Major increases between pre-and post-breakfast glucose levels may predict nocturnal hypoglycemia in type 2 diabetes

Internal Medicine

Volumn 55, Issue 20, 2016, Pages 2933-2938

  Takeishi, Soichi ^a   Mori, Akihiro ^a   Kawai, Miyuka ^a   Yoshida, Yohei ^a   Hachiya, Hiroki ^a   Yumura, Takayuki ^a   Ito, Shun ^a   Shibuya, Takashi ^a   Fushimi, Nobutoshi ^a   Ohashi, Noritsugu ^a   Kawai, Hiromi ^a  

^a Ichinomiyanishi Hospital   (Japan)

Author keywords

Morning glucose increases; Nocturnal hypoglycemia; Type 2 diabetes

Indexed keywords

2,4 THIAZOLIDINEDIONE DERIVATIVE; ANTIDIABETIC AGENT; C PEPTIDE; DIPEPTIDYL PEPTIDASE IV INHIBITOR; GLUCAGON LIKE PEPTIDE 1 RECEPTOR AGONIST; GLUCOSE; HEMOGLOBIN A1C; INSULIN; METFORMIN; SODIUM GLUCOSE COTRANSPORTER 2 INHIBITOR; SULFONYLUREA; GLUCOSE BLOOD LEVEL; GLYCOSYLATED HEMOGLOBIN;

AGE; AGED; AREA UNDER THE CURVE; ARTICLE; BLOOD GLUCOSE MONITORING; BODY MASS; CONTROLLED STUDY; DIAGNOSTIC TEST ACCURACY STUDY; DISEASE DURATION; FEMALE; GENDER; GLUCOSE BLOOD LEVEL; HUMAN; INSULIN TREATMENT; MAJOR CLINICAL STUDY; MALE; NOCTURNAL HYPOGLYCEMIA; NON INSULIN DEPENDENT DIABETES MELLITUS; OUTCOME ASSESSMENT; POSTPRANDIAL STATE; PREDICTIVE VALUE; RECEIVER OPERATING CHARACTERISTIC; RETROSPECTIVE STUDY; SENSITIVITY AND SPECIFICITY; ADULT; ANALYSIS; COMPARATIVE STUDY; HYPOGLYCEMIA; MEAL; METABOLISM; MIDDLE AGED; PROCEDURES;

ADULT; AGED; BLOOD GLUCOSE; BLOOD GLUCOSE SELF-MONITORING; BREAKFAST; DIABETES MELLITUS, TYPE 2; FEMALE; HEMOGLOBIN A, GLYCOSYLATED; HUMANS; HYPOGLYCEMIA; HYPOGLYCEMIC AGENTS; MALE; MIDDLE AGED; POSTPRANDIAL PERIOD; RETROSPECTIVE STUDIES;

EID: 84991583733     PISSN: 09182918     EISSN: 13497235     Source Type: Journal    
DOI: 10.2169/internalmedicine.55.7085     Document Type: Article

References (24)

1. Zoungas S, Patel A, Chalmers J, et al. Severe hypoglycemia and risks of vascular events and death. N Engl J Med 363: 1410-1418, 2010.
2. Currie JC, Peters RJ, Tynan A, et al. Survival as a function of HbA1c in people with type 2 diabetes: a retrospective cohort study. Lancet 375: 481-489, 2010.
3. Turchin A, Matheny ME, Shubina M, Scanlon JV, Greenwood B, Pendergrass ML. Hypoglycemia and clinical outcomes in patients with diabetes hospitalized in the general ward. Diabetes Care 32: 1153-1157, 2009.
4. Takeishi S, Mori A, Hachiya H, et al. Hypoglycemia and glycemic variability are associated with mortality in non-intensive care unit hospitalized infectious disease patients with diabetes mellitus. J Diabetes Investig 7: 429-435, 2016.
5. Tsujimoto T, Yamamoto-Honda R, Kajio H, et al. Vital signs, QT prolongation, and newly diagnosed cardiovascular disease during severe hypoglycemia in type 1 and type 2 diabetic patients. Diabetes Care 37: 217-225, 2014.
6. Bremer JP, Jauch-Chara K, Hallschmid M, Schmid S, Schultes B. Hypoglycemia unawareness in older compared with middle-aged patients with type 2 diabetes. Diabetes Care 32: 1196-1198, 2009.
7. Hirsch IB, Smith LJ, Havlin CE, Shah SD, Clutter WE, Cryer PE. Failure of nocturnal hypoglycemia to cause daytime hyperglycemia in patients with IDDM. Diabetes Care 13: 133-142, 1990.
8. Lerman IG, Wolfsdorf JI. Relationship of nocturnal hypoglycemia to daytime glycemia in IDDM. Diabetes Care 11: 636-642, 1988.
9. Schmidt MI, Hadji-Georgopoulos A, Rendell M, Margolis S, Kowarski A. The dawn phenomenon, an early morning glucose rise: implications for diabetic intraday blood glucose variation. Diabetes Care 4: 579-585, 1981.
10. Stephenson JM, Schernthaner G. Dawn phenomenon and Somogyi effect in IDDM. Diabetes Care 12: 245-251, 1989.
11. Rybicka M, Krysiak R, Okopień B. The dawn phenomenon and the Somogyi effect: two phenomena of morning hyperglycaemia. Endokrynol Pol 62: 276-284, 2011.
12. Monnier L, Colette C, Dejager S, Owens D. Magnitude of the dawn phenomenon and its impact on the overall glucose exposure in type 2 diabetes: is this of concern? Diabetes Care 36: 4057-4062, 2013.
13. Leinung M, Thompson S, Nardacci E. Benefits of continuous glucose monitor use in clinical practice. Endocr Pract 16: 371-375, 2010.
14. Sakamoto M, Nishimura R, Irako T, Tsujino D, Ando K, Utsunomiya K. Comparison of vildagliptin twice daily vs. sitagliptin once daily using continuous glucose monitoring (CGM): crossover pilot study (J-VICTORIA study). Cardiovasc Diabetol 11: 92, 2012.
15. Mitsuishi S, Nishimura R, Ando K, Tsujino D, Utsunomiya K. Can fasting glucose levels or post-breakfast glucose fluctuations predict the occurrence of nocturnal asymptomatic hypoglycemia in type 1 diabetic patients receiving basal-bolus insulin therapy with long-acting insulin? PLoS One 10: e0144041, 2015.
16. Tsujimoto T, Yamamoto-Honda R, Kajio H, et al. High risk of abnormal QT prolongation in the early morning in diabetic and nondiabetic patients with severe hypoglycemia. Ann Med 47: 238-244, 2015.
17. Hanefeld M, Ganz X, Nolte C. Hypoglycemia and cardiac arrhythmia in patients with diabetes mellitus type 2. Herz 39: 312-319, 2014 (in German, Abstract in English).
18. Stahn A, Pistrosch F, Ganz X, et al. Relationship between hypoglycemic episodes and ventricular arrhythmias in patients with type 2 diabetes and cardiovascular diseases: silent hypoglycemias and silent arrhythmias. Diabetes Care 37: 516-520, 2014.
19. Bolli GB, Perriello G, Fanelli CG, De Feo P. Nocturnal blood glucose control in type I diabetes mellitus. Diabetes Care 16: 71-89, 1993.
20. Monnier L, Colette C, Sardinoux M, Baptista G, Regnier-Zerbib A, Owens D. Frequency and severity of the dawn phenomenon in type 2 diabetes: relationship to age. Diabetes Care 35: 2597-2599, 2012.
21. Jovanovic A, Gerrard J, Taylor R. The second-meal phenomenon in type 2 diabetes. Diabetes Care 32: 1199-1201, 2009.
22. Havlin CE, Cryer PE. Nocturnal hypoglycemia does not commonly result in major morning hyperglycemia in patients with diabetes mellitus. Diabetes Care 10: 141-147, 1987.
23. Klonoff DC. Continuous glucose monitoring continuous glucose monitoring: roadmap for 21st century diabetes therapy. Diabetes Care 28: 1231-1239, 2005.
24. Takeishi S, Mori A, Fushimi N, et al. Evaluation of safety of insulin degludec on undergoing total-colonoscopy using continuous glucose monitoring. J Diabetes Investig 7: 374-380, 2016.