus 로고
    • Sodium tauocholated cotransporting polypeptide is a functional receptor for human hepatitis B and D virus
    • [21] H. Yan G.C. Zhong, Xu, G.W., He, W.H., Jing, Z.Y., Gao, Z.C., et al. Sodium tauocholated cotransporting polypeptide is a functional receptor for human hepatitis B and D virus. eLife, 1, 2012, e00049.
    • (2012) eLife , vol.1
    • Yan, B.1    Zhong, B.C.2    Xu, G.W.3    He, W.H.4    Jing, Z.Y.5    Gao, Z.C.6
  • 22
    • 77952990855 scopus 로고    scopus 로고
    • Androgen receptor promotes hepatitis B virus-induced hepatocarcinogenesis through modulation of hepatitis B virus RNA transcription
    • [22] M.H. Wu W.L. Ma C.L. Hsu, Chen, Y.L., Ou, J.H., Ryan, C.K., et al. Androgen receptor promotes hepatitis B virus-induced hepatocarcinogenesis through modulation of hepatitis B virus RNA transcription. Sci Transl Med, 2, 2010, 32ra35.
    • (2010) Sci Transl Med , vol.2 , pp. 32ra35
    • Wu, B.H.1    Ma, B.L.2    Hsu, B.L.3    Chen, Y.L.4    Ou, J.H.5    Ryan, C.K.6
  • 23
    • 84865773658 scopus 로고    scopus 로고
    • In vitro inhibition of HBV replication by a novel compound, GLS4, and its efficacy against adefovir-dipivoxil-resistant HBV mutations
    • [23] Wang, X.Y., Wei, Z.M., Wu, G.Y., Wang, J.H., Zhang, Y.J., Li, J., et al. In vitro inhibition of HBV replication by a novel compound, GLS4, and its efficacy against adefovir-dipivoxil-resistant HBV mutations. Antivir Ther 17 (2012), 793–803.
    • (2012) Antivir Ther , vol.17 , pp. 793-803
    • Wang, X.Y.1    Wei, Z.M.2    Wu, G.Y.3    Wang, J.H.4    Zhang, Y.J.5    Li, J.6
  • 24
    • 0037221770 scopus 로고    scopus 로고
    • Effect of the G1896A precore mutation on drug sensitivity and replication yield of lamivudine-resistant HBV in vitro
    • [24] Chen, R.Y., Edwards, R., Shaw, T., Colledge, D., Delaney, W.T., Isom, H., et al. Effect of the G1896A precore mutation on drug sensitivity and replication yield of lamivudine-resistant HBV in vitro. Hepatology 37 (2003), 27–35.
    • (2003) Hepatology , vol.37 , pp. 27-35
    • Chen, R.Y.1    Edwards, R.2    Shaw, T.3    Colledge, D.4    Delaney, W.T.5    Isom, H.6
  • 25
    • 0027221167 scopus 로고
    • Reproducible high level infection of cultured adult human hepatocytes by hepatitis B virus: effect of polyethylene glycol on adsorption and penetration
    • [25] Gripon, P., Diot, C., Guguen-Guillouzo, C., Reproducible high level infection of cultured adult human hepatocytes by hepatitis B virus: effect of polyethylene glycol on adsorption and penetration. Virology 192 (1993), 534–540.
    • (1993) Virology , vol.192 , pp. 534-540
    • Gripon, P.1    Diot, C.2    Guguen-Guillouzo, C.3
  • 26
    • 2142641891 scopus 로고    scopus 로고
    • Study of the endocytosis and intracellular localization of subviral particles of hepatitis B virus in primary hepatocytes
    • [26] Glebe, D., Gerlich, W.H., Study of the endocytosis and intracellular localization of subviral particles of hepatitis B virus in primary hepatocytes. Methods Mol Med 96 (2004), 143–151.
    • (2004) Methods Mol Med , vol.96 , pp. 143-151
    • Glebe, D.1    Gerlich, W.H.2
  • 27
    • 84908349078 scopus 로고    scopus 로고
    • Exosomes from hepatitis C infected patients transmit HCV infection and contain replication competent viral RNA in complex with Ago2-miR122-HSP90
    • [27] T.N. Bukong F. Momen-Heravi, Kodys, K., Bala, S., Szabo, G., Exosomes from hepatitis C infected patients transmit HCV infection and contain replication competent viral RNA in complex with Ago2-miR122-HSP90. PLoS Pathog, 10, 2014, e1004424.
    • (2014) PLoS Pathog , vol.10
    • Bukong, B.N.1    Momen-Heravi, B.2    Kodys, K.3    Bala, S.4    Szabo, G.5
  • 28
    • 84934759283 scopus 로고    scopus 로고
    • Exosomes and their role in the life cycle and pathogenesis of RNA viruses
    • [28] Chahar, H.S., Bao, X., Casola, A., Exosomes and their role in the life cycle and pathogenesis of RNA viruses. Viruses 7 (2015), 3204–3225.
    • (2015) Viruses , vol.7 , pp. 3204-3225
    • Chahar, H.S.1    Bao, X.2    Casola, A.3
  • 29
    • 84885924778 scopus 로고    scopus 로고
    • Preclinical characterization of GLS4, an inhibitor of hepatitis B virus core particle assembly
    • [29] Wu, G., Liu, B., Zhang, Y., Li, J., Arzumanyan, A., Clayton, M.M., et al. Preclinical characterization of GLS4, an inhibitor of hepatitis B virus core particle assembly. Antimicrob Agents Chemother. 57 (2013), 5344–5354.
    • (2013) Antimicrob Agents Chemother. , vol.57 , pp. 5344-5354
    • Wu, G.1    Liu, B.2    Zhang, Y.3    Li, J.4    Arzumanyan, A.5    Clayton, M.M.6
  • 30
    • 84926354344 scopus 로고    scopus 로고
    • Hepadnavirus genome replication and persistence
    • [30] Hu, J., Seeger, C., Hepadnavirus genome replication and persistence. Cold Spring Harb Perspect Med, 5, 2015, a21386.
    • (2015) Cold Spring Harb Perspect Med , vol.5 , pp. a21386
    • Hu, J.1    Seeger, C.2
  • 31
    • 84905665941 scopus 로고    scopus 로고
    • Encapsidated hepatitis B virus reverse transcriptase is poised on an ordered RNA lattice
    • [31] Wang, J.C., Nickens, D.G., Lentz, T.B., Loeb, D.D., Zlotnick, A., Encapsidated hepatitis B virus reverse transcriptase is poised on an ordered RNA lattice. Proc Natl Acad Sci U S A 111 (2014), 11329–11334.
    • (2014) Proc Natl Acad Sci U S A , vol.111 , pp. 11329-11334
    • Wang, J.C.1    Nickens, D.G.2    Lentz, T.B.3    Loeb, D.D.4    Zlotnick, A.5
  • 32
    • 0029950091 scopus 로고    scopus 로고
    • Hepatitis B virus nucleocapsid envelopment does not occur without genomic DNA synthesis
    • [32] Gerelsaikhan, T., Tavis, J.E., Bruss, V., Hepatitis B virus nucleocapsid envelopment does not occur without genomic DNA synthesis. J Virol 70 (1996), 4269–4274.
    • (1996) J Virol , vol.70 , pp. 4269-4274
    • Gerelsaikhan, T.1    Tavis, J.E.2    Bruss, V.3
  • 34
    • 0016744698 scopus 로고
    • Biochemical characterization of Australia antigen. Evidence for defective particles of hepatitis B virus
    • [34] Gerin, J.L., Ford, E.C., Purcell, R.H., Biochemical characterization of Australia antigen. Evidence for defective particles of hepatitis B virus. Am J Pathol 81 (1975), 651–668.
    • (1975) Am J Pathol , vol.81 , pp. 651-668
    • Gerin, J.L.1    Ford, E.C.2    Purcell, R.H.3
  • 35
    • 0017295839 scopus 로고
    • Demonstration of subpopulations of Dane particles
    • [35] Kaplan, P.M., Ford, E.C., Purcell, R.H., Gerin, J.L., Demonstration of subpopulations of Dane particles. J Virol 17 (1976), 885–893.
    • (1976) J Virol , vol.17 , pp. 885-893
    • Kaplan, P.M.1    Ford, E.C.2    Purcell, R.H.3    Gerin, J.L.4
  • 36
    • 0020510298 scopus 로고
    • Full and empty particles of hepatitis B virus in hepatocytes from patients with HBsAg-positive chronic active hepatitis
    • [36] Sakamoto, Y., Yamada, G., Mizuno, M., Nishihara, T., Kinoyama, S., Kobayashi, T., et al. Full and empty particles of hepatitis B virus in hepatocytes from patients with HBsAg-positive chronic active hepatitis. Lab Invest 48 (1983), 678–682.
    • (1983) Lab Invest , vol.48 , pp. 678-682
    • Sakamoto, Y.1    Yamada, G.2    Mizuno, M.3    Nishihara, T.4    Kinoyama, S.5    Kobayashi, T.6
  • 37
    • 80053460800 scopus 로고    scopus 로고
    • Secretion of genome-free hepatitis B virus-single strand blocking model for virion morphogenesis of para-retrovirus
    • [37] Ning, X., Nguyen, D., Mentzer, L., Adams, C., Lee, H., Ashley, R., et al. Secretion of genome-free hepatitis B virus-single strand blocking model for virion morphogenesis of para-retrovirus. PLoS Pathog, 7, 2011, e1002255.
    • (2011) PLoS Pathog , vol.7
    • Ning, X.1    Nguyen, D.2    Mentzer, L.3    Adams, C.4    Lee, H.5    Ashley, R.6
  • 38
    • 84930508017 scopus 로고    scopus 로고
    • Genome-free hepatitis B virion levels in patient sera as a potential marker to monitor response to antiviral therapy
    • [38] Luckenbaugh, L., Kitrinos, K.M., Delaney, W.T., Hu, J., Genome-free hepatitis B virion levels in patient sera as a potential marker to monitor response to antiviral therapy. J Viral Hepat 22 (2015), 561–570.
    • (2015) J Viral Hepat , vol.22 , pp. 561-570
    • Luckenbaugh, L.1    Kitrinos, K.M.2    Delaney, W.T.3    Hu, J.4
  • 39
    • 0035154880 scopus 로고    scopus 로고
    • Hepatitis B virus (HBV) virion and covalently closed circular DNA formation in primary tupaia hepatocytes and human hepatoma cell lines upon HBV genome transduction with replication-defective adenovirus vectors
    • [39] Ren, S., Nassal, M., Hepatitis B virus (HBV) virion and covalently closed circular DNA formation in primary tupaia hepatocytes and human hepatoma cell lines upon HBV genome transduction with replication-defective adenovirus vectors. J Virol 75 (2001), 1104–1116.
    • (2001) J Virol , vol.75 , pp. 1104-1116
    • Ren, S.1    Nassal, M.2
  • 40
    • 84953339772 scopus 로고    scopus 로고
    • Origins and evolution of hepatitis B virus and hepatitis D virus
    • [40] Littlejohn, M., Locarnini, S., Yuen, L., Origins and evolution of hepatitis B virus and hepatitis D virus. Cold Spring Harb Perspect Med, 6, 2016, a021360.
    • (2016) Cold Spring Harb Perspect Med , vol.6 , pp. a021360
    • Littlejohn, M.1    Locarnini, S.2    Yuen, L.3
  • 41
    • 84910676511 scopus 로고    scopus 로고
    • Hepatitis D virus infection, replication and cross-talk with the hepatitis B virus
    • [41] Huang, C.R., Lo, S.J., Hepatitis D virus infection, replication and cross-talk with the hepatitis B virus. World J Gastroenterol 20 (2014), 14589–14597.
    • (2014) World J Gastroenterol , vol.20 , pp. 14589-14597
    • Huang, C.R.1    Lo, S.J.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.