Mogamulizumab Treatment Prior to Allogeneic Hematopoietic Stem Cell Transplantation Induces Severe Acute Graft-versus-Host Disease

Biology of Blood and Marrow Transplantation

Volumn 22, Issue 9, 2016, Pages 1608-1614

  Sugio, Takeshi ^a   Kato, Koji ^a   Aoki, Takatoshi ^b   Ohta, Takanori ^c   Saito, Noriyuki ^d   Yoshida, Shuro ^d   Kawano, Ichiro ^d   Henzan, Hideho ^d   Kadowaki, Masanori ^e   Takase, Ken ^e   Muta, Tsuyoshi ^f   Miyawaki, Kohta ^a   Yamauchi, Takuji ^a   Shima, Takahiro ^a   Takashima, Shuichiro ^a   Mori, Yasuo ^a   Yoshimoto, Goichi ^a   Kamezaki, Kenjiro ^a   Takenaka, Katsuto ^a   Iwasaki, Hiromi ^a   Ogawa, Ryosuke ^f   Ohno, Yuju ^c   Eto, Tetsuya ^d   Kamimura, Tomohiko ^b   Miyamoto, Toshihiro ^a   Akashi, Koichi ^a   more..

^a KYUSHU UNIVERSITY   (Japan)

^b HARASANSHIN HOSPITAL   (Japan)

^c KITAKYUSHU MUNICIPAL MEDICAL CENTER   (Japan)

^d HAMANOMACHI HOSPITAL   (Japan)

^e NATIONAL HOSPITAL ORGANIZATION KYUSHU MEDICAL CENTER   (Japan)

^f JCHO Kyushu Hospital   (Japan)

Author keywords

Adult T cell leukemia lymphoma; Allogeneic hematopoietic stem cell transplantation; Graft versus host disease; Mogamulizumab

Indexed keywords

BUSULFAN; CALCINEURIN INHIBITOR; CARBOPLATIN; CYCLOPHOSPHAMIDE; CYTARABINE; DEXAMETHASONE; DOXORUBICIN; ETOPOSIDE; MELPHALAN; METHOTREXATE; MITOXANTRONE; MOGAMULIZUMAB; MYCOPHENOLATE MOFETIL; PREDNISOLONE; RANIMUSTINE; TACROLIMUS; VINCRISTINE; VINDESINE; MONOCLONAL ANTIBODY;

ACUTE GRAFT VERSUS HOST DISEASE; ADULT; AGED; ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION; ARTICLE; ASCITES; BLEEDING; BRAIN INFARCTION; CANCER COMBINATION CHEMOTHERAPY; CANCER IMMUNOTHERAPY; CANCER MORTALITY; CANCER PATIENT; CANCER SURVIVAL; CARDIOTOXICITY; CAUSE OF DEATH; CHRONIC GRAFT VERSUS HOST DISEASE; CONTROLLED STUDY; DISEASE SEVERITY; FEMALE; FLUID RETENTION; FOLLOW UP; HEMORRHAGIC CYSTITIS; HUMAN; LEUKEMIA REMISSION; LUNG TOXICITY; MAJOR CLINICAL STUDY; MALE; OVERALL SURVIVAL; PERICARDIAL EFFUSION; PERIPHERAL BLOOD STEM CELL TRANSPLANTATION; PLEURA EFFUSION; PNEUMATOSIS INTESTINALIS; PROGRESSION FREE SURVIVAL; REDUCED INTENSITY CONDITIONING; RETROSPECTIVE STUDY; T CELL LEUKEMIA; THROMBOTIC THROMBOCYTOPENIC PURPURA; VEIN OCCLUSION; VIRUS PNEUMONIA; WHOLE BODY RADIATION; ACUTE DISEASE; ALLOTRANSPLANTATION; CHEMICALLY INDUCED; COMPLICATION; GRAFT VERSUS HOST REACTION; HEMATOPOIETIC STEM CELL TRANSPLANTATION; MIDDLE AGED; MORTALITY; PROCEDURES; REMISSION; SURVIVAL ANALYSIS;

ACUTE DISEASE; ADULT; AGED; ANTIBODIES, MONOCLONAL, HUMANIZED; FEMALE; GRAFT VS HOST DISEASE; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMANS; LEUKEMIA-LYMPHOMA, ADULT T-CELL; MALE; MIDDLE AGED; REMISSION INDUCTION; RETROSPECTIVE STUDIES; SURVIVAL ANALYSIS; TRANSPLANTATION, HOMOLOGOUS;

EID: 84991248208     PISSN: 10838791     EISSN: 15236536     Source Type: Journal    
DOI: 10.1016/j.bbmt.2016.05.017     Document Type: Article

References (47)

1. 1 Ishitsuka, K., Tamura, K., Human T-cell leukaemia virus type I and adult T-cell leukaemia-lymphoma. Lancet Oncol 15 (2014), e517–e526.
2. 2 Uchiyama, T., Yodoi, J., Sagawa, K., et al. Adult T-cell leukemia: Clinical and hematologic features of 16 cases. Blood 50 (1977), 481–492.
3. 3 Poiesz, B.J., Ruscetti, F.W., Gazdar, A.F., et al. Detection and isolation of type C retrovirus particles from fresh and cultured lymphocytes of a patient with cutaneous T-cell lymphoma. Proc Natl Acad Sci USA 77 (1980), 7415–7419.
4. 4 Taguchi, H., Kinoshita, K.I., Takatsuki, K., et al. An intensive chemotherapy of adult T-cell leukemia/lymphoma: CHOP followed by etoposide, vindesine, ranimustine, and mitoxantrone with granulocyte colony-stimulating factor support. J Acquir Immune Defic Syndr Hum Retrovirol 12 (1996), 182–186.
5. 5 Tsukasaki, K., Maeda, T., Arimura, K., et al. Poor outcome of autologous stem cell transplantation for adult T cell leukemia/lymphoma: a case report and review of the literature. Bone Marrow Transplant 23 (1999), 87–89.
6. 6 Yamada, Y., Tomonaga, M., Fukuda, H., et al. A new G-CSF–supported combination chemotherapy, LSG15, for adult T-cell leukaemia-lymphoma: Japan Clinical Oncology Group Study 9303. Br J Haematol 113 (2001), 375–382.
7. 7 Tsukasaki, K., Utsunomiya, A., Fukuda, H., et al. VCAP-AMP-VECP compared with biweekly CHOP for adult T-cell leukemia-lymphoma: Japan Clinical Oncology Group Study JCOG9801. J Clin Oncol 25 (2007), 5458–5464.
8. 8 Utsunomiya, A., Miyazaki, Y., Takatsuka, Y., et al. Improved outcome of adult T cell leukemia/lymphoma with allogeneic hematopoietic stem cell transplantation. Bone Marrow Transplant 27 (2001), 15–20.
9. 9 Kami, M., Hamaki, T., Miyakoshi, S., et al. Allogeneic haematopoietic stem cell transplantation for the treatment of adult T-cell leukaemia/lymphoma. Br J Haematol 120 (2003), 304–309.
10. 10 Fukushima, T., Miyazaki, Y., Honda, S., et al. Allogeneic hematopoietic stem cell transplantation provides sustained long-term survival for patients with adult T-cell leukemia/lymphoma. Leukemia 19 (2005), 829–834.
11. 11 Okamura, J., Utsunomiya, A., Tanosaki, R., et al. Allogeneic stem-cell transplantation with reduced conditioning intensity as a novel immunotherapy and antiviral therapy for adult T-cell leukemia/lymphoma. Blood 105 (2005), 4143–4145.
12. 12 Nakase, K., Hara, M., Kozuka, T., et al. Bone marrow transplantation from unrelated donors for patients with adult T-cell leukaemia/lymphoma. Bone Marrow Transplant 37 (2006), 41–44.
13. 13 Kato, K., Kanda, Y., Eto, T., et al. Allogeneic bone marrow transplantation from unrelated human T cell leukemia virus-I-negative donors for adult T cell leukemia/lymphoma: retrospective analysis of data from the Japan Marrow Donor Program. Biol Blood Marrow Transplant 13 (2007), 90–99.
14. 14 Shiratori, S., Yasumoto, A., Tanaka, J., et al. A retrospective analysis of allogeneic hematopoietic stem cell transplantation for adult T cell leukemia/lymphoma (ATL): clinical impact of graft-versus-leukemia/lymphoma effect. Biol Blood Marrow Transplant 14 (2008), 817–823.
15. 15 Yonekura, K., Utsunomiya, A., Takatsuka, Y., et al. Graft-versus-adult T-cell leukemia/lymphoma effect following allogeneic hematopoietic stem cell transplantation. Bone Marrow Transplant 41 (2008), 1029–1035.
16. 16 Hishizawa, M., Kanda, J., Utsunomiya, A., et al. Transplantation of allogeneic hematopoietic stem cells for adult T-cell leukemia: a nationwide retrospective study. Blood 116 (2010), 1369–1376.
17. 17 Ishida, T., Hishizawa, M., Kato, K., et al. Allogeneic hematopoietic stem cell transplantation for adult T-cell leukemia-lymphoma with special emphasis on preconditioning regimen: a nationwide retrospective study. Blood 120 (2012), 1734–1741.
18. 18 Kanda, J., Hishizawa, M., Utsunomiya, A., et al. Impact of graft-versus-host disease on outcomes after allogeneic hematopoietic cell transplantation for adult T-cell leukemia: a retrospective cohort study. Blood 119 (2012), 2141–2148.
19. 19 Bazarbachi, A., Cwynarski, K., Boumendil, A., et al. Outcome of patients with HTLV-1–associated adult T-cell leukemia/lymphoma after SCT: a retrospective study by the EBMT LWP. Bone Marrow Transplant 49 (2014), 1266–1268.
20. 20 Kato, K., Choi, I., Wake, A., et al. Treatment of patients with adult T cell leukemia/lymphoma with cord blood transplantation: a Japanese nationwide retrospective survey. Biol Blood Marrow Transplant 20 (2014), 1968–1974.
21. 21 Choi, I., Tanosaki, R., Uike, N., et al. Long-term outcomes after hematopoietic SCT for adult T-cell leukemia/lymphoma: results of prospective trials. Bone Marrow Transplant 46 (2011), 116–118.
22. 22 Yamamoto, K., Utsunomiya, A., Tobinai, K., et al. Phase I study of KW-0761, a defucosylated humanized anti-CCR4 antibody, in relapsed patients with adult T-cell leukemia-lymphoma and peripheral T-cell lymphoma. J Clin Oncol 28 (2010), 1591–1598.
23. 23 Ishida, T., Joh, T., Uike, N., et al. Defucosylated anti-CCR4 monoclonal antibody (KW-0761) for relapsed adult T-cell leukemia-lymphoma: a multicenter phase II study. J Clin Oncol 30 (2012), 837–842.
24. 24 Ogura, M., Ishida, T., Hatake, K., et al. Multicenter phase II study of mogamulizumab (KW-0761), a defucosylated anti-CC chemokine receptor 4 antibody, in patients with relapsed peripheral T-cell lymphoma and cutaneous T-cell lymphoma. J Clin Oncol 32 (2014), 1157–1163.
25. 25 Duvic, M., Pinter-Brown, L.C., Foss, F.M., et al. Phase 1/2 study of mogamulizumab, a defucosylated anti-CCR4 antibody, in previously treated patients with cutaneous T-cell lymphoma. Blood 125 (2015), 1883–1889.
26. 26 Ishida, T., Jo, T., Takemoto, S., et al. Dose-intensified chemotherapy alone or in combination with mogamulizumab in newly diagnosed aggressive adult T-cell leukaemia-lymphoma: a randomized phase II study. Br J Haematol 169 (2015), 672–682.
27. 27 Rezvani, K., Mielke, S., Ahmadzadeh, M., et al. High donor FOXP3-positive regulatory T-cell (Treg) content is associated with a low risk of GVHD following HLA-matched allogeneic SCT. Blood 108 (2006), 1291–1297.
28. 28 Li, Q., Zhai, Z., Xu, X., et al. Decrease of CD4(+)CD25(+) regulatory T cells and TGF-beta at early immune reconstitution is associated to the onset and severity of graft-versus-host disease following allogeneic haematogenesis stem cell transplantation. Leuk Res 34 (2010), 1158–1168.
29. + lymphopenia following allogeneic hematopoietic stem cell transplantation. J Clin Invest 120 (2010), 1479–1493.
30. 30 Di Ianni, M., Falzetti, F., Carotti, A., et al. Tregs prevent GVHD and promote immune reconstitution in HLA-haploidentical transplantation. Blood 117 (2011), 3921–3928.
31. + regulatory T cells, evoking antitumor immune responses in humans. Proc Natl Acad Sci USA 110 (2013), 17945–17950.
32. 32 Przepiorka, D., Weisdorf, D., Martin, P., et al. 1994 Consensus Conference on Acute GVHD Grading. Bone Marrow Transplant 15 (1995), 825–828.
33. 33 Shulman, H.M., Sullivan, K.M., Weiden, P.L., et al. Chronic graft-versus-host syndrome in man: a long-term clinicopathologic study of 20 Seattle patients. Am J Med 69 (1980), 204–217.
34. 34 Giralt, S., Ballen, K., Rizzo, D., et al. Reduced-intensity conditioning regimen workshop: defining the dose spectrum. Report of a workshop convened by the Center for International Blood and Marrow Transplant Research. Biol Blood Marrow Transplant 15 (2009), 367–369.
35. 35 Bacigalupo, A., Ballen, K., Rizzo, D., et al. Defining the intensity of conditioning regimens: working definitions. Biol Blood Marrow Transplant 15 (2009), 1628–1633.
36. 36 Gooley, T.A., Leisenring, W., Crowley, J., Storer, B.E., Estimation of failure probabilities in the presence of competing risks: new representations of old estimators. Stat Med 18 (1999), 695–706.
37. 37 Kanda, Y., Investigation of the freely available easy-to-use software EZR for medical statistics. Bone Marrow Transplant 48 (2013), 452–458.
38. 38 Itonaga, H., Taguchi, J., Fukushima, T., et al. Distinct clinical features of infectious complications in adult T cell leukemia/lymphoma patients after allogeneic hematopoietic stem cell transplantation: a retrospective analysis in the Nagasaki transplant group. Biol Blood Marrow Transplant 19 (2013), 607–615.
39. 39 Ishida, T., Hishizawa, M., Kato, K., et al. Impact of graft-versus-host disease on allogeneic hematopoietic cell transplantation for adult T cell leukemia-lymphoma focusing on preconditioning regimens: nationwide retrospective study. Biol Blood Marrow Transplant 19 (2013), 1731–1739.
40. 40 Fowler, D.H., Gress, R.E., Th2 and Tc2 cells in the regulation of GVHD, GVL, and graft rejection: considerations for the allogeneic transplantation therapy of leukemia and lymphoma. Leuk Lymphoma 38 (2000), 221–234.
41. 41 Ishida, T., Ito, A., Sato, F., et al. Stevens-Johnson Syndrome associated with mogamulizumab treatment of adult T-cell leukemia/lymphoma. Cancer Sci 104 (2013), 647–650.
42. 42 Honda, T., Hishizawa, M., Kataoka, T.R., et al. Stevens-Johnson syndrome associated with mogamulizumab-induced deficiency of regulatory T cells in an adult T-cell leukaemia patient. Acta Derm Venereol 95 (2015), 606–607.
43. 43 Kato, K., Miyamoto, T., Numata, A., et al. Diffuse panbronchiolitis after humanized anti-CCR4 monoclonal antibody therapy for relapsed adult T-cell leukemia/lymphoma. Int J Hematol 97 (2013), 430–432.
44. 44 Ishitsuka, K., Murahashi, M., Katsuya, H., et al. Colitis mimicking graft-versus-host disease during treatment with the anti-CCR4 monoclonal antibody, mogamulizumab. Int J Hematol 102 (2015), 493–497.
45. 45 Utsunomiya, A., Choi, I., Chihara, D., Seto, M., Recent advances in the treatment of adult T-cell leukemia-lymphomas. Cancer Sci 106 (2015), 344–351.
46. 46 Ito, Y., Miyamoto, T., Chong, Y., et al. Successful treatment with anti-CC chemokine receptor 4 MoAb of relapsed adult T-cell leukemia/lymphoma after umbilical cord blood transplantation. Bone Marrow Transplant 48 (2013), 998–999.
47. 47 Suehiro, Y., Hasegawa, A., Iino, T., et al. Clinical outcomes of a novel therapeutic vaccine with Tax peptide-pulsed dendritic cells for adult T cell leukaemia/lymphoma in a pilot study. Br J Haematol 169 (2015), 356–367.