Hypoglycemia and glycemic variability are associated with mortality in non-intensive care unit hospitalized infectious disease patients with diabetes mellitus

Journal of Diabetes Investigation

Volumn 7, Issue 3, 2016, Pages 429-435

  Takeishi, Soichi ^a   Mori, Akihiro ^a   Hachiya, Hiroki ^a   Yumura, Takayuki ^a   Ito, Shun ^a   Shibuya, Takashi ^a   Hayashi, Shintaro ^a   Fushimi, Nobutoshi ^a   Ohashi, Noritsugu ^a   Kawai, Hiromi ^a  

^a Ichinomiyanishi Hospital   (Japan)

Author keywords

Glycemic variability; Hypoglycemia; Mortality

Indexed keywords

GLUCOSE; BIOLOGICAL MARKER;

AGED; ARTICLE; BACTEREMIA; BILIARY TRACT INFECTION; DIABETES MELLITUS; FEMALE; GASTROINTESTINAL INFECTION; GLYCEMIC CONTROL; HUMAN; HYPOGLYCEMIA; INFECTION; INSULIN DEPENDENT DIABETES MELLITUS; MAJOR CLINICAL STUDY; MALE; MORTALITY; NON INSULIN DEPENDENT DIABETES MELLITUS; PNEUMONIA; PRIORITY JOURNAL; RECEIVER OPERATING CHARACTERISTIC; RETROSPECTIVE STUDY; SURGICAL INFECTION; URINARY TRACT INFECTION; COMMUNICABLE DISEASES; COMPLICATION; DIABETES COMPLICATIONS; GLYCEMIC INDEX; HOSPITAL MORTALITY; INFLAMMATION; METABOLISM; VERY ELDERLY; VITAL SIGN;

AGED; AGED, 80 AND OVER; BIOMARKERS; COMMUNICABLE DISEASES; DIABETES COMPLICATIONS; FEMALE; GLYCEMIC INDEX; HOSPITAL MORTALITY; HUMANS; HYPOGLYCEMIA; INFLAMMATION; MALE; ROC CURVE; VITAL SIGNS;

EID: 84947310729     PISSN: 20401116     EISSN: 20401124     Source Type: Journal    
DOI: 10.1111/jdi.12436     Document Type: Article

References (31)

1. Currie JC, Peters RJ, Tynan A, et al. Survival as a function of HbA1c in people with type 2 diabetes: a retrospective cohort study. Lancet 2010; 375: 481-489.
2. Khunti K, Davies M, Majeed A, et al. Hypoglycemia and risk of cardiovascular disease and all-cause mortality in insulin-treated people with type 1 and type 2 diabetes: a cohort study. Diabetes Care 2015; 38: 316-322.
3. Kalfon P, Le Manach Y, Ichai C, et al. Severe and multiple hypoglycemic episodes are associated with increased risk of death in ICU patients. Crit Care 2015; 19: 153.
4. Bagshaw SM, Bellomo R, Jacka MJ, et al. The impact of early hypoglycemia and blood glucose variability on outcome in critical illness. Crit Care 2009; 13: 91.
5. Krinsley JS, Grover A. Severe hypoglycemia in critically ill patients: risk factors and outcomes. Crit Care Med 2007; 35: 2262-2267.
6. Egi M, Bellomo R, Stachowski E, et al. Hypoglycemia and outcome in critically ill patients. Mayo Clin Proc 2010; 85: 217-224.
7. Turchin A, Matheny ME, Shubina M, et al. Hypoglycemia and clinical outcomes in patients with diabetes hospitalized in the general ward. Diabetes Care 2009; 32: 1153-1157.
8. Ley SC, Kindgen-Milles D. Variability of blood glucose concentration and short-term mortality in critically ill patient. Anaesthesist 2007; 56: 820-821.
9. Mendez CE, Mok KT, Ata A, et al. Increased glycemic variability is independently associated with length of stay and mortality in noncritically ill hospitalized patients. Diabetes Care 2013; 36: 4091-4097.
10. Chalmers JD, Singanayagam A, Hill AT. C-reactive protein is an independent predictor of severity in community-acquired pneumonia. Am J Med 2008; 121: 219-225.
11. Watanabe A, Yanagihara K, Kohno S, et al. Multicenter survey on hospital-acquired pneumonia and the clinical efficacy of first-line antibiotics in Japan. Intern Med 2008; 47: 245-254.
12. Johansen TE, Botto H, Cek M, et al. Critical review of current definitions of urinary tract infections and proposal of an EAU/ESIU classification system. Int J Antimicrob Agents 2011; 38: 64-70.
13. Csendes A, Diaz JC, Burdiles P, et al. Risk factors and classification of acute suppurative cholangitis. Br J Surg 1992; 79: 655-658.
14. Yacoub WN, Petrosyan M, Sehgal I, et al. Prediction of patients with acute cholecystitis requiring emergent cholecystectomy: a simple score. Gastroenterol Res Pract. 2010; 2010: 901739.
15. Bagdade JD, Stewart M, Walters E. Impaired granulocyte adherence: a reversible defect in host defense in patients with poorly controlled diabetes. Diabetes 1978; 27: 677-681.
16. Robinson LE, van Soeren MH. Insulin resistance and hyperglycemia in critical illness: role of insulin in glycemic control. AACN Clin Issues 2004; 15: 45-62.
17. Sano T, Umeda F, Hashimoto T, et al. Oxidative stress measurement by in vivo electron spin resonance spectroscopy in rats with streptozotocin-induced diabetes. Diabetologia 1998; 41: 1355-1360.
18. Latham R, Lancaster AD, Covington JF, et al. The association of diabetes and glucose control with surgical-site infections among cardiothoracic surgery patients. Infect Control Hosp Epidemiol 2001; 22: 607-612.
19. Krinsley JS. Glycemic variability: a strong independent predictor of mortality in critically ill patients. Crit Care Med 2008; 36: 3008-3013.
20. Egi M, Bellomo R, Stachowski E, et al. Variability of blood glucose concentration and short-term mortality in critically ill patients. Anesthesiology 2006; 105: 244-252.
21. Rodbard D. Clinical interpretation of indices of quality of glycemic control and glycemic variability. Postgrad Med 2011; 123: 107-118.
22. Siegelaar SE, Holleman F, Hoekstra JB, et al. Glucose variability; does it matter? Endocr Rev 2010; 31: 171-182.
23. Lepper PM, Ott S, Nüesch E, et al. Serum glucose levels for predicting death in patients admitted to hospital for community acquired pneumonia: prospective cohort study. BMJ 2012; 344: 3397.
24. Cryer PE. Severe hypoglycemia predicts mortality in diabetes. Diabetes Care 2012; 35: 1814-1816.
25. Gerich JE. Hypoglycaemia and counterregulation in type 2 diabetes. Lancet 2000; 356: 1946-1947.
26. Ssekitoleko R, Jacob ST, Banura P, et al. Hypoglycemia at admission is associated with inhospital mortality in Ugandan patients with severe sepsis. Crit Care Med 2011; 39: 2271-2276.
27. Peter JV, Mani RK. Association between glycemic variability and mortality: How robust is the evidence? Indian J Crit Care Med 2014; 18: 269-270.
28. Zhao G, Seng J, Yan B, et al. Diagnosis and surgical treatment of ruptured aneurysm in sinus of Valsalva. Chin Med J (Engl) 2003; 116: 1047-1050.
29. Quagliaro L, Piconi L, Assaloni R, et al. Intermittent high glucose enhances apoptosis related to oxidative stress in human umbilical vein endothelial cells: the role of protein kinase C and NAD(P)H-oxidase activation. Diabetes 2003; 52: 2795-2804.
30. Monnier L, Mas E, Ginet C, et al. Activation of oxidative stress by acute glucose fluctuations compared with sustained chronic hyperglycemia in patients with type 2 diabetes. JAMA 2006; 295: 1681-1687.
31. Samuel VT, Shulman GI. Mechanisms for insulin resistance: common threads and missing links. Cell 2012; 148: 852-871.