An aberrant leukotriene A4 hydrolase-proline-glycine-proline pathway in the pathogenesis of chronic obstructive pulmonary disease

American Journal of Respiratory and Critical Care Medicine

Volumn 190, Issue 1, 2014, Pages 51-61

  Wells, J Michael ^a,b,c   O'Reilly, Philip J ^a   Szul, Tomasz ^a   Sullivan, Daniel I ^a   Handley, Guy ^a   Garrett, Chris ^b   McNicholas, Carmel M ^d   Roda, Mojtaba Abdul ^a,e   Miller, Bruce E ^f   Tal Singer, Ruth ^f   Gaggar, Amit ^a,c   Rennard, Stephen I ^g   Jackson, Patricia L ^a,b   Blalock, J Edwin ^a,b  

^a University of Alabama at Birmingham   (United States)

^b UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^c BIRMINGHAM VA MEDICAL CENTER   (United States)

^d UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^e UTRECHT UNIVERSITY   (Netherlands)

^f GLAXOSMITHKLINE   (United States)

^g UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

Author keywords

Acrolein; COPD; Inflammation; PGP

Indexed keywords

ACROLEIN; AMINOPEPTIDASE; CIGARETTE SMOKE; CIGARETTE SMOKE CONDENSATE; EPOXIDE HYDROLASE; GLYCINE; LEUKOTRIENE A4 HYDROLASE; MESSENGER RNA; PROLINE;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHRONIC BRONCHITIS; CHRONIC INFLAMMATION; CHRONIC OBSTRUCTIVE LUNG DISEASE; COHORT ANALYSIS; COMPARATIVE STUDY; CONTROLLED STUDY; COR PULMONALE; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FORCED EXPIRATORY VOLUME; HEART; HEART RIGHT VENTRICLE HYPERTROPHY; HUMAN; LUNG EMPHYSEMA; LUNG LAVAGE; LUNG PARENCHYMA; MAJOR CLINICAL STUDY; MASS SPECTROMETRY; MOUSE; NEUTROPHIL; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; SMOKING; SPUTUM; WESTERN BLOTTING; AGED; ANIMAL; CHEMISTRY; CLINICAL TRIAL; DISEASE MODEL; EMPHYSEMA; HEART MUSCLE; IMMUNOLOGY; INFLAMMATION; LUNG; MALE; METABOLISM; MIDDLE AGED; PATHOPHYSIOLOGY; PGP;

ACROLEIN; COPD; INFLAMMATION; LEUKOTRIENE A4 HYDROLASE; PGP;

AGED; ANIMALS; BRONCHOALVEOLAR LAVAGE FLUID; COHORT STUDIES; DISEASE MODELS, ANIMAL; EMPHYSEMA; EPOXIDE HYDROLASES; FEMALE; GLYCINE; HUMANS; INFLAMMATION; LUNG; MALE; MICE; MIDDLE AGED; MYOCARDIUM; NEUTROPHILS; PROLINE; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE; SMOKING;

EID: 84903833855     PISSN: 1073449X     EISSN: 15354970     Source Type: Journal    
DOI: 10.1164/rccm.201401-0145OC     Document Type: Article

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