Efficacy of High-Dose Vitamin D Supplements for Elite Athletes

Medicine and Science in Sports and Exercise

Volumn 49, Issue 2, 2017, Pages 349-356

  Owens, Daniel J ^a   Tang, Jonathan C Y ^b   Bradley, Warren J ^a   Sparks, Andy S ^c   Fraser, William D ^b   Morton, James P ^a   Close, Graeme L ^a  

^a LIVERPOOL JOHN MOORES UNIVERSITY   (United Kingdom)

^b UNIVERSITY OF EAST ANGLIA   (United Kingdom)

^c EDGE HILL UNIVERSITY   (United Kingdom)

Author keywords

1,25 DIHYDROXYVITAMIN D3; 24,25 DIHYDROXYVITAMIN D; 25 HYDROXYVITAMIN D; PARATHYROID HORMONE; Vitamin D

Indexed keywords

CALCIFEDIOL; CALCITRIOL; COLECALCIFEROL; DIHYDROXYCOLECALCIFEROL; PARATHYROID HORMONE; SECALCIFEROL;

ADULT; BLOOD; DIETARY SUPPLEMENT; HUMAN; MALE; PHYSIOLOGY; SPORT;

24,25-DIHYDROXYVITAMIN D 3; ADULT; CALCIFEDIOL; CALCITRIOL; CHOLECALCIFEROL; DIETARY SUPPLEMENTS; DIHYDROXYCHOLECALCIFEROLS; HUMANS; MALE; PARATHYROID HORMONE; SPORTS;

EID: 84991517721     PISSN: 01959131     EISSN: 15300315     Source Type: Journal    
DOI: 10.1249/MSS.0000000000001105     Document Type: Article

References (34)

1. Anderson PH, OLoughlin PD, May BK, Morris HA. Determinants of circulating 1,25-dihydroxyVitamin D3 levels: the role of renal synthesis and catabolism of Vitamin D. J Steroid Biochem Mol Biol. 2004;89-90(1-5):111-3.
2. Carlberg C. Genome-wide (over)view on the actions of Vitamin D. Front Physiol. 2014;5:167.
3. Close GL, Russell J, Cobley JN, et al. Assessment of Vitamin D concentration in non-supplemented professional athletes and healthy adults during the winter months in the UK: implications for skeletal muscle function. J Sports Sci. 2013;31(4):344-53.
4. Cranney A, Horsley T, ODonnell S, et al. Effectiveness and safety of Vitamin D in relation to bone health. Evid Rep Technol Assess (Full Rep). 2007;(158):1-235.
5. Curtis KM, Aenlle KK, Roos BA, Howard GA. 24R,25-dihydroxyVitamin D3 promotes the osteoblastic differentiation of human mesenchymal stem cells. Mol Endocrinol. 2014;28(5):644-58.
6. Demay MB, Kiernan MS, DeLuca HF, Kronenberg HM. Sequences in the human parathyroid hormone gene that bind the 1,25-dihydroxyVitamin D3 receptor and mediate transcriptional repression in response to 1,25-dihydroxyVitamin D3. Proc Natl Acad Sci U S A. 1992;89(17):8097-101.
7. Durup D, JLrgensen HL, Christensen J, Schwarz P, Heegaard AM, Lind B. A reverse J-shaped association of all-cause mortality with serum 25-hydroxyVitamin D in general practice: the CopD study. J Clin Endocrinol Metab. 2012;97(8):2644-52.
8. European Food Safety Authority. Scientific opinion on the tolerable upper intake level of Vitamin D. EFSA J. 2012;10(7):2813.
9. Fu L, Yun F, Oczak M, Wong BY, Vieth R, Cole DE. Common genetic variants of the Vitamin D binding protein (DBP) predict differences in response of serum 25-hydroxyVitamin D [25(OH)D] to Vitamin D supplementation. Clin Biochem. 2009;42(10-11):1174-7.
10. Girgis CM, Mokbel N, Cha KM, et al. The Vitamin D receptor (VDR) is expressed in skeletal muscle of male mice and modulates 25-hydroxyVitamin D (25OHD) uptake in myofibers. Endocrinology. 2014;155(9):3227-37.
11. Haussler MR, Jurutka PW, Mizwicki M, Norman AW. Vitamin D receptor (VDR)-mediated actions of 1,25(OH)2Vitamin D3: genomic and non-genomic mechanisms. Best Pract Res Clin Endocrinol Metab. 2011;25(4):543-59.
12. Hewison M. An update on Vitamin D and human immunity. Clin Endocrinol (Oxf). 2012;76(3):315-25.
13. Holick MF. The photobiology of Vitamin D and its consequences for humans. Ann N Y Acad Sci. 1985;453:1-13.
14. Holick MF, Binkley NC, Bischoff-Ferrari HA, et al. Evaluation, treatment, and prevention of Vitamin D deficiency: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab. 2011;96(7):1911-30.
15. Jones G, Prosser DE, Kaufmann M. 25-HydroxyVitamin D-24-hydroxylase (CYP24A1): its important role in the degradation of Vitamin D. Arch Biochem Biophys. 2012;523(1):9-18.
16. Kadavil J. Guidance for Industry: Bioanalytical Method Validation. Food and Drug Administration, U.S. Department of Health and Human Services. 2001 [cited December 17, 2013]. Available from http://www.fda.gov/downloads/Drugs/Guidances/ucm070107.pdf.
17. Kaufmann M, Gallagher JC, Peacock M, et al. Clinical utility of simultaneous quantitation of 25-hydroxyVitamin D and 24,25-dihydroxyVitamin D by LC-MS/MS involving derivatization with DMEQ-TAD. J Clin Endocrinol Metab. 2014;99(7):2567-74.
18. Kennel KA, Drake MT, Hurley DL. Vitamin D deficiency in adults: when to test and how to treat. Mayo Clin Proc. 2010;85(8):752-77; quiz 757-8.
19. Ketha H, Kumar R, Singh RJ. LC-MS/MS for identifying patients with CYP24A1 mutations. Clin Chem. 2016;62(1):236-42.
20. Lai YH, Fang TC. The pleiotropic effect of Vitamin D. ISRN Nephrol. 2013;2013:898125.
21. Li YC, Pirro AE, Amling M, et al. Targeted ablation of the Vitamin D receptor: an animal model of Vitamin D-dependent rickets type II with alopecia. Proc Natl Acad Sci U S A. 1997;94(18):9831-5.
22. Molin A, Baudoin R, Kaufmann M, et al. CYP24A1 mutations in a cohort of hypercalcemic patients: evidence for a recessive trait. J Clin Endocrinol Metab. 2015;100(10):E1343-52.
23. Morton JP, Iqbal Z, Drust B, Burgess D, Close GL, Brukner PD. Seasonal variation in Vitamin D status in professional soccer players of the English Premier League. Appl Physiol Nutr Metab. 2012;37(4):798-802.
24. Ohyama Y, Ozono K, Uchida M, et al. Functional assessment of two Vitamin D-responsive elements in the rat 25-hydroxyVitamin D3 24-hydroxylase gene. J Biol Chem. 1996;271(48):30381-5.
25. Olsson K, Saini A, Stromberg A, et al. Evidence for Vitamin D receptor expression and direct effects of 1,25(OH)2D3 in human skeletal muscle precursor cells. Endocrinology. 2016;157(1):98-111.
26. Owens DJ, Sharples AP, Polydorou I, et al. A systems-based investigation into Vitamin D and skeletal muscle repair, regeneration, and hypertrophy. Am J Physiol Endocrinol Metab. 2015; 309(12):E1019-31.
27. Owens DJ, Webber D, Impey SG, et al. Vitamin D supplementation does not improve human skeletal muscle contractile properties in insufficient young males. Eur J Appl Physiol. 2014;114(6):1309-20.
28. Quarles LD. Role of FGF23 in Vitamin D and phosphate metabolism: implications in chronic kidney disease. Exp Cell Res. 2012; 318(9):1040-8.
29. Sanders KM, Stuart AL, Williamson EJ, et al. Annual high-dose oral Vitamin D and falls and fractures in older women: a randomized controlled trial. JAMA. 2010;303(18):1815-22.
30. Silver J, Yalcindag C, Sela-Brown A, Kilav R, Naveh-Many T. Regulation of the parathyroid hormone gene by Vitamin D, calcium and phosphate. Kidney Int Suppl. 1999;73:S2-7.
31. Stubbs JR, Zhang S, Friedman PA, Nolin TD. Decreased conversion of 25-hydroxyVitamin D3 to 24,25-dihydroxyVitamin D3 following cholecalciferol therapy in patients with CKD. Clin J Am Soc Nephrol. 2014;9(11):1965-73.
32. The National Academies. Dietary Reference Intakes for Calcium and Vitamin D. Institute of Medicine, Vol.1. Washington (DC): National Academic Press; 2011.
33. van Schoor NM, Lips P. Worldwide Vitamin D status. Best practice &research. Best Pract Res Clin Endocrinol Metab. 2011;25(4):671-80.
34. Wagner D, Hanwell HE, Schnabl K, et al. The ratio of serum 24,25-dihydroxyVitamin D(3) to 25-hydroxyVitamin D(3) is predictive of 25-hydroxyVitamin D(3) response to Vitamin D(3) supplementation. J Steroid Biochem Mol Biol. 2011;126(3-5):72-7.